{"id":"https://openalex.org/W191609860","doi":null,"title":"The role of Neurofibromatosis Type 1 in Schwann Cell development and tumor formation and the influence of steroid hormones.","display_name":"The role of Neurofibromatosis Type 1 in Schwann Cell development and tumor formation and the influence of steroid hormones.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W191609860","mag":"191609860"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/57616","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/57616","pdf_url":"https://hdl.handle.net/2027.42/57616","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/57616","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019630008","display_name":"Therese M. Roth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Therese M. Roth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019630008"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/neurofibromin","display_name":"neurofibromin","score":0.8299999833106995},{"id":"https://openalex.org/keywords/schwann-cell-development","display_name":"Schwann cell development","score":0.7580000162124634},{"id":"https://openalex.org/keywords/neurofibroma","display_name":"neurofibroma","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.5720000267028809},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.5920000076293945},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.7170000076293945},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.781000018119812},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":1.0},{"id":"https://openalex.org/keywords/2-methoxyestradiol","display_name":"2-methoxyestradiol","score":0.9319999814033508},{"id":"https://openalex.org/keywords/steroid-hormones","display_name":"steroid hormones","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6330000162124634},{"id":"https://openalex.org/keywords/peripheral-nerve-tumor","display_name":"peripheral nerve tumor","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2778984943","wikidata":"https://www.wikidata.org/wiki/Q847605","display_name":"Neurofibromatosis","level":2,"score":0.719916582107544},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6778491735458374},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.6315971612930298},{"id":"https://openalex.org/C2777004073","wikidata":"https://www.wikidata.org/wiki/Q465621","display_name":"Schwann cell","level":2,"score":0.5598646998405457},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4322885274887085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42071905732154846},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38784903287887573},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3423640727996826},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32146894931793213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31956106424331665},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2869674861431122},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2797521948814392}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/57616","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/57616","pdf_url":"https://hdl.handle.net/2027.42/57616","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:191609860","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/handle/2027.42/57616?show=full","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/57616","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/57616","pdf_url":"https://hdl.handle.net/2027.42/57616","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320308551","display_name":"Van Andel Research Institute","ror":"https://ror.org/00wm07d60"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W191609860.pdf","grobid_xml":"https://content.openalex.org/works/W191609860.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W7911550","https://openalex.org/W1572148487","https://openalex.org/W1966980518","https://openalex.org/W1970708444","https://openalex.org/W1974744898","https://openalex.org/W1976755134","https://openalex.org/W1981467972","https://openalex.org/W1985185528","https://openalex.org/W1985746223","https://openalex.org/W1988626741","https://openalex.org/W1994359425","https://openalex.org/W1997018409","https://openalex.org/W1997861080","https://openalex.org/W2008029818","https://openalex.org/W2010587333","https://openalex.org/W2017444651","https://openalex.org/W2021880374","https://openalex.org/W2022121553","https://openalex.org/W2025079965","https://openalex.org/W2026262518","https://openalex.org/W2036022311","https://openalex.org/W2051684862","https://openalex.org/W2052377098","https://openalex.org/W2054631