{"id":"https://openalex.org/W1920320509","doi":"https://doi.org/10.1093/ndt/10.3.366","title":"Parathyroid hormone and platelet cytosolic calcium concentration in essential hypertension","display_name":"Parathyroid hormone and platelet cytosolic calcium concentration in essential hypertension","publication_year":1995,"publication_date":"1995-03-01","ids":{"openalex":"https://openalex.org/W1920320509","doi":"https://doi.org/10.1093/ndt/10.3.366","mag":"1920320509","pmid":"https://pubmed.ncbi.nlm.nih.gov/7792032"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/10.3.366","doi":"https://doi.org/10.1093/ndt/10.3.366","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/10.3.366","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055078866","display_name":"Esteban Poch","orcid":"https://orcid.org/0000-0002-6492-024X","observed_orcids":["https://orcid.org/0000-0002-6492-024X"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"E. Poch","raw_affiliation_strings":["Nephrology Service, Hospital Clinic I Provincial, University of Barcelona 1 Catalonia, Spain","Nephrology Service, Hospital Clinic I Provincial, University of Barcelona, Catalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Service, Hospital Clinic I Provincial, University of Barcelona 1 Catalonia, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Nephrology Service, Hospital Clinic I Provincial, University of Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063987542","display_name":"Patricia Fern\u00e1ndez\u2010Llama","orcid":"https://orcid.org/0000-0002-7472-2124","observed_orcids":["https://orcid.org/0000-0002-7472-2124"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"P. Fern\u00e1ndez-Llama","raw_affiliation_strings":["Nephrology Service, Hospital Clinic I Provincial, University of Barcelona 1 Catalonia, Spain","Nephrology Service, Hospital Clinic I Provincial, University of BarcelonaCatalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Service, Hospital Clinic I Provincial, University of Barcelona 1 Catalonia, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Nephrology Service, Hospital Clinic I Provincial, University of BarcelonaCatalonia, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015170887","display_name":"Albert Botey","orcid":"https://orcid.org/0000-0002-6965-6601","observed_orcids":["https://orcid.org/0000-0002-6965-6601"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Botey","raw_affiliation_strings":["Nephrology Service, Hospital Clinic I Provincial, University of Barcelona 1 Catalonia, Spain","Nephrology Service, Hospital Clinic I Provincial, University of BarcelonaCatalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Service, Hospital Clinic I Provincial, University of Barcelona 1 Catalonia, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Nephrology Service, Hospital Clinic I Provincial, University of BarcelonaCatalonia, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Gaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Gaya","raw_affiliation_strings":["Hormonal Laboratory, Hospital Clinic I Provincial, University of Barcelona 2 Catalonia, Spain","Hormonal Laboratory, Hospital Clinic I Provincial, University of BarcelonaCatalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hormonal Laboratory, Hospital Clinic I Provincial, University of Barcelona 2 Catalonia, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Hormonal Laboratory, Hospital Clinic I Provincial, University of BarcelonaCatalonia, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111836676","display_name":"A Darnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Darnell","raw_affiliation_strings":["Nephrology Service, Hospital Clinic I Provincial, University of Barcelona 1 Catalonia, Spain","Nephrology Service, Hospital Clinic I Provincial, University of BarcelonaCatalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Service, Hospital Clinic I Provincial, University of Barcelona 1 Catalonia, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Nephrology Service, Hospital Clinic I Provincial, University of BarcelonaCatalonia, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043321094","display_name":"Francisca Rivera","orcid":"https://orcid.org/0000-0002-6612-5418","observed_orcids":["https://orcid.org/0000-0002-6612-5418"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"F. Rivera","raw_affiliation_strings":["Hormonal Laboratory, Hospital Clinic I Provincial, University of Barcelona 2 Catalonia, Spain","Hormonal Laboratory, Hospital Clinic I Provincial, University of BarcelonaCatalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hormonal Laboratory, Hospital Clinic I Provincial, University of Barcelona 2 Catalonia, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Hormonal Laboratory, Hospital Clinic I Provincial, University of BarcelonaCatalonia, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111774574","display_name":"Lluis Revert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"L. Revert","raw_affiliation_strings":["Nephrology Service, Hospital Clinic I Provincial, University of Barcelona 1 Catalonia, Spain","Nephrology Service, Hospital Clinic I Provincial, University of BarcelonaCatalonia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Service, Hospital Clinic I Provincial, University of Barcelona 1 Catalonia, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Nephrology Service, Hospital Clinic I Provincial, University of