{"id":"https://openalex.org/W1918820105","doi":"https://doi.org/10.1016/s0079-6123(08)62803-4","title":"Chapter 28 Sites of action of opiates in production of analgesia","display_name":"Chapter 28 Sites of action of opiates in production of analgesia","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W1918820105","doi":"https://doi.org/10.1016/s0079-6123(08)62803-4","mag":"1918820105","pmid":"https://pubmed.ncbi.nlm.nih.gov/2851148"},"language":"en","primary_location":{"id":"doi:10.1016/s0079-6123(08)62803-4","doi":"https://doi.org/10.1016/s0079-6123(08)62803-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0079-6123(08)62803-4","pdf_url":null,"source":{"id":"https://openalex.org/S170217976","display_name":"Progress in brain research","issn_l":"0079-6123","issn":["0079-6123","1875-7855"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Brain Research","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4250071116","display_name":null},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042389999","display_name":"Tony L. Yaksh","orcid":"https://orcid.org/0000-0003-4297-536X","observed_orcids":["https://orcid.org/0000-0003-4297-536X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"T.L. Yaksh","raw_affiliation_strings":["Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA","Department of Neurology, University of Copenhagen, KAS, Gentofte, 2900 Hellerup, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Neurology, University of Copenhagen, KAS, Gentofte, 2900 Hellerup, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005010999","display_name":"Nayef R. F. Al-Rodhan","orcid":"https://orcid.org/0000-0002-7719-7038","observed_orcids":["https://orcid.org/0000-0002-7719-7038"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"N.R.F. Al\u2010Rodhan","raw_affiliation_strings":["Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA","Department of Neurology, University of Copenhagen, KAS, Gentofte, 2900 Hellerup, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Neurology, University of Copenhagen, KAS, Gentofte, 2900 Hellerup, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066094707","display_name":"Troels Staehelin Jensen","orcid":"https://orcid.org/0000-0002-3487-6380","observed_orcids":["https://orcid.org/0000-0002-3487-6380"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"T.S. Jensen","raw_affiliation_strings":["Department of Neurology, University of Copenhagen, KAS, Gentofte, 2900 Hellerup, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Copenhagen, KAS, Gentofte, 2900 Hellerup, Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":15.9249,"has_fulltext":false,"cited_by_count":153,"citation_normalized_percentile":{"value":0.99494098,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"77","issue":null,"first_page":"371","last_page":"394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opiates","display_name":"opiates","score":0.8650000095367432},{"id":"https://openalex.org/keywords/opioid-analgesia","display_name":"opioid analgesia","score":0.8880000114440918},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/site-of-action","display_name":"site of action","score":0.7360000014305115},{"id":"https://openalex.org/keywords/nociceptors","display_name":"nociceptors","score":0.8119999766349792},{"id":"https://openalex.org/keywords/primary-afferent-nociceptors","display_name":"primary afferent nociceptors","score":0.8029999732971191},{"id":"https://openalex.org/keywords/peripheral-sensitization","display_name":"peripheral sensitization","score":0.8199999928474426},{"id":"https://openalex.org/keywords/pain-behavior","display_name":"pain behavior","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.7309184670448303},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.4685830771923065},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4098277688026428},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40389952063560486},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3940119743347168},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3713548183441162},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27719125151634216},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.03735607862472534},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.032482922077178955},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004723","descriptor_name":"Endorphins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0079-6123(08)62803-4","doi":"https://doi.org/10.1016/s0079-6123(08)62803-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0079-6123(08)62803-4","pdf_url":null,"source":{"id":"https://openalex.org/S170217976","display_name":"Progress in brain research","issn_l":"0079-6123","issn":["0079-6123","1875-7855"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Brain Research","raw_type":"book-chapter"},{"id":"pmid:2851148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2851148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1573747824","display_name":null,"funder_award_id":"NS 