{"id":"https://openalex.org/W1920108425","doi":null,"title":"Pharmacological studies of compounds targeting glutamate transporter 1 for the attenuation of alcohol-drinking behavior in alcohol preferring rats","display_name":"Pharmacological studies of compounds targeting glutamate transporter 1 for the attenuation of alcohol-drinking behavior in alcohol preferring rats","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1920108425","mag":"1920108425"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:mco1370438659","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1370438659","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1370438659","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1370438659","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1370438659","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051765120","display_name":"Hasan Alhaddad","orcid":"https://orcid.org/0000-0002-3633-5705","observed_orcids":["https://orcid.org/0000-0002-3633-5705"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hasan Alhaddad","raw_affiliation_strings":["University of Toledo"],"raw_orcid":"https://orcid.org/0000-0002-3633-5705","affiliations":[{"raw_affiliation_string":"University of Toledo","institution_ids":["https://openalex.org/I90871651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051765120"],"corresponding_institution_ids":["https://openalex.org/I90871651"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05747877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6967999935150146,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6967999935150146,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.2312999963760376,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glt-1","display_name":"GLT-1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/alcohol-preferring-rats","display_name":"alcohol-preferring rats","score":0.6380000114440918},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.5370000004768372},{"id":"https://openalex.org/keywords/ethanol-self-administration","display_name":"ethanol self-administration","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ceftriaxone","display_name":"ceftriaxone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/slc7a11","display_name":"SLC7A11","score":0.8180000185966492},{"id":"https://openalex.org/keywords/glast","display_name":"GLAST","score":0.9039999842643738},{"id":"https://openalex.org/keywords/glutamatergic-system","display_name":"glutamatergic system","score":0.7369999885559082},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.6460000276565552},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.5759999752044678},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.9679999947547913},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.7643629312515259},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6349037289619446},{"id":"https://openalex.org/C113657865","wikidata":"https://www.wikidata.org/wiki/Q5419641","display_name":"Excitatory amino-acid transporter","level":4,"score":0.6107686161994934},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.596041202545166},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4918816089630127},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4191577434539795},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3737771511077881},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3578508496284485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35365140438079834},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2493738830089569},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08639803528785706},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:mco1370438659","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1370438659","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1370438659","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1370438659","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.687.566","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.687.566","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://utdr.utoledo.edu/cgi/viewcontent.cgi?article%3D1026%26context%3Dtheses-dissertations","raw_type":"text"},{"id":"mag:1920108425","doi":null,"is_oa":false,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1370438659","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:mco1370438659","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1370438659","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1370438659","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1370438659","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326118","display_name":"Higher Committee for Education Development in