{"id":"https://openalex.org/W191206371","doi":null,"title":"Investigation of multidrug resistance and invasion in human cancer cell lines","display_name":"Investigation of multidrug resistance and invasion in human cancer cell lines","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W191206371","mag":"191206371"},"language":"en","primary_location":{"id":"pmh:http://www.rian.ie/63746/","doi":null,"is_oa":true,"landing_page_url":"http://doras.dcu.ie/18962/","pdf_url":"http://doras.dcu.ie/18962/","source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Liang, Yizheng (1999) Investigation of multidrug resistance and invasion in human cancer cell lines. PhD thesis, Dublin City University.","raw_type":"Other"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://doras.dcu.ie/18962/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112839440","display_name":"Yizheng Liang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yizheng Liang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112839440"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7229999899864197},{"id":"https://openalex.org/keywords/melphalan-resistance","display_name":"melphalan resistance","score":0.8709999918937683},{"id":"https://openalex.org/keywords/paclitaxel-resistance","display_name":"paclitaxel resistance","score":0.9739999771118164},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.8859999775886536},{"id":"https://openalex.org/keywords/mrp1","display_name":"MRP1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/mrp2","display_name":"MRP2","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mrp3","display_name":"MRP3","score":0.9950000047683716},{"id":"https://openalex.org/keywords/multidrug-resistance-protein","display_name":"multidrug resistance protein","score":0.5370000004768372},{"id":"https://openalex.org/keywords/cross-resistance","display_name":"cross-resistance","score":0.45100000500679016},{"id":"https://openalex.org/keywords/sulindac","display_name":"sulindac","score":0.7820000052452087},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.968999981880188},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.6129999756813049},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.7990000247955322},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.5239999890327454},{"id":"https://openalex.org/keywords/nasal-cancer","display_name":"nasal cancer","score":0.7120000123977661},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.9053018093109131},{"id":"https://openalex.org/C2777132456","wikidata":"https://www.wikidata.org/wiki/Q282629","display_name":"Vinblastine","level":3,"score":0.7997410893440247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5395592451095581},{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.48001545667648315},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.4692665934562683},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.4539494514465332},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43764370679855347},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4257952570915222},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37626272439956665},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.31352895498275757},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.27353137731552124},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1978141963481903},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17226198315620422},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12137079238891602},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:http://www.rian.ie/63746/","doi":null,"is_oa":true,"landing_page_url":"http://doras.dcu.ie/18962/","pdf_url":"http://doras.dcu.ie/18962/","source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Liang, Yizheng (1999) Investigation of multidrug resistance and invasion in human cancer cell lines. PhD thesis, Dublin City University.","raw_type":"Other"},{"id":"pmh:oai:doras.dcu.ie:18962","doi":null,"is_oa":true,"landing_page_url":"https://doras.dcu.ie/18962/1/Yizheng_Liang.pdf","pdf_url":"https://doras.dcu.ie/18962/1/Yizheng_Liang.pdf","source":{"id":"https://openalex.org/S4306401511","display_name":"Dublin City University Open Access Institutional Repository (Dublin City