{"id":"https://openalex.org/W1913628348","doi":"https://doi.org/10.18632/oncotarget.4681","title":"Characterization of SLC22A18 as a tumor suppressor and novel biomarker in colorectal cancer","display_name":"Characterization of SLC22A18 as a tumor suppressor and novel biomarker in colorectal cancer","publication_year":2015,"publication_date":"2015-06-28","ids":{"openalex":"https://openalex.org/W1913628348","doi":"https://doi.org/10.18632/oncotarget.4681","mag":"1913628348","pmid":"https://pubmed.ncbi.nlm.nih.gov/26196590","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4694837"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.4681","doi":"https://doi.org/10.18632/oncotarget.4681","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.4681","pdf_url":"https://www.oncotarget.com/article/4681/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.oncotarget.com/article/4681/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101438284","display_name":"Yeonjoo Jung","orcid":"https://orcid.org/0000-0002-3096-0091","observed_orcids":["https://orcid.org/0000-0002-3096-0091"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yeonjoo Jung","raw_affiliation_strings":["Department of Life Science, Ewha Womans University, Seoul, Korea","Ewha Research Center for Systems Biology, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, Ewha Womans University, Seoul, Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"Ewha Research Center for Systems Biology, Seoul, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084375776","display_name":"Yukyung Jun","orcid":"https://orcid.org/0000-0002-4025-7164","observed_orcids":["https://orcid.org/0000-0002-4025-7164"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yukyung Jun","raw_affiliation_strings":["Department of Life Science, Ewha Womans University, Seoul, Korea","Ewha Research Center for Systems Biology, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, Ewha Womans University, Seoul, Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"Ewha Research Center for Systems Biology, Seoul, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110697616","display_name":"Hee-Young Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee-Young Lee","raw_affiliation_strings":["Department of Life Science, Ewha Womans University, Seoul, Korea","Ewha Research Center for Systems Biology, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, Ewha Womans University, Seoul, Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"Ewha Research Center for Systems Biology, Seoul, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137003914","display_name":"Suyeon Kim","orcid":"https://orcid.org/0009-0002-0635-1517","observed_orcids":["https://orcid.org/0009-0002-0635-1517"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Suyeon Kim","raw_affiliation_strings":["Department of Life Science, Ewha Womans University, Seoul, Korea","Ewha Research Center for Systems Biology, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, Ewha Womans University, Seoul, Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"Ewha Research Center for Systems Biology, Seoul, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092169425","display_name":"\uc5f0\ud654 \uc815","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeonhwa Jung","raw_affiliation_strings":["Department of Life Science, Ewha Womans University, Seoul, Korea","Ewha Research Center for Systems Biology, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, Ewha Womans University, Seoul, Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"Ewha Research Center for Systems Biology, Seoul, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008637477","display_name":"Juhee Keum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Juhee Keum","raw_affiliation_strings":["Department of Life Science, Ewha Womans University, Seoul, Korea","Ewha Research Center for Systems Biology, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, Ewha Womans University, Seoul, Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"Ewha Research Center for Systems Biology, Seoul, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042379314","display_name":"Yeo Song Lee","orcid":"https://orcid.org/0000-0002-7005-2194","observed_orcids":["https://orcid.org/0000-0002-7005-2194"]},"institutions":[{"id":"https://openalex.org/I2250650973","display_name":"Samsung (South Korea)","ror":"https://ror.org/04w3jy968","country_code":"KR","type":"company","lineage":["https://openalex.org/I2250650973"]},{"id":"https://openalex.org/I4405271894","display_name":"Samsung Biomedical Research Institute","ror":"https://ror.org/037pjb504","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405271894"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeo Song Lee","raw_affiliation_strings":["Samsung Biomedical Research Institute, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Samsung Biomedical Research