{"id":"https://openalex.org/W190949044","doi":"https://doi.org/10.5025/hansen1930.45.3_177","title":"Lepromatoid Lesion Developed in Nude Mouse Inoculated with Mycobacterium leprae","display_name":"Lepromatoid Lesion Developed in Nude Mouse Inoculated with Mycobacterium leprae","publication_year":1976,"publication_date":"1976-01-01","ids":{"openalex":"https://openalex.org/W190949044","doi":"https://doi.org/10.5025/hansen1930.45.3_177","mag":"190949044","pmid":"https://pubmed.ncbi.nlm.nih.gov/801368"},"language":"en","primary_location":{"id":"doi:10.5025/hansen1930.45.3_177","doi":"https://doi.org/10.5025/hansen1930.45.3_177","is_oa":true,"landing_page_url":"https://doi.org/10.5025/hansen1930.45.3_177","pdf_url":"https://www.jstage.jst.go.jp/article/hansen1930/45/3/45_3_177/_pdf","source":{"id":"https://openalex.org/S4210224624","display_name":"Repura","issn_l":"0024-1008","issn":["0024-1008","2185-1352"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Repura","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/hansen1930/45/3/45_3_177/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056285071","display_name":"KENJI KOHSAKA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287703","display_name":"Research Institute for Microbial Diseases, The University of Osaka","ror":"https://ror.org/05y8y8a85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KENJI KOHSAKA","raw_affiliation_strings":["Department of Leprology, Research Institute for Microbial Diseases, Osaka University","Department of Leprology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leprology, Research Institute for Microbial Diseases, Osaka University","institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Leprology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051813285","display_name":"Tatsuo Mori","orcid":"https://orcid.org/0000-0002-0370-1924","observed_orcids":["https://orcid.org/0000-0002-0370-1924"]},"institutions":[{"id":"https://openalex.org/I4405287703","display_name":"Research Institute for Microbial Diseases, The University of Osaka","ror":"https://ror.org/05y8y8a85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TATSUO MORI","raw_affiliation_strings":["Department of Leprology, Research Institute for Microbial Diseases, Osaka University","Department of Leprology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leprology, Research Institute for Microbial Diseases, Osaka University","institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Leprology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110507237","display_name":"TONETARO ITO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287703","display_name":"Research Institute for Microbial Diseases, The University of Osaka","ror":"https://ror.org/05y8y8a85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TONETARO ITO","raw_affiliation_strings":["Department of Leprology, Research Institute for Microbial Diseases, Osaka University","Department of Leprology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leprology, Research Institute for Microbial Diseases, Osaka University","institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Leprology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I4405287703","https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7386,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.70082185,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"45","issue":"3","first_page":"177","last_page":"187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leprosy","display_name":"leprosy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mycobacterium-leprae","display_name":"Mycobacterium