{"id":"https://openalex.org/W1915820185","doi":"https://doi.org/10.1177/135245859600100616","title":"CAMPATH-1H in multiple sclerosis","display_name":"CAMPATH-1H in multiple sclerosis","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W1915820185","doi":"https://doi.org/10.1177/135245859600100616","mag":"1915820185","pmid":"https://pubmed.ncbi.nlm.nih.gov/9345418"},"language":"en","primary_location":{"id":"doi:10.1177/135245859600100616","doi":"https://doi.org/10.1177/135245859600100616","is_oa":false,"landing_page_url":"https://doi.org/10.1177/135245859600100616","pdf_url":null,"source":{"id":"https://openalex.org/S136332993","display_name":"Multiple Sclerosis Journal","issn_l":"1352-4585","issn":["1352-4585","1477-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple Sclerosis Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102081253","display_name":"Th. Moreau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Th Moreau","raw_affiliation_strings":["University of Cambridge Neurology unit, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge Neurology unit, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051127501","display_name":"Alasdair J. Coles","orcid":"https://orcid.org/0000-0003-4738-0760","observed_orcids":["https://orcid.org/0000-0003-4738-0760"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Coles","raw_affiliation_strings":["University of Cambridge, Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge, Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113627634","display_name":"Mark G Wing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Wing","raw_affiliation_strings":["Molecular Immunopathology Unit, MRC Centre, Hills Road, Cambridge CB2 2QH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Immunopathology Unit, MRC Centre, Hills Road, Cambridge CB2 2QH","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073623768","display_name":"John W. Thorpe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Thorpe","raw_affiliation_strings":["Institute of Neurology, London WC1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurology, London WC1","institution_ids":["https://openalex.org/I4405260083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108802446","display_name":"David Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D Miller","raw_affiliation_strings":["Institute of Neurology, London WC1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurology, London WC1","institution_ids":["https://openalex.org/I4405260083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010931430","display_name":"IVAN F. MOSELEY","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I Moseley","raw_affiliation_strings":["National Hospital, London WC12"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hospital, London WC12","institution_ids":["https://openalex.org/I4210151618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010924951","display_name":"Jeremy Issacs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Issacs","raw_affiliation_strings":["Division of Immunology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000120418","display_name":"G Hale","orcid":"https://orcid.org/0000-0001-9473-423X","observed_orcids":["https://orcid.org/0000-0001-9473-423X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G Hale","raw_affiliation_strings":["Division of Immunology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109834870","display_name":"David G Clayton","orcid":"https://orcid.org/0000-0001-5481-0891","observed_orcids":["https://orcid.org/0000-0001-5481-0891"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D Clayton","raw_affiliation_strings":["Division of Immunology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078057490","display_name":"Neil J. Scolding","orcid":"https://orcid.org/0000-0001-9177-1043","observed_orcids":["https://orcid.org/0000-0001-9177-1043"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N Scolding","raw_affiliation_strings":["University of Cambridge, Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge, Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107461980","display_name":"Herman Waldmann","orcid":"https://orcid.org/0000-0001-7519-6720","observed_orcids":["https://orcid.org/0000-0001-7519-6720"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H Waldmann","raw_affiliation_strings":["Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 2QQ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 2QQ","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078796360","display_name":"Alastair Compston","orcid":"https://orcid.org/0000-0002-0734-0185","observed_orcids":["https://orcid.org/0000-0002-0734-0185"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Compston","raw_affiliation_strings":["MRC Cambridge Centre for Brain Repair, University Forvie Site, Robinson Way, Cambridge CB2 2PY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Cambridge Centre for Brain Repair, University Forvie Site, Robinson Way, Cambridge CB2 2PY, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":0.2787,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.53729488,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"1","issue":"6","first_page":"357","last_page":"365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/campath-1h","display_name":"Campath-1H","score":0.9309999942779541},{"id":"https://openalex.org/keywords/anti-cd52-antibody","display_name":"anti-CD52 antibody","score":0.8259999752044678},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.7099999785423279},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8399999737739563},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":0.9179999828338623},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.8230000138282776},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.5770000219345093},{"id":"https://openalex.org/keywords/gadolinium-enhancing-lesions","display_name":"gadolinium-enhancing