{"id":"https://openalex.org/W1920136005","doi":"https://doi.org/10.1111/j.2041-1014.2012.00639.x","title":"Tumor necrosis factor\u2010\u03b1 and interleukin\u20101\u03b2 expression pathway induced by Streptococcus mutans in macrophage cell line RAW 264.7","display_name":"Tumor necrosis factor\u2010\u03b1 and interleukin\u20101\u03b2 expression pathway induced by Streptococcus mutans in macrophage cell line RAW 264.7","publication_year":2012,"publication_date":"2012-02-09","ids":{"openalex":"https://openalex.org/W1920136005","doi":"https://doi.org/10.1111/j.2041-1014.2012.00639.x","mag":"1920136005","pmid":"https://pubmed.ncbi.nlm.nih.gov/22520385"},"language":"en","primary_location":{"id":"doi:10.1111/j.2041-1014.2012.00639.x","doi":"https://doi.org/10.1111/j.2041-1014.2012.00639.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.2041-1014.2012.00639.x","pdf_url":null,"source":{"id":"https://openalex.org/S34700584","display_name":"Molecular Oral Microbiology","issn_l":"2041-1006","issn":["2041-1006","2041-1014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Oral Microbiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1920136005"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074059811","display_name":"J.S. Kim","orcid":"https://orcid.org/0000-0002-4602-8290","observed_orcids":["https://orcid.org/0000-0002-4602-8290"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"J.S. Kim","raw_affiliation_strings":["Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, South Korea","J.S.K. and K.D.K. contributed equally to this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, South Korea","institution_ids":["https://openalex.org/I4921948"]},{"raw_affiliation_string":"J.S.K. and K.D.K. contributed equally to this study","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111506455","display_name":"K.D. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"K.D. Kim","raw_affiliation_strings":["Department of Oral Pathology, School of Dentistry, Pusan National University, Yangsan, South Korea","J.S.K. and K.D.K. contributed equally to this study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, School of Dentistry, Pusan National University, Yangsan, South Korea","institution_ids":["https://openalex.org/I4921948"]},{"raw_affiliation_string":"J.S.K. and K.D.K. contributed equally to this study","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077492810","display_name":"H.S. Na","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"H.S. Na","raw_affiliation_strings":["Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, South Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102975076","display_name":"So\u2010Yeon Jeong","orcid":"https://orcid.org/0000-0001-5737-4634","observed_orcids":["https://orcid.org/0000-0001-5737-4634"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"S.Y. Jeong","raw_affiliation_strings":["Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, South Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007465704","display_name":"Hae Ryoun Park","orcid":"https://orcid.org/0000-0003-1908-0824","observed_orcids":["https://orcid.org/0000-0003-1908-0824"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"H.R. Park","raw_affiliation_strings":["Department of Oral Pathology, School of Dentistry, Pusan National University, Yangsan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, School of Dentistry, Pusan National University, Yangsan, South Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037773992","display_name":"Sangil Kim","orcid":"https://orcid.org/0000-0002-4408-2904","observed_orcids":["https://orcid.org/0000-0002-4408-2904"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"S. Kim","raw_affiliation_strings":["Department of Pediatric Dentistry, School of Dentistry, Pusan National University, Yangsan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Dentistry, School of Dentistry, Pusan National University, Yangsan, South Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032563058","display_name":"Jin Chung","orcid":"https://orcid.org/0000-0002-6859-615X","observed_orcids":["https://orcid.org/0000-0002-6859-615X"]},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"J. Chung","raw_affiliation_strings":["Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, South Korea","institution_ids":["https://openalex.org/I4921948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032563058"],"corresponding_institution_ids":["https://openalex.org/I4921948"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":0.9755,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.72966757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"3","first_page":"149","last_page":"159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-mutans","display_name":"Streptococcus mutans","score":1.0},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.878000020980835},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":1.0},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8379999995231628},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":1.0},{"id":"https://openalex.org/keywords/dental-caries","display_name":"dental caries","score":0.8339999914169312},{"id":"https://openalex.org/keywords/subacute-bacterial-endocarditis","display_name":"subacute bacterial endocarditis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/pyrrolidine-dithiocarbamate","display_name":"pyrrolidine dithiocarbamate","score":0.9089999794960022}],"concepts":[{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6792542934417725},{"id":"https://openalex.org/C2778430296","wikidata":"https://www.wikidata.org/wiki/Q131452","display_name":"Streptococcus mutans","level":3,"score":0.6678687930107117},{"id":"https://openalex.org/C3020084786","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor \u03b1","level":3,"score":0.6241583824157715},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5995334386825562},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5622011423110962},{"id":"https://openalex.org/C3020625565","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin 1\u03b2","level":4,"score":0.46380093693733215},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45066678524017334},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.447148859500885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38783636689186096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35551023483276367},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.29064828157424927},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22960522770881653},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.14756056666374207},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10158449411392212},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09477496147155762},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06158342957496643}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000873","descriptor_name":"Anthracenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013295","descriptor_name":"Streptococcus mutans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013859","descriptor_name":"Thiocarbamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052002","descriptor_name":"NF-kappa B p50 Subunit","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D052002","descriptor_name":"NF-kappa B p50 Subunit","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.2041-1014.2012.00639.x","doi":"https://doi.org/10.1111/j.2041-1014.2012.00639.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.2041-1014.2012.00639.x","pdf_url":null,"source":{"id":"https://openalex.org/S34700584","display_name":"Molecular Oral Microbiology","issn_l":"2041-1006","issn":["2041-1006","2041-1014"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Oral Microbiology","raw_type":"journal-article"},{"id":"pmid:22520385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22520385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular oral microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1482091605","https://openalex.org/W1857824984","https://openalex.org/W1863808583","https://openalex.org/W1868478050","https://openalex.org/W1940788159","https://openalex.org/W1980110441","https://openalex.org/W1983444348","https://openalex.org/W1994401368","https://openalex.org/W1995744610","https://openalex.org/W2004773897","https://openalex.org/W2034184306","https://openalex.org/W2035805275","https://openalex.org/W2041327426","https://openalex.org/W2051026238","https://openalex.org/W2057809738","https://openalex.org/W2069133721","https://openalex.org/W2077567363","https://openalex.org/W2081687035","https://openalex.org/W2085617261","https://openalex.org/W2089904066","https://openalex.org/W2096678608","https://openalex.org/W2100719344","https://openalex.org/W2111111355","https://openalex.org/W2116766330","https://openalex.org/W2129196957","https://openalex.org/W2130616887","https://openalex.org/W2142602618","https://openalex.org/W2143640539","https://openalex.org/W2145803213","https://openalex.org/W2147390013","https://openalex.org/W2152326327","https://openalex.org/W2158140984","https://openalex.org/W2173541155","https://openalex.org/W4210970544"],"related_works":["https://openalex.org/W2311649005","https://openalex.org/W2357427837","https://openalex.org/W1940788159","https://openalex.org/W2119641775","https://openalex.org/W2164266688","https://openalex.org/W2158140984","https://openalex.org/W3181013456","https://openalex.org/W1863808583"],"abstract_inverted_index":{"Streptococcus":[0],"mutans,":[1],"a":[2,50,73,113,128,170,179],"major":[3],"etiological":[4],"agent":[5],"of":[6,29,67,75,77,97,100,140,168,247],"dental":[7],"caries,":[8],"frequently":[9],"causes":[10],"systemic":[11],"disease,":[12],"such":[13],"as":[14],"subacute":[15],"bacterial":[16],"endocarditis,":[17],"if":[18],"it":[19],"enters":[20],"the":[21,26,30,65,95,101,134,150,166,188,212,220,230,235,245,252],"bloodstream.":[22],"In":[23,204],"this":[24],"study,":[25],"production":[27,96,207,225,246],"pathways":[28],"proinflammatory":[31],"cytokines,":[32],"tumor":[33],"necrosis":[34],"factor-\u03b1":[35],"(TNF-\u03b1)":[36],"and":[37,56,69,85,103,111,117,126,142,145,249,262,266],"interleukin-1\u03b2":[38],"(IL-1\u03b2),":[39],"induced":[40,94],"by":[41,149,165,195,259],"S.":[42,62,135,159,242],"mutans":[43,63,136,243],"in":[44,211,219,229,234,251],"mouse":[45,253],"macrophage":[46,254],"were":[47],"examined":[48],"using":[49],"quantitative":[51],"real-time":[52],"polymerase":[53],"chain":[54],"reaction":[55],"an":[57,155],"enzyme-linked":[58],"immunosorbent":[59],"assay.":[60],"The":[61,138,158],"stimulated":[64],"expression":[66,139,162,192],"TNF-\u03b1":[68,102,141,161,206,248],"IL-1\u03b2":[70,104,143,191,224,250],"mRNA":[71,144],"at":[72,83,108,115],"multiplicity":[74],"infection":[76],"1":[78],":":[79],"100,":[80],"which":[81,106],"increased":[82,107],"2":[84,109],"4":[86,116],"h,":[87,119],"respectively,":[88],"to":[89],"24":[90,118],"h.":[91],"It":[92],"also":[93],"high":[98],"levels":[99],"proteins,":[105],"h":[110],"reached":[112,127],"peak":[114],"respectively.":[120,268],"Nuclear":[121],"factor-\u03baB":[122],"(NF-\u03baB)":[123],"was":[124,147,163,193,208,226],"activated":[125],"maximum":[129],"level":[130],"30":[131],"min":[132],"after":[133],"treatment.":[137],"protein":[146,173],"suppressed":[148,164,209,227],"treatment":[151],"with":[152],"pyrrolidine":[153],"dithiocarbamate,":[154],"NF-\u03baB":[156,263],"inhibitor.":[157,186],"mutans-induced":[160],"presence":[167],"SB203580,":[169],"p38":[171],"mitogen-activated":[172],"(MAP)":[174],"kinase":[175,182,185,198,201],"inhibitor,":[176],"or":[177],"SP600125,":[178],"Jun":[180],"N-terminal":[181],"(JNK)":[183],"MAP":[184,200],"On":[187],"other":[189],"hand,":[190],"inhibited":[194],"extracellular":[196],"signal-regulated":[197],"(ERK)/p38/JNK":[199],"inhibitor":[202],"pretreatment.":[203],"addition,":[205],"more":[210,228],"Toll-like":[213],"receptor":[214],"2(-/-)":[215],"(TLR2(-/-))":[216],"macrophages":[217,232],"than":[218,233],"TLR4(-/-)":[221,231],"macrophages,":[222],"whereas":[223],"TLR2(-/-)":[236],"macrophages.":[237],"These":[238],"results":[239],"show":[240],"that":[241],"stimulates":[244],"cell":[255],"line,":[256],"RAW":[257],"264.7,":[258],"activating":[260],"ERK/p38/JNK,":[261],"through":[264],"TLR2":[265],"TLR4,":[267]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}