leprae","score":0.9860000014305115},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cell-mediated-immunity-deficiency","display_name":"cell-mediated immunity deficiency","score":0.6520000100135803},{"id":"https://openalex.org/keywords/balb-c-nude-mice","display_name":"BALB/c nude mice","score":0.6370000243186951},{"id":"https://openalex.org/keywords/animal-inoculation","display_name":"animal inoculation","score":0.34599998593330383},{"id":"https://openalex.org/keywords/footpad-injection","display_name":"footpad injection","score":0.45899999141693115},{"id":"https://openalex.org/keywords/kk-mice","display_name":"KK mice","score":0.4519999921321869},{"id":"https://openalex.org/keywords/animal-model-of-leprosy","display_name":"animal model of leprosy","score":0.5849999785423279},{"id":"https://openalex.org/keywords/self-immunity","display_name":"self-immunity","score":0.3930000066757202},{"id":"https://openalex.org/keywords/xenotransplantation-rejection","display_name":"xenotransplantation rejection","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2779823659","wikidata":"https://www.wikidata.org/wiki/Q155891","display_name":"Mycobacterium leprae","level":3,"score":0.8414458632469177},{"id":"https://openalex.org/C180032290","wikidata":"https://www.wikidata.org/wiki/Q1664296","display_name":"Inoculation","level":2,"score":0.7237331867218018},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5443337559700012},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.4409267008304596},{"id":"https://openalex.org/C115076146","wikidata":"https://www.wikidata.org/wiki/Q1651051","display_name":"Foot (prosody)","level":2,"score":0.4387560784816742},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4241117238998413},{"id":"https://openalex.org/C2780695269","wikidata":"https://www.wikidata.org/wiki/Q36956","display_name":"Leprosy","level":2,"score":0.4031035006046295},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3736523985862732},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33554646372795105},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2763383388519287},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27506107091903687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26905524730682373},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.12304255366325378},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.060710906982421875},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005856","descriptor_name":"Germ-Free Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007918","descriptor_name":"Leprosy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009166","descriptor_name":"Mycobacterium leprae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5025/hansen1930.45.3_177","doi":"https://doi.org/10.5025/hansen1930.45.3_177","is_oa":true,"landing_page_url":"https://doi.org/10.5025/hansen1930.45.3_177","pdf_url":"https://www.jstage.jst.go.jp/article/hansen1930/45/3/45_3_177/_pdf","source":{"id":"https://openalex.org/S4210224624","display_name":"Repura","issn_l":"0024-1008","issn":["0024-1008","2185-1352"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Repura","raw_type":"journal-article"},{"id":"pmid:801368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/801368