{"id":"https://openalex.org/W1921698397","doi":"https://doi.org/10.1002/14651858.cd008877.pub2","title":"Anaesthetic techniques for risk of malignant tumour recurrence","display_name":"Anaesthetic techniques for risk of malignant tumour recurrence","publication_year":2014,"publication_date":"2014-11-07","ids":{"openalex":"https://openalex.org/W1921698397","doi":"https://doi.org/10.1002/14651858.cd008877.pub2","mag":"1921698397","pmid":"https://pubmed.ncbi.nlm.nih.gov/25379840","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10523187"},"language":"en","primary_location":{"id":"doi:10.1002/14651858.cd008877.pub2","doi":"https://doi.org/10.1002/14651858.cd008877.pub2","is_oa":false,"landing_page_url":"https://doi.org/10.1002/14651858.cd008877.pub2","pdf_url":null,"source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10523187/pdf/CD008877.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061671724","display_name":"\u00d6zlem Serpil \u00c7akmakkaya","orcid":"https://orcid.org/0000-0002-3945-1875","observed_orcids":["https://orcid.org/0000-0002-3945-1875"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ozlem S Cakmakkaya","raw_affiliation_strings":["University of Istanbul, Cerrahpasa Medical School; Department of Medical Education; Istanbul Turkey 34500","Department of Medical Education, University of Istanbul, Cerrahpasa Medical School, Istanbul, Turkey, 34500"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Istanbul, Cerrahpasa Medical School; Department of Medical Education; Istanbul Turkey 34500","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]},{"raw_affiliation_string":"Department of Medical Education, University of Istanbul, Cerrahpasa Medical School, Istanbul, Turkey, 34500","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044589108","display_name":"Kerstin Kolodzie","orcid":"https://orcid.org/0000-0002-3395-6207","observed_orcids":["https://orcid.org/0000-0002-3395-6207"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kerstin Kolodzie","raw_affiliation_strings":["UCSF Medical Center at Mt. Zion, University of California San Francisco; Department of Anesthesia & Perioperative Care; 1600 Divisadero Street, C-453 San Francisco CA USA 94115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSF Medical Center at Mt. Zion, University of California San Francisco; Department of Anesthesia & Perioperative Care; 1600 Divisadero Street, C-453 San Francisco CA USA 94115","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015537537","display_name":"Christian C. Apfel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian C Apfel","raw_affiliation_strings":["University of California San Francisco; Department of Epidemiology & Biostatistics; San Francisco CA USA 94115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco; Department of Epidemiology & Biostatistics; San Francisco CA USA 94115","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031716854","display_name":"Nathan Leon Pace","orcid":"https://orcid.org/0000-0002-8646-5276","observed_orcids":["https://orcid.org/0000-0002-8646-5276"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Leon Pace","raw_affiliation_strings":["University of Utah; Department of Anesthesiology; 3C444 SOM 30 North 1900 East Salt Lake City UT USA 84132-2304"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah; Department of Anesthesiology; 3C444 SOM 30 North 1900 East Salt Lake City UT USA 84132-2304","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5100,"currency":"USD","value_usd":5100},"apc_paid":null,"fwci":1.3373,"has_fulltext":true,"cited_by_count":124,"citation_normalized_percentile":{"value":0.79217877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"2014","issue":"11","first_page":"CD008877","last_page":"CD008877"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12020","display_name":"Enhanced Recovery After Surgery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regional-anesthesia","display_name":"regional anesthesia","score":0.8889999985694885},{"id":"https://openalex.org/keywords/general-anesthesia","display_name":"general anesthesia","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/tumor-resection","display_name":"tumor resection","score":0.6639999747276306},{"id":"https://openalex.org/keywords/perioperative-pain","display_name":"perioperative pain","score":0.3610000014305115},{"id":"https://openalex.org/keywords/opioid-analgesia","display_name":"opioid