{"id":"https://openalex.org/W1920281157","doi":"https://doi.org/10.1111/apha.12625","title":"The NADPH Oxidase Nox4 mediates tumour angiogenesis","display_name":"The NADPH Oxidase Nox4 mediates tumour angiogenesis","publication_year":2015,"publication_date":"2015-10-29","ids":{"openalex":"https://openalex.org/W1920281157","doi":"https://doi.org/10.1111/apha.12625","mag":"1920281157","pmid":"https://pubmed.ncbi.nlm.nih.gov/26513738"},"language":"en","primary_location":{"id":"doi:10.1111/apha.12625","doi":"https://doi.org/10.1111/apha.12625","is_oa":false,"landing_page_url":"https://doi.org/10.1111/apha.12625","pdf_url":null,"source":{"id":"https://openalex.org/S204890612","display_name":"Acta Physiologica","issn_l":"1748-1708","issn":["1748-1708","1748-1716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Physiologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083473276","display_name":"Valeska Helfinger","orcid":"https://orcid.org/0000-0002-7103-2144","observed_orcids":["https://orcid.org/0000-0002-7103-2144"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"V. Helfinger","raw_affiliation_strings":["Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051926333","display_name":"Nina Henke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N. Henke","raw_affiliation_strings":["Institute for Biochemistry I/Pathobiochemistry, Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biochemistry I/Pathobiochemistry, Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017434246","display_name":"Sabine Harenkamp","orcid":"https://orcid.org/0000-0001-8160-310X","observed_orcids":["https://orcid.org/0000-0001-8160-310X"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Harenkamp","raw_affiliation_strings":["Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Walter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Walter","raw_affiliation_strings":["Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011987953","display_name":"Jeremy Epah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Epah","raw_affiliation_strings":["Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002578212","display_name":"Cornelia Penski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Penski","raw_affiliation_strings":["Neurological Institute (Edinger Institute) Goethe-University; Frankfurt Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurological Institute (Edinger Institute) Goethe-University; Frankfurt Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017640916","display_name":"Michel Guy Andr\u00e9 Mittelbronn","orcid":"https://orcid.org/0000-0002-2998-052X","observed_orcids":["https://orcid.org/0000-0002-2998-052X"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Mittelbronn","raw_affiliation_strings":["Neurological Institute (Edinger Institute) Goethe-University; Frankfurt Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurological Institute (Edinger Institute) Goethe-University; Frankfurt Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013415164","display_name":"Katrin Schr\u00f6der","orcid":"https://orcid.org/0000-0002-3099-526X","observed_orcids":["https://orcid.org/0000-0002-3099-526X"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"K. Schr\u00f6der","raw_affiliation_strings":["Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Physiology, Goethe-University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013415164"],"corresponding_institution_ids":["https://openalex.org/I114090438"],"apc_list":{"value":5150,"currency":"USD","value_usd":5150},"apc_paid":null,"fwci":2.761,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.91337568,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"216","issue":"4","first_page":"435","last_page":"446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypoxia-signaling","display_name":"hypoxia signaling","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.796999990940094},{"id":"https://openalex.org/keywords/nox1","display_name":"NOX1","score":0.7179999947547913},{"id":"https://openalex.org/keywords/nox2","display_name":"NOX2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/glucose-transporter-1","display_name":"glucose transporter 1","score":0.8140000104904175},{"id":"https://openalex.org/keywords/adrenomedullin","display_name":"adrenomedullin","score":1.0}],"concepts":[{"id":"https://openalex.org/C2779765511","wikidata":"https://www.wikidata.org/wiki/Q18039812","display_name":"NOX4","level":4,"score":0.9011877775192261},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.89668869972229},{"id":"https://openalex.org/C2776061955","wikidata":"https://www.wikidata.org/wiki/Q18038565","display_name":"NOX1","level":4,"score":0.6369725465774536},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.5715996026992798},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.5491398572921753},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4887568950653076},{"id":"https://openalex.org/C2776495794","wikidata":"https://www.wikidata.org/wiki/Q1362453","display_name":"Fibrosarcoma","level":2,"score":0.48873066902160645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46790844202041626},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.44475695490837097},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4277503490447998},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40507638454437256},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22826501727104187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17119738459587097},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.10468924045562744},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08680638670921326},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08177495002746582},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.07516726851463318}],"mesh":[{"descriptor_ui":"D000074663","descriptor_name":"NADPH