{"id":"https://openalex.org/W1919312349","doi":"https://doi.org/10.1002/ptr.5404","title":"Asiaticoside Inhibits TNF-\u03b1-Induced Endothelial Hyperpermeability of Human Aortic Endothelial Cells","display_name":"Asiaticoside Inhibits TNF-\u03b1-Induced Endothelial Hyperpermeability of Human Aortic Endothelial Cells","publication_year":2015,"publication_date":"2015-07-14","ids":{"openalex":"https://openalex.org/W1919312349","doi":"https://doi.org/10.1002/ptr.5404","mag":"1919312349","pmid":"https://pubmed.ncbi.nlm.nih.gov/26171791"},"language":"en","primary_location":{"id":"doi:10.1002/ptr.5404","doi":"https://doi.org/10.1002/ptr.5404","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.5404","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://psasir.upm.edu.my/id/eprint/43838/1/Asiaticoside%20inhibits%20TNF-%CE%B1-induced%20endothelial%20hyperpermeability%20of%20human%20aortic%20endothelial%20cells.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073971958","display_name":"Lai Yen Fong","orcid":"https://orcid.org/0000-0001-7912-6746","observed_orcids":["https://orcid.org/0000-0001-7912-6746"]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Lai Yen Fong","raw_affiliation_strings":["Department of Biomedical Sciences, Faculty of Medicine and Health Sciences; Universiti Putra Malaysia; Serdang Selangor Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Faculty of Medicine and Health Sciences; Universiti Putra Malaysia; Serdang Selangor Malaysia","institution_ids":["https://openalex.org/I130343225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019194317","display_name":"Chin Theng Ng","orcid":"https://orcid.org/0000-0001-6062-2846","observed_orcids":["https://orcid.org/0000-0001-6062-2846"]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Chin Theng Ng","raw_affiliation_strings":["Department of Biomedical Sciences, Faculty of Medicine and Health Sciences; Universiti Putra Malaysia; Serdang Selangor Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Faculty of Medicine and Health Sciences; Universiti Putra Malaysia; Serdang Selangor Malaysia","institution_ids":["https://openalex.org/I130343225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028332715","display_name":"Zainul Amiruddin Zakaria","orcid":"https://orcid.org/0000-0001-5525-7821","observed_orcids":["https://orcid.org/0000-0001-5525-7821"]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Zainul Amiruddin Zakaria","raw_affiliation_strings":["Department of Biomedical Sciences, Faculty of Medicine and Health Sciences; Universiti Putra Malaysia; Serdang Selangor Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Faculty of Medicine and Health Sciences; Universiti Putra Malaysia; Serdang Selangor Malaysia","institution_ids":["https://openalex.org/I130343225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005338612","display_name":"Mohamad Taufik Hidayat Baharuldin","orcid":"https://orcid.org/0000-0003-4773-8531","observed_orcids":["https://orcid.org/0000-0003-4773-8531"]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Mohamad Taufik Hidayat Baharuldin","raw_affiliation_strings":["Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia","institution_ids":["https://openalex.org/I130343225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111520983","display_name":"Abdul Kadir Arifah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Abdul Kadir Arifah","raw_affiliation_strings":["Department of Preclinical Science, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preclinical Science, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia","institution_ids":["https://openalex.org/I130343225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110768937","display_name":"Muhammad Nazrul Hakim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Muhammad Nazrul Hakim","raw_affiliation_strings":["Department of Biomedical Sciences, Faculty of Medicine and Health Sciences; Universiti Putra Malaysia; Serdang Selangor Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Faculty of Medicine and Health Sciences; Universiti Putra Malaysia; Serdang Selangor Malaysia","institution_ids":["https://openalex.org/I130343225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111533543","display_name":"Zuraini Ahmad","orcid":"https://orcid.org/0009-0008-3363-7127","observed_orcids":["https://orcid.org/0009-0008-3363-7127"]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Ahmad Zuraini","raw_affiliation_strings":["Department of Biomedical Sciences, Faculty of Medicine and Health Sciences; Universiti Putra Malaysia; Serdang Selangor Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Faculty of Medicine and Health Sciences; Universiti Putra Malaysia; Serdang Selangor