University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I42934936","host_organization_name":"Dublin City University","host_organization_lineage":["https://openalex.org/I42934936"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:191206371","doi":null,"is_oa":false,"landing_page_url":"http://doras.dcu.ie/18962/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:http://www.rian.ie/63746/","doi":null,"is_oa":true,"landing_page_url":"http://doras.dcu.ie/18962/","pdf_url":"http://doras.dcu.ie/18962/","source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Liang, Yizheng (1999) Investigation of multidrug resistance and invasion in human cancer cell lines. PhD thesis, Dublin City University.","raw_type":"Other"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W191206371.pdf","grobid_xml":"https://content.openalex.org/works/W191206371.grobid-xml"},"referenced_works_count":583,"referenced_works":["https://openalex.org/W2395797","https://openalex.org/W38671391","https://openalex.org/W45574792","https://openalex.org/W57799326","https://openalex.org/W81300945","https://openalex.org/W85667416","https://openalex.org/W85696438","https://openalex.org/W92496820","https://openalex.org/W98131353","https://openalex.org/W101324336","https://openalex.org/W103495436","https://openalex.org/W105644209","https://openalex.org/W113845926","https://openalex.org/W124460621","https://openalex.org/W126956808","https://openalex.org/W131959092","https://openalex.org/W165291943","https://openalex.org/W166591069","https://openalex.org/W167845783","https://openalex.org/W167923556","https://openalex.org/W170323035","https://openalex.org/W186047545","https://openalex.org/W206710202","https://openalex.org/W220750778","https://openalex.org/W370878613","https://openalex.org/W625373530","https://openalex.org/W657267057","https://openalex.org/W998551225","https://openalex.org/W1027971794","https://openalex.org/W1275009225","https://openalex.org/W1275350575","https://openalex.org/W1479699116","https://openalex.org/W1480855744","https://openalex.org/W1482451012","https://openalex.org/W1483190045","https://openalex.org/W1483854239","https://openalex.org/W1489105628","https://openalex.org/W1489123075","https://openalex.org/W1489982644","https://openalex.org/W1490153447","https://openalex.org/W1499083095","https://openalex.org/W1499185242","https://openalex.org/W1499694712","https://openalex.org/W1500465676","https://openalex.org/W1504270866","https://openalex.org/W1507411141","https://openalex.org/W1507962027","https://openalex.org/W1512121436","https://openalex.org/W1514525963","https://openalex.org/W1519177607","https://openalex.org/W1521601065","https://openalex.org/W1522698243","https://openalex.org/W1523034549","https://openalex.org/W1525402398","https://openalex.org/W1526379338","https://openalex.org/W1526872663","https://openalex.org/W1528469664","https://openalex.org/W1528751727","https://openalex.org/W1530172841","https://openalex.org/W1531079490","https://openalex.org/W1541625068","https://openalex.org/W1544366193","https://openalex.org/W1545040647","https://openalex.org/W1545285984","https://openalex.org/W1548939686","https://openalex.org/W1549145380","https://openalex.org/W1549209983","https://openalex.org/W1551959442","https://openalex.org/W1555020544","https://openalex.org/W1557301042","https://openalex.org/W1557322059","https://openalex.org/W1558311166","https://openalex.org/W1559484785","https://openalex.org/W1560326407","https://openalex.org/W1561945723","https://openalex.org/W1562335567","https://openalex.org/W1562380717","https://openalex.org/W1565304586","https://openalex.org/W1565651933","https://openalex.org/W1567907251","https://openalex.org/W1568633684","https://openalex.org/W1568679470","https://openalex.org/W1570865673","https://openalex.org/W1573411722","https://openalex.org/W1576813285","https://openalex.org/W1576833897","https://openalex.org/W1579234620","https://openalex.org/W1580377051","https://openalex.org/W1583233593","https://openalex.org/W1583427298","https://openalex.org/W1585859956","https://openalex.org/W1586581726","https://openalex.org/W1590110830","https://openalex.org/W1592431232","https://openalex.org/W1593113033","https://openalex.org/W1594898068","https://openalex.org/W1595188935","https://openalex.org/W1595529034","https://openalex.org/W1597589931","https