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Repura. Leprosy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5025/hansen1930.45.3_177","doi":"https://doi.org/10.5025/hansen1930.45.3_177","is_oa":true,"landing_page_url":"https://doi.org/10.5025/hansen1930.45.3_177","pdf_url":"https://www.jstage.jst.go.jp/article/hansen1930/45/3/45_3_177/_pdf","source":{"id":"https://openalex.org/S4210224624","display_name":"Repura","issn_l":"0024-1008","issn":["0024-1008","2185-1352"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Repura","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307856","display_name":"World Health Organization","ror":"https://ror.org/01f80g185"},{"id":"https://openalex.org/F4320337191","display_name":"Research Institute for Microbial Diseases, Osaka University","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W190949044.pdf","grobid_xml":"https://content.openalex.org/works/W190949044.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W265577697","https://openalex.org/W1497043879","https://openalex.org/W1506735060","https://openalex.org/W1529366023","https://openalex.org/W1744243234","https://openalex.org/W1995987937","https://openalex.org/W2002677478","https://openalex.org/W2013837057","https://openalex.org/W2030141128","https://openalex.org/W2056687480","https://openalex.org/W2087594683","https://openalex.org/W2289462545","https://openalex.org/W2400609552","https://openalex.org/W2406651925","https://openalex.org/W2413844244","https://openalex.org/W2414541821","https://openalex.org/W2416288021"],"related_works":["https://openalex.org/W2511093887","https://openalex.org/W2335186902","https://openalex.org/W592948162","https://openalex.org/W2327190123","https://openalex.org/W2328203811","https://openalex.org/W2054582722","https://openalex.org/W634454513","https://openalex.org/W2435612466","https://openalex.org/W2317739087","https://openalex.org/W2402930897"],"abstract_inverted_index":{"\u7669\u7814\u7a76\u306e\u9032\u5c55\u306b\u3068\u308a,\u7669\u83cc\u306e\u57f9\u990a\u3068\u5171\u306b,\u305d\u306e\u52d5\u7269\u79fb\u690d\u306e\u9054\u6210\u304c\u5f37\u304f\u8981\u671b\u3055\u308c\u305f\u3053\u3068\u306f\u5f53\u7136\u3067\u3042\u308a,\u6f38\u304f1960\u5e74\u306bShepard\u306e\u30de\u30a6\u30b9foot":[0],"pad\u6cd5\u306b\u89e3\u6c7a\u306e\u624b\u304c\u304b\u308a\u304c\u5f97\u3089\u308c,\u3055\u3089\u306bRees\u3089\u306b\u3088\u308a\u80f8\u817a\u5254\u51fa,":[1],"X\u7dda\u7167\u5c04\u306a\u3069\u514d\u75ab\u80fd\u767a\u73fe\u6291\u5236\u51e6\u7f6e\u52d5\u7269\u306b\u304a\u3044\u3066\u8457\u660e\u306a\u5897\u83cc\u3068\u75c5\u5909\u304c\u5831\u544a\u3055\u308c\u305f\u3002\u4e00\u65b9,\u8fd1\u5e74\u5148\u5929\u6027\u80f8\u817a\u6b20\u640d\u30cc\u30fc\u30c9\u30de\u30a6\u30b9\u304c\u514d\u75ab\u7570\u5e38\u52d5\u7269\u3068\u3057\u3066,\u7d30\u80de\u514d\u75ab\u3092\u62c5\u3046\u3079\u304d\u80f8\u817a\u7d30\u80de\u304c\u8a98\u5c0e\u3055\u308c\u305a,\u5f93\u3063\u3066\u611f\u67d3\u62b5\u6297\u6027\u306e\u6e1b\u5f31,\u81ea\u5df1\u514d\u75ab\u73fe\u8c61\u306e\u4fc3\u9032,\u7570\u7a2e\u7d44\u7e54\u306e\u79fb\u690d\u306b\u5bfe\u3059\u308b\u62d2\u7d76\u53cd\u5fdc\u306e\u6d88\u5931\u306a\u3069,\u7d30\u80de\u514d\u75ab\u4e0d\u5168\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u305f\u3081\u306b\u901a\u5e38\u306e\u98fc\u80b2\u3067\u306f\u8af8\u7a2e\u306e\u611f\u67d3\u75c7\u306b\u3088\u308a\u65e9\u671f\u306b\u6b7b\u4ea1\u3059\u308b\u304c,\u3053\u308c\u3092\u7121\u83cc\u82e5\u3057