{"id":"https://openalex.org/W1920677168","doi":"https://doi.org/10.1186/s40360-015-0025-x","title":"Immune- and miRNA-response to recombinant interferon beta-1a: a biomarker evaluation study to guide the development of novel type I interferon- based therapies","display_name":"Immune- and miRNA-response to recombinant interferon beta-1a: a biomarker evaluation study to guide the development of novel type I interferon- based therapies","publication_year":2015,"publication_date":"2015-09-22","ids":{"openalex":"https://openalex.org/W1920677168","doi":"https://doi.org/10.1186/s40360-015-0025-x","mag":"1920677168","pmid":"https://pubmed.ncbi.nlm.nih.gov/26392348","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4578256"},"language":"en","primary_location":{"id":"doi:10.1186/s40360-015-0025-x","doi":"https://doi.org/10.1186/s40360-015-0025-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40360-015-0025-x","pdf_url":"https://bmcpharmacoltoxicol.biomedcentral.com/track/pdf/10.1186/s40360-015-0025-x","source":{"id":"https://openalex.org/S29101735","display_name":"BMC Pharmacology and Toxicology","issn_l":"2050-6511","issn":["2050-6511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Pharmacology and Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcpharmacoltoxicol.biomedcentral.com/track/pdf/10.1186/s40360-015-0025-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103232549","display_name":"Martin Coenen","orcid":"https://orcid.org/0000-0003-0439-4409","observed_orcids":["https://orcid.org/0000-0003-0439-4409","https://orcid.org/0000-0002-1552-4726"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Martin Coenen","raw_affiliation_strings":["Clinical Study Core Unit, Study Center Bonn (SZB), University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. martin.coenen@ukb.uni-bonn.de","Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. martin.coenen@ukb.uni-bonn.de","Clinical Study Core Unit, Study Center Bonn (SZB), University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Study Core Unit, Study Center Bonn (SZB), University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. martin.coenen@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. martin.coenen@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Clinical Study Core Unit, Study Center Bonn (SZB), University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041906829","display_name":"Annette Viktoria Hinze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123859907","display_name":"Federal Institute for Drugs and Medical Devices","ror":"https://ror.org/05ex5vz81","country_code":"DE","type":"funder","lineage":["https://openalex.org/I123859907"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annette Viktoria Hinze","raw_affiliation_strings":["Federal Institute for Drugs and Medical Devices, Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany. annette-viktoria.hinze@bfarm.de","Federal Institute for Drugs and Medical Devices, Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Institute for Drugs and Medical Devices, Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany. annette-viktoria.hinze@bfarm.de","institution_ids":["https://openalex.org/I123859907"]},{"raw_affiliation_string":"Federal Institute for Drugs and Medical Devices, Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany","institution_ids":["https://openalex.org/I123859907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Martin Mengel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123859907","display_name":"Federal Institute for Drugs and Medical Devices","ror":"https://ror.org/05ex5vz81","country_code":"DE","type":"funder","lineage":["https://openalex.org/I123859907"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Mengel","raw_affiliation_strings":["Federal Institute for Drugs and Medical Devices, Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany. martin.mengel@bfarm.de","Federal Institute for Drugs and Medical Devices, Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Institute for Drugs and Medical Devices, Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany. martin.mengel@bfarm.de","institution_ids":["https://openalex.org/I123859907"]},{"raw_affiliation_string":"Federal Institute for Drugs and Medical Devices, Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany","institution_ids":["https://openalex.org/I123859907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003545407","display_name":"Christine Fuhrmann","orcid":"https://orcid.org/0009-0004-1527-145X","observed_orcids":["https://orcid.org/0009-0004-1527-145X"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christine Fuhrmann","raw_affiliation_strings":["Clinical Study Core Unit, Study Center Bonn (SZB), University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. christine.fuhrmann@ukb.uni-bonn.de","Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. christine.fuhrmann@ukb.uni-bonn.de","Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Study Core Unit, Study Center Bonn (SZB), University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. christine.fuhrmann@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. christine.fuhrmann@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001858544","display_name":"Bastian L\u00fcdenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bastian