{"id":"https://openalex.org/W1921020135","doi":"https://doi.org/10.1128/aac.04332-14","title":"Salinomycin and Other Ionophores as a New Class of Antimalarial Drugs with Transmission-Blocking Activity","display_name":"Salinomycin and Other Ionophores as a New Class of Antimalarial Drugs with Transmission-Blocking Activity","publication_year":2015,"publication_date":"2015-06-10","ids":{"openalex":"https://openalex.org/W1921020135","doi":"https://doi.org/10.1128/aac.04332-14","mag":"1921020135","pmid":"https://pubmed.ncbi.nlm.nih.gov/26055362","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4538477"},"language":"en","primary_location":{"id":"doi:10.1128/aac.04332-14","doi":"https://doi.org/10.1128/aac.04332-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.04332-14","pdf_url":"https://aac.asm.org/content/aac/59/9/5135.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aac.asm.org/content/aac/59/9/5135.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085047550","display_name":"Sarah D\u2019Alessandro","orcid":"https://orcid.org/0000-0001-9241-9762","observed_orcids":["https://orcid.org/0000-0001-9241-9762"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sarah D'Alessandro","raw_affiliation_strings":["Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062575247","display_name":"Yolanda Corbett","orcid":"https://orcid.org/0000-0002-7629-846X","observed_orcids":["https://orcid.org/0000-0002-7629-846X"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Yolanda Corbett","raw_affiliation_strings":["Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032984466","display_name":"D\u00e9nise P. Ilboudo","orcid":"https://orcid.org/0000-0002-3315-356X","observed_orcids":["https://orcid.org/0000-0002-3315-356X"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Denise P. Ilboudo","raw_affiliation_strings":["Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049629325","display_name":"Paola Misiano","orcid":"https://orcid.org/0000-0002-6801-9889","observed_orcids":["https://orcid.org/0000-0002-6801-9889"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Misiano","raw_affiliation_strings":["Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069965729","display_name":"Nisha Rani Dahiya","orcid":"https://orcid.org/0000-0002-8452-7947","observed_orcids":["https://orcid.org/0000-0002-8452-7947"]},"institutions":[{"id":"https://openalex.org/I112859197","display_name":"Universit\u00e0 di Camerino","ror":"https://ror.org/0005w8d69","country_code":"IT","type":"education","lineage":["https://openalex.org/I112859197"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nisha Dahiya","raw_affiliation_strings":["Scuola di Scienze del Farmaco e dei Prodotti della Salute, Universit\u00e0 di Camerino, Camerino, Macerata, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scuola di Scienze del Farmaco e dei Prodotti della Salute, Universit\u00e0 di Camerino, Camerino, Macerata, Italy","institution_ids":["https://openalex.org/I112859197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053204143","display_name":"Solom\u00f3n Mequanente Abay","orcid":"https://orcid.org/0000-0002-7844-3771","observed_orcids":["https://orcid.org/0000-0002-7844-3771"]},"institutions":[{"id":"https://openalex.org/I112859197","display_name":"Universit\u00e0 di Camerino","ror":"https://ror.org/0005w8d69","country_code":"IT","type":"education","lineage":["https://openalex.org/I112859197"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Solomon M. Abay","raw_affiliation_strings":["Scuola di Scienze del Farmaco e dei Prodotti della Salute, Universit\u00e0 di Camerino, Camerino, Macerata, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scuola di Scienze del Farmaco e dei Prodotti della Salute, Universit\u00e0 di Camerino, Camerino, Macerata, Italy","institution_ids":["https://openalex.org/I112859197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061540294","display_name":"Annette Habluetzel","orcid":"https://orcid.org/0000-0002-4940-9064","observed_orcids":["https://orcid.org/0000-0002-4940-9064"]},"institutions":[{"id":"https://openalex.org/I112859197","display_name":"Universit\u00e0 di Camerino","ror":"https://ror.org/0005w8d69","country_code":"IT","type":"education","lineage":["https://openalex.org/I112859197"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annette Habluetzel","raw_affiliation_strings":["Scuola di Scienze del Farmaco e dei Prodotti della Salute, Universit\u00e0 di Camerino, Camerino, Macerata, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scuola di Scienze del Farmaco e dei Prodotti della Salute, Universit\u00e0 di Camerino, Camerino, Macerata, Italy","institution_ids":["https://openalex.org/I112859197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103356982","display_name":"Romualdo Grande","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087773","display_name":"Luigi Sacco Hospital","ror":"https://ror.org/0025g8755","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087773","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Romualdo Grande","raw_affiliation_strings":["L. Sacco