Iraq","ror":"https://ror.org/00wnaaa58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1920108425.pdf","grobid_xml":"https://content.openalex.org/works/W1920108425.grobid-xml"},"referenced_works_count":159,"referenced_works":["https://openalex.org/W14199531","https://openalex.org/W104238112","https://openalex.org/W112510839","https://openalex.org/W165035761","https://openalex.org/W207551684","https://openalex.org/W1491875775","https://openalex.org/W1592375995","https://openalex.org/W1599662080","https://openalex.org/W1601296623","https://openalex.org/W1630907922","https://openalex.org/W1635084872","https://openalex.org/W1918535853","https://openalex.org/W1963790626","https://openalex.org/W1966793802","https://openalex.org/W1968338376","https://openalex.org/W1969728057","https://openalex.org/W1971395905","https://openalex.org/W1971402629","https://openalex.org/W1971752070","https://openalex.org/W1972906411","https://openalex.org/W1973590039","https://openalex.org/W1974778230","https://openalex.org/W1974840438","https://openalex.org/W1977850361","https://openalex.org/W1978104883","https://openalex.org/W1978411103","https://openalex.org/W1979575761","https://openalex.org/W1980527519","https://openalex.org/W1981444301","https://openalex.org/W1981505515","https://openalex.org/W1982214096","https://openalex.org/W1982414338","https://openalex.org/W1983661921","https://openalex.org/W1983955342","https://openalex.org/W1985180181","https://openalex.org/W1985647606","https://openalex.org/W1988594055","https://openalex.org/W1989416066","https://openalex.org/W1990859267","https://openalex.org/W1994662713","https://openalex.org/W1995085986","https://openalex.org/W1996589674","https://openalex.org/W1998441599","https://openalex.org/W2000021590","https://openalex.org/W2003410399","https://openalex.org/W2004006565","https://openalex.org/W2005111389","https://openalex.org/W2006588864","https://openalex.org/W2008803292","https://openalex.org/W2009548083","https://openalex.org/W2010555262","https://openalex.org/W2010739745","https://openalex.org/W2012753018","https://openalex.org/W2013032254","https://openalex.org/W2014692841","https://openalex.org/W2014776578","https://openalex.org/W2014987993","https://openalex.org/W2015046028","https://openalex.org/W2015805931","https://openalex.org/W2018075757","https://openalex.org/W2020058206","https://openalex.org/W2020680441","https://openalex.org/W2022748226","https://openalex.org/W2023391636","https://openalex.org/W2024031866","https://openalex.org/W2024680557","https://openalex.org/W2026265399","https://openalex.org/W2026776322","https://openalex.org/W2030585808","https://openalex.org/W2033374123","https://openalex.org/W2036236167","https://openalex.org/W2037414045","https://openalex.org/W2037457092","https://openalex.org/W2038859198","https://openalex.org/W2039211605","https://openalex.org/W2042377944","https://openalex.org/W2042740099","https://openalex.org/W2042857010","https://openalex.org/W2042894136","https://openalex.org/W2043354652","https://openalex.org/W2045165595","https://openalex.org/W2045185962","https://openalex.org/W2045484191","https://openalex.org/W2045621697","https://openalex.org/W2046649514","https://openalex.org/W2050813458","https://openalex.org/W2051554010","https://openalex.org/W2052676337","https://openalex.org/W2054329349","https://openalex.org/W2056498477","https://openalex.org/W2056797993","https://openalex.org/W2056923392","https://openalex.org/W2061017106","https://openalex.org/W2061893279","https://openalex.org/W2062849330","https://openalex.org/W2063413296","https://openalex.org/W2063771096","https://openalex.org/W2064323618","https://openalex.org/W2065354704","https://openalex.org/W2067701751","https://openalex.org/W2069027482","https://openalex.org/W2073016063","https://openalex.org/W2073537077","https://openalex.org/W2074361406","https://openalex.org/W2075312117","https://openalex.org/W2075770826","https://openalex.org/W2077335179","https://openalex.org/W2080512018","https://openalex.org/W2081900799","https://openalex.org/W2082206299","https://openalex.org/W2083192315","https://openalex.org/W2083204774","https://openalex.org/W2084250976","https://openalex.org/W2084689743","https://openalex.org/W2085971650","https://openalex.org/W2086628207","https://openalex.org/W2086950122","https://openalex.org/W2087566431","https://openalex.org/W2088991430","https://openalex.org/W2089151887","https://openalex.org/W2090517702","https://openalex.org/W2091212498","https://openalex.org/W2091421444","https://openalex.org/W2092358916","https://openalex.org/W2092939335","https://openalex.org/W2093398004","https://openalex.org/W2097249485","https://openalex.org/W2099858791","https://openalex.org/W2106139304","https://openalex.org/W2108908759","https://openalex.org/W2109993485","https://openalex.org/W2116730131","https://openalex.org/W2117040533","https://openalex.org/W2117287657","https://openalex.org/W2119588378","https://openalex.org/W2120307371","https://openalex.org/W2121792692","https://openalex.org/W2126033464","https://openalex.org/W2127319921","https://openalex.org/W2130634332","https://openalex.org/W2136006910","https://openalex.org/W2137341857","https://openalex.org/W2138524791","https://openalex.org/W2141636993","https://openalex.org/W2141778647","https://openalex.org/W2144851077","https://openalex.org/W2152732725","https://openalex.org/W2160585483","https://openalex.org/W2160644313","https://openalex.org/W2163314018","https://openalex.org/W2167624775","https://openalex.org/W2170081966","https://openalex.org/W2174764226","https://openalex.org/W2175469462","https://openalex.org/W2315613727","https://openalex.org/W2319137765","https://openalex.org/W2395273171","https://openalex.org/W2442219175","https://openalex.org/W4406059073"],"related_works":["https://openalex.org/W69557452","https://openalex.org/W324306875","https://openalex.org/W602138353","https://openalex.org/W1981505515","https://openalex.org/W2054329349","https://openalex.org/W1981444301","https://openalex.org/W1978222306","https://openalex.org/W2057072518","https://openalex.org/W2182693265","https://openalex.org/W4225275391"],"abstract_inverted_index":{"Alcoholism":[0],"is":[1,55,79],"a":[2,68,100,174,309,328],"disorder":[3],"involving":[4],"chronic":[5,119],"and":[6,15,34,47,120,137,142,181,184,198,236,271,296],"progressive":[7],"alcohol":[8,18,30,61,113,335],"intake":[9,258],"which":[10],"leads":[11],"to":[12,105],"mental,":[13],"physical":[14],"social":[16],"problems.Drinking":[17],"has":[19],"an":[20],"impact":[21],"on":[22,132,178],"various":[23],"neurotransmitter":[24],"systems":[25],"within":[26],"the":[27,58,89,127,170,225,305,316],"brain.For":[28],"example,":[29],"self-administration":[31],"increases":[32],"dopamine":[33],"glutamate":[35,63,71,75],"neurotransmission":[36],"in":[37,57,112,117,151,188,214,220,224,234,245,259,269,276,298],"central":[38],"reward":[39],"brain":[40],"regions":[41],"such":[42],"as":[43,230,232,327],"prefrontal":[44],"cortex":[45],"(PFC)":[46],"nucleus":[48],"accumbens":[49],"(NAC).Evidence":[50],"demonstrated":[51,325],"that":[52,97,207,253,280,308],"glutamatergic":[53],"system":[54],"implicated":[56],"development":[59],"of":[60,70,83,88,130,172,227,282,289,334],"dependence.Extracellular":[62],"levels":[64,226,268],"are":[65],"regulated":[66],"by":[67],"number":[69],"transporters.Among":[72],"these":[73],"transporters,":[74],"transporter":[76,144],"1":[77],"(GLT-1)":[78],"responsible":[80],"for":[81,304,319,332],"clearance":[82],"more":[84],"than":[85],"90":[86],"%":[87],"extracellular":[90],"glutamate.Studies":[91],"from":[92],"our":[93,323],"lab":[94],"have":[95],"shown":[96],"ceftriaxone":[98],"(CEF),":[99],"beta":[101],"lactam":[102],"antibiotic":[103],"known":[104],"upregulate":[106],"GLT-1":[107,134,267,283,314,326],"level,":[108],"reduced":[109,256],"ethanol-drinking":[110,122,212],"behavior":[111,123,213],"preferring":[114],"(P)":[115],"rats":[116,261],"both":[118],"relapse-like":[121,211],"paradigms.In":[124],"this":[125],"study,":[126],"differential":[128],"effects":[129],"CEF":[131,160,208],"iv":[133],"isoforms":[135],"(GLT-1a":[136],"GLT-1b),":[138],"cystine-glutamate":[139],"antiporter":[140],"(xCT)":[141],"glutamate-aspartate":[143],"(GLAST)":[145],"were":[146],"examined":[147,169],"(using":[148],"Western":[149],"blot)":[150],"na\u00efve":[152,189],"(water)":[153,190],"control,":[154,191],"saline":[155,192],"vehicle":[156,193],"control":[157,194],"(relapse-like":[158],"ethanol),":[159],"(100":[161],"mg/kg,":[162,200],"i.p.)":[163,201],"treated":[164,202],"P":[165,203,215,260],"rat":[166],"groups.Furthermore,":[167],"we":[168,238,251,278],"effect":[171,318],"MS-153,":[173,312],"novel":[175,310],"neuroprotective":[176],"agent,":[177],"ethanol":[179,257,321],"consumption":[180],"GLT1":[182],"expression":[183],"its":[185],"signaling":[186],"pathway":[187],"(ethanol),":[195],"MS-153":[196,254,265],"(20":[197],"50":[199],"rats.Our":[204],"results":[205],"showed":[206,303],"treatment":[209,333],"attenuated":[210],"rats.This":[216],"attenuation":[217],"was":[218,285],"associated,":[219],"part,":[221],"with":[222,287],"upregulation":[223],"GLT-1a,":[228],"GLT-1b,":[229],"well":[231],"xCT":[233],"PFC":[235],"NAC.However,":[237],"did":[239],"not":[240,275],"observe":[241],"any":[242],"significant":[243],"change":[244],"GLAST":[246],"level":[247,284],"between":[248],"all":[249],"groups.Alternatively,":[250],"found":[252,279],"significantly":[255],"at":[262],"dose-dependent":[263],"manner.Importantly,":[264],"up-regulated":[266],"NAC":[270],"amygdala":[272],"(AMG)":[273],"but":[274],"PFC.Furthermore,":[277],"up-regulation":[281,288],"associated":[286],"translocated":[290],"Nuclear":[291],"Factor":[292],"kappa":[293],"B":[294],"(NF\u03baB)":[295],"reduction":[297],"cytosolic":[299],"I\u03baB-\u03b1":[300],"levels.Our":[301],"data":[302],"first":[306],"time":[307],"compound,":[311],"targeting":[313],"had":[315],"beneficiary":[317],"attenuating":[320],"intake.Together,":[322],"findings":[324],"potential":[329],"therapeutic":[330],"target":[331],"dependence.v":[336]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
