{"id":"https://openalex.org/W192146159","doi":null,"title":"Dose-dependent efficacy of miglitol, an alpha-glucosidase inhibitor, in type 2 diabetic patients on diet alone: results of a 24-week double-blind placebo-controlled study.","display_name":"Dose-dependent efficacy of miglitol, an alpha-glucosidase inhibitor, in type 2 diabetic patients on diet alone: results of a 24-week double-blind placebo-controlled study.","publication_year":2002,"publication_date":"2002-06-01","ids":{"openalex":"https://openalex.org/W192146159","mag":"192146159","pmid":"https://pubmed.ncbi.nlm.nih.gov/12173729"},"language":"en","primary_location":{"id":"pmid:12173729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12173729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, nutrition & metabolism","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103608675","display_name":"Madeleine L. Drent","orcid":"https://orcid.org/0000-0003-2758-2509","observed_orcids":["https://orcid.org/0000-0003-2758-2509"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M L Drent","raw_affiliation_strings":["Department of Endocrinology, VU Medical Center, Amsterdam, The Netherlands. ml.drent@vumc.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, VU Medical Center, Amsterdam, The Netherlands. ml.drent@vumc.nl","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079657211","display_name":"A T M Tollefsen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A T M Tollefsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014640598","display_name":"FRED H. J. A VAN HEUSDEN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F H J A van Heusden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046431040","display_name":"E B M Hoenderdos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E B M Hoenderdos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076927617","display_name":"Jan J C Jonker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J C Jonker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110095560","display_name":"Eduard A van der Veen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E A van der Veen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0959,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.78393352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"15","issue":"3","first_page":"152","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-glucosidase-inhibitors","display_name":"alpha-glucosidase inhibitors","score":0.968999981880188},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dose-dependent-efficacy","display_name":"dose-dependent efficacy","score":0.7059999704360962},{"id":"https://openalex.org/keywords/dietary-therapy","display_name":"dietary therapy","score":0.5109999775886536},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.7720000147819519},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9900000095367432},{"id":"https://openalex.org/keywords/postprandial-blood-glucose","display_name":"postprandial blood glucose","score":0.9449999928474426},{"id":"https://openalex.org/keywords/serum-insulin","display_name":"serum insulin","score":0.7390000224113464},{"id":"https://openalex.org/keywords/antidiabetic-drug-comparison","display_name":"antidiabetic drug comparison","score":0.5830000042915344},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.38499999046325684},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.7009999752044678},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.5920000076293945},{"id":"https://openalex.org/keywords/medication-discontinuation","display_name":"drug discontinuation","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8489341735839844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8381553888320923},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7425892949104309},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7028645873069763},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5595758557319641},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5036324858665466},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3931647539138794},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.27458763122558594},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005502","descriptor_name":"Food","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005944","descriptor_name":"Glucosamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005944","descriptor_name":"Glucosamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005944","descriptor_name":"Glucosamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017485","descriptor_name":"1-Deoxynojirimycin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D050112","descriptor_name":"Imino Pyranoses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmid:12173729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12173729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, nutrition & metabolism","raw_type":"Clinical Trial"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/491d7c17-fa3b-4201-82d2-5cf26f31dccd","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/491d7c17-fa3b-4201-82d2-5cf26f31dccd","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drent, M L, Tollefsen, A T M, van Heusden, F H J A, Hoenderdos, E B M, Jonker, J J C & van der Veen, E A 2002, 'Dose-dependent efficacy of miglitol, an alpha-glucosidase inhibitor, in type 2 diabetic patients on diet alone : results of a 24-week double-blind placebo-controlled study', Diabetes, nutrition & metabolism, vol. 15, no. 3, pp. 152-9.