{"id":"https://openalex.org/W1909823907","doi":null,"title":"Neuropsychiatric manifestations and their clinical associations in southern Chinese patients with systemic lupus erythematosus.","display_name":"Neuropsychiatric manifestations and their clinical associations in southern Chinese patients with systemic lupus erythematosus.","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W1909823907","mag":"1909823907","pmid":"https://pubmed.ncbi.nlm.nih.gov/11327248"},"language":"en","primary_location":{"id":"pmid:11327248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11327248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"C C Mok","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800783597","display_name":"Tuen Mun Hospital","ror":"https://ror.org/018nkky79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800783597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"C C Mok","raw_affiliation_strings":["Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong, China","institution_ids":["https://openalex.org/I2800783597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004488408","display_name":"Chak Sing Lau","orcid":"https://orcid.org/0000-0001-6698-8355","observed_orcids":["https://orcid.org/0000-0001-6698-8355"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C S Lau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048098017","display_name":"Rws Wong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R W Wong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.4632,"has_fulltext":false,"cited_by_count":143,"citation_normalized_percentile":{"value":0.95826585,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"28","issue":"4","first_page":"766","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropsychiatric-systemic-lupus-erythematosus","display_name":"neuropsychiatric lupus","score":0.8460000157356262},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9620000123977661},{"id":"https://openalex.org/keywords/neuropsychiatric-symptoms","display_name":"neuropsychiatric symptoms","score":0.7699999809265137},{"id":"https://openalex.org/keywords/lupus-anticoagulant","display_name":"lupus anticoagulant","score":0.890999972820282},{"id":"https://openalex.org/keywords/anticardiolipin-antibodies","display_name":"anticardiolipin antibodies","score":0.953000009059906},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7129999995231628},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.6679999828338623},{"id":"https://openalex.org/keywords/cerebrovascular-disease","display_name":"cerebrovascular disease","score":0.8560000061988831},{"id":"https://openalex.org/keywords/psychosis","display_name":"psychosis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/myelopathy","display_name":"myelopathy","score":0.6769999861717224},{"id":"https://openalex.org/keywords/mood-disorders","display_name":"mood disorders","score":0.6579999923706055},{"id":"https://openalex.org/keywords/leukopenia","display_name":"leukopenia","score":0.6150000095367432},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9490000009536743},{"id":"https://openalex.org/keywords/pulmonary-involvement","display_name":"pulmonary involvement","score":0.8489999771118164},{"id":"https://openalex.org/keywords/clinical-associations","display_name":"clinical associations","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9583975672721863},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.663213849067688},{"id":"https://openalex.org/C2780022809","wikidata":"https://www.wikidata.org/wiki/Q5786759","display_name":"Lupus anticoagulant","level":3,"score":0.5302260518074036},{"id":"https://openalex.org/C2777604421","wikidata":"https://www.wikidata.org/wiki/Q2303951","display_name":"Myelopathy","level":3,"score":0.4778420627117157},{"id":"https://openalex.org/C2909431760","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Mononeuritis Multiplex","level":4,"score":0.4720476567745209},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.46996089816093445},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.43884673714637756},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.43775683641433716},{"id":"https://openalex.org/C2781304901","wikidata":"https://www.wikidata.org/wiki/Q4804182","display_name":"Aseptic meningitis","level":3,"score":0.4163546562194824},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.378667950630188},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26042914390563965},{"id":"https://openalex.org/C2776015282","wikidata":"https://www.wikidata.org/wiki/Q644318","display_name":"Vasculitis","level":3,"score":0.23091402649879456},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16519317030906677},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.09891587495803833},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.0},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020945","descriptor_name":"Lupus Vasculitis, Central Nervous System","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D020945","descriptor_name":"Lupus Vasculitis, Central Nervous