{"id":"https://openalex.org/W1911489485","doi":null,"title":"Treatment of relapsed or refractory Waldenstr\u00f6m's macroglobulinemia with bortezomib.","display_name":"Treatment of relapsed or refractory Waldenstr\u00f6m's macroglobulinemia with bortezomib.","publication_year":2005,"publication_date":"2005-12-01","ids":{"openalex":"https://openalex.org/W1911489485","mag":"1911489485","pmid":"https://pubmed.ncbi.nlm.nih.gov/16330439"},"language":"en","primary_location":{"id":"pmid:16330439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16330439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033573338","display_name":"Meletios Athanasios Dimopoulos","orcid":"https://orcid.org/0000-0001-8990-3254","observed_orcids":["https://orcid.org/0000-0001-8990-3254"]},"institutions":[{"id":"https://openalex.org/I4210151634","display_name":"Athens Euroclinic","ror":"https://ror.org/05vhxx644","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210151634"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Meletios A Dimopoulos","raw_affiliation_strings":["Department of Clinical Therapeutics, Euroclinic Hospital, Athens, Greece. mdimop@med.uoa.gr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Therapeutics, Euroclinic Hospital, Athens, Greece. mdimop@med.uoa.gr","institution_ids":["https://openalex.org/I4210151634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041216749","display_name":"Athanasios K. Anagnostopoulos","orcid":"https://orcid.org/0000-0001-5161-7850","observed_orcids":["https://orcid.org/0000-0001-5161-7850"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Athanasios Anagnostopoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110642717","display_name":"Maria Christina Kyrtsonis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Christina Kyrtsonis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077655158","display_name":"Efstathios Castritis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Efstathios Castritis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006266130","display_name":"Athanasios Bitsaktsis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Athanasios Bitsaktsis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070690484","display_name":"Gerassimos A. Pangalis","orcid":"https://orcid.org/0000-0001-5970-5839","observed_orcids":["https://orcid.org/0000-0001-5970-5839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerassimos A Pangalis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.3655,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.95930128,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"90","issue":"12","first_page":"1655","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/waldenstrom-macroglobulinemia","display_name":"Waldenstr\u00f6m macroglobulinemia","score":0.984000027179718},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9940000176429749},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/relapsed-refractory-disease","display_name":"relapsed/refractory disease","score":0.9279999732971191},{"id":"https://openalex.org/keywords/heavily-pretreated-patients","display_name":"heavily pretreated patients","score":0.8230000138282776},{"id":"https://openalex.org/keywords/partial-response","display_name":"partial response","score":0.8029999732971191},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.796999990940094},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.8550000190734863},{"id":"https://openalex.org/keywords/paralytic-ileus","display_name":"paralytic ileus","score":0.8040000200271606},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.9533951282501221},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8430551886558533},{"id":"https://openalex.org/C2781038049","wikidata":"https://www.wikidata.org/wiki/Q1778287","display_name":"Waldenstrom macroglobulinemia","level":3,"score":0.7469560503959656},{"id":"https://openalex.org/C2776391228","wikidata":"https://www.wikidata.org/wiki/Q4118092","display_name":"Macroglobulinemia","level":3,"score":0.7311078906059265},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6436073780059814},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6189738512039185},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5804300904273987},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.565498411655426},{"id":"https://openalex.org/C2777525834","wikidata":"https://www.wikidata.org/wiki/Q268713","display_name":"Mantle cell lymphoma","level":3,"score":0.5056447982788086},{"id":"https://openalex.org/C70616116","wikidata":"https://www.wikidata.org/wiki/Q1736732","display_name":"Refractory