Institute, Seoul, Korea","institution_ids":["https://openalex.org/I2250650973","https://openalex.org/I4405271894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159691183","display_name":"Yong Beom Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong Beom Cho","raw_affiliation_strings":["Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100604980","display_name":"Sanghyuk Lee","orcid":"https://orcid.org/0000-0001-9230-7461","observed_orcids":["https://orcid.org/0000-0001-9230-7461"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sanghyuk Lee","raw_affiliation_strings":["Department of Life Science, Ewha Womans University, Seoul, Korea","Ewha Research Center for Systems Biology, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, Ewha Womans University, Seoul, Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"Ewha Research Center for Systems Biology, Seoul, Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103135203","display_name":"Jaesang Kim","orcid":"https://orcid.org/0000-0002-7659-4242","observed_orcids":["https://orcid.org/0000-0002-7659-4242"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jaesang Kim","raw_affiliation_strings":["Department of Life Science, Ewha Womans University, Seoul, Korea","Ewha Research Center for Systems Biology, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, Ewha Womans University, Seoul, Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"Ewha Research Center for Systems Biology, Seoul, Korea","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5084375776","https://openalex.org/A5101438284"],"corresponding_institution_ids":["https://openalex.org/I138925566"],"apc_list":null,"apc_paid":null,"fwci":0.8076,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.6843223,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"28","first_page":"25368","last_page":"25380"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.05559999868273735,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/slc22a18","display_name":"SLC22A18","score":0.8930000066757202},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9190000295639038},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7319999933242798},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8619999885559082},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.8529999852180481},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.9409999847412109},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.5529999732971191},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8349999785423279},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.8870000243186951},{"id":"https://openalex.org/keywords/11p15-5","display_name":"11p15.5","score":0.8080000281333923},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.7549999952316284},{"id":"https://openalex.org/keywords/colony-formation","display_name":"colony formation","score":0.4480000138282776},{"id":"https://openalex.org/keywords/tcga-data","display_name":"TCGA data","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6992555856704712},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.6168084740638733},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5914031863212585},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5298551917076111},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5221817493438721},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5062302947044373},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34059250354766846},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.332506388425827}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027701","descriptor_name":"Organic Cation Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027701","descriptor_name":"Organic Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059565","descriptor_name":"G2 Phase Cell Cycle Checkpoints","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.18632/oncotarget.4681","doi":"https://doi.org/10.18632/oncotarget.4681","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.4681","pdf_url":"https://www.oncotarget.com/article/4681/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmid:26196590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26196590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4694837","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4694837/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.4681","doi":"https://doi.org/10.18632/oncotarget.4681","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.4681","pdf_url":"https://www.oncotarget.com/article/4681/pdf/","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7093757842","display_name":null,"funder_award_id":"10050154","funder_id":"https://openalex.org/F4320321681","funder_display_name":"Ministry of Trade, Industry and Energy"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321365","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05"},{"id":"https://openalex.org/F4320321681","display_name":"Ministry of Trade, Industry and Energy","ror":"https://ror.org/008nkqk13"},{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1913628348.pdf","grobid_xml":"https://content.openalex.org/works/W1913628348.