{"id":"https://openalex.org/W1911494151","doi":"https://doi.org/10.1002/9780470027318.a9310","title":"Ion Dissociation Methods in Proteomics","display_name":"Ion Dissociation Methods in Proteomics","publication_year":2015,"publication_date":"2015-09-10","ids":{"openalex":"https://openalex.org/W1911494151","doi":"https://doi.org/10.1002/9780470027318.a9310","mag":"1911494151"},"language":"en","primary_location":{"id":"doi:10.1002/9780470027318.a9310","doi":"https://doi.org/10.1002/9780470027318.a9310","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470027318.a9310","pdf_url":null,"source":{"id":"https://openalex.org/S4306509318","display_name":"Encyclopedia of Analytical Chemistry","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Analytical Chemistry","raw_type":"other"},"volume":{"id":"https://openalex.org/W3035579699","display_name":"Encyclopedia of Analytical Chemistry"},"type":"reference-entry","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079415198","display_name":"Deepali Rathore","orcid":"https://orcid.org/0000-0002-3157-7000","observed_orcids":["https://orcid.org/0000-0002-3157-7000"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepali Rathore","raw_affiliation_strings":["University of Nebraska \u2013 Lincoln, Lincoln, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska \u2013 Lincoln, Lincoln, NE, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035138319","display_name":"Forouzan Aboufazeli","orcid":"https://orcid.org/0000-0002-4764-0991","observed_orcids":["https://orcid.org/0000-0002-4764-0991"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Forouzan Aboufazeli","raw_affiliation_strings":["University of Nebraska \u2013 Lincoln, Lincoln, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska \u2013 Lincoln, Lincoln, NE, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070346418","display_name":"Yuting Huang","orcid":"https://orcid.org/0000-0001-9986-5124","observed_orcids":["https://orcid.org/0000-0001-9986-5124","https://orcid.org/0009-0000-4358-5422","https://orcid.org/0009-0004-6744-4420","https://orcid.org/0009-0005-4142-9385","https://orcid.org/0009-0008-2987-1279"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuting Huang","raw_affiliation_strings":["University of Nebraska \u2013 Lincoln, Lincoln, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska \u2013 Lincoln, Lincoln, NE, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025717953","display_name":"V. S. Kumar Kolli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkata Kolli","raw_affiliation_strings":["University of Nebraska \u2013 Lincoln, Lincoln, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska \u2013 Lincoln, Lincoln, NE, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008806893","display_name":"Ganga S. Fernando","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ganga S. Fernando","raw_affiliation_strings":["University of Nebraska \u2013 Lincoln, Lincoln, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska \u2013 Lincoln, Lincoln, NE, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072075494","display_name":"Eric D. Dodds","orcid":"https://orcid.org/0000-0002-7721-394X","observed_orcids":["https://orcid.org/0000-0002-7721-394X"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric D. Dodds","raw_affiliation_strings":["University of Nebraska \u2013 Lincoln, Lincoln, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska \u2013 Lincoln, Lincoln, NE, USA","institution_ids":["https://openalex.org/I114395901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114395901"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.3253999948501587,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ionic-dissociation","display_name":"ion dissociation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"tandem mass spectrometry","score":0.8939999938011169},{"id":"https://openalex.org/keywords/fragmentation-pathways","display_name":"fragmentation pathways","score":0.6759999990463257},{"id":"https://openalex.org/keywords/fragment-ion-structure","display_name":"fragment ion