University Hospital, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L. Sacco University Hospital, Milan, Italy","institution_ids":["https://openalex.org/I4210087773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018107636","display_name":"Maria Rita Gismondo","orcid":"https://orcid.org/0000-0001-6926-8660","observed_orcids":["https://orcid.org/0000-0001-6926-8660"]},"institutions":[{"id":"https://openalex.org/I4210087773","display_name":"Luigi Sacco Hospital","ror":"https://ror.org/0025g8755","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087773","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria R. Gismondo","raw_affiliation_strings":["L. Sacco University Hospital, Milan, Italy","cL. Sacco University Hospital, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L. Sacco University Hospital, Milan, Italy","institution_ids":["https://openalex.org/I4210087773"]},{"raw_affiliation_string":"cL. Sacco University Hospital, Milan, Italy","institution_ids":["https://openalex.org/I4210087773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001000902","display_name":"Koen J. Dechering","orcid":"https://orcid.org/0000-0002-8124-4634","observed_orcids":["https://orcid.org/0000-0002-8124-4634"]},"institutions":[{"id":"https://openalex.org/I4210162625","display_name":"TropIQ Health Sciences","ror":"https://ror.org/050xscb48","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210162625"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Koen J. Dechering","raw_affiliation_strings":["TropIQ Health Sciences, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TropIQ Health Sciences, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210162625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049839078","display_name":"Karin M. J. Koolen","orcid":"https://orcid.org/0000-0003-2464-7215","observed_orcids":["https://orcid.org/0000-0003-2464-7215"]},"institutions":[{"id":"https://openalex.org/I4210162625","display_name":"TropIQ Health Sciences","ror":"https://ror.org/050xscb48","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210162625"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Karin M. J. Koolen","raw_affiliation_strings":["TropIQ Health Sciences, Nijmegen, The Netherlands","dTropIQ Health Sciences, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TropIQ Health Sciences, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210162625"]},{"raw_affiliation_string":"dTropIQ Health Sciences, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210162625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073424910","display_name":"Robert W. Sauerwein","orcid":"https://orcid.org/0000-0002-3163-7202","observed_orcids":["https://orcid.org/0000-0002-3163-7202"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Robert W. Sauerwein","raw_affiliation_strings":["Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007546821","display_name":"Donatella Taramelli","orcid":"https://orcid.org/0000-0001-5108-4492","observed_orcids":["https://orcid.org/0000-0001-5108-4492"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Donatella Taramelli","raw_affiliation_strings":["Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025946835","display_name":"Nicoletta Basilico","orcid":"https://orcid.org/0000-0001-9030-1066","observed_orcids":["https://orcid.org/0000-0001-9030-1066"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicoletta Basilico","raw_affiliation_strings":["Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Universit\u00e0 degli Studi di Milano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Universit\u00e0 degli Studi di Milano, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073911826","display_name":"Silvia Parapini","orcid":"https://orcid.org/0000-0003-2079-8892","observed_orcids":["https://orcid.org/0000-0003-2079-8892"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Parapini","raw_affiliation_strings":["Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit\u00e0 degli Studi di Milano, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.1261,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.93324758,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"59","issue":"9","first_page":"5135","last_page":"5144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salinomycin","display_name":"salinomycin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.9039999842643738},{"id":"https://openalex.org/keywords/transmission-blocking-activity","display_name":"transmission-blocking activity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9909999966621399},{"id":"https://openalex.org/keywords/plasmodium-berghei","display_name":"Plasmodium berghei","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gametocytes","display_name":"gametocytes","score":0.8370000123977661},{"id":"https://openalex.org/keywords/ookinete-development","display_name":"ookinete development","score":0.8100000023841858},{"id":"https://openalex.org/keywords/oocyst-formation","display_name":"oocyst