://openalex.org/W1605102643","https://openalex.org/W1606308790","https://openalex.org/W1606829096","https://openalex.org/W1613283346","https://openalex.org/W1613470888","https://openalex.org/W1613791948","https://openalex.org/W1618268377","https://openalex.org/W1620132817","https://openalex.org/W1625390868","https://openalex.org/W1628719417","https://openalex.org/W1634520049","https://openalex.org/W1635038849","https://openalex.org/W1648100608","https://openalex.org/W1651705209","https://openalex.org/W1660272883","https://openalex.org/W1664158328","https://openalex.org/W1670939209","https://openalex.org/W1754065147","https://openalex.org/W1758361781","https://openalex.org/W1766532836","https://openalex.org/W1768069605","https://openalex.org/W1768545249","https://openalex.org/W1770217187","https://openalex.org/W1774025539","https://openalex.org/W1774476527","https://openalex.org/W1795440804","https://openalex.org/W1795833015","https://openalex.org/W1799131074","https://openalex.org/W1801106228","https://openalex.org/W1808672184","https://openalex.org/W1814545573","https://openalex.org/W1815735775","https://openalex.org/W1824640790","https://openalex.org/W1829804413","https://openalex.org/W1840819038","https://openalex.org/W1854896859","https://openalex.org/W1865504766","https://openalex.org/W1883117432","https://openalex.org/W1886830245","https://openalex.org/W1890023926","https://openalex.org/W1896861650","https://openalex.org/W1901412126","https://openalex.org/W1902352259","https://openalex.org/W1903921724","https://openalex.org/W1910704132","https://openalex.org/W1911655428","https://openalex.org/W1911976151","https://openalex.org/W1924266790","https://openalex.org/W1924307075","https://openalex.org/W1928009957","https://openalex.org/W1929405822","https://openalex.org/W1931964440","https://openalex.org/W1932414675","https://openalex.org/W1938617858","https://openalex.org/W1946967684","https://openalex.org/W1947299108","https://openalex.org/W1948829298","https://openalex.org/W1955840624","https://openalex.org/W1957963400","https://openalex.org/W1960717480","https://openalex.org/W1963502802","https://openalex.org/W1964402086","https://openalex.org/W1964470226","https://openalex.org/W1964973685","https://openalex.org/W1965365783","https://openalex.org/W1965581535","https://openalex.org/W1966286149","https://openalex.org/W1966377054","https://openalex.org/W1966932371","https://openalex.org/W1967127679","https://openalex.org/W1967233045","https://openalex.org/W1967493163","https://openalex.org/W1967688094","https://openalex.org/W1967786501","https://openalex.org/W1968169368","https://openalex.org/W1968490536","https://openalex.org/W1968513798","https://openalex.org/W1969059462","https://openalex.org/W1969262864","https://openalex.org/W1969795656","https://openalex.org/W1970448480","https://openalex.org/W1970734978","https://openalex.org/W1970969867","https://openalex.org/W1971140306","https://openalex.org/W1971593005","https://openalex.org/W1971639797","https://openalex.org/W1972562299","https://openalex.org/W1974338599","https://openalex.org/W1974375149","https://openalex.org/W1974391793","https://openalex.org/W1975573788","https://openalex.org/W1976852537","https://openalex.org/W1977860453","https://openalex.org/W1978160288","https://openalex.org/W1978162138","https://openalex.org/W1978459262","https://openalex.org/W1978609854","https://openalex.org/W1979121408","https://openalex.org/W1979319210","https://openalex.org/W1979861744","https://openalex.org/W1980411311","https://openalex.org/W1981176937","https://openalex.org/W1981393628","https://openalex.org/W1981409816","https://openalex.org/W1981534406","https://openalex.org/W1983228193","https://openalex.org/W1983347917","https://openalex.org/W1985014981","https://openalex.org/W1985355265","https://openalex.org/W1985460342","https://openalex.org/W1985478809","https://openalex.org/W1985499095","https://openalex.org/W1985727076","https://openalex.org/W1986260241","https://openalex.org/W1986265345","https://openalex.org/W1986531401","https://openalex.org/W1986981812","https://openalex.org/W1987003289","https://openalex.org/W1987498682","https://openalex.org/W1987568997","https://openalex.org/W1987649511","https://openalex.org/W1987893215","https://openalex.org/W1988357599","https