{"id":"https://openalex.org/W1919253579","doi":null,"title":"Tissue-specific carcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutation.","display_name":"Tissue-specific carcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutation.","publication_year":2000,"publication_date":"2000-09-15","ids":{"openalex":"https://openalex.org/W1919253579","mag":"1919253579","pmid":"https://pubmed.ncbi.nlm.nih.gov/11016655"},"language":"en","primary_location":{"id":"pmid:11016655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11016655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"K Kawai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Kawai","raw_affiliation_strings":["Department of Pathology, Nagoya University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Nagoya University School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069033857","display_name":"Toshihide Iwashita","orcid":"https://orcid.org/0000-0003-4909-3933","observed_orcids":["https://orcid.org/0000-0003-4909-3933"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Iwashita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032962315","display_name":"Hideki Murakami","orcid":"https://orcid.org/0000-0003-0515-540X","observed_orcids":["https://orcid.org/0000-0003-0515-540X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Murakami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069791898","display_name":"Noriko Hiraiwa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Hiraiwa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006385979","display_name":"Atsushi Yoshiki","orcid":"https://orcid.org/0000-0002-9450-5151","observed_orcids":["https://orcid.org/0000-0002-9450-5151"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Yoshiki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045690729","display_name":"Masashi Kusakabe","orcid":"https://orcid.org/0000-0003-1795-4778","observed_orcids":["https://orcid.org/0000-0003-1795-4778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kusakabe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101749646","display_name":"Koji Ono","orcid":"https://orcid.org/0000-0003-2268-0804","observed_orcids":["https://orcid.org/0000-0003-2268-0804"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Ono","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113670981","display_name":"Ken-ichi Iida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Iida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044509304","display_name":"Atsushi Nakayama","orcid":"https://orcid.org/0000-0001-6487-504X","observed_orcids":["https://orcid.org/0000-0001-6487-504X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Nakayama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000822704","display_name":"Miho Takahashi","orcid":"https://orcid.org/0000-0002-4483-3894","observed_orcids":["https://orcid.org/0000-0002-4483-3894","https://orcid.org/0000-0002-4987-0651"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Takahashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1558,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.91500858,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"60","issue":"18","first_page":"5254","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ret-proto-oncogene","display_name":"RET proto-oncogene","score":1.0},{"id":"https://openalex.org/keywords/multiple-endocrine-neoplasia-type-2a","display_name":"multiple endocrine neoplasia type 2A","score":0.9909999966621399},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.7049999833106995},{"id":"https://openalex.org/keywords/tissue-specific-carcinogenesis","display_name":"tissue-specific carcinogenesis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/shc","display_name":"Shc","score":0.5809999704360962},{"id":"https://openalex.org/keywords/grb2","display_name":"Grb2","score":0.9769999980926514},{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.8989999890327454},{"id":"https://openalex.org/keywords/c-cell-hyperplasia","display_name":"C-cell hyperplasia","score":0.8080000281333923},{"id":"https://openalex.org/keywords/parotid-gland-adenocarcinoma","display_name":"parotid gland adenocarcinoma","score":0.9169999957084656},{"id":"https://openalex.org/keywords/mammary-adenocarcinoma","display_name":"mammary adenocarcinoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/calcitonin","display_name":"calcitonin","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C2776512331","wikidata":"https://www.wikidata.org/wiki/Q604075","display_name":"Multiple endocrine neoplasia type 2","level":5,"score":0.6488016843795776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.566060483455658},{"id":"https://openalex.org/C2776667971","wikidata":"https://www.wikidata.org/wiki/Q6807316","display_name":"Medullary carcinoma","level":4,"score":0.5622504353523254},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5333886742591858},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4499451220035553},{"id":"https://openalex.org/C2780103800","wikidata":"https://www.wikidata.org/wiki/Q1553018","display_name":"Multiple endocrine neoplasia","level":3,"score":0.4429955780506134},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4154427647590637},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3858407735824585},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.3765738606452942},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3337247967720032},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.29644718766212463},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.285566121339798},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27392706274986267},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.183176189661026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1667330265045166},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1031232476234436},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071425","descriptor_name":"Src