BarcelonaCatalonia, Spain","institution_ids":["https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055078866"],"corresponding_institution_ids":["https://openalex.org/I71999127"],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":null,"fwci":1.0657,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.75023923,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"10","issue":"3","first_page":"366","last_page":"371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.6963000297546387,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.6963000297546387,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.1273999959230423,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.08940000087022781,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.9729999899864197},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9869999885559082},{"id":"https://openalex.org/keywords/serum-ionized-calcium","display_name":"serum ionized calcium","score":0.7419999837875366},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.8450000286102295},{"id":"https://openalex.org/keywords/extracellular-calcium","display_name":"extracellular calcium","score":0.8370000123977661},{"id":"https://openalex.org/keywords/platelet-function","display_name":"platelet function","score":0.6140000224113464},{"id":"https://openalex.org/keywords/blood-pressure-regulation","display_name":"blood pressure regulation","score":0.703000009059906},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.5799999833106995},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.6740000247955322},{"id":"https://openalex.org/keywords/hyperparathyroidism","display_name":"hyperparathyroidism","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8166286945343018},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7981918454170227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7513860464096069},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.6831266283988953},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6794809699058533},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.6360286474227905},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.5731344223022461},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.5703649520874023},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5264069437980652},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.48806893825531006},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.46226632595062256},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14185184240341187},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08325758576393127}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ndt/10.3.366","doi":"https://doi.org/10.1093/ndt/10.3.366","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/10.3.366","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},{"id":"pmid:7792032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7792032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2138785628","https://openalex.org/W2000781946","https://openalex.org/W2416264456","https://openalex.org/W1975776044","https://openalex.org/W2038500363","https://openalex.org/W7100767274","https://openalex.org/W2050651555","https://openalex.org/W2341617508","https://openalex.org/W2425222307","https://openalex.org/W2017289908"],"abstract_inverted_index":{"Abstract":[0],"To":[1],"investigate":[2],"the":[3,47,79,97,137,150,179,186,212,241,245,278],"possible":[4],"relationships":[5],"between":[6,197],"blood":[7,267],"pressure,":[8,268],"parathyroid":[9],"hormone":[10],"(PTH)":[11],"and":[12,33,67,184,202,243,259],"platelet":[13,115,231,257,280],"cytosolic":[14],"Ca2+":[15,61,154,249],"concentration":[16],"([Ca2+]i)":[17],"in":[18,96,120,123,133,139,144,147,149,162,172,178,185,205,211,221,237,240,244,250,277,283],"patients":[19,26,121,145,181,209,284],"with":[20,27,52,91,135,176,223,285],"essential":[21,53,286],"hypertension,":[22],"we":[23],"studied":[24],"17":[25,34],"this":[28],"disease":[29],"aged":[30,37],"48\u00b12":[31],"years":[32],"normotensive":[35,80],"controls":[36,124,148],"44\u00b13":[38],"years.":[39],"Platelet":[40],"[Ca2+]i":[41,116,201,232,258,281],"was":[42,105,111,117,141,174,194],"measured":[43],"by":[44],"spectrofluorimetry":[45],"using":[46],"dye":[48],"Fura-2":[49],"acetoxymethylester.":[50],"Patients":[51],"hypertension":[54],"displayed":[55],"lower":[56],"levels":[57,72,84],"of":[58,85,100,152,189,208,215,219,247,253],"serum":[59,69,83,203,260],"ionized":[60],"(0.99\u00b10.03":[62],"versus":[63,74,126,156,166],"1.1\u00b10.01":[64],"mmol/l,":[65],"P<0.05)":[66,159],"higher":[68,119],"intact":[70,86],"PTH":[71,87,204,224,261,272],"(37\u00b13":[73],"26\u00b12":[75],"pg/ml,":[76],"P<0.01)":[77,183],"than":[78,122,146],"controls.":[81],"Although":[82],"were":[88,131],"significantly":[89],"correlated":[90,175],"mean":[92],"arterial":[93],"pressure":[94],"(MAP)":[95],"combined":[98,187,213],"group":[99,110,188,207,214,252],"subjects":[101,190],"(r=0.42,":[102,191],"P<0.05),":[103],"there":[104],"no":[106,195,226],"correlation":[107],"when":[108],"each":[109],"considered":[112],"separately.":[113],"Resting":[114],"also":[118,142],"(57\u00b13":[125],"48\u00b12nmol/l,":[127],"P<0.005).":[128],"When":[129],"platelets":[130,220],"stimulated":[132],"vitro":[134,222],"thrombin,":[136],"increment":[138,171],"[ca2+]i":[140,173],"greater":[143],"presence":[151,242],"extracellular":[153,248],"(264\u00b124":[155],"194\u00b119":[157],"nmol/l,":[158],"but":[160],"not":[161,274],"its":[163],"absence":[164,246],"(123\u00b112":[165],"112\u00b110":[167],"nmol/l).":[168],"The":[169],"thrombin-induced":[170,200,235],"MAP":[177],"hypertensive":[180],"(r=0.64,":[182],"P<0.05).":[192],"There":[193],"relationship":[196],"resting":[198,230],"or":[199,210,233],"either":[206,251],"subjects.":[216,254],"Furthermore,":[217],"preincubation":[218],"had":[225],"effect":[227],"neither":[228],"on":[229,234],"increments":[236],"[ca2+]i,":[238],"both":[239],"Therefore,":[255],"despite":[256],"seem":[262],"to":[263,266],"be":[264],"related":[265],"it":[269],"appears":[270],"that":[271],"does":[273],"participate":[275],"directly":[276],"elevated":[279],"found":[282],"hypertension.":[287]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}