analgesia","score":0.7739999890327454},{"id":"https://openalex.org/keywords/surgical-stress-response","display_name":"surgical stress response","score":0.722000002861023},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.7269999980926514},{"id":"https://openalex.org/keywords/tumour-cell-dissemination","display_name":"tumour cell dissemination","score":0.5789999961853027},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7039999961853027},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cancer-recurrence-prevention","display_name":"tumor recurrence prevention","score":0.367000013589859},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.4189999997615814},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8665376901626587},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.6732302904129028},{"id":"https://openalex.org/C2776983577","wikidata":"https://www.wikidata.org/wiki/Q166543","display_name":"General anaesthesia","level":2,"score":0.6667932271957397},{"id":"https://openalex.org/C2776098842","wikidata":"https://www.wikidata.org/wiki/Q17152720","display_name":"Surgical stress","level":2,"score":0.6404509544372559},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.48115789890289307},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4528655409812927},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.4422483444213867},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3277393579483032}],"mesh":[{"descriptor_ui":"D000008","descriptor_name":"Abdominal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000008","descriptor_name":"Abdominal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000765","descriptor_name":"Anesthesia, Conduction","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000765","descriptor_name":"Anesthesia, Conduction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000765","descriptor_name":"Anesthesia, Conduction","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019162","descriptor_name":"Anesthetics, Combined","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019162","descriptor_name":"Anesthetics, Combined","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/14651858.cd008877.pub2","doi":"https://doi.org/10.1002/14651858.cd008877.pub2","is_oa":false,"landing_page_url":"https://doi.org/10.1002/14651858.cd008877.pub2","pdf_url":null,"source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10523187","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10523187","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10523187/pdf/CD008877.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database Syst Rev","raw_type":"Text"},{"id":"pmid:25379840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25379840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cochrane database of systematic reviews","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10523187","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10523187","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10523187/pdf/CD008877.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database Syst Rev","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1921698397.pdf","grobid_xml":"https://content.openalex.org/works/W1921698397.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W38419729","https://openalex.org/W1510511771","https://openalex.org/W1585447837","https://openalex.org/W1963721344","https://openalex.org/W1964375059","https://openalex.org/W1979538859","https://openalex.org/W1980770042","https://openalex.org/W1985065014","https://openalex.org/W1985979682","https://openalex.org/W1992326726","https://openalex.org/W1993606888","https://openalex.org/W1994525571","https://openalex.org/W1997402936","https://openalex.org/W1999216860","https://openalex.org/W2001453669","https://openalex.org/W2003605951","https://openalex.org/W2006975316","https://openalex.org/W2009240587","https://openalex.org/W2010477960","https://openalex.org/W2010738780","https://openalex.org/W2012746905","https://openalex.org/W2013569801","https://openalex.org/W2014020177","https://openalex.org/W2018031515","https://openalex.org/W2018211582","https://openalex.org/W2028240889","https://openalex.org/W2033890227","https://openalex.org/W2035632263","https://openalex.org/W2036250674","https://openalex.org/W2040935952","https://openalex.org/W2043041181","https://openalex.org/W2044936430","https://openalex.org/W2047504893","https://openalex.org/W2047891646","https://openalex.org/W2056341285","https://