://openalex.org/W1988508701","https://openalex.org/W1988746362","https://openalex.org/W1988866780","https://openalex.org/W1989057019","https://openalex.org/W1989494625","https://openalex.org/W1991644963","https://openalex.org/W1992290533","https://openalex.org/W1992670294","https://openalex.org/W1992693154","https://openalex.org/W1993101179","https://openalex.org/W1993265798","https://openalex.org/W1993480392","https://openalex.org/W1994277288","https://openalex.org/W1994294394","https://openalex.org/W1994766102","https://openalex.org/W1995054939","https://openalex.org/W1995100484","https://openalex.org/W1995230824","https://openalex.org/W1995249913","https://openalex.org/W1995411620","https://openalex.org/W1996211746","https://openalex.org/W1996522179","https://openalex.org/W1997904779","https://openalex.org/W1998811052","https://openalex.org/W1999086357","https://openalex.org/W1999790244","https://openalex.org/W1999882163","https://openalex.org/W2001258296","https://openalex.org/W2001473164","https://openalex.org/W2002452703","https://openalex.org/W2002728401","https://openalex.org/W2002777079","https://openalex.org/W2004072274","https://openalex.org/W2004101410","https://openalex.org/W2004205718","https://openalex.org/W2006041162","https://openalex.org/W2006298308","https://openalex.org/W2006642363","https://openalex.org/W2006912182","https://openalex.org/W2006974151","https://openalex.org/W2007718340","https://openalex.org/W2007965142","https://openalex.org/W2008118175","https://openalex.org/W2008249338","https://openalex.org/W2008821959","https://openalex.org/W2008863543","https://openalex.org/W2009007332","https://openalex.org/W2010027735","https://openalex.org/W2010426855","https://openalex.org/W2010511880","https://openalex.org/W2010911302","https://openalex.org/W2011761081","https://openalex.org/W2011770034","https://openalex.org/W2011826653","https://openalex.org/W2012400518","https://openalex.org/W2012617112","https://openalex.org/W2012754297","https://openalex.org/W2012841076","https://openalex.org/W2012939857","https://openalex.org/W2012989068","https://openalex.org/W2013540958","https://openalex.org/W2013948741","https://openalex.org/W2014231740","https://openalex.org/W2014865384","https://openalex.org/W2015319769","https://openalex.org/W2015545351","https://openalex.org/W2015759068","https://openalex.org/W2016693266","https://openalex.org/W2016985284","https://openalex.org/W2018835423","https://openalex.org/W2019392946","https://openalex.org/W2020445671","https://openalex.org/W2020532584","https://openalex.org/W2021180110","https://openalex.org/W2021841041","https://openalex.org/W2022448099","https://openalex.org/W2022797781","https://openalex.org/W2023300542","https://openalex.org/W2023949965","https://openalex.org/W2024463580","https://openalex.org/W2024656597","https://openalex.org/W2025173911","https://openalex.org/W2025260035","https://openalex.org/W2026327431","https://openalex.org/W2026392633","https://openalex.org/W2026834760","https://openalex.org/W2028533496","https://openalex.org/W2029863361","https://openalex.org/W2030229397","https://openalex.org/W2030451664","https://openalex.org/W2030462937","https://openalex.org/W2030533124","https://openalex.org/W2030542269","https://openalex.org/W2031255931","https://openalex.org/W2031295742","https://openalex.org/W2031489596","https://openalex.org/W2031672990","https://openalex.org/W2031749514","https://openalex.org/W2032920533","https://openalex.org/W2033272151","https://openalex.org/W2033507154","https://openalex.org/W2033553519","https://openalex.org/W2033934810","https://openalex.org/W2034797989","https://openalex.org/W2035664521","https://openalex.org/W2035776517","https://openalex.org/W2037490361","https://openalex.org/W2037588602","https://openalex.org/W2037605675","https://openalex.org/W2037720810","https://openalex.org/W2037902796","https://openalex.org/W2038170131","https://openalex.org/W2038608092","https://openalex.org/W2039278712","https://openalex.org/W2040150238","https://openalex.org/W2040403957","https://openalex.org/W2040786744","https://openalex.org/W2040804282","https://openalex.org/W2041209857","https://openalex.org/W2041985793","https://openalex.org/W2042044981","https://openalex.org/W2042274919","https://openalex.org/W2042283185","