lesions","score":0.9589999914169312}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.839035153388977},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8264758586883545},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.7407402992248535},{"id":"https://openalex.org/C2780372218","wikidata":"https://www.wikidata.org/wiki/Q417222","display_name":"Methylprednisolone","level":2,"score":0.6273512244224548},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5743952393531799},{"id":"https://openalex.org/C2778384904","wikidata":"https://www.wikidata.org/wiki/Q21108353","display_name":"CD52","level":4,"score":0.49206799268722534},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46268072724342346},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4571641683578491},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4315783381462097},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3986542522907257},{"id":"https://openalex.org/C2779015954","wikidata":"https://www.wikidata.org/wiki/Q420164","display_name":"Alemtuzumab","level":3,"score":0.19591179490089417}],"mesh":[{"descriptor_ui":"D000074323","descriptor_name":"Alemtuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000912","descriptor_name":"Antibodies, Neoplasm","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/135245859600100616","doi":"https://doi.org/10.1177/135245859600100616","is_oa":false,"landing_page_url":"https://doi.org/10.1177/135245859600100616","pdf_url":null,"source":{"id":"https://openalex.org/S136332993","display_name":"Multiple Sclerosis Journal","issn_l":"1352-4585","issn":["1352-4585","1477-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple Sclerosis Journal","raw_type":"journal-article"},{"id":"pmid:9345418","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9345418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Multiple sclerosis (Houndmills, Basingstoke, England)","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1448453","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1448453/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mult Scler , 1 (6) pp. 357-365. (1996)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320084","display_name":"Multiple Sclerosis Society","ror":"https://ror.org/043fwdk81"},{"id":"https://openalex.org/F4320320104","display_name":"Kay Kendall Leukaemia Fund","ror":"https://ror.org/03j2wfg84"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1605445856","https://openalex.org/W1609977045","https://openalex.org/W1979454694","https://openalex.org/W1981866033","https://openalex.org/W1986117595","https://openalex.org/W1989053318","https://openalex.org/W1989091670","https://openalex.org/W1993074873","https://openalex.org/W1999382185","https://openalex.org/W2001070192","https://openalex.org/W2001200592","https://openalex.org/W2016990089","https://openalex.org/W2017449946","https://openalex.org/W2043613949","https://openalex.org/W2044412629","https://openalex.org/W2046110140","https://openalex.org/W2050608821","https://openalex.org/W2063302591","https://openalex.org/W2075286850","https://openalex.org/W2085937163","https://openalex.org/W2086677951","https://openalex.org/W2117581174","https://openalex.org/W2120563866","https://openalex.org/W2130355701","https://openalex.org/W2151735361","https://openalex.org/W2246548868","https://openalex.org/W3099854634"],"related_works":["https://openalex.org/W2151735361","https://openalex.org/W1965112519","https://openalex.org/W7097226313","https://openalex.org/W1993653389","https://openalex.org/W7098420363","https://openalex.org/W7063115547","https://openalex.org/W2355344166","https://openalex.org/W2127795080","https://openalex.org/W1979454694","https://openalex.org/W2112044962"],"abstract_inverted_index":{"In":[0,67,160],"a":[1,25,42,165],"pilot":[2],"study,":[3],"seven":[4,44],"patients":[5,45],"with":[6,11,49,95,168],"multiple":[7,197],"sclerosis":[8,198],"were":[9,148],"treated":[10,48],"CAMPATH-IH":[12],"which":[13],"targets":[14],"the":[15,70,120,161,175,182],"CD52":[16],"antigen":[17],"present":[18],"on":[19,36],"lymphocytes":[20],"and":[21,59,110,128,147,181],"monocytes.":[22],"There":[23],"was":[24,60,75,125],"substantial":[26],"reduction":[27],"in":[28,122,158,178,196],"disease":[29],"activity":[30],"as":[31],"measured":[32],"by":[33,39,77,154,199],"gadoliunium-enhancing":[34],"lesions":[35],"MRI.":[37],"Encouraged":[38],"this":[40],"result":[41],"further":[43],"have":[46],"been":[47],"CAMPATH-IH;":[50],"four":[51],"also":[52],"received":[53],"anti-CD4":[54],"antibody.":[55],"Lymphopaenia":[56],"developed":[57],"rapidly":[58],"sustained":[61],"for":[62],"at":[63,116,130],"least":[64],"one":[65,152],"year.":[66],"12":[68],"patients,":[69,164],"first":[71],"infusion":[72],"of":[73,82,91,98,103],"antibody":[74,92,135],"characterised":[76],"significant":[78],"exacerbation":[79],"or":[80,201],"re-awakening":[81],"pre-existing":[83],"symptoms":[84,139,180],"lasting":[85],"several":[86],"hours.":[87],"These":[88],"clinical":[89],"effects":[90],"treatment":[93],"correlated":[94],"increased":[96],"levels":[97,102],"circulating":[99],"cytokines.":[100],"Peak":[101],"tumour":[104],"necrosis":[105],"factor":[106],"alpha":[107],"(TNF":[108],"alpha)":[109],"interferon":[111],"gamma":[112],"(IFN":[113],"gamma)":[114],"occurred":[115],"2":[117],"h":[118,132],"whereas":[119],"rise":[121,157],"interleukin-6":[123],"(IL-6)":[124],"significantly":[126],"delayed":[127],"peaked":[129],"4":[131],"after":[133],"starting":[134],"treatment.":[136],"The":[137],"neurological":[138,179],"could":[140],"not":[141,149],"be":[142],"attributed":[143],"directly":[144,200],"to":[145,193],"pyrexia":[146],"provoked":[150],"(in":[151],"patient)":[153],"an":[155],"artificial":[156],"temperature.":[159],"remaining":[162],"two":[163],"single":[166],"pre-treatment":[167],"intravenous":[169],"methylprednisolone":[170],"(500":[171],"mg)":[172],"prevented":[173],"both":[174],"transient":[176],"increase":[177],"cytokine":[183],"release.":[184],"Our":[185],"results":[186],"suggest":[187],"that":[188],"soluble":[189],"immune":[190],"mediators":[191],"contribute":[192],"symptom":[194],"production":[195],"indirectly":[202],"blocking":[203],"conduction":[204],"through":[205],"partially":[206],"demyelinated":[207],"pathways.":[208]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}