Oxidase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/apha.12625","doi":"https://doi.org/10.1111/apha.12625","is_oa":false,"landing_page_url":"https://doi.org/10.1111/apha.12625","pdf_url":null,"source":{"id":"https://openalex.org/S204890612","display_name":"Acta Physiologica","issn_l":"1748-1708","issn":["1748-1708","1748-1716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Physiologica","raw_type":"journal-article"},{"id":"pmid:26513738","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26513738","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta physiologica (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1374194149","display_name":null,"funder_award_id":"SCHR 1241/1-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8107261377","display_name":null,"funder_award_id":"SFB815/TP1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1543662618","https://openalex.org/W1578283200","https://openalex.org/W1971403257","https://openalex.org/W1977185778","https://openalex.org/W1980986856","https://openalex.org/W1982859282","https://openalex.org/W1985125414","https://openalex.org/W1986948325","https://openalex.org/W1998073026","https://openalex.org/W2003112634","https://openalex.org/W2004118426","https://openalex.org/W2008031616","https://openalex.org/W2008533319","https://openalex.org/W2008967297","https://openalex.org/W2018964420","https://openalex.org/W2021469759","https://openalex.org/W2026587757","https://openalex.org/W2027851837","https://openalex.org/W2038019472","https://openalex.org/W2056574134","https://openalex.org/W2056852634","https://openalex.org/W2064710522","https://openalex.org/W2071874738","https://openalex.org/W2085128107","https://openalex.org/W2085609942","https://openalex.org/W2093234681","https://openalex.org/W2102744645","https://openalex.org/W2106925175","https://openalex.org/W2111397801","https://openalex.org/W2125435853","https://openalex.org/W2128635872","https://openalex.org/W2140011724","https://openalex.org/W2140545013","https://openalex.org/W2141366659","https://openalex.org/W2144026946","https://openalex.org/W2150459982","https://openalex.org/W2159127121","https://openalex.org/W2163069245","https://openalex.org/W2167473316","https://openalex.org/W2320703070"],"related_works":["https://openalex.org/W2257954384","https://openalex.org/W1972468602","https://openalex.org/W7098288288","https://openalex.org/W2141366659","https://openalex.org/W1977185778","https://openalex.org/W7095655933","https://openalex.org/W184182026","https://openalex.org/W2133093019","https://openalex.org/W2097383376","https://openalex.org/W2329884677"],"abstract_inverted_index":{"AIM:":[0],"The":[1],"aim":[2],"of":[3,11,54,80,96,111,146,168,172],"this":[4],"work":[5],"was":[6,29,60,103,140,143],"to":[7],"identify":[8],"the":[9,12,35,49,138,144,147,163],"role":[10],"NADPH":[13],"oxidase":[14],"Nox4":[15,175],"for":[16,62,185],"tumour":[17,22,50,58,92,101,177,187],"angiogenesis":[18,28,102,178],"in":[19,24,31,39,71,91,94,105,126,129,137],"a":[20,52,87,124,182],"slow-growing":[21],"model":[23],"mice.":[25,44,77,98,131],"METHODS:":[26],"Tumour":[27],"studied":[30],"tumours":[32,139],"induced":[33,69],"by":[34],"carcinogen":[36],"3-methylcholanthrene":[37,68],"(MCA)":[38],"wild-type":[40],"and":[41,57,64,75,158,170,179],"Nox":[42],"knockout":[43,107,110],"Mice":[45],"were":[46],"killed":[47],"when":[48],"reached":[51],"diameter":[53],"1.5":[55],"cm":[56],"tissue":[59],"used":[61],"histological":[63],"molecular":[65],"analysis.":[66],"RESULTS:":[67],"fibrosarcoma":[70],"wild-type,":[72],"Nox1y/-,":[73],"Nox2y/-":[74],"Nox4-/-":[76,97,130],"Histological":[78],"analysis":[79],"vessel":[81],"density":[82,165],"using":[83],"anti-CD31":[84],"staining":[85],"showed":[86],"significant":[88],"38%":[89],"reduction":[90],"vascularization":[93],"fibrosarcomas":[95],"In":[99],"contrast,":[100],"doubled":[104],"Nox1":[106],"mice,":[108],"whereas":[109],"Nox2":[112],"had":[113],"no":[114],"effect":[115],"on":[116],"tumour-vessel":[117,164],"density.":[118],"As":[119],"underlying":[120],"mechanisms,":[121],"we":[122],"identified":[123],"defect":[125],"hypoxia":[127],"signalling":[128],"Hypoxia-inducible":[132],"factor":[133],"1-alpha":[134],"(Hif-1\u03b1)":[135],"accumulation":[136],"attenuated":[141],"as":[142],"expression":[145],"Hif-1\u03b1-dependent":[148],"pro-angiogenic":[149],"genes":[150],"vascular":[151],"endothelial":[152],"growth":[153],"factor-A,":[154],"glucose":[155],"transporter":[156],"1":[157],"adrenomedullin.":[159],"CONCLUSION:":[160],"By":[161],"regulating":[162],"through":[166],"stabilization":[167],"Hif-1\u03b1":[169],"induction":[171],"VEGF":[173],"expression,":[174],"promotes":[176],"may":[180],"represent":[181],"novel":[183],"target":[184],"anti-angiogenic":[186],"therapy.":[188]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
