{"id":"https://openalex.org/W191509075","doi":null,"title":"An in vitro investigation of the anti-inflammatory and immunosuppressive effects of the synthetic contraceptives medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A)","display_name":"An in vitro investigation of the anti-inflammatory and immunosuppressive effects of the synthetic contraceptives medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A)","publication_year":2005,"publication_date":"2005-03-01","ids":{"openalex":"https://openalex.org/W191509075","mag":"191509075"},"language":"en","primary_location":{"id":"pmh:oai:scholar.sun.ac.za:10019.1/2172","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10019.1/2172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006883667","display_name":"W. J. Kriek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"W. J. Kriek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006883667"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.5181000232696533,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.5181000232696533,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.24789999425411224,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.11479999870061874,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medroxyprogesterone-acetate","display_name":"medroxyprogesterone acetate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/norethisterone-acetate","display_name":"norethisterone acetate","score":1.0},{"id":"https://openalex.org/keywords/synthetic-progestogens","display_name":"synthetic progestins","score":0.9229999780654907},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7269999980926514},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9169999957084656},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7549999952316284},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.6320000290870667},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cd69","display_name":"CD69","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9330000281333923},{"id":"https://openalex.org/keywords/contraceptive-side-effects","display_name":"contraceptive side effects","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2776306185","wikidata":"https://www.wikidata.org/wiki/Q2823834","display_name":"Medroxyprogesterone acetate","level":3,"score":0.9375751614570618},{"id":"https://openalex.org/C2781039349","wikidata":"https://www.wikidata.org/wiki/Q421352","display_name":"Norethisterone","level":4,"score":0.7424713373184204},{"id":"https://openalex.org/C2780835420","wikidata":"https://www.wikidata.org/wiki/Q47495694","display_name":"Norethisterone acetate","level":3,"score":0.6648034453392029},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5801357626914978},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4431282877922058},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4223294258117676},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41305696964263916},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2880728542804718},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.263719379901886},{"id":"https://openalex.org/C2986740045","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health services","level":3,"score":0.20027217268943787},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1860082447528839},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.17287230491638184},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholar.sun.ac.za:10019.1/2172","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10019.1/2172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:191509075","doi":null,"is_oa":false,"landing_page_url":"https://scholar.sun.ac.za:443/bitstream/10019.1/2172/1/kriek_invitro_2005.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":223,"referenced_works":["https://openalex.org/W50435660","https://openalex.org/W143316405","https://openalex.org/W159203288","https://openalex.org/W163520811","https://openalex.org/W280558879","https://openalex.org/W300962634","https://openalex.org/W584412046","https://openalex.org/W1415391322","https://openalex.org/W1450103918","https://openalex.org/W1480920464","https://openalex.org/W1485705546","https://openalex.org/W1490177189","https://openalex.org/W1492123281","https://openalex.org/W1492340325","https://openalex.org/W1508985019","https://openalex.org/W1519063308","https://openalex.org/W1519441922","https://openalex.org/W1522758356","https://openalex.org/W1522773084","https://openalex.org/W1523180751","https://openalex.org/W1527933794","https://openalex.org/W1546899495","https://openalex.org/W1553380369","https://openalex.org/W1579791414","https://openalex.org/W1595805439","https://openalex.org/W1631909044","https://openalex.org/W1650418312","https://openalex.org/W1657108383","https://openalex.org/W1666992496","https://openalex.org/W1768026244","https://openalex.org/W1800390635","https://openalex.org/W1898357572","https://openalex.org/W1917885463","https://openalex.org/W1925266814","https://openalex.org/W1930073633","https://openalex.org/W1942668068","https://openalex.org/W1963958510","https://openalex.org/W1964279670","https://openalex.org/W1967020365","https://openalex.org/W1968431107","https://openalex.org/W1968801618","https://openalex.org/W1969315784","https://openalex.org/W1969525670","https://openalex.org/W1970581527","https://openalex.org/W1970951164","https://openalex.org/W1974453813","https://openalex.org/W1975643940","https://openalex.org/W1975932832","https://openalex.org/W1977408485","https://openalex.org/W1977737843","https://openalex.org/W1981490069","https://openalex.org/W1987183940","https://openalex.org/W1987758746","https://openalex.org/W1988105358","https://openalex.org/W1988436066","https://openalex.org/W1991601077","https://openalex.org/W1991680525","https://openalex.org/W1991748966","https://openalex.org/W1996548067","https://openalex.org/W1997423797","https://openalex.org/W1998731098","https://openalex.org/W2000755503","https://openalex.org/W2001527731","https://openalex.org/W2002076761","https://openalex.org/W2002589663","https://openalex.org/W2003039443","https://openalex.org/W2003871572","https://openalex.org/W2005668937","https://openalex.org/W2008360081","https://openalex.org/W2012740474","https://openalex.org/W2013688315","https://openalex.org/W2017656441","https://openalex.org/W2019273304","https://openalex.org/W2019540125","https://openalex.org/W2019737795","https://openalex.org/W2021434111","https://openalex.org/W2021794070","https://openalex.org/W2022166029","https://openalex.org/W2022205459","https://openalex.org/W2023929246","https://openalex.org/W2025619704","https://openalex.org/W2025704460","https://openalex.org/W2025746727","https://openalex.org/W2026530459","https://openalex.org/W2026680707","https://openalex.org/W2027035932","https://openalex.org/W2027344845","https://openalex.org/W2028524718","https://openalex.org/W2029926610","https://openalex.org/W2030226186","https://openalex.org/W2030279593","https://openalex.org/W2030953821","https://openalex.org/W2031501484","https://openalex.org/W2033850769","https://openalex.org/W2034490377","https://openalex.org/W2035343326","https://openalex.org/W2035646265","https://openalex.org/W2035664993","https://openalex.org/W2037043326","https://openalex.org/W2037169858","https://openalex.org/W2040127461","https://openalex.org/W2040241114","https://openalex.org/W2040362798","https://openalex.org/W2041138634","https://openalex.org/W2041529679","https://openalex.org/W2043848949","https://openalex.org/W2043863194","https://openalex.org/W2043952256","https://openalex.org/W2045820968","https://openalex.org/W2046130374","https://openalex.org/W2049775473","https://openalex.org/W2050301619","https://openalex.org/W2050810394","https://openalex.org/W2051394389","https://openalex.org/W2052321819","https://openalex.org/W2052445040","https://openalex.org/W2052450826","https://openalex.org/W2052969831","https://openalex.org/W2053252733","https://openalex.org/W2053666225","https://openalex.org/W2053972308","https://openalex.org/W2054258725","https://openalex.org/W2054935693","https://openalex.org/W2056760436","https://openalex.org/W2060903877","https://openalex.org/W2061517625","https://openalex.org/W2062893281","https://openalex.org/W2064643739","https://openalex.org/W2064876671","https://openalex.org/W2065264027","https://openalex.org/W2065379430","https://openalex.org/W2066046731","https://openalex.org/W2066143558","https://openalex.org/W2066449513","https://openalex.org/W2067761476","https://openalex.org/W2068406884","https://openalex.org/W2070334947","https://openalex.org/W2073015829","https://openalex.org/W2073056113","https://openalex.org/W2073953824","https://openalex.org/W2074993294","https://openalex.org/W2075169407","https://openalex.org/W2076171364","https://openalex.org/W2076845466","https://openalex.org/W2078873122","https://openalex.org/W2081650885","https://openalex.org/W2082538655","https://openalex.org/W2084990572","https://openalex.org/W2085124463","https://openalex.org/W2085944780","https://openalex.org/W2088433924","https://openalex.org/W2090809474","https://openalex.org/W2091215253","https