{"id":"https://openalex.org/W1912373825","doi":null,"title":"Activated oncogenes in human skin tumors from a repair-deficient syndrome, xeroderma pigmentosum.","display_name":"Activated oncogenes in human skin tumors from a repair-deficient syndrome, xeroderma pigmentosum.","publication_year":1989,"publication_date":"1989-03-01","ids":{"openalex":"https://openalex.org/W1912373825","mag":"1912373825","pmid":"https://pubmed.ncbi.nlm.nih.gov/2645047"},"language":"en","primary_location":{"id":"pmid:2645047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2645047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108432058","display_name":"Horacio Guillermo Suarez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H G Suarez","raw_affiliation_strings":["Institut de Recherches Scientifiques sur le Cancer, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Scientifiques sur le Cancer, Villejuif, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002289819","display_name":"Leela Daya\u2013Grosjean","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Daya-Grosjean","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012476442","display_name":"Daniel Schlaifer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Schlaifer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113604675","display_name":"P. Nardeux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Nardeux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077593485","display_name":"Georges Renault","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Renault","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012633181","display_name":"Johannes L. Bos","orcid":"https://orcid.org/0000-0002-5656-2091","observed_orcids":["https://orcid.org/0000-0002-5656-2091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Bos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002451432","display_name":"Alain R. Sarasin","orcid":"https://orcid.org/0000-0002-2445-6016","observed_orcids":["https://orcid.org/0000-0002-2445-6016"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Sarasin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.046,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.88118272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"49","issue":"5","first_page":"1223","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.4456000030040741,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.4456000030040741,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":0.17649999260902405,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.06560000032186508,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xeroderma-pigmentosum","display_name":"xeroderma pigmentosum","score":1.0},{"id":"https://openalex.org/keywords/skin-tumors","display_name":"skin tumors","score":0.8970000147819519},{"id":"https://openalex.org/keywords/oncogene-activation","display_name":"oncogene activation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/nras-mutation","display_name":"NRAS mutation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/myc-overexpression","display_name":"MYC overexpression","score":0.8420000076293945},{"id":"https://openalex.org/keywords/dna-repair-deficiency","display_name":"DNA repair deficiency","score":0.6990000009536743},{"id":"https://openalex.org/keywords/uv-induced-dna-damage","display_name":"UV-induced DNA damage","score":0.7889999747276306},{"id":"https://openalex.org/keywords/uv-mutagenesis","display_name":"UV mutagenesis","score":0.5509999990463257},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.7689999938011169},{"id":"https://openalex.org/keywords/hereditary-cancer-syndromes","display_name":"hereditary cancer","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C2778378917","wikidata":"https://www.wikidata.org/wiki/Q612693","display_name":"Xeroderma pigmentosum","level":4,"score":0.9675074815750122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6496224403381348},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5937583446502686},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5629664659500122},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5490635633468628},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5187504291534424},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.500281572341919},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.4909830391407013},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4675288200378418},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.4456263780593872},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4243777394294739},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4200168251991272},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25386303663253784},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.06420886516571045}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2645047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2645047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1912373825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2645047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2137587123","https://openalex.org/W2054764151","https://openalex.org/W2120862121","https://openalex.org/W2013600293","https://openalex.org/W2028064895","https://openalex.org/W2059373596","https://openalex.org/W4306252659","https://openalex.org/W89856530","https://openalex.org/W4368368417","https://openalex.org/W1989954632"],"abstract_inverted_index":{"The":[0,19,94,160,177],"recessive":[1],"autosomal":[2],"hereditary":[3],"disease,":[4],"xeroderma":[5],"pigmentosum":[6],"(XP),":[7],"is":[8,179],"characterized":[9],"by":[10,98,112],"a":[11,56],"high":[12,197],"incidence":[13],"of":[14,24,27,104,115,138,150,157,171,184,199,212],"tumors":[15,40,53,79,141],"in":[16,21,74,85,101,109,154,188,204,209],"sun-exposed":[17],"skin.":[18],"defect":[20],"early":[22],"steps":[23],"excision":[25],"repair":[26],"XP":[28,39,57,140,165],"cells":[29],"leads":[30],"to":[31,70,82,92,195],"hypermutability":[32],"towards":[33],"UV-mimicking":[34],"agents.":[35],"DNA":[36,201],"from":[37,55,90,164],"eight":[38],"were":[41,68,80,134],"screened":[42],"for":[43],"activated":[44,60],"transforming":[45],"genes":[46],"using":[47],"3T3":[48],"transfection.":[49],"In":[50,119],"two":[51],"skin":[52,162,207],"isolated":[54],"child,":[58],"an":[59,99,148],"N-ras":[61,88,105],"oncogene":[62,145,186],"was":[63,96],"detected.":[64,136],"Synthetic":[65],"oligonucleotide":[66],"probes":[67,146],"used":[69],"characterize":[71],"the":[72,75,86,102,113,116,120,151,182,189,196,205,210],"mutation":[73,95],"ras":[76],"gene.":[77],"Both":[78],"found":[81,203],"be":[83,193],"mutated":[84],"61st":[87],"codon":[89],"gln":[91],"his.":[93],"accompanied":[97],"increase":[100],"level":[103],"specific":[106],"mRNA":[107],"and":[108,125,128,132,174],"one":[110],"transformant,":[111],"alteration":[114],"p21":[117],"protein.":[118],"same":[121,190],"tumors,":[122],"c-myc":[123,173],"amplification":[124,133,149],"over":[126],"transcription,":[127],"Ha-ras":[129,152,175],"gene":[130,153],"rearrangement":[131],"also":[135],"Analysis":[137],"other":[139],"with":[142],"eleven":[143],"different":[144],"revealed":[147],"6":[155],"out":[156],"10":[158],"cases.":[159],"normal":[161,168],"fibroblasts":[163],"patients":[166],"show":[167],"pattern":[169],"levels":[170],"N-ras,":[172],"sequences.":[176],"hypothesis":[178],"proposed":[180],"that":[181],"presence":[183],"several":[185],"alterations":[187],"tumor":[191],"could":[192],"due":[194],"amount":[198],"UV-induced":[200],"lesions":[202],"exposed":[206],"cells,":[208],"absence":[211],"efficient":[213],"repair.":[214]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