Malaysia","institution_ids":["https://openalex.org/I130343225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111533543"],"corresponding_institution_ids":["https://openalex.org/I130343225"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":1.2311,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.74215896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"10","first_page":"1501","last_page":"1508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.17990000545978546,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asiaticoside","display_name":"asiaticoside","score":0.9980000257492065},{"id":"https://openalex.org/keywords/centella-asiatica","display_name":"Centella asiatica","score":0.9049999713897705},{"id":"https://openalex.org/keywords/triterpenoids","display_name":"triterpenoids","score":0.9480000138282776},{"id":"https://openalex.org/keywords/endothelial-hyperpermeability","display_name":"endothelial hyperpermeability","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8180000185966492},{"id":"https://openalex.org/keywords/endothelial-barrier-function","display_name":"endothelial barrier function","score":0.8809999823570251},{"id":"https://openalex.org/keywords/human-aortic-endothelial-cells","display_name":"human aortic endothelial cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9559999704360962},{"id":"https://openalex.org/keywords/stress-fiber-formation","display_name":"stress fiber formation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7229999899864197},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/fitc-dextran-permeability","display_name":"FITC-dextran permeability","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C2776041460","wikidata":"https://www.wikidata.org/wiki/Q5201339","display_name":"Cytochalasin D","level":4,"score":0.7521610260009766},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.609538197517395},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.595711886882782},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.563198983669281},{"id":"https://openalex.org/C2781099445","wikidata":"https://www.wikidata.org/wiki/Q4121060","display_name":"Stress fiber","level":4,"score":0.5390642881393433},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.5136401057243347},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.498854398727417},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.4868749678134918},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.46525105834007263},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4599567651748657},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.45478570461273193},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.4448360800743103},{"id":"https://openalex.org/C2775995422","wikidata":"https://www.wikidata.org/wiki/Q5201335","display_name":"Cytochalasin","level":4,"score":0.4271708130836487},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41510677337646484},{"id":"https://openalex.org/C2779012151","wikidata":"https://www.wikidata.org/wiki/Q26998028","display_name":"Cytochalasin B","level":3,"score":0.410063773393631},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32143256068229675},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3156372904777527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3083187937736511},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.2988321781158447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23149240016937256},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2311476469039917},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2113494575023651},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.14804419875144958},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1335873007774353}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004336","descriptor_name":"Drug Antagonism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D028041","descriptor_name":"Centella","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/ptr.5404","doi":"https://doi.org/10.1002/ptr.5404","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.5404","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},{"id":"pmid:26171791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26171791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy research : PTR","raw_type":"Journal Article"},{"id":"pmh:oai:psasir.upm.edu.my:43838","doi":null,"is_oa":true,"landing_page_url":"http://psasir.upm.edu.my/id/eprint/43838/1/Asiaticoside%20inhibits%20TNF-%CE%B1-induced%20endothelial%20hyperpermeability%20of%20human%20aortic%20endothelial%20cells.pdf","pdf_url":"http://psasir.upm.edu.my/id/eprint/43838/1/Asiaticoside%20inhibits%20TNF-%CE%B1-induced%20endothelial%20hyperpermeability%20of%20human%20aortic%20endothelial%20cells.pdf","source":{"id":"https://openalex.org/S4377196260","display_name":"Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130343225","host_organization_name":"Universiti Putra