{"id":"https://openalex.org/W1921689342","doi":"https://doi.org/10.1183/13993003/erj.42.suppl_57.p613","title":"Reduced airway expression of cytoprotective CC10 in COPD patients and mice exposed to cigarette smoke","display_name":"Reduced airway expression of cytoprotective CC10 in COPD patients and mice exposed to cigarette smoke","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W1921689342","doi":"https://doi.org/10.1183/13993003/erj.42.suppl_57.p613","mag":"1921689342"},"language":"en","primary_location":{"id":"doi:10.1183/13993003/erj.42.suppl_57.p613","doi":"https://doi.org/10.1183/13993003/erj.42.suppl_57.p613","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003/erj.42.suppl_57.p613","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037733639","display_name":"Francesca Polverino","orcid":"https://orcid.org/0000-0001-9686-5698","observed_orcids":["https://orcid.org/0000-0001-9686-5698"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesca Polverino","raw_affiliation_strings":["1Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States","Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053025512","display_name":"V\u00edctor Pinto-Plata","orcid":"https://orcid.org/0000-0002-8038-1952","observed_orcids":["https://orcid.org/0000-0002-8038-1952"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Pinto-Plata","raw_affiliation_strings":["1Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States","Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008555938","display_name":"Bartolom\u00e9 R. Celli","orcid":"https://orcid.org/0000-0002-7266-8371","observed_orcids":["https://orcid.org/0000-0002-7266-8371"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bartolome Celli","raw_affiliation_strings":["1Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States","Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022680952","display_name":"Caroline Ann Owen","orcid":"https://orcid.org/0000-0003-4377-3591","observed_orcids":["https://orcid.org/0000-0003-4377-3591"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Owen","raw_affiliation_strings":["1Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States","Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"Suppl 57","first_page":"P613","last_page":"P613"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.8209999799728394},{"id":"https://openalex.org/keywords/airway-epithelium","display_name":"airway epithelium","score":0.9909999966621399},{"id":"https://openalex.org/keywords/airway-epithelial-injury","display_name":"airway epithelial injury","score":0.7310000061988831},{"id":"https://openalex.org/keywords/airway-repair","display_name":"airway repair","score":0.7329999804496765},{"id":"https://openalex.org/keywords/club-cells","display_name":"Clara cells","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8757772445678711},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8342704772949219},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.7519195079803467},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.6974883675575256},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.6937880516052246},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6123571991920471},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.5301552414894104},{"id":"https://openalex.org/C2993351451","wikidata":"https://www.wikidata.org/wiki/Q2386268","display_name":"Cigarette smoke","level":2,"score":0.49687936902046204},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.490658164024353},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.43320998549461365},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3986501395702362},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3814128339290619},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3228132128715515},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.25362175703048706},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1183/13993003/erj.42.suppl_57.p613","doi":"https://doi.org/10.1183/13993003/erj.42.suppl_57.p613","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003/erj.42.suppl_57.p613","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},{"id":"mag:1921689342","doi":null,"is_oa":false,"landing_page_url":"http://erj.ersjournals.com/content/erj/42/Suppl_57/P613.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Respiratory Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8899999856948853,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7100692795","https://openalex.org/W2081306994","https://openalex.org/W2149895452","https://openalex.org/W1955004129","https://openalex.org/W2417869339","https://openalex.org/W2644262902","https://openalex.org/W7015225964","https://openalex.org/W2377918002","https://openalex.org/W4410275550","https://openalex.org/W7095612916"],"abstract_inverted_index":{"Background:":[0],"Clara":[1,11],"cell":[2],"protein":[3,9],"(CC10)":[4],"is":[5,13,40,216],"the":[6,31,47,162,175,232],"major":[7],"secretory":[8],"of":[10,17,44,49,64,177,234,261],"and":[12,51,73,205,258],"crucial":[14],"for":[15,127,190,238],"maintenance":[16],"airway":[18,65,137,219,252,263],"epithelium":[19,138,220],"in":[20,27,46,68,83,85,136,141,174,218,221,251],"health.":[21],"CC10":[22,45,81,134,169,198,214,243,249],"plasma":[23],"levels":[24],"are":[25,34],"reduced":[26,173,217],"COPD":[28,101,110,143,166,222],"patients,":[29],"but":[30,156,185],"underlying":[32],"reasons":[33],"unclear.":[35],"We":[36,113],"tested":[37],"whether":[38],"there":[39],"a":[41,256],"blunted":[42],"expression":[43,82,135,170,215,250],"airways":[48,84,233],"human":[50,147],"mice":[52,121,180,183,186,203,235],"exposed":[53,122,187],"to":[54,61,79,97,106,123,188,236],"cigarette":[55],"smoke":[56],"(CS)":[57],"which":[58],"may":[59,254],"contribute":[60],"impaired":[62],"repair":[63],"epithelial":[66],"injury":[67],"smoke-exposed":[69],"animals.":[70],"Methods:":[71],"Immunostaining":[72],"image":[74],"analysis":[75],"software":[76],"were":[77],"used":[78],"measure":[80],"lung":[86,116],"sections":[87,117],"from":[88,118],"6":[89,93,131,193],"healthy":[90,146],"controls":[91],"vs.":[92,125,145,150,164,181,207],"patients":[94,144,223,225],"with":[95,201,226],"mild":[96,227],"moderately":[98],"severe":[99,105,108],"(M-M)":[100],"(Gold":[102,111],"I-II)":[103],"or":[104,130,192],"very":[107],"(S-VS)":[109],"III-IV).":[112],"also":[114],"immunostained":[115],"C57BL/6":[119],"WT":[120],"air":[124],"CS":[126,189,237],"1,":[128],"3,":[129],"months.":[132],"Results:":[133],"was":[139,157,171],"lower":[140,197],"all":[142],"subjects":[148],"(median=724.2X103":[149],"2806.4x103":[151],"FL":[152],"Units/pixel2,":[153],"respectively":[154],"p<0.001),":[155],"not":[158,172],"significantly":[159,196],"different":[160],"between":[161],"M-M":[163],"S-VS":[165],"groups":[167],"(p=0.09).":[168],"bronchi":[176],"1":[178],"month-smoking":[179],"air-exposed":[182,202],"(p=0.57),":[184],"3":[191],"months":[194,240],"had":[195],"staining":[199],"compared":[200],"(median=1661.2X103":[204],"22.9":[206],"3510X103":[208],"Fl":[209],"Units/px2,":[210],"respectively;":[211],"p<0.001).":[212],"Conclusions:":[213],"including":[224],"disease.":[228],"In":[229],"addition,":[230],"exposing":[231],"3-6":[239],"reduces":[241],"their":[242],"expression.":[244],"These":[245],"results":[246],"indicate":[247],"that":[248],"epithelia":[253],"be":[255],"rapid":[257],"sensitive":[259],"marker":[260],"smoke-induced":[262],"injury.":[264]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}
