{"id":"https://openalex.org/W1917705486","doi":"https://doi.org/10.1111/j.1523-5378.2011.00871.x","title":"Histopathology of Gastric Erosions Association with Etiological Factors and Chronicity","display_name":"Histopathology of Gastric Erosions Association with Etiological Factors and Chronicity","publication_year":2011,"publication_date":"2011-11-08","ids":{"openalex":"https://openalex.org/W1917705486","doi":"https://doi.org/10.1111/j.1523-5378.2011.00871.x","mag":"1917705486","pmid":"https://pubmed.ncbi.nlm.nih.gov/22059395"},"language":"en","primary_location":{"id":"doi:10.1111/j.1523-5378.2011.00871.x","doi":"https://doi.org/10.1111/j.1523-5378.2011.00871.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1523-5378.2011.00871.x","pdf_url":null,"source":{"id":"https://openalex.org/S45434965","display_name":"Helicobacter","issn_l":"1083-4389","issn":["1083-4389","1523-5378"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Helicobacter","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051867048","display_name":"Kari Toljamo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Kari Toljamo","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology, University of Oulu, PL 5000, FI-90014 Oulu, Finland. kari.toljamo@tyks.fi","Department of Internal Medicine, Division of Gastroenterology, University of Oulu, PL 5000, FI\u201090014 Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology, University of Oulu, PL 5000, FI-90014 Oulu, Finland. kari.toljamo@tyks.fi","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology, University of Oulu, PL 5000, FI\u201090014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110267013","display_name":"Seppo Niemel\u00e4","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Seppo Niemel\u00e4","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology, University of Oulu, PL 5000, FI-90014 Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology, University of Oulu, PL 5000, FI-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113630647","display_name":"Anna\u2013Liisa Karvonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153886","display_name":"University of Tampere","ror":"https://ror.org/05p6qqk79","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387153886"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Anna-Liisa Karvonen","raw_affiliation_strings":["Medical School, University of Tampere, FI-33014, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, University of Tampere, FI-33014, Finland","institution_ids":["https://openalex.org/I4387153886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111925902","display_name":"Riitta A. Karttunen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Riitta Karttunen","raw_affiliation_strings":["Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, PL 21, FI-00014 Helsinki, Finland","Department of Medical Microbiology, Institute of Diagnostics, University of Oulu, PL 5000, FI-90014 Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, PL 21, FI-00014 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Department of Medical Microbiology, Institute of Diagnostics, University of Oulu, PL 5000, FI-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077468190","display_name":"Tuomo J. Karttunen","orcid":"https://orcid.org/0000-0002-8843-7957","observed_orcids":["https://orcid.org/0000-0002-8843-7957"]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tuomo J. Karttunen","raw_affiliation_strings":["Department of Pathology, Institute of Diagnostics, University of Oulu, PL 5000, FI-90014 Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute of Diagnostics, University of Oulu, PL 5000, FI-90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051867048"],"corresponding_institution_ids":["https://openalex.org/I98381234"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.59,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.71698733,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"6","first_page":"444","last_page":"451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-erosions","display_name":"gastric erosions","score":0.9150000214576721},{"id":"https://openalex.org/keywords/gastric-antrum","display_name":"gastric antrum","score":0.8629999756813049},{"id":"https://openalex.org/keywords/gastric-mucosal-histopathology","display_name":"gastric mucosal histopathology","score":0.8330000042915344},{"id":"https://openalex.org/keywords/helicobacter-pylori-infection","display_name":"Helicobacter pylori infection","score":0.8920000195503235},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8960000276565552},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.6460000276565552},{"id":"https://openalex.org/keywords/focal-inflammation","display_name":"focal inflammation","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8292998671531677},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.801190972328186},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.7357907295227051},{"id":"https://openalex.org/C131253125","wikidata":"https://www.wikidata.org/wiki/Q609361","display_name":"Antrum","level":3,"score":0.7247022986412048},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6593652963638306},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.5654822587966919},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5609033703804016},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5003166198730469},{"id":"https://openalex.org/C2781443798","wikidata":"https://www.wikidata.org/wiki/Q383249","display_name":"Gastric mucosa","level":3,"score":0.49082860350608826},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.4774478077888489},{"id":"https://openalex.org/C2778677798","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Gastritis","level":3,"score":0.4627499580383301},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3982837200164795}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004363","descriptor_name":"Drug Utilization","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011706","descriptor_name":"Pyloric Antrum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013272","descriptor_name":"Stomach Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D013272","descriptor_name":"Stomach Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1523-5378.2011.00871.x","doi":"https://doi.org/10.1111/j.1523-5378.2011.00871.