L\u00fcdenbach","raw_affiliation_strings":["Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. bastian.luedenbach@ukb.uni-bonn.de","Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. bastian.luedenbach@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006635945","display_name":"Julian Zimmermann","orcid":"https://orcid.org/0000-0003-1964-0078","observed_orcids":["https://orcid.org/0000-0003-1964-0078"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julian Zimmermann","raw_affiliation_strings":["Deparment of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. julian.zimmermann@ukb.uni-bonn.de","Deparment of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deparment of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. julian.zimmermann@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Deparment of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058417955","display_name":"Verena Dykstra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Verena Dykstra","raw_affiliation_strings":["Clinical Study Core Unit, Study Center Bonn (SZB), University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. verena.dykstra@ukb.uni-bonn.de","Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. verena.dykstra@ukb.uni-bonn.de","Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Study Core Unit, Study Center Bonn (SZB), University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. verena.dykstra@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. verena.dykstra@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108083579","display_name":"Rolf Fimmers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I4210093117","display_name":"Institut f\u00fcr Medizinische Biometrie, Informatik und Epidemiologie","ror":"https://ror.org/00hyd8090","country_code":"DE","type":"facility","lineage":["https://openalex.org/I135140700","https://openalex.org/I4210093117"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf Fimmers","raw_affiliation_strings":["Institute of Medical Biometrics, Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. fimmers@imbie.meb.uni-bonn.de","Institute of Medical Biometrics, Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Biometrics, Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. fimmers@imbie.meb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I4210093117"]},{"raw_affiliation_string":"Institute of Medical Biometrics, Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I4210093117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028938424","display_name":"Roberto Viviani","orcid":"https://orcid.org/0000-0002-7517-6006","observed_orcids":["https://orcid.org/0000-0002-7517-6006"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roberto Viviani","raw_affiliation_strings":["Department of Psychiatry and Psychotherapy III, University of Ulm, Ulm, Germany. roberto.viviani@uni-ulm.de","Department of Psychiatry and Psychotherapy III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy III, University of Ulm, Ulm, Germany. roberto.viviani@uni-ulm.de","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080262638","display_name":"Julia Stingl","orcid":"https://orcid.org/0000-0002-1566-8156","observed_orcids":["https://orcid.org/0000-0002-1566-8156"]},"institutions":[{"id":"https://openalex.org/I123859907","display_name":"Federal Institute for Drugs and Medical Devices","ror":"https://ror.org/05ex5vz81","country_code":"DE","type":"funder","lineage":["https://openalex.org/I123859907"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Stingl","raw_affiliation_strings":["Federal Institute for Drugs and Medical Devices, Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany. Julia.Stingl@bfarm.de","Federal Institute for Drugs and Medical Devices, Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Institute for Drugs and Medical Devices, Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany. Julia.Stingl@bfarm.de","institution_ids":["https://openalex.org/I123859907"]},{"raw_affiliation_string":"Federal Institute for Drugs and Medical Devices, Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany","institution_ids":["https://openalex.org/I123859907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103194549","display_name":"Stefan Holdenrieder","orcid":"https://orcid.org/0000-0001-8893-1253","observed_orcids":["https://orcid.org/0000-0001-8893-1253"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Holdenrieder","raw_affiliation_strings":["Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. stefan.holdenrieder@ukb.uni-bonn.de","Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. stefan.holdenrieder@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101804925","display_name":"Marcus M\u00fcller","orcid":"https://orcid.org/0000-0001-5797-1527","observed_orcids":["https://orcid.org/0000-0001-5797-1527"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcus M\u00fcller","raw_affiliation_strings":["Deparment of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. marcus_m.mueller@ukb.uni-bonn.de","Deparment of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deparment of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. marcus_m.mueller@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Deparment