formation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/gametocytogenesis","display_name":"gametocytogenesis","score":0.7429999709129333},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7889999747276306},{"id":"https://openalex.org/keywords/hemolysis-toxicity","display_name":"hemolysis toxicity","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C99389464","wikidata":"https://www.wikidata.org/wiki/Q3319949","display_name":"Gametocyte","level":4,"score":0.9179096221923828},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.8194893598556519},{"id":"https://openalex.org/C2777877089","wikidata":"https://www.wikidata.org/wiki/Q411909","display_name":"Salinomycin","level":3,"score":0.7850760221481323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5884751081466675},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5199026465415955},{"id":"https://openalex.org/C2777330628","wikidata":"https://www.wikidata.org/wiki/Q7033077","display_name":"Nigericin","level":3,"score":0.46389296650886536},{"id":"https://openalex.org/C2777617192","wikidata":"https://www.wikidata.org/wiki/Q189522","display_name":"Quinine","level":3,"score":0.4437094032764435},{"id":"https://openalex.org/C2777199930","wikidata":"https://www.wikidata.org/wiki/Q736270","display_name":"Mefloquine","level":4,"score":0.4346393942832947},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.342776894569397},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.27367258071899414},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2701580226421356},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1402730643749237},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000095662","descriptor_name":"Polyether Polyketides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008985","descriptor_name":"Monensin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008985","descriptor_name":"Monensin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009550","descriptor_name":"Nigericin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009550","descriptor_name":"Nigericin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010962","descriptor_name":"Plasmodium berghei","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010962","descriptor_name":"Plasmodium berghei","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D011714","descriptor_name":"Pyrans","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011714","descriptor_name":"Pyrans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1128/aac.04332-14","doi":"https://doi.org/10.1128/aac.04332-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.04332-14","pdf_url":"https://aac.asm.org/content/aac/59/9/5135.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4538477","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4538477","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:26055362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26055362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/152690","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/152690","pdf_url":"http://hdl.handle.net/2066/152690","source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antimicrobial Agents and Chemotherapy, 59, 5135 - 44","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:air.unimi.it:2434/312486","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2434/312486","pdf_url":null,"source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubblicazioni.unicam.it:11581/387058","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11581/387058","pdf_url":null,"source":{"id":"https://openalex.org/S4306400819","display_name":"Unicam Scientific Publications (University of Camerino)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I112859197","host_organization_name":"Universit\u00e0 di Camerino","host_organization_lineage":["https://openalex.org/I112859197"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/152690","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/152690","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antimicrobial Agents and Chemotherapy, 59, 9, pp. 5135-44","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1128/aac.04332-14","doi":"https://doi.org/10.1128/aac.04332-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.04332-14","pdf_url":"https://aac.asm.org/content/aac/59/9/5135.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3686734904","display_name":"Istituto Superiore di Sanit\u00e0 - to develop two quantitative MTS-HTS gametocyte differentiation assays: a dual luciferase assay monitoring early and late maturation stages in trans...","funder_award_id":"OPP1040394","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1921020135.pdf","grobid_xml":"https://content.openalex.org/works/W1921020135.