{"id":"https://openalex.org/W191820774","doi":"https://doi.org/10.1042/bj2160753","title":"The role of a guanine nucleotide-binding protein in the activation of rat liver plasma-membrane adenylate cyclase by forskolin","display_name":"The role of a guanine nucleotide-binding protein in the activation of rat liver plasma-membrane adenylate cyclase by forskolin","publication_year":1983,"publication_date":"1983-12-15","ids":{"openalex":"https://openalex.org/W191820774","doi":"https://doi.org/10.1042/bj2160753","mag":"191820774","pmid":"https://pubmed.ncbi.nlm.nih.gov/6320798","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1152571"},"language":"en","primary_location":{"id":"doi:10.1042/bj2160753","doi":"https://doi.org/10.1042/bj2160753","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2160753","pdf_url":"https://portlandpress.com/biochemj/article-pdf/216/3/753/580369/bj2160753.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/216/3/753/580369/bj2160753.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S K F Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S K F Wong","raw_affiliation_strings":["Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 IQ W, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 IQ W, U.K","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":null,"display_name":"B R Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B R Martin","raw_affiliation_strings":["Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 IQ W, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 IQ W, U.K","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":null,"apc_paid":null,"fwci":2.2703,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.88416945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"216","issue":"3","first_page":"753","last_page":"759"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.08630000054836273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-proteins","display_name":"G proteins","score":0.902999997138977},{"id":"https://openalex.org/keywords/adenylyl-cyclase-activation","display_name":"adenylate cyclase activation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/liver-plasma-membrane","display_name":"liver plasma membrane","score":0.8349999785423279},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.8730000257492065},{"id":"https://openalex.org/keywords/rat-liver","display_name":"rat liver","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.8681706190109253},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.8609942197799683},{"id":"https://openalex.org/C2777995097","wikidata":"https://www.wikidata.org/wiki/Q422462","display_name":"Guanosine","level":2,"score":0.7670132517814636},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.7591307163238525},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.7283245325088501},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.549990177154541},{"id":"https://openalex.org/C2776638253","wikidata":"https://www.wikidata.org/wiki/Q392227","display_name":"Guanosine triphosphate","level":4,"score":0.5478548407554626},{"id":"https://openalex.org/C85771745","wikidata":"https://www.wikidata.org/wiki/Q5514732","display_name":"GTP-binding protein regulators","level":4,"score":0.5142967104911804},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5137382745742798},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.5058205127716064},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.44968926906585693},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44026055932044983},{"id":"https://openalex.org/C176303035","wikidata":"https://www.wikidata.org/wiki/Q5513929","display_name":"Gs alpha subunit","level":4,"score":0.4166964888572693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39240050315856934},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1713923215866089},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.12875401973724365},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10740405321121216},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067956","descriptor_name":"Adenylyl Cyclase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001386","descriptor_name":"Azides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj2160753","doi":"https://doi.org/10.1042/bj2160753","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2160753","pdf_url":"https://portlandpress.com/biochemj/article-pdf/216/3/753/580369/bj2160753.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1152571","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1152571","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:6320798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6320798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj2160753","doi":"https://doi.org/10.1042/bj2160753","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2160753","pdf_url":"https://portlandpress.com/biochemj/article-pdf/216/3/753/580369/bj2160753.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W191820774.pdf","grobid_xml":"https://content.openalex.org/works/W191820774.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W53423959","https://openalex.org/W989164380","https://openalex.org/W1486205509","https://openalex.org/W1530060724","https://openalex.org/W1539631646","https://openalex.org/W1576014737","https://openalex.org/W1580199166","https://openalex.org/W1926371675","https://openalex.org/W2009291798","https://openalex.org/W2075676530","https://openalex.org/W2081363427","https://openalex.org/W2158543975","https://openalex.org/W2169503005","https://openalex.org/W2399814777","https://openalex.org/W2418662542","https://openalex.org/W2438841486","https://openalex.org/W6800134218"],"related_works":["https://openalex.org/W252213112","https://openalex.org/W2064256766","https://openalex.org/W1975637946","https://openalex.org/W2230177212","https://openalex.org/W2011796686","https://openalex.org/W1576014737","https://openalex.org/W1597906482","https://openalex.org/W2063423031","https://openalex.org/W2418569409","https://openalex.org/W2003993054"],"abstract_inverted_index":{"The":[0,105],"effects":[1,71],"of":[2,21,31,72,79,85,96,117,129],"the":[3,19,22,36,64,68,70,73,83,115,118,127,142,147,159],"photoreactive":[4],"GTP":[5,110],"analogue":[6,23,74],"GTP-gamma-azidoanilide":[7,56,86],"on":[8],"rat":[9,97],"liver":[10,98],"plasma-membrane":[11],"adenylate":[12,101,123],"cyclase":[13,102,124],"are":[14,155],"described.":[15],"U.v.":[16],"irradiation":[17],"in":[18,82,126],"presence":[20,84,128],"abolished":[24],"activation":[25,95,106],"by":[26,47,58,103,107],"any":[27],"effector":[28],"or":[29],"combination":[30],"effectors":[32],"that":[33,55,153],"function":[34],"via":[35,146],"activatory":[37],"G":[38,65,148],"protein.":[39,66,149],"Partial":[40],"protection":[41],"against":[42],"this":[43],"inhibition":[44],"was":[45,87],"given":[46],"F-":[48],"and":[49,109,131,165],"guanosine":[50,132],"5'-[gamma-thio]triphosphate.":[51],"It":[52,150],"is":[53,151],"concluded":[54,152],"acts":[57],"a":[59,162,166],"light-induced":[60],"covalent":[61],"reaction":[62],"with":[63],"In":[67],"dark":[69],"were":[75,112],"similar":[76],"to":[77,89,93,139,141,158],"those":[78],"GTP.":[80],"Irradiation":[81],"found":[88],"reduce":[90],"but":[91],"not":[92],"abolish":[94],"plasma":[99],"membrane":[100],"forskolin.":[104],"forskolin":[108,160],"together":[111],"greater":[113],"than":[114],"sum":[116],"individual":[119],"activations.":[120],"Forskolin":[121],"doubled":[122],"activity":[125],"glucagon":[130],"5'-[beta,":[133],"gamma-imido]triphosphate,":[134],"which":[135],"might":[136],"be":[137],"expected":[138],"activate":[140],"maximum":[143],"possible":[144],"extent":[145],"there":[154],"two":[156],"components":[157],"activation,":[161],"guanine":[163,167],"nucleotide-dependent":[164],"nucleotide-independent":[168],"component.":[169]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