https://openalex.org/W2043445899","https://openalex.org/W2043946887","https://openalex.org/W2045627528","https://openalex.org/W2046208473","https://openalex.org/W2047414858","https://openalex.org/W2049313420","https://openalex.org/W2049513882","https://openalex.org/W2050750704","https://openalex.org/W2051021771","https://openalex.org/W2053706150","https://openalex.org/W2053919896","https://openalex.org/W2057876887","https://openalex.org/W2057949435","https://openalex.org/W2058215061","https://openalex.org/W2058265493","https://openalex.org/W2058273909","https://openalex.org/W2058591356","https://openalex.org/W2059453596","https://openalex.org/W2062375210","https://openalex.org/W2062381728","https://openalex.org/W2062552900","https://openalex.org/W2063960633","https://openalex.org/W2063968553","https://openalex.org/W2064035407","https://openalex.org/W2064086130","https://openalex.org/W2064160631","https://openalex.org/W2064735316","https://openalex.org/W2066109395","https://openalex.org/W2067299834","https://openalex.org/W2067898376","https://openalex.org/W2068124694","https://openalex.org/W2069172395","https://openalex.org/W2069294982","https://openalex.org/W2069412395","https://openalex.org/W2069415301","https://openalex.org/W2070289331","https://openalex.org/W2070412924","https://openalex.org/W2071522985","https://openalex.org/W2072753905","https://openalex.org/W2073622804","https://openalex.org/W2073651193","https://openalex.org/W2074602124","https://openalex.org/W2074687520","https://openalex.org/W2075439988","https://openalex.org/W2075733574","https://openalex.org/W2076149108","https://openalex.org/W2076536269","https://openalex.org/W2077483002","https://openalex.org/W2078298214","https://openalex.org/W2078860382","https://openalex.org/W2078877172","https://openalex.org/W2078998991","https://openalex.org/W2079088649","https://openalex.org/W2079529944","https://openalex.org/W2080304059","https://openalex.org/W2081406767","https://openalex.org/W2082623428","https://openalex.org/W2082737810","https://openalex.org/W2084064523","https://openalex.org/W2084088795","https://openalex.org/W2085452141","https://openalex.org/W2085875957","https://openalex.org/W2085928086","https://openalex.org/W2086803868","https://openalex.org/W2086945724","https://openalex.org/W2087833146","https://openalex.org/W2088023845","https://openalex.org/W2088214653","https://openalex.org/W2088817932","https://openalex.org/W2089432505","https://openalex.org/W2090073172","https://openalex.org/W2090350127","https://openalex.org/W2090594676","https://openalex.org/W2092929271","https://openalex.org/W2093531978","https://openalex.org/W2094194578","https://openalex.org/W2094543320","https://openalex.org/W2095317176","https://openalex.org/W2095382516","https://openalex.org/W2096204304","https://openalex.org/W2096428903","https://openalex.org/W2098114024","https://openalex.org/W2099212515","https://openalex.org/W2100341370","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2101119358","https://openalex.org/W2101411803","https://openalex.org/W2103590067","https://openalex.org/W2103750788","https://openalex.org/W2103826752","https://openalex.org/W2104093895","https://openalex.org/W2104733808","https://openalex.org/W2104947013","https://openalex.org/W2105416994","https://openalex.org/W2105500381","https://openalex.org/W2108360007","https://openalex.org/W2110652761","https://openalex.org/W2111072594","https://openalex.org/W2112359216","https://openalex.org/W2113035953","https://openalex.org/W2113214957","https://openalex.org/W2113746859","https://openalex.org/W2113796216","https://openalex.org/W2115059683","https://openalex.org/W2116479391","https://openalex.org/W2118713537","https://openalex.org/W2118873545","https://openalex.org/W2119297613","https://openalex.org/W2121167726","https://openalex.org/W2122216689","https://openalex.org/W2123495555","https://openalex.org/W2125089526","https://openalex.org/W2125205754","https://openalex.org/W2126091070","https://openalex.org/W2126268944","https://openalex.org/W2127229019","https://openalex.org/W2127819051","https://openalex.org/W2128848742","https://openalex.org/W2129263135","https://openalex.org/W2130613069","https://openalex.org/W2131348463","https://openalex.org/W2132574756","https://openalex.org/W2132831990","