{"id":"https://openalex.org/W1916948552","doi":"https://doi.org/10.4269/ajtmh.2001.65.90","title":"Plasmodium vivax clinically resistant to chloroquine in Colombia.","display_name":"Plasmodium vivax clinically resistant to chloroquine in Colombia.","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W1916948552","doi":"https://doi.org/10.4269/ajtmh.2001.65.90","mag":"1916948552","pmid":"https://pubmed.ncbi.nlm.nih.gov/11508397"},"language":"en","primary_location":{"id":"doi:10.4269/ajtmh.2001.65.90","doi":"https://doi.org/10.4269/ajtmh.2001.65.90","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.2001.65.90","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040929214","display_name":"Jaime Soto","orcid":"https://orcid.org/0000-0002-0330-1242","observed_orcids":["https://orcid.org/0000-0002-0330-1242"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Soto","raw_affiliation_strings":["Consorcio de Investigaciones Biocl\u00ednicas, Bogot\u00e1, Colombia. JSoto@elsitio.net.co"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consorcio de Investigaciones Biocl\u00ednicas, Bogot\u00e1, Colombia. JSoto@elsitio.net.co","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108097086","display_name":"Julia T Toledo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Toledo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111517696","display_name":"P. Guti\u00e9rrez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Gutierrez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042111589","display_name":"MAGDA LUZZ","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Luzz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"N Llinas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Llinas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114269845","display_name":"N Cede\u00c3\u00b1o","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Cede\u00c3\u00b1o","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056809600","display_name":"Michael W. Dunne","orcid":"https://orcid.org/0000-0001-6186-5196","observed_orcids":["https://orcid.org/0000-0001-6186-5196"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Dunne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049261039","display_name":"J D Berman","orcid":"https://orcid.org/0000-0002-5127-9094","observed_orcids":["https://orcid.org/0000-0002-5127-9094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Berman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.8054,"has_fulltext":false,"cited_by_count":131,"citation_normalized_percentile":{"value":0.95527842,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"65","issue":"2","first_page":"90","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12402","display_name":"Travel-related health issues","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-vivax","display_name":"Plasmodium vivax","score":1.0},{"id":"https://openalex.org/keywords/chloroquine-resistance","display_name":"chloroquine resistance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/clinical-resistance","display_name":"clinical resistance","score":0.5070000290870667},{"id":"https://openalex.org/keywords/primaquine","display_name":"primaquine","score":0.6890000104904175},{"id":"https://openalex.org/keywords/recrudescence","display_name":"recrudescence","score":0.6320000290870667},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.5860000252723694},{"id":"https://openalex.org/keywords/blood-stage-parasites","display_name":"blood-stage parasites","score":0.4650000035762787},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.6019999980926514},{"id":"https://openalex.org/keywords/colombia","display_name":"Colombia","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.9397165775299072},{"id":"https://openalex.org/C2776793103","wikidata":"https://www.wikidata.org/wiki/Q419834","display_name":"Primaquine","level":4,"score":0.8216360807418823},{"id":"https://openalex.org/C2779997623","wikidata":"https://www.wikidata.org/wiki/Q311376","display_name":"Plasmodium vivax","level":4,"score":0.807558536529541},{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.7551543116569519},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.6484637260437012},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5450757145881653},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5175832509994507},{"id":"https://openalex.org/C2909011893","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Vivax malaria","level":5,"score":0.4999711513519287},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4578619599342346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3647855520248413},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35772988200187683},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3555222749710083},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.30964720249176025},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.05103287100791931}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002738","descriptor_name":"Chloroquine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003105","descriptor_name":"Colombia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010966","descriptor_name":"Plasmodium vivax","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010966","descriptor_name":"Plasmodium vivax","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011319","descriptor_name":"Primaquine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018512","descriptor_name":"Parasitemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4269/ajtmh.2001.65.90","doi":"https://doi.org/10.4269/ajtmh.2001.65.90","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.2001.65.90","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"journal-article"},{"id":"pmid:11508397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11508397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1984913401","https://openalex.org/W1986339906","https://openalex.org/W2007154151","https://openalex.org/W2019038471","https://openalex.org/W2098738039","https://openalex.org/W2121405778","https://openalex.org/W2123174600","https://openalex.org/W2125089473","https://openalex.org/W2166261288","https://openalex.org/W2168670624","https://openalex.org/W2223307961","https://openalex.org/W2315758134","https://openalex.org/W2401730911","https://openalex.org/W2416597985"],"related_works":["https://openalex.org/W2415344991","https://openalex.org/W2007154151","https://openalex.org/W1594396564","https://openalex.org/W2107827765","https://openalex.org/W2304185576","https://openalex.org/W1988173309","https://openalex.org/W7095344995","https://openalex.org/W1960873595","https://openalex.org/W2087920664","https://openalex.org/W2111135204"],"abstract_inverted_index":{"Chloroquine-resistant":[0],"Plasmodium":[1],"vivax":[2,135],"has":[3,116],"been":[4],"the":[5,25,58,147],"subject":[6],"of":[7,35,45,49,61,65,86,98,105,129,133],"numerous":[8],"case":[9,21],"reports":[10,22],"and":[11,16,92,142],"prospective":[12,30],"studies":[13],"from":[14,24],"Oceania":[15],"Asia.":[17],"In":[18],"contrast,":[19],"only":[20],"exist":[23],"Americas.":[26,148],"We":[27],"performed":[28],"a":[29,126],"study":[31],"with":[32,57,113,125],"28-day":[33],"follow-up":[34],"clinical":[36],"responses":[37],"to":[38,53,55,84,136],"chloroquine":[39,62,137],"in":[40,140,146],"2":[41],"P.":[42,122,134],"vivax-endemic":[43],"regions":[44],"Colombia.":[46],"Three":[47],"(11%)":[48],"27":[50],"patients":[51,109],"failed":[52],"respond":[54],"treatment":[56],"standard":[59],"regimen":[60],"(1,500":[63],"mg":[64],"base":[66],"over":[67],"3":[68],"days).":[69],"One":[70],"patient":[71,79,94],"demonstrated":[72,80,95],"RI":[73,81],"resistance":[74,82,97,132],"on":[75,89],"Day":[76,90],"26;":[77],"one":[78,93],"due":[83],"recrudescence":[85],"blood":[87,99,118],"stages":[88,100],"11;":[91],"RII":[96],"by":[101],"never":[102],"displaying":[103],"clearing":[104],"peripheral":[106],"parasitemia.":[107],"All":[108],"were":[110],"successfully":[111],"treated":[112],"primaquine,":[114],"which":[115],"some":[117],"stage":[119],"efficacy":[120],"against":[121],"vivax,":[123],"combined":[124],"second":[127],"course":[128],"chloroquine.":[130],"Clinical":[131],"is":[138],"present":[139],"Colombia":[141],"should":[143],"be":[144],"monitored":[145]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