of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070273513","display_name":"Gunther Hartmann","orcid":"https://orcid.org/0000-0003-1021-2018","observed_orcids":["https://orcid.org/0000-0003-1021-2018"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gunther Hartmann","raw_affiliation_strings":["Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. gunther.hartmann@ukb.uni-bonn.de","Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. gunther.hartmann@ukb.uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071467980","display_name":"Christoph Coch","orcid":"https://orcid.org/0000-0002-0815-6750","observed_orcids":["https://orcid.org/0000-0002-0815-6750"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christoph Coch","raw_affiliation_strings":["Clinical Study Core Unit, Study Center Bonn (SZB), University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. ccoch@uni-bonn.de","Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. ccoch@uni-bonn.de","Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Study Core Unit, Study Center Bonn (SZB), University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. ccoch@uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany. ccoch@uni-bonn.de","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5071467980","https://openalex.org/A5103232549"],"corresponding_institution_ids":["https://openalex.org/I135140700"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.328,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.6069436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"16","issue":"1","first_page":"25","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-beta-1a","display_name":"interferon beta-1a","score":0.878000020980835},{"id":"https://openalex.org/keywords/rig-i","display_name":"RIG-I","score":0.8980000019073486},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8610000014305115},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.4819999933242798},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6050000190734863},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7419999837875366},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cytokine-response","display_name":"cytokine response","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tlr-ligands","display_name":"TLR ligands","score":0.7670000195503235},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.6589999794960022},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6956347227096558},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6073882579803467},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5802509784698486},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5470649600028992},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5261563658714294},{"id":"https://openalex.org/C2908698914","wikidata":"https://www.wikidata.org/wiki/Q2450337","display_name":"Interferon beta-1a","level":4,"score":0.5044494867324829},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4721940755844116},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46019649505615234},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.45214447379112244},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34672659635543823},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32645973563194275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2783406972885132},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2750898003578186},{"id":"https://openalex.org/C2994247566","wikidata":"https://www.wikidata.org/wiki/Q2450337","display_name":"Interferon beta","level":3,"score":0.12756448984146118},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068556","descriptor_name":"Interferon beta-1a","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000068556","descriptor_name":"Interferon beta-1a","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000068556","descriptor_name":"Interferon beta-1a","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000071457","descriptor_name":"DEAD Box Protein 58","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054357","descriptor_name":"Chemokine CXCL10","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054357","descriptor_name":"Chemokine CXCL10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s40360-015-0025-x","doi":"https://doi.org/10.1186/s40360-015-0025-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40360-015-0025-x","pdf_url":"https://bmcpharmacoltoxicol.biomedcentral.com/track/pdf/10.1186/s40360-015-0025-x","source":{"id":"https://openalex.org/S29101735","display_name":"BMC Pharmacology and Toxicology","issn_l":"2050-6511","issn":["2050-6511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Pharmacology and Toxicology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3552048","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4578256","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4578256","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4578256","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Pharmacol Toxicol","raw_type":"Text"},{"id":"pmid:26392348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26392348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC pharmacology & toxicology","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":{"id":"doi:10.1186/s40360-015-0025-x","doi":"https://doi.org/10.1186/s40360-015-0025-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40360-015-0025-x","pdf_url":"https://bmcpharmacoltoxicol.biomedcentral.com/track/pdf/10.1186/s40360-015-0025-x","source":{"id":"https://openalex.org/S29101735","display_name":"BMC Pharmacology and Toxicology","issn_l":"2050-6511","issn":["2050-6511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Pharmacology and Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1126196567","display_name":null,"funder_award_id":"KFO177","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1920677168.pdf","grobid_xml":"https://content.openalex.org/works/W1920677168.