System","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:11327248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11327248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.926.615","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.926.615","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jrheum.org/content/28/4/766.full.pdf","raw_type":"text"},{"id":"pmh:oai:hub.hku.hk:10722/162502","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/162502","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:1909823907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11327248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1589234555","https://openalex.org/W1966171928","https://openalex.org/W1972577052","https://openalex.org/W1976055548","https://openalex.org/W1979473764","https://openalex.org/W1993295284","https://openalex.org/W1997265458","https://openalex.org/W2004632147","https://openalex.org/W2027624699","https://openalex.org/W2027816939","https://openalex.org/W2029667694","https://openalex.org/W2033876646","https://openalex.org/W2036173620","https://openalex.org/W2036223015","https://openalex.org/W2037420818","https://openalex.org/W2051281031","https://openalex.org/W2053057309","https://openalex.org/W2069219704","https://openalex.org/W2073601022","https://openalex.org/W2080250903","https://openalex.org/W2085101409","https://openalex.org/W2092016578","https://openalex.org/W2092195322","https://openalex.org/W2102246133","https://openalex.org/W2109451688","https://openalex.org/W2111583515","https://openalex.org/W2146203649","https://openalex.org/W2147812141","https://openalex.org/W2156209618","https://openalex.org/W2246585239","https://openalex.org/W2277156285","https://openalex.org/W2403726203"],"related_works":["https://openalex.org/W2280156427","https://openalex.org/W2914347194","https://openalex.org/W1773184831","https://openalex.org/W4292348658","https://openalex.org/W2325762052","https://openalex.org/W4390503749","https://openalex.org/W7133222995","https://openalex.org/W4412835595","https://openalex.org/W2554785833","https://openalex.org/W2402659232"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2],"the":[3,22,64,105,138,204,293,302,357],"neuropsychiatric":[4],"(NP)":[5],"manifestations":[6,53,74,288,331],"in":[7,289,332],"a":[8,221,229,260,272,313],"large":[9],"cohort":[10,334],"of":[11,27,66,72,108,121,141,145,152,203,206,274,304,328,335,364],"southern":[12],"Chinese":[13],"patients":[14,90,131,336],"with":[15,38,51,63,75,91,220,286,301,337,370],"systemic":[16],"lupus":[17,223],"erythematosus":[18],"(SLE)":[19],"according":[20],"to":[21,45,97,102],"new":[23],"1999":[24],"American":[25],"College":[26],"Rheumatology":[28],"(ACR)":[29],"case":[30],"definitions":[31],"and":[32,56,68,79,104,137,194,250,271,312,353],"their":[33],"clinical":[34,77],"associations.":[35],"METHOD:":[36],"Patients":[37,50],"SLE":[39,92,338],"who":[40],"were":[41,47,54,93,283,356],"followed":[42],"from":[43],"1984":[44],"2000":[46],"retrospectively":[48],"reviewed.":[49],"NP":[52,73,135,287,294,330,360,371],"ascertained":[55],"classified":[57,201],"by":[58,83],"at":[59],"least":[60],"2":[61],"rheumatologists,":[62],"collaboration":[65],"neurologists":[67],"psychiatrists.":[69],"The":[70,95,118,325,362],"association":[71],"other":[76],"features":[78],"autoantibodies":[80],"was":[81,100,111,123,147,199,218,298,339,343,350,367],"studied":[82],"statistical":[84],"analysis.":[85],"RESULTS:":[86],"Five":[87],"hundred":[88],"eighteen":[89],"studied.":[94],"female":[96],"male":[98],"ratio":[99],"7.8":[101],"1":[103],"mean":[106,119,139],"age":[107],"disease":[109,161],"onset":[110],"29.5":[112],"+/-":[113,125],"12.0":[114],"years":[115,127],"(range":[116,128],"9-80).":[117],"duration":[120],"followup":[122,146],"7.3":[124],"6.7":[126],"0.3-23.0).":[129],"Ninety-six":[130],"(19%)":[132],"had":[133],"133":[134],"events":[136,142,155],"number":[140],"per":[143],"patient-year":[144],"0.035.":[148],"In":[149],"decreasing":[150],"order":[151],"frequency.":[153],"these":[154],"were:":[156],"seizure":[157],"disorder":[158,172,177,186,297],"(28%),":[159],"cerebrovascular":[160,296,354,374],"(19%),":[162],"acute":[163],"confusional":[164],"state":[165],"(14%),":[166],"psychosis":[167],"(11%),":[168],"myelopathy":[169],"(8%),":[170],"mood":[171],"(6%),":[173],"headache":[174],"(4%),":[175],"movement":[176],"(2%),":[178],"cranial":[179],"neuropathy":[180],"(3%),":[181],"demyelinating":[182],"syndrome":[183],"(1.5%),":[184,187,190],"anxiety":[185],"mononeuritis":[188],"multiplex/mononeuropathy":[189],"aseptic":[191],"meningitis":[192],"(1%),":[193],"polyneuropathy":[195],"(1%).":[196],"Cognitive":[197],"dysfunction":[198,349],"not":[200],"because":[202],"lack":[205],"standard":[207],"neuropsychological":[208],"testing":[209],"for":[210],"every":[211],"patient.":[212],"Univariate":[213],"analysis":[214,257],"revealed":[215],"that":[216,259],"NP-SLE":[217],"associated":[219,285,300,369],"positive":[222,231,262,315],"anticoagulant":[224],"(LAC)":[225],"(p":[226,235,239,243,247,253],"=":[227,236,240,244,248,254,269,310,322],"0.001),":[228],"strongly":[230,261,314],"IgG":[232,263,316],"anticardiolipin":[233],"(aCL)":[234],"0.01).":[237],"leukopenia":[238],"0.01),":[241],"lymphopenia":[242],"0.03),":[245,249],"thrombocytopenia":[246],"pulmonary":[251],"involvement":[252],"0.03).":[255],"Multivariate":[256],"showed":[258],"aCL":[264,317],"[RR":[265,277],"3.1":[266,319],"(1.3-7.7),":[267],"p":[268,280,309,321],"0.01]":[270,311],"history":[273],"cyclophosphamide":[275],"treatment":[276],"4.3":[278],"(2.1-9.0),":[279],"<":[281],"0.001]":[282],"independently":[284],"our":[290,333],"cohort.":[291],"Among":[292],"features,":[295],"particularly":[299],"presence":[303,363],"LAC":[305],"[OR":[306,318],"3.3":[307],"(1.4-8.0),":[308],"(1.1-8.2),":[320],"0.031].":[323],"CONCLUSION:":[324],"point":[326],"prevalence":[327],"overt":[329],"19%.":[340],"This":[341],"percentage":[342],"likely":[344],"higher":[345],"if":[346],"subtle":[347],"cognitive":[348],"included.":[351],"Seizure":[352],"disorders":[355],"most":[358],"common":[359],"features.":[361],"antiphospholipid":[365],"antibodies":[366],"significantly":[368],"manifestations,":[372],"especially":[373],"disorders.":[375]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