structure","score":0.7820000052452087},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.8112258911132812},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.6458151936531067},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5873767137527466},{"id":"https://openalex.org/C102931765","wikidata":"https://www.wikidata.org/wiki/Q189673","display_name":"Dissociation (chemistry)","level":2,"score":0.578020453453064},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5149391293525696},{"id":"https://openalex.org/C176107965","wikidata":"https://www.wikidata.org/wiki/Q3710336","display_name":"Collision-induced dissociation","level":4,"score":0.5133408904075623},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.5128836631774902},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4938245713710785},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38507020473480225},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2281685769557953},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10663425922393799},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.07105663418769836},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9780470027318.a9310","doi":"https://doi.org/10.1002/9780470027318.a9310","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470027318.a9310","pdf_url":null,"source":{"id":"https://openalex.org/S4306509318","display_name":"Encyclopedia of Analytical Chemistry","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Analytical Chemistry","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W35024136","https://openalex.org/W42428588","https://openalex.org/W1459329288","https://openalex.org/W1495926848","https://openalex.org/W1549345436","https://openalex.org/W1964110286","https://openalex.org/W1968713053","https://openalex.org/W1969569756","https://openalex.org/W1970652806","https://openalex.org/W1971887998","https://openalex.org/W1975508076","https://openalex.org/W1975813836","https://openalex.org/W1976147793","https://openalex.org/W1976730218","https://openalex.org/W1979715681","https://openalex.org/W1980701099","https://openalex.org/W1981593008","https://openalex.org/W1983191700","https://openalex.org/W1984596349","https://openalex.org/W1988791332","https://openalex.org/W1989772986","https://openalex.org/W1992930552","https://openalex.org/W1993018008","https://openalex.org/W1994495696","https://openalex.org/W1994776398","https://openalex.org/W1997410835","https://openalex.org/W1998047592","https://openalex.org/W1998274795","https://openalex.org/W2000180981","https://openalex.org/W2000798961","https://openalex.org/W2003085771","https://openalex.org/W2003607269","https://openalex.org/W2003763500","https://openalex.org/W2005611531","https://openalex.org/W2008317045","https://openalex.org/W2008515515","https://openalex.org/W2013902810","https://openalex.org/W2017792299","https://openalex.org/W2018046812","https://openalex.org/W2020630954","https://openalex.org/W2021071169","https://openalex.org/W2021274263","https://openalex.org/W2023012124","https://openalex.org/W2023096047","https://openalex.org/W2023963613","https://openalex.org/W2026465178","https://openalex.org/W2028040703","https://openalex.org/W2033823000","https://openalex.org/W2035283832","https://openalex.org/W2037207885","https://openalex.org/W2037860871","https://openalex.org/W2038563588","https://openalex.org/W2040720717","https://openalex.org/W2045327931","https://openalex.org/W2045485893","https://openalex.org/W2047475186","https://openalex.org/W2047566749","https://openalex.org/W2047906201","https://openalex.org/W2051192900","https://openalex.org/W2051978415","https://openalex.org/W2053697292","https://openalex.org/W2053888138","https://openalex.org/W2054900890","https://openalex.org/W2055934103","https://openalex.org/W2056339663","https://openalex.org/W2057365035","https://openalex.org/W2060171924","https://openalex.org/W2062106476","https://openalex.org/W2062431664","https://openalex.org/W2063514959","https://openalex.org/W2064329980","https://openalex.org/W2067092486","https://openalex.org/W2067708744","https://openalex.org/W2072596767","https://openalex.org/W2072648212","https://openalex.org/W2073401456","https://openalex.org/W2074877005","https://openalex.org/W2074947572","https://openalex.org/W2075036506","https://