{"id":"https://openalex.org/W192158293","doi":"https://doi.org/10.1164/arrd.1974.109.3.345","title":"A clinical method for assessing the ventilatory response to hypoxia.","display_name":"A clinical method for assessing the ventilatory response to hypoxia.","publication_year":1974,"publication_date":"1974-03-01","ids":{"openalex":"https://openalex.org/W192158293","doi":"https://doi.org/10.1164/arrd.1974.109.3.345","mag":"192158293","pmid":"https://pubmed.ncbi.nlm.nih.gov/4814696"},"language":"en","primary_location":{"id":"pmid:4814696","doi":"https://doi.org/10.1164/arrd.1974.109.3.345","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4814696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Journal Article"},"parent_works":[],"lineage":["https://openalex.org/W192158293"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009768214","display_name":"Anthony S. Rebuck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A S Rebuck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059224064","display_name":"E. J. M. Campbell","orcid":"https://orcid.org/0000-0003-3600-7995","observed_orcids":["https://orcid.org/0000-0003-3600-7995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E J Campbell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6894,"has_fulltext":false,"cited_by_count":311,"citation_normalized_percentile":{"value":0.88760218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"109","issue":"3","first_page":"345","last_page":"350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ventilatory-response-to-hypoxia","display_name":"ventilatory response to hypoxia","score":0.925000011920929},{"id":"https://openalex.org/keywords/rebreathing","display_name":"rebreathing","score":0.6650000214576721},{"id":"https://openalex.org/keywords/oxygen-saturation","display_name":"oxygen saturation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/hypoxic-ventilatory-drive","display_name":"hypoxic ventilatory drive","score":0.7400000095367432},{"id":"https://openalex.org/keywords/end-tidal-carbon-dioxide","display_name":"end-tidal carbon dioxide","score":0.6859999895095825},{"id":"https://openalex.org/keywords/ear-oximetry","display_name":"ear oximetry","score":0.7039999961853027},{"id":"https://openalex.org/keywords/hypoxia-tolerance","display_name":"hypoxia tolerance","score":0.37299999594688416},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6853078603744507},{"id":"https://openalex.org/C2777140959","wikidata":"https://www.wikidata.org/wiki/Q10343041","display_name":"pCO2","level":2,"score":0.6794186234474182},{"id":"https://openalex.org/C176674119","wikidata":"https://www.wikidata.org/wiki/Q11582","display_name":"Liter","level":2,"score":0.6151180863380432},{"id":"https://openalex.org/C9930424","wikidata":"https://www.wikidata.org/wiki/Q7426587","display_name":"Saturation (graph theory)","level":2,"score":0.5027799606323242},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4948717951774597},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.480991005897522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4787822961807251},{"id":"https://openalex.org/C2777257755","wikidata":"https://www.wikidata.org/wiki/Q3493813","display_name":"Tidal volume","level":3,"score":0.4418225884437561},{"id":"https://openalex.org/C182215343","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiration","level":2,"score":0.4383390545845032},{"id":"https://openalex.org/C3019162307","wikidata":"https://www.wikidata.org/wiki/Q9530","display_name":"Expired air","level":2,"score":0.41205090284347534},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.35946232080459595},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.3587724566459656},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28169846534729004},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2235933542251587},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20286774635314941},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11360597610473633},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0908937156200409},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002628","descriptor_name":"Chemoreceptor Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005069","descriptor_name":"Evaluation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008722","descriptor_name":"Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010092","descriptor_name":"Oximetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:4814696","doi":"https://doi.org/10.1164/arrd.1974.109.3.345","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4814696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Journal Article"},{"id":"mag:192158293","doi":"https://doi.org/10.1164/arrd.1974.109.3.345","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4814696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1977333663","https://openalex.org/W1979790818","https://openalex.org/W1987832256","https://openalex.org/W2005917726","https://openalex.org/W2054578730","https://openalex.org/W2110791526","https://openalex.org/W2173721970","https://openalex.org/W2260551612","https://openalex.org/W2264646263","https://openalex.org/W2413201780","https://openalex.org/W2425626384","https://openalex.org/W2563870002"],"related_works":["https://openalex.org/W1986009223","https://openalex.org/W2196898764","https://openalex.org/W2460626019","https://openalex.org/W2596562187","https://openalex.org/W2180412447","https://openalex.org/W2260551612","https://openalex.org/W2008985231","https://openalex.org/W4241030872","https://openalex.org/W2037907184","https://openalex.org/W2132944800"],"abstract_inverted_index":{"A":[0],"method":[1,19],"for":[2,10,106],"assessing":[3],"the":[4,55,107,114],"ventilatory":[5],"response":[6,148],"to":[7,20,79,81,87,121],"hypoxia":[8],"suitable":[9],"clinical":[11],"application":[12],"was":[13,60,73,93,119,151],"developed.":[14],"We":[15],"used":[16],"a":[17,41,67],"rebreathing":[18],"create":[21],"progressive":[22],"hypoxia,":[23],"kept":[24],"Pco2":[25,59],"constant,":[26],"and":[27,54,135],"plotted":[28],"ventilation":[29,111],"against":[30,35],"oxygen":[31,36,117,132],"saturation":[32,92,118,133],"rather":[33],"than":[34,154],"tension.":[37],"Subjects":[38],"rebreathed":[39],"from":[40],"6-liter":[42],"bag":[43],"initially":[44],"containing":[45],"7":[46],"per":[47,51,89,124,126,128],"cent":[48,52,129],"CO2,":[49],"24":[50],"O2,":[53],"balance":[56],"N2.":[57],"End-tidal":[58],"held":[61],"at":[62],"\u201cmixed":[63],"venous\u201d":[64],"level":[65],"by":[66,96,113],"variable":[68],"CO2":[69],"absorbing":[70],"bypass.":[71],"Rebreathing":[72],"continued":[74],"until":[75],"end-tidal":[76],"Po2":[77],"fell":[78],"30":[80],"40":[82],"mm":[83],"Hg":[84],"(saturation":[85],"50":[86],"60":[88],"cent).":[90],"Oxygen":[91],"measured":[94],"continuously":[95],"ear":[97],"oximetry.":[98],"The":[99],"interindividual":[100],"range":[101],"in":[102,109,116,131,136,147],"9":[103],"normal":[104],"subjects":[105,150,156],"change":[108,115],"expired":[110],"divided":[112],"0.26":[120],"4.12":[122],"liters":[123],"min":[125],"1":[127],"fall":[130],"(So2),":[134],"all":[137],"studies,":[138,145],"linear":[139],"plots":[140],"were":[141],"obtained.":[142],"In":[143],"repeated":[144],"variation":[146],"within":[149],"significantly":[152],"less":[153],"between":[155],"(F":[157],"=":[158],"10.15;":[159],"p":[160],"<":[161],"0.01).":[162],"Venti...":[163]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}