Malaysia","host_organization_lineage":["https://openalex.org/I130343225"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:psasir.upm.edu.my:43838","doi":null,"is_oa":true,"landing_page_url":"http://psasir.upm.edu.my/id/eprint/43838/1/Asiaticoside%20inhibits%20TNF-%CE%B1-induced%20endothelial%20hyperpermeability%20of%20human%20aortic%20endothelial%20cells.pdf","pdf_url":"http://psasir.upm.edu.my/id/eprint/43838/1/Asiaticoside%20inhibits%20TNF-%CE%B1-induced%20endothelial%20hyperpermeability%20of%20human%20aortic%20endothelial%20cells.pdf","source":{"id":"https://openalex.org/S4377196260","display_name":"Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130343225","host_organization_name":"Universiti Putra Malaysia","host_organization_lineage":["https://openalex.org/I130343225"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322714","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1919312349.pdf"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W97987599","https://openalex.org/W1598910025","https://openalex.org/W1849988336","https://openalex.org/W1952455177","https://openalex.org/W1969615558","https://openalex.org/W1976886448","https://openalex.org/W1981736545","https://openalex.org/W1990362896","https://openalex.org/W1996581644","https://openalex.org/W2004201349","https://openalex.org/W2004298891","https://openalex.org/W2005727179","https://openalex.org/W2006801801","https://openalex.org/W2009141857","https://openalex.org/W2016814059","https://openalex.org/W2021856167","https://openalex.org/W2031936247","https://openalex.org/W2066886841","https://openalex.org/W2071965792","https://openalex.org/W2088980710","https://openalex.org/W2093878678","https://openalex.org/W2094403983","https://openalex.org/W2111134333","https://openalex.org/W2119632652","https://openalex.org/W2120379770","https://openalex.org/W2124424618","https://openalex.org/W2126350489","https://openalex.org/W2130943336","https://openalex.org/W2144065167","https://openalex.org/W2149199950","https://openalex.org/W2155144135","https://openalex.org/W2160062367","https://openalex.org/W2165463540","https://openalex.org/W2399470735","https://openalex.org/W2404218913","https://openalex.org/W6642702895"],"related_works":["https://openalex.org/W7063866623","https://openalex.org/W2519373823","https://openalex.org/W2887254908","https://openalex.org/W2942596467","https://openalex.org/W2316143044","https://openalex.org/W2226090085","https://openalex.org/W6980161594","https://openalex.org/W2996262589","https://openalex.org/W2315189124","https://openalex.org/W2788027683"],"abstract_inverted_index":{"The":[0],"increase":[1,85],"in":[2,9,28,56,76,86,176],"endothelial":[3,21,26,59,66,79,87,164,193],"permeability":[4,88],"often":[5],"promotes":[6],"edema":[7],"formation":[8],"various":[10],"pathological":[11],"conditions.":[12],"Tumor":[13],"necrosis":[14],"factor-alpha":[15],"(TNF-\u03b1),":[16],"a":[17,173],"pro-atherogenic":[18],"cytokine,":[19],"impairs":[20],"barrier":[22,165,194],"function":[23],"and":[24,68,166],"causes":[25],"dysfunction":[27],"early":[29],"stage":[30],"of":[31,35,54,70,140,163,192],"atherosclerosis.":[32],"Asiaticoside,":[33],"one":[34],"the":[36,52,58,112,137,161,190,198],"triterpenoids":[37],"derived":[38],"from":[39],"Centella":[40],"asiatica,":[41],"is":[42],"known":[43],"to":[44,50,89,115,135,148,183,188],"possess":[45],"antiinflammatory":[46],"activity.":[47],"In":[48],"order":[49],"examine":[51],"role":[53],"asiaticoside":[55,141,146,158,181],"preserving":[57],"barrier,":[60],"we":[61],"assessed":[62],"its":[63],"effects":[64],"on":[65],"hyperpermeability":[67],"disruption":[69,162],"actin":[71,104,117,130,143,167,178],"filaments":[72],"evoked":[73],"by":[74,106,120,125,170,185],"TNF-\u03b1":[75,82,121,171],"human":[77],"aortic":[78],"cells":[80],"(HAEC).":[81],"caused":[83],"an":[84,129],"fluorescein":[90],"isothiocyanate":[91],"(FITC)-dextran.":[92],"Asiaticoside":[93,100],"pretreatment":[94],"significantly":[95],"suppressed":[96],"TNF-\u03b1-induced":[97,103],"increased":[98,113,152],"permeability.":[99,153],"also":[101],"prevented":[102],"redistribution":[105],"suppressing":[107],"stress":[108],"fiber":[109],"formation.":[110],"However,":[111,180],"F":[114],"G":[116],"ratio":[118],"stimulated":[119],"was":[122,133],"not":[123],"changed":[124],"asiaticoside.":[126],"Cytochalasin":[127],"D,":[128],"depolymerizing":[131],"agent,":[132],"used":[134],"correlate":[136],"anti-hyperpermeability":[138],"effect":[139],"with":[142],"cytoskeleton.":[144],"Surprisingly,":[145],"failed":[147],"prevent":[149],"cytochalasin":[150],"D-induced":[151],"These":[154],"results":[155],"suggest":[156],"that":[157],"protects":[159],"against":[160],"rearrangement":[168],"triggered":[169],"without":[172],"significant":[174],"change":[175],"total":[177],"pool.":[179],"seems":[182],"work":[184],"other":[186],"mechanisms":[187],"maintain":[189],"integrity":[191],"rather":[195],"than":[196],"stabilizing":[197],"F-actin":[199],"organization.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