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1511027285","https://openalex.org/W1970925597","https://openalex.org/W1984742254","https://openalex.org/W2001011373","https://openalex.org/W2006351633","https://openalex.org/W2008118174","https://openalex.org/W2022496591","https://openalex.org/W2051047807","https://openalex.org/W2112779230","https://openalex.org/W2119320880","https://openalex.org/W2120341265","https://openalex.org/W2120899273","https://openalex.org/W2121355008","https://openalex.org/W2127905772","https://openalex.org/W2130370322","https://openalex.org/W2135911436","https://openalex.org/W2150286564","https://openalex.org/W2156334585","https://openalex.org/W2160130560","https://openalex.org/W2160899498","https://openalex.org/W2161273286","https://openalex.org/W2163214467","https://openalex.org/W2169798600"],"related_works":["https://openalex.org/W2056127268","https://openalex.org/W3034171196","https://openalex.org/W4391876896","https://openalex.org/W1509533156","https://openalex.org/W2792154784","https://openalex.org/W2751085315","https://openalex.org/W2902864531","https://openalex.org/W2963519304","https://openalex.org/W4309411741","https://openalex.org/W4402994126"],"abstract_inverted_index":{"//":[0,98],"Yeonjoo":[1],"Jung":[2,18,84],"1,2,*":[3,7],",":[4,8,12,16,20,24,29,34,126],"Yukyung":[5],"Jun":[6,87],"Hee-Young":[9],"Lee":[10,27,36],"1,2":[11,15,19,23,37,41],"Suyeon":[13],"Kim":[14,40],"Yeonhwa":[17],"Juhee":[21],"Keum":[22],"Yeo":[25],"Song":[26],"3":[28,61],"Yong":[30],"Beom":[31],"Cho":[32],"4":[33,68],"Sanghyuk":[35],"and":[38,85,150,158,181,229,250,275,282,315,325],"Jaesang":[39,95],"1":[42],"Ewha":[43,56],"Research":[44,64],"Center":[45],"for":[46,185,295],"Systems":[47],"Biology,":[48],"Seoul,":[49,59,66,80],"Korea":[50,60,67,81],"2":[51],"Department":[52,69],"of":[53,70,78,156,171,194,231,242,252,263,278,323],"Life":[54],"Science,":[55],"Womans":[57],"University,":[58],"Samsung":[62,72],"Biomedical":[63],"Institute,":[65],"Surgery,":[71],"Medical":[73],"Center,":[74],"Sungkyunkwan":[75],"University":[76],"School":[77],"Medicine,":[79],"*":[82],"Y.":[83,86],"contributed":[88],"equally":[89],"to":[90,136,167],"this":[91,163],"work":[92],"Correspondence":[93],"to:":[94],"Kim,":[96],"email:":[97],"Keywords":[99],":":[100,110,115,120],"SLC22A18,":[101],"tumor":[102,140,175,200,238,309],"suppressor,":[103],"colorectal":[104,178],"cancer,":[105],"G2/M":[106,232],"arrest,":[107],"KRAS":[108,243,257],"Received":[109],"November":[111],"26,":[112],"2014":[113],"Accepted":[114],"June":[116,121],"18,":[117,132],"2015":[118,123],"Published":[119],"28,":[122],"Abstract":[124],"SLC22A18":[125,172,195,225,248,253,279,300,306,318],"solute":[127],"carrier":[128],"family":[129],"22,":[130],"member":[131],"has":[133],"been":[134],"proposed":[135],"function":[137],"as":[138,173,307],"a":[139,174,237,267,290,308,321],"suppressor":[141,176,310],"based":[142],"on":[143],"its":[144,186],"chromosomal":[145],"location":[146],"at":[147],"11p15.5,":[148],"mutations":[149],"aberrant":[151],"splicing":[152],"in":[153,160,177,199,254,311],"several":[154],"types":[155],"cancer":[157,179],"down-regulation":[159],"glioblastoma.":[161],"In":[162,302],"study,":[164],"we":[165,272,304],"sought":[166],"demonstrate":[168],"the":[169,192],"significance":[170],"(CRC)":[180],"provide":[182],"mechanistic":[183],"bases":[184],"function.":[187],"We":[188],"first":[189],"showed":[190],"that":[191,317],"expression":[193,251,284],"is":[196,319],"significantly":[197,291],"down-regulated":[198],"tissues":[201],"using":[202,280],"matched":[203],"normal-tumor":[204],"samples":[205],"from":[206,218,286],"CRC":[207],"patients.":[208],"This":[209],"finding":[210],"was":[211],"also":[212],"supported":[213],"by":[214,244],"publically":[215],"accessible":[216],"data":[217,285],"The":[219],"Cancer":[220],"Genome":[221],"Atlas":[222],"(TCGA).":[223],"Functionally,":[224],"inhibits":[226,256],"colony":[227],"formation":[228],"induces":[230],"arrest":[233],"consistent":[234],"with":[235,297],"being":[236],"suppressor.":[239],"Interestingly,":[240],"suppression":[241],"RNA":[245],"interference":[246],"promotes":[247],"expression,":[249],"turn":[255],"G12D":[258],"-mediated":[259],"anchorage":[260],"independent":[261],"growth":[262],"NIH3T3":[264],"cells":[265,314],"indicating":[266],"mutual":[268],"negative":[269],"interaction.":[270],"Finally,":[271],"evaluated":[273],"diagnostic":[274,324],"prognostic":[276,326],"values":[277],"clinical":[281],"gene":[283],"TCGA":[287],"which":[288],"revealed":[289],"worse":[292],"long-term":[293],"prognosis":[294],"patients":[296],"low":[298],"level":[299],"expression.":[301],"sum,":[303],"established":[305],"colon":[312],"epithelial":[313],"propose":[316],"potentially":[320],"marker":[322],"values.":[327]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}