16541","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320310483","display_name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","ror":"https://ror.org/03ge1nb22"},{"id":"https://openalex.org/F4320321144","display_name":"King Faisal Specialist Hospital and Research Centre","ror":"https://ror.org/05n0wgt02"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":122,"referenced_works":["https://openalex.org/W21925403","https://openalex.org/W1639077754","https://openalex.org/W1852747819","https://openalex.org/W1855035655","https://openalex.org/W1900414416","https://openalex.org/W1905648986","https://openalex.org/W1908535950","https://openalex.org/W1934959161","https://openalex.org/W1960421706","https://openalex.org/W1963879244","https://openalex.org/W1964859878","https://openalex.org/W1965695732","https://openalex.org/W1967110060","https://openalex.org/W1970018860","https://openalex.org/W1970198582","https://openalex.org/W1971866692","https://openalex.org/W1977294562","https://openalex.org/W1979257541","https://openalex.org/W1979257935","https://openalex.org/W1981568012","https://openalex.org/W1982152340","https://openalex.org/W1982324672","https://openalex.org/W1987781967","https://openalex.org/W1988571628","https://openalex.org/W1989138468","https://openalex.org/W1989423171","https://openalex.org/W1989944583","https://openalex.org/W1989990644","https://openalex.org/W1990959945","https://openalex.org/W1991667225","https://openalex.org/W1992907842","https://openalex.org/W1993373127","https://openalex.org/W1993672558","https://openalex.org/W1995506737","https://openalex.org/W1996195482","https://openalex.org/W1996328947","https://openalex.org/W1997595847","https://openalex.org/W2001933690","https://openalex.org/W2004222924","https://openalex.org/W2004491740","https://openalex.org/W2005918447","https://openalex.org/W2005988907","https://openalex.org/W2008411223","https://openalex.org/W2008608419","https://openalex.org/W2008795728","https://openalex.org/W2009749144","https://openalex.org/W2010433623","https://openalex.org/W2012260976","https://openalex.org/W2012517805","https://openalex.org/W2013579580","https://openalex.org/W2015498527","https://openalex.org/W2016501178","https://openalex.org/W2017058118","https://openalex.org/W2017238521","https://openalex.org/W2017483496","https://openalex.org/W2018843065","https://openalex.org/W2019879999","https://openalex.org/W2021908531","https://openalex.org/W2023021788","https://openalex.org/W2023858005","https://openalex.org/W2024133387","https://openalex.org/W2026787509","https://openalex.org/W2028833035","https://openalex.org/W2032446267","https://openalex.org/W2034849341","https://openalex.org/W2035953150","https://openalex.org/W2038650381","https://openalex.org/W2044879864","https://openalex.org/W2046094549","https://openalex.org/W2046562280","https://openalex.org/W2046828973","https://openalex.org/W2050637257","https://openalex.org/W2050715943","https://openalex.org/W2051853745","https://openalex.org/W2052131212","https://openalex.org/W2052650080","https://openalex.org/W2053303835","https://openalex.org/W2055882351","https://openalex.org/W2057384920","https://openalex.org/W2060581684","https://openalex.org/W2060957767","https://openalex.org/W2062053205","https://openalex.org/W2063765075","https://openalex.org/W2065546873","https://openalex.org/W2068092009","https://openalex.org/W2068210407","https://openalex.org/W2070490008","https://openalex.org/W2070580638","https://openalex.org/W2072291822","https://openalex.org/W2072868278","https://openalex.org/W2074052843","https://openalex.org/W2075692886","https://openalex.org/W2076351968","https://openalex.org/W2081317505","https://openalex.org/W2082881579","https://openalex.org/W2083142828","https://openalex.org/W2083686894","https://openalex.org/W2084890070","https://openalex.org/W2085190172","https://openalex.org/W2090408408","https://openalex.org/W2095326121","https://openalex.org/W2098612726","https://openalex.org/W2112973554","https://openalex.org/W2141873077","https://openalex.org/W2171740240","https://openalex.org/W2206043426","https://openalex.org/W2252667869","https://openalex.org/W2254071939","https://openalex.org/W2256167805","https://openalex.org/W2262029073","https://openalex.org/W2262277517","https://openalex.org/W2268392304","https://openalex.org/W2271349088","https://openalex.org/W2405295211","https://openalex.org/W2412105915","https://openalex.org/W2417999496","https://openalex.org/W2468191006","https://openalex.org/W2484002398","https://openalex.org/W4230915672","https://openalex.org/W4238418955","https://openalex.org/W4407037087","https://openalex.org/W6693010445"],"related_works":["https://openalex.org/W2070036878","https://openalex.org/W2075599163","https://openalex.org/W108471838","https://openalex.org/W133096771","https://openalex.org/W1575703908","https://openalex.org/W7073761975","https://openalex.org/W1990487641","https://openalex.org/W2432916369","https://openalex.org/W2109195121","https://openalex.org/W2085611562"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