676","https://openalex.org/W2054674800","https://openalex.org/W2058306120","https://openalex.org/W2059617980","https://openalex.org/W2060425936","https://openalex.org/W2061551473","https://openalex.org/W2064890294","https://openalex.org/W2066858088","https://openalex.org/W2075760429","https://openalex.org/W2102763487","https://openalex.org/W2111241532","https://openalex.org/W2115721402","https://openalex.org/W2133927414","https://openalex.org/W2147087574","https://openalex.org/W2148788638","https://openalex.org/W2161045674","https://openalex.org/W2166435019","https://openalex.org/W2292249227"],"related_works":["https://openalex.org/W2025079965","https://openalex.org/W2066862457","https://openalex.org/W4296251721","https://openalex.org/W3095241579","https://openalex.org/W2047552396","https://openalex.org/W1499621409","https://openalex.org/W2124524275","https://openalex.org/W603852103","https://openalex.org/W2121651129","https://openalex.org/W2708066215"],"abstract_inverted_index":{"The":[0,172,185,224],"Neurofibromatosis":[1],"Type":[2],"1":[3],"(NF1)":[4],"gene":[5],"functions":[6],"as":[7],"a":[8,169,255,258],"tumor":[9,105,250,313],"suppressor":[10],"gene.":[11],"One":[12],"known":[13],"NF1":[14,44,83,100,113,142,155,176,210,231,249,334],"function":[15],"is":[16,45,62,307],"to":[17,30,95,154,164,236,264,269,309],"turn":[18],"off":[19],"the":[20,40,50,58,63,97,191,207,217,280,310,320],"p21ras":[21],"pathway":[22],"by":[23,222],"accelerating":[24],"Ras":[25],"hydrolyzation":[26],"of":[27,34,49,99,111,138,174,190,206,209,216,228,246,285,293,339],"active":[28],"rasGTP":[29],"inactive":[31],"rasGDP.":[32],"Loss":[33],"neurofibromin":[35,247],"(the":[36],"protein":[37],"product)":[38],"in":[39,56,71,101,211,230,267,279,287,295,319],"autosomal":[41],"dominant":[42],"disorder":[43],"associated":[46],"with":[47,243],"tumors":[48,336],"peripheral":[51],"nervous":[52],"system,":[53],"particularly":[54],"neurofibromas":[55,229],"which":[57],"major":[59],"cell":[60,212,219,251,314,322],"type":[61,85,166],"Schwann":[64],"Cell":[65],"(SC).":[66],"We":[67,298],"have":[68,299],"developed":[69],"an":[70,150,201,303],"vitro":[72],"system":[73],"for":[74,119,204,333],"differentiating":[75],"mouse":[76],"embryonic":[77,132],"stem":[78],"cells":[79,94,147,192],"(mESC)":[80],"that":[81,302],"are":[82,135],"wild":[84,156,165],"(+/+),":[86],"heterozygous":[87,145],"(+/-),":[88],"or":[89,325],"null":[90,143],"(-/-)":[91],"into":[92,182],"SC-like":[93,108,146,240],"study":[96,265],"role":[98,208],"SC":[102,116],"development":[103],"and":[104,123,125,144,187,214,226,248,257,272,290,316],"formation.":[106],"These":[107],"cells,":[109,282,289],"regardless":[110],"their":[112,120],"status,":[114],"express":[115],"markers":[117],"appropriate":[118],"developmental":[121,195],"stage,":[122],"support":[124],"preferentially":[126],"direct":[127],"neurite":[128],"outgrowth":[129],"from":[130,254],"primary":[131],"neurons.":[133],"They":[134],"also":[136,179,300],"capable":[137],"expressing":[139],"myelin":[140],"proteins.":[141],"proliferate":[148],"at":[149,337],"accelerated":[151],"rate":[152],"compared":[153],"type;":[157],"this":[158],"growth":[159,213],"advantage":[160],"can":[161,178,197],"be":[162,180,198],"reverted":[163],"levels":[167,245,284,292],"using":[168],"Mek":[170],"inhibitor":[171],"mESC":[173,242],"all":[175],"types":[177,220],"differentiated":[181,241],"neuron-like":[183],"cells.":[184,297],"behavior":[186],"genetic":[188],"repertoires":[189],"under":[193],"different":[194,218],"conditions":[196],"compared,":[199],"providing":[200],"ideal":[202],"paradigm":[203],"studies":[205],"differentiation":[215],"affected":[221],"NF1.":[223],"number":[225],"size":[227],"patients":[232],"has":[233],"been":[234],"shown":[235],"increase":[237],"during":[238],"pregnancy.":[239],"varying":[244],"lines":[252],"derived":[253],"malignant":[256,312],"benign":[259],"human":[260],"tumor,":[261],"were":[262],"used":[263],"proliferation":[266,318],"response":[268],"hormones.":[270],"Estrogen":[271],"androgen":[273],"receptors":[274],"showed":[275],"very":[276],"low/no":[277],"expression":[278,286,294],"NF1+/+":[281],"low":[283],"NF1+/-":[288],"high":[291],"NF1-/-":[296,311],"found":[301],"E2":[304],"metabolite,":[305],"2Methoxyestradiol,":[306],"cytotoxic":[308],"line,":[315],"inhibits":[317],"other":[321],"lines.":[323],"2ME2":[324],"its":[326],"derivatives":[327],"could":[328],"provide":[329],"new":[330],"treatment":[331],"avenues":[332],"hormone-sensitive":[335],"times":[338],"greatest":[340],"hormonal":[341],"influence.":[342]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