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W193542914","https://openalex.org/W202927145","https://openalex.org/W1935563522","https://openalex.org/W1971756265","https://openalex.org/W1979867635","https://openalex.org/W1981710440","https://openalex.org/W1986573622","https://openalex.org/W1987098385","https://openalex.org/W1990805655","https://openalex.org/W1991788075","https://openalex.org/W1994357970","https://openalex.org/W1995011527","https://openalex.org/W1999911901","https://openalex.org/W2000508330","https://openalex.org/W2006307101","https://openalex.org/W2009259923","https://openalex.org/W2015787058","https://openalex.org/W2021302679","https://openalex.org/W2026742412","https://openalex.org/W2027790689","https://openalex.org/W2034825883","https://openalex.org/W2035888977","https://openalex.org/W2037588005","https://openalex.org/W2044851002","https://openalex.org/W2049060164","https://openalex.org/W2054001413","https://openalex.org/W2055845643","https://openalex.org/W2071935516","https://openalex.org/W2083216217","https://openalex.org/W2086944623","https://openalex.org/W2090852337","https://openalex.org/W2095344789","https://openalex.org/W2098572157","https://openalex.org/W2099327429","https://openalex.org/W2101792514","https://openalex.org/W2102750214","https://openalex.org/W2111442859","https://openalex.org/W2112127160","https://openalex.org/W2120656656","https://openalex.org/W2125306514","https://openalex.org/W2126638918","https://openalex.org/W2128246136","https://openalex.org/W2133685504","https://openalex.org/W2135797423","https://openalex.org/W2136963773","https://openalex.org/W2138990228","https://openalex.org/W2141190197","https://openalex.org/W2143546607","https://openalex.org/W2151035762","https://openalex.org/W2153783740","https://openalex.org/W2154313767","https://openalex.org/W2156342760","https://openalex.org/W2158302001","https://openalex.org/W2159282513","https://openalex.org/W2161029289","https://openalex.org/W2161083472","https://openalex.org/W2161311583","https://openalex.org/W2163142364","https://openalex.org/W2164862526","https://openalex.org/W2170749429","https://openalex.org/W2171875683","https://openalex.org/W2296263363","https://openalex.org/W2468828447","https://openalex.org/W2576097533","https://openalex.org/W2788073857","https://openalex.org/W3166618611","https://openalex.org/W4211061385","https://openalex.org/W4211136995"],"related_works":["https://openalex.org/W1935563522","https://openalex.org/W2902314524","https://openalex.org/W2098572157","https://openalex.org/W2219517786","https://openalex.org/W4388668350","https://openalex.org/W2101792514","https://openalex.org/W111597113","https://openalex.org/W3019939450","https://openalex.org/W4385283572","https://openalex.org/W1982361753"],"abstract_inverted_index":{"The":[0,35,69,146,193],"drug":[1],"target":[2],"profile":[3],"proposed":[4,61],"by":[5,226],"the":[6,38,45,86,89,102,133,140,177,203,232],"Medicines":[7],"for":[8,11,127,238],"Malaria":[9],"Venture":[10],"a":[12,157,165],"malaria":[13],"elimination/eradication":[14],"policy":[15],"focuses":[16],"on":[17,20,76,85,181,187],"molecules":[18],"active":[19],"both":[21,30,151],"asexual":[22,79,152],"and":[23,32,57,74,80,84,92,111,116,121,135,154,176,184,190,198,220,243],"sexual":[24,81],"stages":[25,83,96],"of":[26,37,47,71,88,101,123,130,168,173,235],"Plasmodium,":[27],"thus":[28],"with":[29,132,139,156],"curative":[31],"transmission-blocking":[33,208,244],"activities.":[34],"aim":[36],"present":[39],"work":[40],"was":[41,107,179,215],"to":[42,171,213],"investigate":[43],"whether":[44],"class":[46],"monovalent":[48,147,236],"ionophores,":[49],"which":[50],"includes":[51],"drugs":[52],"used":[53],"in":[54,109,202],"veterinary":[55],"medicine":[56],"that":[58,172],"were":[59,125,224],"recently":[60],"as":[62,240],"human":[63],"anticancer":[64],"agents,":[65],"meets":[66],"these":[67],"requirements.":[68],"activity":[70],"salinomycin,":[72],"monensin,":[73],"nigericin":[75],"Plasmodium":[77,90],"falciparum":[78,94,104],"erythrocytic":[82],"development":[87,124,197],"berghei":[91],"P.":[93,103],"mosquito":[95,204],"is":[97],"reported":[98],"here.":[99],"Gametocytogenesis":[100],"strain":[105],"3D7":[106],"induced":[108],"vitro,":[110],"gametocytes":[112,155],"at":[113],"stage":[114,119,182,188],"II":[115,189],"III":[117,191],"or":[118],"IV":[120,183],"V":[122,185],"treated":[126],"different":[128],"lengths":[129],"time":[131],"ionophores":[134,148,194,237],"their":[136,207],"viability":[137],"measured":[138],"parasite":[141],"lactate":[142],"dehydrogenase":[143],"(pLDH)":[144],"assay.":[145],"efficiently":[149],"killed":[150],"parasites":[153],"nanomolar":[158],"50%":[159],"inhibitory":[160],"concentration":[161],"(IC50).":[162],"Salinomycin":[163],"showed":[164],"fast":[166],"speed":[167],"kill":[169],"compared":[170],"standard":[174],"drugs,":[175],"potency":[178],"higher":[180],"than":[186],"gametocytes.":[192],"inhibited":[195],"ookinete":[196],"subsequent":[199],"oocyst":[200],"formation":[201],"midgut,":[205],"confirming":[206],"activity.":[209],"Potential":[210],"toxicity":[211],"due":[212],"hemolysis":[214],"excluded,":[216],"since":[217],"only":[218],"infected":[219],"not":[221],"normal":[222],"erythrocytes":[223],"damaged":[225],"ionophores.":[227],"Our":[228],"data":[229],"strongly":[230],"support":[231],"downstream":[233],"exploration":[234],"repositioning":[239],"new":[241],"antimalarial":[242],"leads.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}