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vu:oai:research.vu.nl:publications/5c93057f-9f41-4630-9176-7e71448c9f7c","doi":null,"is_oa":false,"landing_page_url":"https://research.vu.nl/en/publications/5c93057f-9f41-4630-9176-7e71448c9f7c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes, Nutrition and Metabolism, Clinical and Experimental, 15, 152 - 159. Editrice Kurtis s.r.l.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/eeb7c94f-3a8f-4b2b-a315-e04a935c5bff","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/eeb7c94f-3a8f-4b2b-a315-e04a935c5bff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes, nutrition & metabolism, 15(3), 152 - 9. Editrice Kurtis s.r.l.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:192146159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12173729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7009107687","https://openalex.org/W2414869606","https://openalex.org/W2396911918","https://openalex.org/W2003163814","https://openalex.org/W75050017","https://openalex.org/W2023815847","https://openalex.org/W3028815480","https://openalex.org/W2170496172","https://openalex.org/W2146327872","https://openalex.org/W23695760"],"abstract_inverted_index":{"AIMS:":[0],"A":[1],"double-blind":[2],"randomised":[3,75],"study":[4],"was":[5,127,245],"performed":[6],"to":[7,207,270,310,358,374],"compare":[8],"the":[9,15,97,101,104,117,145,155,165,176,196,267,293,300,359,362,370],"dose-effect":[10],"and":[11,28,72,92,129,169,191,201,221,227,237,259,264,289,292,335,338,354],"dose-tolerability":[12],"relationships":[13],"between":[14,70],"alpha-glucosidase":[16,320],"inhibitor":[17,321],"miglitol":[18,133,197,230,322,366],"in":[19,36,116,124,144,154,164,175,209,323,341,369],"doses":[20,198,273],"of":[21,84,93,204,274,282,352,365,372],"25":[22,146,231,268],"mg,":[23,25,232,234],"50":[24,156,233,373],"100":[26,166,235,375],"mg":[27,30,147,157,167,178,236,239,269,272,376],"200":[29,177,238,271],"all":[31,132,195],"t.i.d.":[32,35,240,377],"vs":[33],"placebo":[34,50,102,220,258],"patients":[37,54,86,95,327],"with":[38,55,112,136,211,219,229,247,266,296,316],"Type":[39,324],"2":[40,325],"diabetes":[41],"mellitus":[42],"on":[43,328],"diet":[44,329],"only.":[45],"METHODS:":[46],"After":[47],"a":[48,56,68,77,184,311,342],"6-week":[49],"run-in":[51],"period":[52],"468":[53],"fasting":[57],"blood":[58,214],"glucose":[59,181,215,337],">":[60],"or":[61],"=":[62],"7":[63],"mmol/l":[64],"as":[65,67,110],"well":[66],"HbA1c":[69,105,119,333],"6.1%":[71],"10.4%":[73],"were":[74,87,189,280,303,307],"for":[76,89,96,122,131,194],"24-week":[78],"treatment":[79,205],"period.":[80],"RESULTS:":[81],"The":[82,114,242,276,319],"results":[83,356],"465":[85],"valid":[88],"safety":[90,355],"analysis":[91],"384":[94],"efficacy":[98,353],"analysis.":[99],"In":[100],"group":[103,168],"level":[106],"increased":[107,216,295],"by":[108,217,223,255,260],"0.40+/-1.46%":[109],"compared":[111,135,206],"baseline.":[113],"decrease":[115],"mean":[118],"values":[120],"(corrected":[121],"differences":[123],"baseline":[125,212],"values)":[126],"significant":[128],"dose-dependent":[130,343],"groups":[134],"placebo,":[137],"being":[138,286],"-0.46%":[139],"(95%":[140,150,160,171],"CI:":[141,151,161,172],"-0.91%,":[142],"-0.01%)":[143],"group,":[148,158],"-0.45%":[149],"-0.90%,":[152],"-0.003%)":[153],"-0.84%":[159],"-1.31%,":[162],"-0.37%)":[163],"-1.26%":[170],"-1.76%,":[173],"-0.76%)":[174],"group.":[179],"Blood":[180],"levels":[182,252,334,340],"following":[183],"standardised":[185],"breakfast":[186],"tolerance":[187],"test":[188],"significantly":[190],"dose-dependently":[192],"lower":[193],"at":[199],"12":[200],"24":[202],"wk":[203],"baseline:":[208],"comparison":[210],"maximum":[213],"4%":[218],"decreased":[222,254],"7%,":[224],"14%,":[225],"24%":[226],"33%":[228],"respectively.":[241],"same":[243],"pattern":[244],"seen":[246],"postprandial":[248,336],"maximal":[249],"serum":[250],"insulin":[251,339],"which":[253],"8%":[256],"under":[257],"17%,":[261],"26%,":[262],"25%":[263],"35%":[265],"miglitol.":[275],"adverse":[277],"events":[278],"reported":[279],"mainly":[281],"gastrointestinal":[283],"nature,":[284],"mostly":[285],"flatulence,":[287],"diarrhoea":[288],"abdominal":[290],"pain":[291],"incidence":[294],"increasing":[297,315],"dose.":[298,317],"Although":[299],"side":[301,346],"effects":[302,347],"not":[304],"serious,":[305],"they":[306],"troublesome,":[308],"leading":[309],"considerable":[312],"drop-out":[313],"rate":[314],"CONCLUSIONS:":[318],"diabetic":[326],"alone":[330],"decreases":[331],"both":[332],"manner.":[344],"Gastrointestinal":[345],"also":[348],"showed":[349],"dose-dependency.":[350],"Combination":[351],"leads":[357],"conclusion":[360],"that":[361],"optimal":[363],"dose":[364],"will":[367],"be":[368],"range":[371]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}