Homology 2 Domain-Containing, Transforming Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003433","descriptor_name":"Crosses, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008979","descriptor_name":"Moloney murine leukemia virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018813","descriptor_name":"Multiple Endocrine Neoplasia Type 2a","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018813","descriptor_name":"Multiple Endocrine Neoplasia Type 2a","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018814","descriptor_name":"Multiple Endocrine Neoplasia Type 2b","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018814","descriptor_name":"Multiple Endocrine Neoplasia Type 2b","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020079","descriptor_name":"Terminal Repeat Sequences","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051096","descriptor_name":"Proto-Oncogene Proteins c-ret","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051380","descriptor_name":"GRB2 Adaptor Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055765","descriptor_name":"Shc Signaling Adaptor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11016655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11016655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},{"id":"mag:1919253579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11016655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1510857662","https://openalex.org/W1578346366","https://openalex.org/W1601190908","https://openalex.org/W1964429855","https://openalex.org/W1970988928","https://openalex.org/W1974824979","https://openalex.org/W1981810931","https://openalex.org/W1987566228","https://openalex.org/W1988241038","https://openalex.org/W1993404368","https://openalex.org/W1999693507","https://openalex.org/W2014078232","https://openalex.org/W2018957880","https://openalex.org/W2023285758","https://openalex.org/W2024811932","https://openalex.org/W2026907934","https://openalex.org/W2027322371","https://openalex.org/W2028093783","https://openalex.org/W2030185095","https://openalex.org/W2030996806","https://openalex.org/W2031238707","https://openalex.org/W2032457962","https://openalex.org/W2043072647","https://openalex.org/W2044761914","https://openalex.org/W2048169148","https://openalex.org/W2051998916","https://openalex.org/W2056728789","https://openalex.org/W2057936106","https://openalex.org/W2079437220","https://openalex.org/W2082584428","https://openalex.org/W2083970030","https://openalex.org/W2087619652","https://openalex.org/W2089343676","https://openalex.org/W2101151768","https://openalex.org/W2109968674","https://openalex.org/W2128805986","https://openalex.org/W2139680027","https://openalex.org/W2146205118","https://openalex.org/W2150094887","https://openalex.org/W2160863198","https://openalex.org/W2167423680","https://openalex.org/W2278490082","https://openalex.org/W2316227579","https://openalex.org/W2325514588","https://openalex.org/W2329619823"],"related_works":["https://openalex.org/W2032457962","https://openalex.org/W2036308386","https://openalex.org/W2323500245","https://openalex.org/W2155935661","https://openalex.org/W1604548398","https://openalex.org/W2113242315","https://openalex.org/W7217981101","https://openalex.org/W2044761914","https://openalex.org/W2101151768","https://openalex.org/W2399227650"],"abstract_inverted_index":{"Germ":[0],"line":[1],"mutations":[2],"of":[3,12,37,68,82,94,108,114,124,193],"the":[4,10,35,55,69,125,191,194],"RET":[5,42,128,158],"proto-oncogene":[6],"are":[7],"responsible":[8],"for":[9],"development":[11,40,113,202],"multiple":[13],"endocrine":[14],"neoplasia":[15],"type":[16],"2A":[17],"(MEN":[18],"2A),":[19],"an":[20],"inherited":[21],"cancer":[22],"syndrome":[23],"characterized":[24],"by":[25,41,53],"medullary":[26,103],"thyroid":[27,99],"carcinoma,":[28,104],"pheochromocytoma,":[29],"and":[30,71,91,130,136],"parathyroid":[31],"hyperplasia.":[32],"To":[33],"study":[34],"mechanism":[36],"tissue-specific":[38,200],"tumor":[39,143,147,201],"with":[43,134],"a":[44,80],"MEN2A":[45],"(cysteine":[46],"634-->arginine)":[47],"mutation,":[48],"we":[49],"generated":[50],"transgenic":[51,126],"mice":[52,96],"introducing":[54],"RET-MEN2A":[56,155,195],"gene":[57],"fused":[58],"to":[59,199],"Moloney":[60],"murine":[61],"leukemia":[62],"virus":[63],"long":[64],"terminal":[65],"repeat.":[66],"Expression":[67],"transgene":[70],"its":[72,131],"product":[73],"was":[74,120,149,160],"detected":[75,141],"at":[76,179],"variable":[77],"levels":[78,107],"in":[79,122,142,151,190,203],"variety":[81],"tissues":[83,153,164],"including":[84],"thyroid,":[85],"heart,":[86],"liver,":[87],"colon,":[88],"parotid":[89,117],"gland,":[90],"brain.":[92],"All":[93],"29":[95],"analyzed":[97],"developed":[98],"C-cell":[100],"hyperplasia":[101],"or":[102,116],"accompanying":[105],"high":[106,180],"serum":[109],"calcitonin.":[110],"In":[111],"addition,":[112],"mammary":[115],"gland":[118],"adenocarcinoma":[119],"observed":[121],"one-half":[123],"mice.":[127],"dimerization":[129,159,192],"complex":[132],"formation":[133,148],"Shc":[135],"Grb2":[137],"adaptor":[138],"proteins":[139],"were":[140],"tissues.":[144],"Unexpectedly,":[145],"no":[146],"found":[150],"other":[152],"despite":[154],"expression":[156,187],"where":[157],"undetectable.":[161],"Because":[162],"these":[163],"but":[165],"not":[166],"tumors":[167],"expressed":[168],"glial":[169],"cell":[170],"line-derived":[171],"neurotrophic":[172],"factor":[173],"family":[174],"receptor":[175],"alpha":[176,186],"(GFR":[177],"alpha)":[178],"levels,":[181],"this":[182],"suggested":[183],"that":[184],"GFR":[185],"may":[188],"interfere":[189],"mutant":[196],"proteins,":[197],"leading":[198],"vivo.":[204]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}