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1523-5378.2011.00871.x","pdf_url":null,"source":{"id":"https://openalex.org/S45434965","display_name":"Helicobacter","issn_l":"1083-4389","issn":["1083-4389","1523-5378"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Helicobacter","raw_type":"journal-article"},{"id":"pmid:22059395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22059395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Helicobacter","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W147479224","https://openalex.org/W1848570373","https://openalex.org/W1947012729","https://openalex.org/W1964326897","https://openalex.org/W1980235822","https://openalex.org/W2013023955","https://openalex.org/W2015449706","https://openalex.org/W2030740759","https://openalex.org/W2035675399","https://openalex.org/W2037947874","https://openalex.org/W2059873870","https://openalex.org/W2069368135","https://openalex.org/W2071179731","https://openalex.org/W2074062237","https://openalex.org/W2080451253","https://openalex.org/W2083434660","https://openalex.org/W2088432516","https://openalex.org/W2129091209","https://openalex.org/W2145952115","https://openalex.org/W2160115508","https://openalex.org/W2321082521","https://openalex.org/W2337814027","https://openalex.org/W2409045359","https://openalex.org/W2948387191","https://openalex.org/W4300364029","https://openalex.org/W7155224343"],"related_works":["https://openalex.org/W2271601489","https://openalex.org/W2035675399","https://openalex.org/W2080451253","https://openalex.org/W1246271932","https://openalex.org/W2030740759","https://openalex.org/W93149536","https://openalex.org/W59480852","https://openalex.org/W2082114898","https://openalex.org/W2438886074","https://openalex.org/W2059873870"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,108,188],"histopathologic":[2],"characteristics":[3],"of":[4,30,39,54,69,78,110,120,137,162,175,183,202,252],"the":[5,16,28,52,91,95,129,135,148,159,165,250,260],"antral":[6,18,104,142,168,254],"erosions,":[7],"and":[8,37,71,76,97,118,158,179],"a":[9,63],"comparison":[10],"with":[11,33,48,152,193,207,236,263],"samples":[12],"systematically":[13],"collected":[14],"from":[15,90],"background":[17,72],"mucosa,":[19],"have":[20],"not":[21],"been":[22],"studied":[23,45],"previously.":[24],"Similarly,":[25],"unknown":[26],"is":[27,226],"association":[29],"these":[31],"features":[32],"suspected":[34],"etiological":[35],"factors":[36],"chronicity":[38],"erosion.":[40],"MATERIAL":[41],"AND":[42],"METHODS:":[43],"We":[44],"117":[46],"patients":[47,60],"gastric":[49,229,253],"erosions":[50,70,105,138,169,197,211,261],"in":[51,94,134,141,147,172,180,249,259],"absence":[53],"peptic":[55],"ulcer":[56],"disease.":[57],"With":[58],"28":[59],"available":[61],"for":[62,228],"follow-up":[64,98,166],"19":[65],"years":[66],"later,":[67],"sites":[68],"mucosa":[73],"were":[74,106,170],"biopsied":[75],"histopathology":[77],"both":[79,83],"independently":[80],"assessed":[81],"at":[82],"visits.":[84],"Helicobacter":[85,155,176,189],"pylori":[86,156,177,190],"status":[87],"was":[88,116,125,131,150,234],"examined":[89],"biopsies":[92],"taken":[93],"initial":[96],"gastroscopies.":[99],"Only":[100],"subjects":[101,192,206],"originally":[102],"displaying":[103],"included.":[107],"presence":[109],"Herpes":[111],"simplex":[112],"virus":[113],"(HSV)":[114],"antibodies":[115],"analyzed":[117],"use":[119,161,241],"nonsteroidal":[121],"anti-inflammatory":[122],"drug":[123],"(NSAID)":[124],"inquired.":[126],"RESULTS:":[127],"Initially,":[128],"inflammation":[130,146,225,233,245,258],"more":[132],"active":[133,145,257],"region":[136],"than":[139],"elsewhere":[140],"mucosa.":[143],"More":[144],"erosion":[149],"associated":[151,235],"HSV":[153,237],"seropositivity,":[154],"infection,":[157],"recent":[160],"NSAIDs.":[163],"In":[164],"visit,":[167],"present":[171],"38%":[173],"(3/8)":[174],"negatives":[178],"35%":[181],"(7/20)":[182],"positives":[184],"(p":[185],"=":[186,220],"ns).":[187],"positive":[191],"chronic":[194],"or":[195,209,239],"recurrent":[196],"had":[198],"initially":[199],"higher":[200],"scores":[201],"neutrophils":[203],"compared":[204],"to":[205],"nonrecurrent":[208],"nonchronic":[210],"(2.7":[212],"\u00b1":[213,217],"0.5":[214],"vs":[215],"1.2":[216],"1.0;":[218],"p":[219],".002).":[221],"CONCLUSIONS:":[222],"Focally":[223],"enhanced":[224],"characteristic":[227],"erosions.":[230,255],"This":[231],"focal":[232],"seropositivity":[238],"NSAID":[240],"suggesting":[242],"that":[243],"such":[244],"may":[246],"be":[247],"important":[248],"pathogenesis":[251],"Highly":[256],"associates":[262],"their":[264],"chronicity.":[265]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}