://openalex.org/W2094876036","https://openalex.org/W2095351296","https://openalex.org/W2095433128","https://openalex.org/W2101860597","https://openalex.org/W2107759391","https://openalex.org/W2108473659","https://openalex.org/W2113115816","https://openalex.org/W2114240016","https://openalex.org/W2115727942","https://openalex.org/W2119624092","https://openalex.org/W2119631902","https://openalex.org/W2120012263","https://openalex.org/W2124312719","https://openalex.org/W2124561299","https://openalex.org/W2124969212","https://openalex.org/W2125151536","https://openalex.org/W2125856315","https://openalex.org/W2126440764","https://openalex.org/W2128175762","https://openalex.org/W2128396019","https://openalex.org/W2128840922","https://openalex.org/W2129134761","https://openalex.org/W2131983554","https://openalex.org/W2134735073","https://openalex.org/W2135538523","https://openalex.org/W2138050543","https://openalex.org/W2140298451","https://openalex.org/W2140554379","https://openalex.org/W2140574812","https://openalex.org/W2140627356","https://openalex.org/W2141655588","https://openalex.org/W2142170543","https://openalex.org/W2142482515","https://openalex.org/W2142940299","https://openalex.org/W2146150501","https://openalex.org/W2147435027","https://openalex.org/W2149602538","https://openalex.org/W2154896750","https://openalex.org/W2155922333","https://openalex.org/W2156989210","https://openalex.org/W2157803979","https://openalex.org/W2160148379","https://openalex.org/W2161896219","https://openalex.org/W2163479389","https://openalex.org/W2165234706","https://openalex.org/W2165787609","https://openalex.org/W2172256092","https://openalex.org/W2175077154","https://openalex.org/W2175293547","https://openalex.org/W2181050057","https://openalex.org/W2223567557","https://openalex.org/W2231861525","https://openalex.org/W2232581351","https://openalex.org/W2266987102","https://openalex.org/W2275109486","https://openalex.org/W2310081349","https://openalex.org/W2320349682","https://openalex.org/W2320541385","https://openalex.org/W2323484692","https://openalex.org/W2339022261","https://openalex.org/W2343977995","https://openalex.org/W2346038399","https://openalex.org/W2396341425","https://openalex.org/W2402262667","https://openalex.org/W2410063414","https://openalex.org/W2419134914","https://openalex.org/W2439919751","https://openalex.org/W2464847135","https://openalex.org/W2468229271","https://openalex.org/W2774865635"],"related_works":["https://openalex.org/W2131545113","https://openalex.org/W2887087194","https://openalex.org/W7096912643","https://openalex.org/W226417650","https://openalex.org/W2157408971","https://openalex.org/W2090456077","https://openalex.org/W2077970142","https://openalex.org/W1535620886","https://openalex.org/W2080728743","https://openalex.org/W2259702770"],"abstract_inverted_index":{"The":[0,36,118,196,438,495],"aim":[1],"of":[2,13,38,57,71,85,120,202,220,234,275,289,296,306,309,335,349,360,390,393,396,409,425,442,452,462,497,510,524,534,543,573,592,622,641,650,654,661],"this":[3,139,157,237,453,498,518,579],"study":[4],"was":[5,56,79,160,212,300,369,414,470,556,640],"to":[6,43,59,61,404,474,489,539,609,644,658,721],"investigate":[7,62,540],"the":[8,14,32,83,116,143,151,174,183,218,226,273,287,294,307,310,333,347,358,373,376,394,401,431,443,450,467,475,479,483,511,541,549,560,602,618,648,659,682],"anti-inflammatory":[9,198,249,260,678,695],"and":[10,18,47,105,134,204,230,291,317,338,362,380,398,406,436,440,526,563,583,589,620,646,692,724],"immunosuppressive":[11,46,185,674,687],"effects":[12,84,186,201,219,288,395,523,542,561],"synthetic":[15,41,88,158,223,546,709],"progestins,":[16],"MPA":[17,133,203,290,325,368,397,419,503,525,562,582],"NET-A":[19,135,205,292,343,399,421,505,527,564,584,723],"on":[20,92,102,131,142,225,251,293,332,400,465,478,528,548,566,605,681],"human":[21,280,297],"cells":[22,428],"in":[23,90,138,150,166,191,208,214,381,449,487,536,569,578,636,689,703,719],"vitro.":[24],"These":[25,697],"injectable":[26],"contraceptives":[27],"are":[28,206,447],"used":[29,161],"extensively":[30],"throughout":[31],"world,":[33],"including":[34],"Africa.":[35],"potential":[37],"these":[39,64,72,86,187,221,544,708],"two":[40,65,87,188,222,545],"hormones":[42,66,89,224,547],"have":[44,50,700],"certain":[45,93],"GC":[48,165],"properties":[49,74,250,688],"previously":[51,127],"been":[52],"shown.":[53],"Therefore,":[54],"it":[55,532],"concern":[58],"us":[60],"whether":[63,418],"could":[67,194,699],"possibly":[68],"demonstrate":[69,240],"any":[70],"GC-like":[73],"at":[75,244,669],"contraceptive":[76,189,245,670],"doses.":[77],"This":[78,107,170,211,299,413,555],"achieved":[80,301,415,557],"by":[81,216,232,302,315,367,416,429,558,571],"determining":[82,417],"vitro":[91,215,570],"immunologic":[94],"parameters.":[95],"Chapter":[96,209,283,387,537,637],"1":[97],"is":[98,136,147,632,634],"a":[99,111,163,327,460,610,614],"literature":[100],"review":[101],"MPA,":[103,193,242,667,722],"NET":[104],"GCs.":[106],"chapter":[108,171,238,499,580],"starts":[109],"with":[110,154,707],"short":[112],"introduction":[113,451],"that":[114,181,241,269,324,357,501,581,599,631,666],"sets":[115],"scene.":[117],"mode":[119],"action,":[121],"effectiveness,":[122],"sideeffects":[123],"as":[124,126,162,375,459,625,627,675,677],"well":[125,626,676],"reported":[128],"relevant":[129],"data":[130,651],"both":[132,252,276,336],"portrayed":[137,458],"review.":[140],"Research":[141],"known":[144,377],"GC,":[145,378],"Dex,":[146,379],"also":[148,597,712],"included":[149],"section":[152],"dealing":[153],"GCs,":[155],"because":[156],"hormone":[159],"comparative":[164],"all":[167,655],"our":[168,521,623,656,662,690],"experiments.":[169],"soon":[172],"makes":[173],"reader":[175],"realize":[176],"how":[177],"much":[178],"evidence":[179],"exists":[180],"indicate":[182],"possible":[184,197,628],"hormones,":[190],"particular":[192],"have.":[195],"or":[199,371],"pro-inflammatory":[200],"investigated":[207,286],"2.":[210],"done":[213,477],"measuring":[217,430,559],"inflammatory":[227,277],"markers,":[228],"IL-6":[229],"TNF\u03b1,":[231],"means":[233,572],"ELISA.":[235,574],"In":[236,262,282,353,472],"we":[239,267,285,322,355,481,576],"even":[243,384,668],"doses,":[246,671],"exhibits":[247],"significant":[248,329,673,694,714],"cytokines":[253,402],"tested,":[254],"while":[255,342,514],"NETA":[256],"displayed":[257,672],"considerably":[258],"less":[259,372],"tendencies.":[261],"its":[263],"true":[264],"antiinflammatory":[265],"manner,":[266],"found":[268,356,598,665,716],"Dex":[270,515,600],"significantly":[271,345,506,516],"inhibited":[272,346],"release":[274],"markers":[278],"from":[279],"monocytes.":[281],"3,":[284],"activation":[295,311,334,348,366,591],"lymphocytes.":[298],"flow":[303],"cytometric":[304],"measurement":[305],"expression":[308],"membrane":[312],"marker":[313],"CD69":[314],"CD4":[316,410],"CD8":[318,529,550,593],"T":[319,340,351,364,411,426,444,530,551,594],"cells.":[320,352,412,595],"Here":[321],"discovered":[323,577],"had":[326,565,601],"very":[328],"inhibitory":[330],"effect":[331,604],"CD4+":[337,361],"CD8+":[339,350,363],"cells,":[341,531],"only":[344],"addition,":[354],"inhibition":[359],"cell":[365],"more":[370,385],"same":[374,603],"some":[382],"cases":[383],"potent.":[386],"4":[388],"consists":[389],"an":[391],"investigation":[392],"belonging":[403],"TH1":[405,464],"TH2":[407],"subsets":[408,424,446,485],"and/or":[420],"targeted":[422],"specific":[423],"helper":[427,445,484,512],"distinct":[432],"regulatory":[433],"cytokines,":[434],"IFN\u03b3":[435],"IL-4.":[437],"mechanism":[439],"role":[441],"discussed":[448],"chapter.":[454],"Our":[455],"results":[456,496,624],"were":[457,493],"ratio":[461],"TH2:":[463],"which":[466,491],"statistical":[468],"analysis":[469,476],"done.":[471],"addition":[473],"ratio,":[480],"analyzed":[482],"separately":[486],"order":[488],"determine":[490],"subset(s)":[492],"influenced.":[494],"showed":[500],"neither":[502],"nor":[504],"affected":[507],"either":[508],"one":[509],"subsets,":[513],"decreased":[517],"ratio.":[519],"After":[520],"observed":[522],"became":[533],"interest":[535],"5":[538],"cell-specific":[552],"chemokine,":[553],"RANTES.":[554],"RANTES":[567,586,606],"production":[568,587],"Surprisingly,":[575],"enhanced":[585],"before":[588],"after":[590],"We":[596,664,711],"production,":[607],"but":[608],"lesser":[611],"degree.":[612],"Finally,":[613],"general":[615],"conclusion":[616],"depicting":[617],"significance":[619],"implications":[621,702],"future":[629],"research":[630,691],"required":[633],"presented":[635],"6.":[638],"It":[639],"great":[642],"importance":[643],"discuss":[645],"interpret":[647],"magnitude":[649],"generated":[652],"out":[653],"experiments":[657],"utmost":[660],"capabilities.":[663],"properties.":[679,696],"NET-A,":[680],"other":[683],"hand,":[684],"demonstrated":[685,713],"weaker":[686],"no":[693],"findings":[698],"clinical":[701],"females":[704],"being":[705],"treated":[706],"contraceptives.":[710],"variation":[715],"amongst":[717],"genders":[718],"response":[720],"Dex.":[725]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
