{"id":"https://openalex.org/W1919987165","doi":null,"title":"EFFECTS OF CO-TRIMOXAZOLE CO-ADMINISTRATION ON THE PHARMACOKINETICS OF AMODIAQUINE IN HEALTHY VOLUNTEERS","display_name":"EFFECTS OF CO-TRIMOXAZOLE CO-ADMINISTRATION ON THE PHARMACOKINETICS OF AMODIAQUINE IN HEALTHY VOLUNTEERS","publication_year":2015,"publication_date":"2015-07-17","ids":{"openalex":"https://openalex.org/W1919987165","mag":"1919987165"},"language":"en","primary_location":{"id":"mag:1919987165","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/6383/6440","pdf_url":null,"source":{"id":"https://openalex.org/S2764469077","display_name":"International Journal of Pharmacy and Pharmaceutical Sciences","issn_l":"0975-1491","issn":["0975-1491","2656-0097"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacy and Pharmaceutical Sciences","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/6383/6440","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116297151","display_name":"Adebusuyi Akande Ademisoye","orcid":"https://orcid.org/0009-0000-4387-4582","observed_orcids":["https://orcid.org/0009-0000-4387-4582"]},"institutions":[{"id":"https://openalex.org/I28653996","display_name":"Adekunle Ajasin University","ror":"https://ror.org/04e27p903","country_code":"NG","type":"education","lineage":["https://openalex.org/I28653996"]},{"id":"https://openalex.org/I45711476","display_name":"Obafemi Awolowo University","ror":"https://ror.org/04snhqa82","country_code":"NG","type":"education","lineage":["https://openalex.org/I45711476"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Ademisoye Adebusuyi Akande","raw_affiliation_strings":["OBAFEMI AWOLOWO UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OBAFEMI AWOLOWO UNIVERSITY","institution_ids":["https://openalex.org/I28653996","https://openalex.org/I45711476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086972630","display_name":"Soyinka Julius Olugbenga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134542131","display_name":"University of Ilorin","ror":"https://ror.org/032kdwk38","country_code":"NG","type":"education","lineage":["https://openalex.org/I134542131"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Soyinka Julius Olugbenga","raw_affiliation_strings":["Department of Pharmaceutical & Medicinal Chemistry, University of Ilorin, Ilorin, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical & Medicinal Chemistry, University of Ilorin, Ilorin, Nigeria","institution_ids":["https://openalex.org/I134542131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002318250","display_name":"Jonathan Adebanjo Adegbola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28653996","display_name":"Adekunle Ajasin University","ror":"https://ror.org/04e27p903","country_code":"NG","type":"education","lineage":["https://openalex.org/I28653996"]},{"id":"https://openalex.org/I45711476","display_name":"Obafemi Awolowo University","ror":"https://ror.org/04snhqa82","country_code":"NG","type":"education","lineage":["https://openalex.org/I45711476"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Adegbola Jonathan Adebanjo","raw_affiliation_strings":["OBAFEMI AWOLOWO UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OBAFEMI AWOLOWO UNIVERSITY","institution_ids":["https://openalex.org/I28653996","https://openalex.org/I45711476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032120523","display_name":"Abdullahi Sa\u2019ad Toyin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28653996","display_name":"Adekunle Ajasin University","ror":"https://ror.org/04e27p903","country_code":"NG","type":"education","lineage":["https://openalex.org/I28653996"]},{"id":"https://openalex.org/I45711476","display_name":"Obafemi Awolowo University","ror":"https://ror.org/04snhqa82","country_code":"NG","type":"education","lineage":["https://openalex.org/I45711476"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Abdullahi Sa\u2019ad Toyin","raw_affiliation_strings":["OBAFEMI AWOLOWO UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OBAFEMI AWOLOWO UNIVERSITY","institution_ids":["https://openalex.org/I28653996","https://openalex.org/I45711476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030621772","display_name":"Cyprian