period","level":2,"score":0.4718596637248993},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.4687789976596832},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4425666332244873},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4122299551963806},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40705278515815735},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069286","descriptor_name":"Bortezomib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001897","descriptor_name":"Boronic Acids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001897","descriptor_name":"Boronic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008258","descriptor_name":"Waldenstrom Macroglobulinemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D016879","descriptor_name":"Salvage Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061988","descriptor_name":"Proteasome Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:16330439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16330439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:fac81a191a2a47b8970b1606feea3630","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fac81a191a2a47b8970b1606feea3630","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 90, Iss 12 (2005)","raw_type":"article"},{"id":"mag:1911489485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16330439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1995735611","https://openalex.org/W2100608938","https://openalex.org/W2119680582","https://openalex.org/W2120590293","https://openalex.org/W2138077682","https://openalex.org/W2587075560"],"related_works":["https://openalex.org/W2150945698","https://openalex.org/W2055127103","https://openalex.org/W2160542415","https://openalex.org/W4306925959","https://openalex.org/W2124433242","https://openalex.org/W2262457586","https://openalex.org/W4283380725","https://openalex.org/W2579432827","https://openalex.org/W2587075560","https://openalex.org/W4406296696"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,43,174],"OBJECTIVES:":[2],"Bortezomib":[3,142],"is":[4,33,136,182],"a":[5,15,58,71,75,116,122],"selective":[6],"proteasome":[7],"inhibitor":[8],"which":[9,119],"has":[10],"shown":[11],"significant":[12],"activity":[13],"in":[14,36,70,132,163,186,204],"variety":[16],"of":[17,60,77,112,124,195,219],"hematologic":[18],"malignancies":[19],"including":[20],"multiple":[21],"myeloma,":[22],"mantle":[23],"cell":[24],"lymphoma":[25],"and":[26,68,102,157,166,215],"marginal":[27],"zone":[28],"lymphoma.":[29],"Thus,":[30],"this":[31,196,205],"agent":[32,185,197],"worth":[34],"studying":[35],"patients":[37,84,92,104,114,135,165,187],"with":[38,46,53,85,89,188,221],"Waldenstr\u00f6m's":[39],"macroglobulinemia":[40],"(WM).":[41],"DESIGN":[42],"METHODS:":[44],"Patients":[45],"refractory":[47],"or":[48,108,153],"relapsed":[49],"WM":[50,86,101],"were":[51,87,151],"treated":[52,83,88],"bortezomib":[54,181,220],"administered":[55],"intravenously":[56],"at":[57,121],"dose":[59],"1.3":[61],"mg/m2":[62],"on":[63],"days":[64],"1,":[65],"4,":[66],"8":[67],"11":[69,140],"21-day":[72],"cycle":[73],"for":[74,100],"total":[76],"four":[78],"cycles.":[79],"RESULTS:":[80],"Ten":[81],"previously":[82],"bortezomib.":[90],"Most":[91],"had":[93,105],"been":[94],"exposed":[95],"to":[96,130,138,201,211,216],"all":[97],"active":[98,184,223],"agents":[99],"eight":[103],"received":[106],"three":[107,164],"more":[109,148],"regimens.":[110],"Six":[111],"these":[113],"achieved":[115],"partial":[117],"response":[118],"occurred":[120,162],"median":[123,128],"1":[125],"month.":[126],"The":[127,147],"time":[129],"progression":[131],"the":[133],"responding":[134],"expected":[137],"exceed":[139],"months.":[141],"was":[143],"relatively":[144],"well":[145],"tolerated.":[146],"common":[149],"toxicities":[150],"mild":[152],"moderate":[154],"thrombocytopenia,":[155],"fever":[156],"fatigue":[158],"while":[159],"peripheral":[160],"neuropathy":[161],"one":[167],"patient":[168],"developed":[169],"severe":[170],"paralytic":[171],"ileus.":[172],"INTERPRETATION":[173],"CONCLUSIONS:":[175],"Our":[176],"preliminary":[177],"data":[178],"indicate":[179],"that":[180],"an":[183],"heavily":[189],"pretreated":[190],"relapsed/refractory":[191],"WM.":[192],"Four":[193],"cycles":[194],"may":[198],"be":[199],"adequate":[200],"assess":[202],"sensitivity":[203],"disease.":[206],"Further":[207],"studies":[208],"are":[209],"needed":[210],"confirm":[212],"our":[213],"results":[214],"evaluate":[217],"combinations":[218],"other":[222],"agents.":[224]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}