https://openalex.org/W2134422373","https://openalex.org/W2134957545","https://openalex.org/W2136210338","https://openalex.org/W2136530652","https://openalex.org/W2137128911","https://openalex.org/W2137498367","https://openalex.org/W2138792907","https://openalex.org/W2139397808","https://openalex.org/W2140123544","https://openalex.org/W2141019400","https://openalex.org/W2141918532","https://openalex.org/W2142283567","https://openalex.org/W2142385577","https://openalex.org/W2143214103","https://openalex.org/W2143862282","https://openalex.org/W2144985870","https://openalex.org/W2145330633","https://openalex.org/W2146502475","https://openalex.org/W2149372899","https://openalex.org/W2149987837","https://openalex.org/W2150765758","https://openalex.org/W2152029190","https://openalex.org/W2152149683","https://openalex.org/W2152885380","https://openalex.org/W2153042760","https://openalex.org/W2153402584","https://openalex.org/W2153685597","https://openalex.org/W2154046995","https://openalex.org/W2154283357","https://openalex.org/W2155007470","https://openalex.org/W2155882331","https://openalex.org/W2156181265","https://openalex.org/W2157548366","https://openalex.org/W2158132718","https://openalex.org/W2159110682","https://openalex.org/W2160376723","https://openalex.org/W2161155942","https://openalex.org/W2161330936","https://openalex.org/W2161395124","https://openalex.org/W2162097287","https://openalex.org/W2162452305","https://openalex.org/W2164033056","https://openalex.org/W2165284248","https://openalex.org/W2165756811","https://openalex.org/W2165785619","https://openalex.org/W2166278790","https://openalex.org/W2166452296","https://openalex.org/W2166591651","https://openalex.org/W2167120728","https://openalex.org/W2167302014","https://openalex.org/W2167621975","https://openalex.org/W2167709602","https://openalex.org/W2167900923","https://openalex.org/W2168070336","https://openalex.org/W2170424061","https://openalex.org/W2171344824","https://openalex.org/W2172144171","https://openalex.org/W2172820356","https://openalex.org/W2182736053","https://openalex.org/W2188357563","https://openalex.org/W2188422153","https://openalex.org/W2226301921","https://openalex.org/W2230711222","https://openalex.org/W2230992387","https://openalex.org/W2235963441","https://openalex.org/W2248741218","https://openalex.org/W2256271429","https://openalex.org/W2272813072","https://openalex.org/W2286276337","https://openalex.org/W2290695793","https://openalex.org/W2313885860","https://openalex.org/W2314789569","https://openalex.org/W2326620573","https://openalex.org/W2337855333","https://openalex.org/W2339705539","https://openalex.org/W2344121449","https://openalex.org/W2396175511","https://openalex.org/W2396796971","https://openalex.org/W2397099151","https://openalex.org/W2397707498","https://openalex.org/W2398179886","https://openalex.org/W2399943279","https://openalex.org/W2401460060","https://openalex.org/W2402625153","https://openalex.org/W2405750565","https://openalex.org/W2406643706","https://openalex.org/W2411695456","https://openalex.org/W2412126079","https://openalex.org/W2413531993","https://openalex.org/W2413590643","https://openalex.org/W2414672022","https://openalex.org/W2415075579","https://openalex.org/W2415252347","https://openalex.org/W2415375148","https://openalex.org/W2416008504","https://openalex.org/W2416238671","https://openalex.org/W2416726113","https://openalex.org/W2417193816","https://openalex.org/W2418506126","https://openalex.org/W2418973234","https://openalex.org/W2430193768","https://openalex.org/W2440694235","https://openalex.org/W2442118097","https://openalex.org/W2443862010","https://openalex.org/W2461506912","https://openalex.org/W2466100037","https://openalex.org/W2468871094","https://openalex.org/W2475001342","https://openalex.org/W2478934896","https://openalex.org/W2490441885","https://openalex.org/W2497192675","https://openalex.org/W2526606309","https://openalex.org/W3024152856","https://openalex.org/W4298060372"],"related_works":["https://openalex.org/W2014761690","https://openalex.org/W85696438","https://openalex.org/W2151059791","https://openalex.org/W2376875757","https://openalex.org/W2054063372","https://openalex.org/W2112201043","https://openalex.org/W2045810308","https://openalex.org/W2038548255","https://openalex