openalex.org/W2075184570","https://openalex.org/W2077546612","https://openalex.org/W2078132920","https://openalex.org/W2078275236","https://openalex.org/W2078697305","https://openalex.org/W2079056345","https://openalex.org/W2081620687","https://openalex.org/W2081961557","https://openalex.org/W2082954827","https://openalex.org/W2084885918","https://openalex.org/W2086482125","https://openalex.org/W2090402744","https://openalex.org/W2090943942","https://openalex.org/W2098960413","https://openalex.org/W2102415529","https://openalex.org/W2107161977","https://openalex.org/W2109583721","https://openalex.org/W2118310130","https://openalex.org/W2121612064","https://openalex.org/W2122070726","https://openalex.org/W2122312191","https://openalex.org/W2123089021","https://openalex.org/W2124227077","https://openalex.org/W2125811069","https://openalex.org/W2127111516","https://openalex.org/W2130669719","https://openalex.org/W2131741443","https://openalex.org/W2137285891","https://openalex.org/W2139091980","https://openalex.org/W2143706586","https://openalex.org/W2143922730","https://openalex.org/W2146482199","https://openalex.org/W2148352340","https://openalex.org/W2148632411","https://openalex.org/W2154666633","https://openalex.org/W2155482447","https://openalex.org/W2167056206","https://openalex.org/W2170676214","https://openalex.org/W2322259242","https://openalex.org/W2330015256","https://openalex.org/W2330376945","https://openalex.org/W2335117233"],"related_works":["https://openalex.org/W2041000110","https://openalex.org/W2404670384","https://openalex.org/W2152851216","https://openalex.org/W1961810717","https://openalex.org/W7097860042","https://openalex.org/W2078275236","https://openalex.org/W1459329288","https://openalex.org/W2047322168","https://openalex.org/W4403732759","https://openalex.org/W2162068629"],"abstract_inverted_index":{"Abstract":[0],"This":[1],"article":[2],"serves":[3],"as":[4],"a":[5,67,151],"review":[6],"of":[7,15,58,70,76,87,106,137,142,153,190],"polypeptide":[8,145],"ion":[9,31,51,113,146,159,198,203],"dissociation":[10,71,160,192],"methods":[11,117],"in":[12,35,46,109,118,134,168],"the":[13,22,37,61,74,80,85,103,107,135,154,176,184],"context":[14],"mass":[16,25],"spectrometry":[17,26],"(MS)\u2010based":[18],"proteomic":[19,38,122],"analysis.":[20],"Given":[21],"many":[23],"tandem":[24],"(MS/MS)":[27],"instrument":[28],"types":[29],"and":[30,48,63,84,111,124,144,162,187,201],"fragmentation":[32,52,90,114,147,199],"approaches":[33,130,161],"presently":[34],"use,":[36],"analyst":[39],"is":[40,148,166],"confronted":[41],"with":[42,131,181],"numerous":[43],"methodological":[44],"considerations":[45],"selecting":[47],"implementing":[49],"an":[50,77],"technique":[53,165],"for":[54,66,121,157],"primary":[55],"structure":[56],"determination":[57],"polypeptides.":[59],"Because":[60],"physical":[62],"chemical":[64],"bases":[65],"given":[68],"mode":[69],"largely":[72],"dictate":[73],"outcome":[75],"MS/MS":[78,143,170],"experiment,":[79],"underlying":[81],"fundamental":[82,155],"principles":[83],"manner":[86],"executing":[88],"each":[89,164,191],"approach":[91],"must":[92],"inform":[93],"any":[94],"subsequent":[95],"spectral":[96],"interpretation.":[97],"Here,":[98],"we":[99],"endeavor":[100],"to":[101],"encapsulate":[102],"current":[104],"state":[105],"art":[108],"peptide":[110,197],"protein":[112],"methods,":[115],"including":[116],"widespread":[119],"use":[120],"analysis":[123],"maturing":[125],"but":[126],"less":[127],"commonly":[128],"applied":[129],"significant":[132],"potential":[133],"field":[136],"proteomics.":[138],"A":[139],"general":[140],"overview":[141],"followed":[149],"by":[150],"discussion":[152],"basis":[156],"several":[158,195],"how":[163],"implemented":[167],"various":[169],"hardware":[171],"configurations.":[172],"Representative":[173],"examples":[174],"from":[175],"literature":[177],"are":[178,205],"also":[179],"highlighted,":[180],"emphasis":[182],"on":[183],"unique":[185],"features":[186],"specific":[188],"strengths":[189],"method.":[193],"Finally,":[194],"proposed":[196],"mechanisms":[200],"fragment":[202],"structures":[204],"presented.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}