openalex.org/W2059515466","https://openalex.org/W2059740940","https://openalex.org/W2068203282","https://openalex.org/W2070314916","https://openalex.org/W2070659456","https://openalex.org/W2071176742","https://openalex.org/W2071379408","https://openalex.org/W2072872588","https://openalex.org/W2075642745","https://openalex.org/W2081276163","https://openalex.org/W2082833813","https://openalex.org/W2088095316","https://openalex.org/W2088412827","https://openalex.org/W2096446731","https://openalex.org/W2101582799","https://openalex.org/W2109408314","https://openalex.org/W2114892134","https://openalex.org/W2115514072","https://openalex.org/W2121544816","https://openalex.org/W2129168946","https://openalex.org/W2133469067","https://openalex.org/W2145950876","https://openalex.org/W2149453435","https://openalex.org/W2149680769","https://openalex.org/W2150081271","https://openalex.org/W2157230982","https://openalex.org/W2158734599","https://openalex.org/W2158770939","https://openalex.org/W2159732031","https://openalex.org/W2162725795","https://openalex.org/W2168180243","https://openalex.org/W2406481272","https://openalex.org/W2411235124","https://openalex.org/W2413593418","https://openalex.org/W2433275279","https://openalex.org/W2434102454","https://openalex.org/W2598936606","https://openalex.org/W2703135627","https://openalex.org/W4253250767","https://openalex.org/W6718021880"],"related_works":["https://openalex.org/W2046194675","https://openalex.org/W2280801541","https://openalex.org/W2087352004","https://openalex.org/W4312357666","https://openalex.org/W7099432408","https://openalex.org/W2048894064","https://openalex.org/W4406183851","https://openalex.org/W4392315321","https://openalex.org/W4399416578","https://openalex.org/W3160089757"],"abstract_inverted_index":{"BACKGROUND:":[0],"Surgery":[1],"remains":[2],"a":[3,15,158,409,580],"mainstay":[4],"of":[5,19,36,42,53,68,84,88,112,160,203,220,244,252,260,265,268,342,389,411,489,506,515,539,568,607,628,641,658,661,679,691],"treatment":[6],"for":[7,116,168,421,436,445,455,532,536,574,584,612,618,633,652,676,710],"malignant":[8,171,253,262],"tumours;":[9],"however,":[10],"surgical":[11,103],"manipulation":[12],"leads":[13],"to":[14,26,98,138,185,191,197,206,326,375,463,503,512,520,551,561,576,605,623,646],"significant":[16],"systemic":[17,85],"release":[18],"tumour":[20,38,117,254,327,423,521,577,624,647,684],"cells.":[21],"Whether":[22],"these":[23],"cells":[24,39],"lead":[25],"metastases":[27],"is":[28,686,700],"largely":[29],"dependent":[30],"on":[31,249,683],"the":[32,37,43,64,82,102,109,130,140,161,165,242,250,338,356,377,381,393,496,504,513,537,566,585,593,677,714],"balance":[33,65],"between":[34],"aggressiveness":[35],"and":[40,51,61,87,123,144,201,214,217,302,323,340,345,429,448,480,509,518,553,597,615,621,636,644,655,666,698],"resilience":[41],"body.":[44],"Surgical":[45],"stress":[46,104],"per":[47],"se,":[48],"anaesthetic":[49,89,150,282,293,300,312],"agents":[50,90],"administration":[52],"opioid":[54],"analgesics":[55],"perioperatively":[56],"can":[57],"compromise":[58],"immune":[59],"function":[60],"might":[62],"shift":[63],"towards":[66],"progression":[67,578,648],"minimal":[69],"residual":[70],"disease.":[71],"Regional":[72],"anaesthesia":[73,94,114,153,156,248,271,275,286,305,471,475,479,589,681],"techniques":[74,95,115,294,682],"provide":[75],"perioperative":[76],"pain":[77],"relief;":[78],"they":[79],"therefore":[80],"reduce":[81],"quantity":[83],"opioids":[86],"used.":[91],"Additionally,":[92],"regional":[93,113,155,247,281,292,299,311,680],"are":[96,352,485,696],"known":[97],"prevent":[99],"or":[100,157,236,279,290,297,309,368],"attenuate":[101],"response.":[105],"In":[106,132,523],"recent":[107],"years,":[108],"potential":[110],"benefit":[111,678],"recurrence":[118,255,685],"has":[119,124],"received":[120],"major":[121,433],"attention":[122],"been":[125],"discussed":[126],"many":[127],"times":[128],"in":[129,256,713],"literature.":[131],"preparing":[133],"this":[134,711],"review,":[135],"we":[136,391,526],"aimed":[137],"summarize":[139],"current":[141],"evidence":[142,608,675,709],"systematically":[143],"comprehensively.":[145],"OBJECTIVES:":[146],"To":[147,386],"establish":[148],"whether":[149],"technique":[151],"(general":[152,588],"versus":[154,246,273,295,307,473],"combination":[159],"two":[162,510],"techniques)":[163],"influences":[164],"long-term":[166],"prognosis":[167],"individuals":[169],"with":[170,277,288,363,408