.org/W1964478475","https://openalex.org/W2061918502"],"abstract_inverted_index":{"Through":[0],"exposure":[1,354],"to":[2,39,50,66,96,135,163,266,283,327,355],"melphalan":[3,172,188,204,356],"or":[4,168],"taxol,":[5],"four":[6],"novel":[7],"multidrug":[8,363],"resistant":[9,128],"variants":[10,208,315],"of":[11,152,183,262,276,287,293,302,311,318,332,338,347],"the":[12,32,81,86,106,127,158,181,186,228,242,284,288,309,312,345,348],"human":[13,19],"nasal\\ncarcinoma":[14],"cell":[15,22,166],"line,":[16,23],"RPMI-2650":[17,33,45,107,159,229,243,289,349],"and":[18,42,56,71,120,141,147,155,191,213,230,241,257,272,274,296,300,304,335,373],"lung":[20],"carcinoma":[21],"DLKP,":[24],"were":[25,219,233],"established":[26],"In":[27],"vitro\\ntoxicity":[28],"tests":[29],"revealed":[30,100],"that":[31,88,126,227,247,353],"taxol-resistant":[34,132,244],"variant":[35,47,62,90,133],"exhibited":[36,48,63],"significant":[37,64],"resistance":[38,65,76,95,205,364],"taxol,\\nvincristine,":[40],"adriamycin":[41],"vinblastine.":[43,72],"The":[44,58],"melphalan-resistant":[46,160,290],"significant\\nresistance":[49],"melphalan,":[51,67],"cadmium":[52,68],"chlonde,":[53,69],"adriamycin,":[54],"vinblastine":[55,97],"VP-16.":[57],"DLKP":[59,82,187,231,313],"long":[60,189],"term\\nmelphalan-selected":[61],"cisplatin,\\nadnamycm":[70],"A":[73,122],"similar":[74],"cross":[75,94],"profile":[77],"was":[78,115],"observed":[79,116],"in":[80,105,130,185,202,210,324,359],"pulse":[83,192],"selection\\nvariant":[84],"with":[85],"exception":[87],"this":[89,175],"displayed":[91],"no":[92],"obvious":[93],"Adnamycm\\ndistnbution":[98],"studies":[99,124],"decreased":[101,260,325],"intracellular":[102],"adnamycm":[103],"accumulation":[104],"taxol-":[108],"and\\nmelphalan-resistant":[109],"variants.":[110],"However,":[111],"intense":[112],"nuclear":[113],"fluorescence":[114],"following":[117],"treatment":[118],"with\\nverapamil":[119],"cyclosporin":[121],"Charactensation":[123],"demonstrated":[125,149,226],"phenotype":[129,365],"the\\nRPMI-2650":[131],"appeared":[134],"be":[136,342],"mainly":[137],"P-glycoprotem":[138],"mediated":[139],"Protein":[140],"mRNA\\nanalysis":[142],"by":[143],"Western":[144,177],"blotting,":[145],"immunocytochemistry":[146],"RT-PCR":[148],"an":[150],"overexpression":[151,182,301],"MRP1,\\ncMOAT":[153],"(MRP2)":[154],"MRP3":[156],"m":[157,174,206,216],"vanant":[161,176],"compared":[162],"its":[164],"parental":[165,239],"line\\nSulindac":[167],"indomethacin":[169],"could":[170],"reverse":[171],"toxicity":[173],"blotting":[178],"analysis":[179],"also\\nshowed":[180],"MRP1":[184],"term":[190],"selection":[193],"cells,":[194],"suggesting\\nthe":[195],"involvement":[196],"o":[197,250],"f":[198,251],"MRP":[199],"family":[200],"members":[201],"mediating":[203],"these":[207,217],"Significant\\niterations":[209],"GST":[211],"activity":[212],"metallothionem":[214],"expression":[215,249,261,275,292,317,337],"vanants":[218],"not":[220,360],"observed.\\n\\nResults":[221],"obtained":[222],"from":[223],"invasion":[224],"assays":[225],"melphalan-resistant\\n/ariants":[232],"more":[234,371],"invasive":[235,372],"than":[236],"their":[237],"respective":[238],"cells":[240,370],"vanant.":[245],"It\\nippears":[246],"increased":[248],"a":[252,255,263,294,319,362],"2Pi,":[253],"CX5P1,":[254],"6P)":[256],"a,6^4":[258],"integrins,":[259],"4p1;\\nitronger":[264],"adhesion":[265],"collagen":[267,328],"type":[268,329],"IV,":[269,330],"lamirun,":[270],"fibronectin":[271],"matngel":[273],"MMP-2,":[277],"MMP-9\\nmd":[278],"c-myc":[279],"may":[280,306,322,341],"all":[281],"contribute":[282],"high":[285],"mvasiveness":[286],"vanant\\nncreased":[291],"2":[295],"Pi":[297],"integnn":[298],"subunits":[299],"MMP-2":[303],"MMP-9":[305],"be\\nesponsible":[307],"for":[308,344],"invasiveness":[310],"melphalan-selected":[314],"Decreased":[316],"2\\nntegrin":[320],"which":[321],"result":[323,358],"attachment":[326],"lack":[331],"cytokeratin":[333],"18":[334],"no\\nletectable":[336],"any":[339],"proteases":[340],"responsible":[343],"non-invasiveness":[346],"taxolssistant\\nvanant.\\n\\nThese":[350],"results":[351],"suggest":[352],"can":[357],"only":[361],"but\\nould":[366],"also":[367],"make":[368],"cancer":[369],"metastatic.":[374]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}