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W117116436","https://openalex.org/W1909313221","https://openalex.org/W1964196894","https://openalex.org/W1976752701","https://openalex.org/W1981407617","https://openalex.org/W2004312418","https://openalex.org/W2007962626","https://openalex.org/W2011868039","https://openalex.org/W2013469022","https://openalex.org/W2017515700","https://openalex.org/W2021140221","https://openalex.org/W2028575270","https://openalex.org/W2032948492","https://openalex.org/W2035244702","https://openalex.org/W2062372394","https://openalex.org/W2063876087","https://openalex.org/W2065577539","https://openalex.org/W2071670416","https://openalex.org/W2115161796","https://openalex.org/W2119293746","https://openalex.org/W2141989396","https://openalex.org/W2152842365","https://openalex.org/W2233606434"],"related_works":["https://openalex.org/W7095328050","https://openalex.org/W2111264374","https://openalex.org/W1910043311","https://openalex.org/W1966339678","https://openalex.org/W2131391469","https://openalex.org/W3010374237","https://openalex.org/W2107333717","https://openalex.org/W4249107987","https://openalex.org/W1963879942","https://openalex.org/W6980769439"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,72,164,232,276],"innate":[2],"immune":[3,98,215,307],"receptor":[4],"RIG-I":[5,17,46,66,120,256],"detects":[6],"viral":[7],"RNA":[8],"within":[9,248],"the":[10,20,30,40,53,88,96,114,119,171,174,181,186,191,201,245,249,266,269,283,304,316],"cytosol":[11],"of":[12,16,22,32,42,55,113,173,183,190,193,203,268,272,285],"infected":[13],"cells.":[14],"Activation":[15],"leads":[18],"to":[19,39,77,81,94,100,106,170,240,243,264,302],"induction":[21,293],"antiviral":[23],"cytokines,":[24],"in":[25,69,200,238,309,312,315],"particular":[26],"type":[27,290],"I":[28,133,188,291],"interferon,":[29],"inhibition":[31],"a":[33,48,125,253,261,273,310],"T(H)17":[34],"response":[35,99,224,239,308],"as":[36,38,57,59,220,222,228,295],"well":[37,58,221],"suppression":[41],"tumor":[43],"growth.":[44],"Therefore,":[45,87],"is":[47,67,124,260],"promising":[49],"drug":[50],"target":[51,229],"for":[52,65,109,161,282],"treatment":[54,102,149,242],"cancer":[56],"multiple":[60],"sclerosis.":[61],"A":[62],"specific":[63],"ligand":[64],"currently":[68],"preclinical":[70],"testing.":[71],"first-in-human":[73,116,250],"trial":[74,117,251],"will":[75,156,166,225,235,300],"need":[76],"be":[78,167,226,280],"carefully":[79],"designed":[80],"avoid":[82],"an":[83],"overshooting":[84],"cytokine":[85,210],"response.":[86],"ResI":[89,123,233,259],"study":[90,165,234,263],"was":[91],"set":[92],"up":[93],"analyze":[95],"human":[97,317],"standard":[101,158],"with":[103,144,252],"recombinant":[104],"interferon-beta":[105,148,305],"establish":[107],"biomarkers":[108,237],"safety":[110,267],"and":[111,146,150,180,196,199,218],"efficacy":[112],"upcoming":[115],"investigating":[118],"ligand.":[121,257],"METHODS/DESIGN:":[122],"single":[126],"center,":[127],"prospective,":[128],"open":[129],"label,":[130],"non-randomized":[131],"phase":[132,187],"clinical":[134,270],"trial.":[135],"Three":[136],"different":[137],"cohorts":[138],"(20":[139],"healthy":[140],"volunteers,":[141],"20":[142],"patients":[143,152],"RRMS":[145],"ongoing":[147],"10":[151],"starting":[153],"on":[154,185,214,289],"interferon-beta)":[155],"receive":[157],"interferon-beta-1a":[159],"therapy":[160],"nine":[162],"days.":[163],"conducted":[168],"according":[169],"principles":[172],"german":[175],"medicinal":[176],"products":[177],"act,":[178],"ICH-GCP,":[179],"Declaration":[182],"Helsinki":[184],"unit":[189],"Institute":[192],"Clinical":[194,197],"Chemistry":[195],"Pharmacology":[198],"Department":[202],"Neurology,":[204],"both":[205],"University":[206],"Hospital":[207],"Bonn.":[208],"Interferon-beta-induced":[209],"levels,":[211],"surface":[212],"marker":[213],"cells,":[216],"mRNA-":[217],"miRNA-expression":[219],"psychometric":[223],"investigated":[227],"variables.":[230],"DISCUSSION:":[231],"assess":[236],"interferon-\u03b2":[241],"guide":[244],"dose":[246],"steps":[247],"newly":[254],"developed":[255],"Thus,":[258],"biomarker":[262],"enhance":[265],"development":[271,284],"first-in-class":[274],"compound.":[275],"data":[277],"can":[278],"additionally":[279],"used":[281],"other":[286],"therapies":[287],"based":[288],"interferon":[292],"such":[294],"TLR":[296],"ligands.":[297],"Moreover,":[298],"it":[299],"help":[301],"understand":[303],"induced":[306],"controlled":[311],"vivo":[313],"setting":[314],"system.":[318],"TRIAL":[319],"REGISTRATION:":[320],"clinicaltrials.gov":[321],"ID":[322],"NCT02364986.":[323]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
