{"id":"https://openalex.org/W192104791","doi":null,"title":"Activated adherent large granular lymphocytes/natural killer (LGL/NK) cells change their migratory behaviour.","display_name":"Activated adherent large granular lymphocytes/natural killer (LGL/NK) cells change their migratory behaviour.","publication_year":1988,"publication_date":"1988-12-01","ids":{"openalex":"https://openalex.org/W192104791","mag":"192104791","pmid":"https://pubmed.ncbi.nlm.nih.gov/3220508","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385579"},"language":"en","primary_location":{"id":"pmid:3220508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3220508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1385579/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085476917","display_name":"Anna Pirelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Pirelli","raw_affiliation_strings":["Laboratory of Human Immunology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Immunology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065211137","display_name":"Paola Allavena","orcid":"https://orcid.org/0000-0002-6697-6028","observed_orcids":["https://orcid.org/0000-0002-6697-6028"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Allavena","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048654641","display_name":"Alberto Mantovani","orcid":"https://orcid.org/0000-0001-5578-236X","observed_orcids":["https://orcid.org/0000-0001-5578-236X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Mantovani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2921,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.50816446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"4","first_page":"651","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/large-granular-lymphocytes","display_name":"large granular lymphocytes","score":0.9879999756813049},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7940000295639038},{"id":"https://openalex.org/keywords/phorbol-12-13-dibutyrate","display_name":"phorbol 12,13-dibutyrate","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cell-activation","display_name":"cell activation","score":0.718999981880188},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7129999995231628},{"id":"https://openalex.org/keywords/tissue-localization","display_name":"tissue localization","score":0.5479999780654907},{"id":"https://openalex.org/keywords/vascular-adhesion","display_name":"vascular adhesion","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5087404847145081},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5056765079498291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46804356575012207},{"id":"https://openalex.org/C3017602531","wikidata":"https://www.wikidata.org/wiki/Q632518","display_name":"Lymphocyte activation","level":4,"score":0.467719703912735},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.46207430958747864},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.46062391996383667},{"id":"https://openalex.org/C3017695315","wikidata":"https://www.wikidata.org/wiki/Q37713691","display_name":"Phorbol ester","level":4,"score":0.435464471578598},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.28417834639549255},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.27079010009765625},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.1663494110107422},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.156430184841156},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13673245906829834},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1274578869342804},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05359536409378052},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015240","descriptor_name":"Phorbol 12,13-Dibutyrate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:3220508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3220508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1385579","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1385579/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"mag:192104791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3220508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1385579","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1385579/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W89090273","https://openalex.org/W1482236031","https://openalex.org/W1516147959","https://openalex.org/W1572747961","https://openalex.org/W1643485318","https://openalex.org/W1674651902","https://openalex.org/W1970318139","https://openalex.org/W1980535421","https://openalex.org/W2076551413","https://openalex.org/W2118183417","https://openalex.org/W2435318668"],"related_works":["https://openalex.org/W2118183417","https://openalex.org/W2048579356","https://openalex.org/W2010668925","https://openalex.org/W2076551413","https://openalex.org/W1674651902","https://openalex.org/W1482236031","https://openalex.org/W2953589651","https://openalex.org/W2186572826","https://openalex.org/W1966810382","https://openalex.org/W2110818166"],"abstract_inverted_index":{"Unstimulated":[0],"large":[1],"granular":[2],"lymphocytes/natural":[3],"killer":[4],"(LGL/NK)":[5],"cells,":[6],"unlike":[7,22],"small":[8],"T":[9,63],"lymphocytes,":[10],"exhibit":[11],"prompt":[12],"locomotion":[13],"into":[14],"nitrocellulose":[15],"filters":[16],"in":[17,76,100],"response":[18],"to":[19,26,53,93,95],"chemo-attactrants,":[20],"but,":[21],"monocytes,":[23],"are":[24],"unable":[25],"migrate":[27,54],"as":[28,55],"adherent":[29,44,56],"cells":[30,42,57,92],"across":[31,58],"polycarbonate":[32,59],"filters.":[33,60],"Upon":[34],"activation":[35,80],"with":[36],"4-B-phorbol":[37],"12,13":[38],"dibutyrate":[39],"(PDBU),":[40],"LGL/NK":[41,91],"become":[43],"and":[45,98],"change":[46,75],"their":[47],"migratory":[48,77],"behaviour,":[49],"having":[50],"the":[51,69,87],"ability":[52,88],"PDBU-treated":[61],"high-density":[62],"lymphocytes":[64],"did":[65],"not":[66],"show,":[67],"under":[68],"same":[70],"conditions,":[71],"locomotory":[72],"activity.":[73],"The":[74],"behaviour":[78],"following":[79],"may":[81],"represent":[82],"an":[83],"important":[84],"determinant":[85],"of":[86,89],"activated":[90],"adhere":[94],"vascular":[96],"linings":[97],"localize":[99],"tissues.":[101]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}