,477,592],"tumours.":[172,263],"SEARCH":[173],"METHODS:":[174],"We":[175,210,223,230,404],"searched":[176],"The":[177,399,626,639],"Cochrane":[178,400],"Library":[179],"(2013,":[180],"Issue":[181],"12),":[182],"PubMed":[183],"(1950":[184],"15":[186,192,198,207],"December":[187,193,199,208],"2013),":[188,194],"EMBASE":[189],"(1974":[190],"BIOSIS":[195],"(1926":[196],"2013)":[200],"Web":[202],"Science":[204],"(1965":[205],"2013).":[209],"handsearched":[211],"relevant":[212],"websites":[213],"conference":[215],"proceedings":[216],"reference":[218],"lists":[219],"cited":[221],"articles.":[222],"applied":[224],"no":[225],"language":[226],"restrictions.":[227],"SELECTION":[228],"CRITERIA:":[229],"included":[231,316,405,416,498],"all":[232],"randomized":[233,493,693],"controlled":[234,237,494,694],"trials":[235,239,695],"clinical":[238],"that":[240,702],"investigated":[241],"effects":[243],"general":[245,270,274,285,304,470,474,598],"risk":[251,388,657],"patients":[257,418],"undergoing":[258,419,432,443,453],"resection":[259],"primary":[261,349,422],"Comparisons":[264],"interventions":[266],"consisted":[267],"(1)":[269,317],"alone":[272,306,472],"combined":[276,287,476],"one":[278,289,296,308,449],"more":[280,291,298,310],"techniques;":[283,301],"(2)":[284,320],"(3)":[303,324],"techniques.":[313],"Primary":[314],"outcomes":[315,514,538,640],"overall":[318,507,540,613,629],"survival,":[319,508,565],"progression-free":[321,516,554,564,619,642],"survival":[322,517,541,555,614,620,630,643],"time":[325,459,519,575,622,645],"progression.":[328,522,625],"DATA":[329],"COLLECTION":[330],"AND":[331],"ANALYSIS:":[332],"Two":[333,425],"review":[334],"authors":[335],"independently":[336],"scanned":[337],"titles":[339],"abstracts":[341],"identified":[343],"reports":[344],"extracted":[346,371],"study":[347,439,450,534],"data.All":[348],"outcome":[350,505,583,627],"variables":[351],"time-to-event":[353],"data.":[354],"If":[355],"individual":[357],"trial":[358],"report":[359],"provided":[360],"summary":[361],"statistics":[362],"odds":[364],"ratios,":[365],"relative":[366],"risks":[367],"Kaplan-Meier":[369],"curves,":[370],"data":[372,487,573,667],"enabled":[373],"us":[374],"calculate":[376],"hazard":[378,382],"ratio":[379,383,543],"using":[380],"calculating":[384],"spreadsheet.":[385],"assess":[387],"bias,":[390,659],"used":[392],"standard":[394],"methodological":[395],"procedures":[396],"expected":[397],"by":[398],"Collaboration.":[401],"MAIN":[402],"RESULTS:":[403],"four":[406,467,483,497],"studies":[407,415,426,468,484],"total":[410],"746":[412],"participants.":[413],"All":[414,466,482],"adult":[417],"surgery":[420,435,444,454],"resection.":[424],"enrolled":[427,440],"male":[428,441,451],"female":[430],"participants":[431,442,452],"abdominal":[434],"cancer.":[437,457],"One":[438],"prostate":[446],"cancer,":[447],"colon":[456],"Follow-up":[458],"ranged":[460],"from":[461],"nine":[462],"17":[464],"years.":[465],"compared":[469,591],"epidural":[478],"analgesia.":[481],"secondary":[486],"analyses":[488],"previously":[490],"conducted":[491],"prospective":[492,692],"trials.Of":[495],"studies,":[499],"only":[500],"three":[501],"contributed":[502],"each":[511],"our":[524],"meta-analysis,":[525],"could":[527,668],"not":[528,669],"find":[529],"an":[530],"advantage":[531],"either":[533],"group":[535,587,595],"(hazard":[542],"(HR)":[544],"1.03,":[545],"95%":[546,558,602],"confidence":[547],"interval":[548],"(CI)":[549],"0.86":[550],"1.24)":[552],"(HR":[556,600],"0.88,":[557],"CI":[559,603],"0.56":[560],"1.38).":[562],"For":[563],"level":[567],"inconsistency":[569,654],"was":[570,609,631,664],"high.":[571],"Pooled":[572],"showed":[579],"slightly":[581],"favourable":[582],"control":[586],"alone)":[590],"intervention":[594],"(epidural":[596],"anaesthesia)":[599],"1.50,":[601],"1.00":[604],"2.25).Quality":[606],"graded":[610],"low":[611,617],"very":[616],"downgraded":[632,651],"serious":[634,637,653,656],"imprecision":[635],"indirectness.":[638],"were":[649],"also":[650],"respectively.Reporting":[660],"adverse":[662],"events":[663],"sparse,":[665],"be":[670],"analysed.":[671],"AUTHORS'":[672],"CONCLUSIONS:":[673],"Currently,":[674],"inadequate.":[687],"An":[688],"encouraging":[689],"number":[690],"ongoing,":[697],"it":[699],"hoped":[701],"their":[703],"results,":[704],"when":[705],"reported,":[706],"will":[707],"add":[708],"topic":[712],"near":[715],"future.":[716]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}