\u304f\u306fSPF\u6761\u4ef6\u4e0b\u3067\u98fc\u80b2\u3059\u308b\u3068\u9577\u671f\u751f\u5b58\u304c\u53ef\u80fd\u3067\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u3053\u3067,\u3053\u306e\u30cc\u30fc\u30c9\u30de\u30a6\u30b9\u306b\u7669\u83cc\u3092\u63a5\u7a2e\u3057,\u30d3\u30cb\u30fc\u30eb\u30a2\u30a4\u30bd\u30ec\u30fc\u30bf\u30fc\u5185\u3067SPF\u98fc\u80b2,\u89b3\u5bdf\u3059\u308b\u3053\u3068\u3092\u8a08\u753b\u3057,1974\u5e747\u670811\u65e5\u306b\u5b9f\u9a13\u3092\u958b\u59cb\u3057\u305f\u3002\u30de\u30a6\u30b9\u306f5\u9031\u9f62\u30cc\u30fc\u30c9\u30de\u30a6\u30b9(BALB,/c-nc/nu)\u3092\u5b9f\u4e2d\u7814\u3088\u308a\u8cfc\u5165\u3057,8\u5339\u3092\u5b9f\u9a13\u306b\u4f9b\u3057\u305f\u3002\u307e\u305f\u5bfe\u7167\u3068\u3057\u3066KK\u30de\u30a6\u30b9\u3092\u52a0\u3048\u305f\u3002\u7669\u83cc\u6d6e\u904a\u6db2\u306f\u518d\u71c3\u60a3\u8005\u7d50\u7bc0\u3088\u308a\u8abf\u88fd,1.0\u00d7104/0.03ml\u3092\u53f3\u5074\u5f8c\u8dbe\u8db3\u8e60\u5185\u306b\u6ce8\u5c04\u3057,\u30a2\u30a4\u30bd\u30ec\u30fc\u30bf\u30fc\u5185\u3067\u98fc\u80b2\u3057\u305f\u3002\u98fc\u6599,\u98f2\u6599\u6c34\u306a\u3069\u30a2\u30a4\u30bd\u30ec\u30fc\u30bf\u30fc\u5185\u306b\u642c\u5165\u3059\u308b\u3082\u306e\u306f\u3059\u3079\u3066\u30aa\u30fc\u30c8\u30af\u30ec\u30fc\u30d6\u3067\u6ec5\u83cc\u6e08\u307f\u306e\u3082\u306e\u3067\u3042\u308b\u3002\u4e00\u65b9KK\u30de\u30a6\u30b9\u306f\u540c\u69d8\u306b\u6ce8\u5c04\u3057,\u666e\u901a\u98fc\u80b2\u3092\u884c\u3063\u305f\u3002\u98fc\u80b2\u5ba4\u6e29\u5ea6\u306f20\u2103\uff5e25\u2103\u3067\u3042\u308b\u3002\u6210\u7e3e:\u30cc\u30fc\u30c9\u30de\u30a6\u30b98\u5339\u306e\u3046\u3061,\u65e9\u671f\u306b\u6b7b\u4ea1\u3057\u305f2\u5339\u3092\u9664\u304d,6\u5339\u304c\u5b9f\u9a13\u306e\u5bfe\u8c61\u306b\u306a\u3063\u305f\u3002\u63a5\u7a2e8\u30f5\u6708\u5f8c\u306e\u5256\u691c\u306b\u304a\u3044\u3066,2\u5339\u306e\u8db3\u8e60\u90e8\u304b\u3089\u305d\u308c\u305e\u308c3.5\u00d7105,4.6\u00d7105\u306e\u83cc\u6570\u304c\u7b97\u3048\u3089\u308c,\u3068\u304f\u306b\u524d\u8005\u3067\u306f\u53f3\u30bd\u30b1\u30a4\u30ea\u30f3\u30d1\u7bc0\u306e\u5857\u62b9\u6a19\u672c\u306b200\u500b\u8fd1\u3044\u6297\u9178\u83cc\u304c\u691c\u51fa\u3055\u308c\u305f\u3002\u3055\u3089\u306b13\u30f5\u6708\u5f8c\u6b7b\u4ea1\u3057\u305f1\u4f8b\u3067\u306f,2.6\u00d7106\u4ee5\u4e0a\u306e\u83cc\u304c\u7b97\u3048\u3089\u308c\u305f\u307b\u304b,\u7d44\u7e54\u7247\u306b\u6df7\u5728\u3057\u3066\u7121\u6570\u306e\u83cc\u584a\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u540c\u6642\u306b\u5de6\u53f3\u306e\u30bd\u30b1\u30a4\u30ea\u30f3\u30d1\u7bc0\u304a\u3088\u3073\u809d\u81d3\u306e\u5857\u62b9\u306b\u3082\u6297\u9178\u83cc\u304c\u898b\u51fa\u3055\u308c,\u8db3\u8e60\u5185\u306b\u304a\u3051\u308b\u7d4c\u6642\u7684\u306a\u5897\u83cc\u3068\u5168\u8eab\u6027\u611f\u67d3\u306e\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u305f\u300217\u30f5\u6708\u306b\u81f3\u308a,\u751f\u5b58\u3057\u305f3\u5339\u306e\u83cc\u63a5\u7a2e\u8db3\u8e60\u306b\u8089\u773c\u7684\u816b\u8139\u304c\u8a8d\u3081\u3089\u308c,\u3053\u306e\u3046\u30612\u5339\u306f\u5c3e\u6839\u90e8\u306b\u6f70\u760d\u3092,2\u5339\u306b\u306f\u773c\u77bc\u306e\u816b\u8139\u304c\u540c\u6642\u306b\u898b\u3089\u308c\u305f\u30023\u5339\u3092\u305d\u308c\u305e\u308c17\u30f5\u6708,19\u30f5\u6708\u304a\u3088\u307322\u30f5\u6708\u76ee\u306b\u5256\u691c\u3057\u305f\u304c,3\u4f8b\u306f\u3068\u3082\u306b\u307b\u307c\u540c\u7a0b\u5ea6\u306e\u75c5\u72b6\u3092\u5448\u3057,\u8089\u773