O. Onyeji","orcid":"https://orcid.org/0000-0002-2743-5501","observed_orcids":["https://orcid.org/0000-0002-2743-5501"]},"institutions":[{"id":"https://openalex.org/I28653996","display_name":"Adekunle Ajasin University","ror":"https://ror.org/04e27p903","country_code":"NG","type":"education","lineage":["https://openalex.org/I28653996"]},{"id":"https://openalex.org/I45711476","display_name":"Obafemi Awolowo University","ror":"https://ror.org/04snhqa82","country_code":"NG","type":"education","lineage":["https://openalex.org/I45711476"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Cyprian O. Onyeji","raw_affiliation_strings":["OBAFEMI AWOLOWO UNIVERSITY"],"raw_orcid":"https://orcid.org/0000-0002-2743-5501","affiliations":[{"raw_affiliation_string":"OBAFEMI AWOLOWO UNIVERSITY","institution_ids":["https://openalex.org/I28653996","https://openalex.org/I45711476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4678,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58834776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"7","issue":"9","first_page":"272","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amodiaquine","display_name":"amodiaquine","score":0.9670000076293945},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole","display_name":"trimethoprim-sulfamethoxazole","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8669999837875366},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cyp2c8-inhibition","display_name":"CYP2C8 inhibition","score":0.9660000205039978},{"id":"https://openalex.org/keywords/4-aminoquinolines","display_name":"4-aminoquinolines","score":0.8560000061988831},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.921999990940094},{"id":"https://openalex.org/keywords/sulfamethoxazole","display_name":"sulfamethoxazole","score":0.8029999732971191},{"id":"https://openalex.org/keywords/trimethoprim","display_name":"trimethoprim","score":0.9829999804496765},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.822986364364624},{"id":"https://openalex.org/C2776992834","wikidata":"https://www.wikidata.org/wiki/Q239569","display_name":"Amodiaquine","level":4,"score":0.722123384475708},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7064447999000549},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6390266418457031},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.5862552523612976},{"id":"https://openalex.org/C2780728791","wikidata":"https://www.wikidata.org/wiki/Q422665","display_name":"Trimethoprim","level":3,"score":0.5624935626983643},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.5231029987335205},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.48920154571533203},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47546881437301636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4545116424560547},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2697910964488983},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22407367825508118},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.08318698406219482},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.0681561827659607},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06761524081230164},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.04213905334472656},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1919987165","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/6383/6440","pdf_url":null,"source":{"id":"https://openalex.org/S2764469077","display_name":"International Journal of Pharmacy and Pharmaceutical Sciences","issn_l":"0975-1491","issn":["0975-1491","2656-0097"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacy and Pharmaceutical Sciences","raw_type":null}],"best_oa_location":{"id":"mag:1919987165","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/6383/6440","pdf_url":null,"source":{"id":"https://openalex.org/S2764469077","display_name":"International Journal of Pharmacy and Pharmaceutical Sciences","issn_l":"0975-1491","issn":["0975-1491","2656-0097"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacy and Pharmaceutical