c\u7684\u75c5\u5909\u90e8\u3088\u308a\u306e\u5857\u62b9\u6a19\u672c\u306b\u306f\u7121\u6570\u306e\u6297\u9178\u83cc\u304c\u898b\u51fa\u304d\u308c\u305f\u3002\u75c5\u7406\u7d44\u7e54\u5b66\u7684\u691c\u67fb\u306b\u304a\u3044\u3066,\u8db3\u8e60\u306e\u816b\u8139\u90e8\u306f\u6297\u9178\u83cc\u3092\u5145\u6e80\u305b\u308b\u7669\u7d30\u80de\u3068\u7a7a\u6ce1\u7d30\u80de\u304b\u3089\u306a\u308b\u7669\u816b\u69d8\u75c5\u5de3\u306e\u6240\u898b\u3092\u5448\u3057,\u52a0\u3048\u3066\u773c\u77bc,\u8033\u4ecb\u304a\u3088\u3073\u5c3e\u306a\u3069\u4f4e\u4f53\u6e29\u90e8\u3078\u306e\u8ee2\u79fb\u75c5\u5de3\u304c\u307f\u3089\u308c\u305f\u307b\u304b,\u30ea\u30f3\u30d1\u7bc0,\u5185\u81d3\u306b\u3082\u6297\u9178\u83cc\u304c\u898b\u51fa\u3055\u308c\u305f\u3002\u3068\u304f\u306b\u8db3\u8e60\u75c5\u5909\u90e8\u306e\u672b\u68a2\u795e\u7d4c\u306f\u3082\u3068\u3088\u308a,\u5927\u817f\u90e8\u7d4c\u9aa8\u795e\u7d4c\u304a\u3088\u3073\u8153\u9aa8\u795e\u7d4c\u3078\u306e\u83cc\u306e\u4fb5\u5165\u3068\u5897\u6b96\u304c\u9855\u8457\u3067\u3042\u3063\u305f\u3002\u8840\u7ba1\u58c1\u306e\u80a5\u539a\u3068\u8840\u7ba1\u8154\u5185\u306e\u83cc\u306e\u5b58\u5728\u3082\u89b3\u5bdf\u3055\u308c\u305f\u3002\u30cc\u30fc\u30c9\u30de\u30a6\u30b9\u306e\u5168\u8eab\u6027\u306b\u751f\u3058\u305f\u75c5\u5de3\u90e8\u306e\u6297\u9178\u83cc\u304c,\u306f\u305f\u3057\u3066\u63a5\u7a2e\u3055\u308c\u305f\u7669\u83cc\u306e\u5897\u6b96\u306b\u3088\u3063\u305f\u3082\u306e\u304b\u5426\u304b\u3092\u8abf\u3079\u308b\u305f\u3081\u306b,\u75c5\u5de3\u90e8\u3088\u308a\u5206\u96e2\u3057\u305f\u5897\u6b96\u83cc\u306b\u3064\u3044\u3066\u540c\u5b9a\u8a66\u9a13\u3092\u884c\u3044,\u4ee5\u4e0b\u306e\u6210\u7e3e\u3092\u5f97\u305f\u30021)":[2],"\u5c0f\u5ddd\u57f9\u5730\u3067\u96c6\u843d\u306e\u5f62\u6210\u306a\u3057,2)":[3],"\u666e\u901a\u30de\u30a6\u30b9\u306b\u5897\u83cc\u50cf\u304c\u8a8d\u3081\u3089\u308c\u306a\u3044,3)":[4],"\u30d4\u30ea\u30b8\u30f3\u51e6\u7406\u306b\u3088\u308a,\u6297\u9178\u6027\u304c\u5931\u308f\u308c\u305f,4)":[5],"D-dopa":[6],"oxi-dase\u6d3b\u6027\u967d\u6027,5)":[7],"\u30ec\u30d7\u30ed\u30df\u30f3\u53cd\u5fdc\u306fL\u578b\u306b\u9670\u6027,T\u578b\u306b\u967d\u6027\u3002\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089,\u5897\u6b96\u83cc\u306f\u7669\u83cc\u306e\u6027\u72b6\u3092\u3082\u3064\u3053\u3068\u304c\u78ba\u304b\u3081\u3089\u308c,\u3053\u306e\u3053\u3068\u306f\u30cc\u30fc\u30c9\u30de\u30a6\u30b9\u306e\u8db3\u8e60\u5185\u306b\u63a5\u7a2e\u3055\u308c\u305f\u7669\u83cc\u304c,\u305d\u306e\u5c40\u6240\u3067\u5897\u6b96\u3057,\u63a5\u7a2e\u5c40\u6240\u306e\u307f\u306a\u3089\u305a\u5168\u8eab\u6027\u306b\u7669\u816b\u7669\u75c5\u5de3\u3092\u751f\u305c\u3057\u3081\u305f\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u4eca\u56de\u306e\u7814\u7a76\u306f,\u30cc\u30fc\u30c9\u30de\u30a6\u30b9\u304c\u80f8\u817a\u5254\u51fa\u304a\u3088\u3073X\u7dda\u7167\u5c04\u52d5\u7269\u3042\u308b\u3044\u306f\u30a2\u30eb\u30de\u30b8\u30ed\u306b\u3088\u308b\u5b9f\u9a13\u7669\u4ee5\u5916\u306e\u65b0\u3057\u3044\u5b9f\u9a13\u52d5\u7269\u7669\u306e\u30e2\u30c7\u30eb\u306e\u78ba\u7acb\u3092\u793a\u3081\u3057\u305f\u3082\u306e\u3067\u3042\u308a,\u30cc\u30fc\u30c9\u30de\u30a6\u30b9\u306e\u5229\u7528\u306f,\u4eca\u5f8c\u306e\u7669\u306e\u5316\u5b66\u7642\u6cd5\u304a\u3088\u3073\u514d\u75ab\u5b66\u3092\u4e00\u5c64\u767a\u5c55\u305b\u3057\u3081\u308b\u3082\u306e\u3068\u671f\u5f85\u3055\u308c\u308b\u3002":[8]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}