Sciences","raw_type":null},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1594637841","https://openalex.org/W1907598604","https://openalex.org/W1963672269","https://openalex.org/W1963704440","https://openalex.org/W1965187965","https://openalex.org/W1973378038","https://openalex.org/W1985777098","https://openalex.org/W1998758469","https://openalex.org/W2003237988","https://openalex.org/W2005960058","https://openalex.org/W2027860481","https://openalex.org/W2036597966","https://openalex.org/W2038377273","https://openalex.org/W2057760523","https://openalex.org/W2060723109","https://openalex.org/W2063156559","https://openalex.org/W2078108823","https://openalex.org/W2079395738","https://openalex.org/W2087508683","https://openalex.org/W2097611517","https://openalex.org/W2099445570","https://openalex.org/W2100077167","https://openalex.org/W2122294990","https://openalex.org/W2143225906","https://openalex.org/W2154598042","https://openalex.org/W2155033804","https://openalex.org/W2162881343","https://openalex.org/W2163711771","https://openalex.org/W2164407983"],"related_works":["https://openalex.org/W2801507351","https://openalex.org/W1999531606","https://openalex.org/W2061841248","https://openalex.org/W1907598604","https://openalex.org/W1519586906","https://openalex.org/W2981732585","https://openalex.org/W1994860921","https://openalex.org/W1968866616","https://openalex.org/W2462283358","https://openalex.org/W2394560185"],"abstract_inverted_index":{"Objectives:":[0],"Amodiaquine":[2],"(AQ)":[3],"is":[4,10,24],"a":[5,25,37,135,220],"4-aminoquinoline":[6],"antimalarial":[7],"drug":[8],"that":[9],"rapidly":[11],"and":[12,28,43,57,125,129,146,169,234,242,276],"extensively":[13],"metabolized":[14],"mainly":[15],"by":[16],"CYP2C8":[17],"enzyme":[18],"to":[19,47,92,219],"N-desethylamodiaquine":[20],"(DEAQ).":[21],"Co-trimoxazole":[22],"(CTZ)":[23],"combination":[26],"(sulfamethoxazole":[27],"trimethoprim)":[29],"antimicrobial":[30],"agent":[31],"with":[32,55,101,179,181],"the":[33,51,64,70,104,153,157,206,224,245,254,257,263,281],"trimethoprim":[34],"component":[35],"being":[36],"potent":[38],"inhibitor":[39],"of":[40,53,66,72,99,107,144,176,226,244,259,265,280],"CYP2C8.":[41],"AQ":[42,100,128,145,177,182,266,274],"CTZ":[44,67,108,147,260,271],"are":[45],"likely":[46],"be":[48],"co-administered":[49],"in":[50,149,152,223,238,267],"treatment":[52],"patients":[54],"malaria":[56],"susceptible":[58],"bacterial":[59],"infections.":[60],"This":[61],"study":[62],"evaluates":[63],"effect":[65,258],"co-administration":[68,261],"on":[69,262],"pharmacokinetics":[71,264],"AQ.":[73],"Methods:":[79],"In":[81],"an":[82],"open,":[83],"two-way":[84],"crossover":[85],"study,":[86],"16":[87],"healthy":[88,268],"volunteers":[89],"were":[90,119],"randomized":[91],"receive":[93],"600":[94],"mg":[95,110],"single":[96],"oral":[97,207],"dose":[98,106],"or":[102],"without":[103],"eleventh":[105],"(960":[109],"every":[111],"12":[112],"h":[113,190],"for":[114,127,253],"7":[115],"days.)":[116],"Blood":[117],"samples":[118],"collected":[120],"at":[121],"pre-determined":[122],"time":[123,256],"intervals":[124],"analyzed":[126],"its":[130],"major":[131],"metabolite,":[132],"DEAQ":[133],"using":[134],"validated":[136],"HPLC":[137],"method.":[138],"Results:":[141],"Co-administration":[143,216],"resulted":[148],"significant":[150,236],"increases":[151],"total":[154],"area":[155],"under":[156],"concentration\u2013time":[158],"curve":[159],"(AUC":[160,185],"T":[161,186,198],"),":[162],"maximum":[163],"plasma":[164,208,278],"concentration":[165],"(C":[166],"max":[167,193,240],")":[168,175],"terminal":[170],"elimination":[171],"half-life":[172],"(T":[173],"\u00bd":[174,199],"compared":[178],"values":[180],"dosing":[183],"alone":[184],":234.36\u00b157.21":[187],"vs":[188,195,202,213],"366.42\u00b162.48":[189],"ng/ml;":[191,197],"C":[192,239],":24.86\u00b17.28":[194],"40.28\u00b111.15":[196],":":[200],"6.49\u00b13.56":[201],"9.24\u00b12.97":[203],"h),":[204],"while":[205],"clearance":[209],"markedly":[210],"decreased":[211,277],"(3862.66\u00b1756.38":[212],"2654.28\u00b1650.12":[214],"L/h).":[215],"also":[217],"led":[218],"pronounced":[221],"decrease":[222],"ratio":[225],"AUC":[227,243],"(metabolite)":[228],"/AUC":[229],"(unchanged":[231],"drug)":[232],"highly":[235],"decreases":[237],"metabolite.":[246],"Conclusion:":[249],"Study":[251],"evaluated":[252],"first":[255],"adult":[269],"volunteers.":[270],"significantly":[272],"increased":[273],"exposure":[275],"levels":[279],"active":[282],"metabolite":[283],"DEAQ.":[284]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}