{"id":"https://openalex.org/W1909284136","doi":"https://doi.org/10.1128/iai.26.2.415-421.1979","title":"Chemical composition and biological activities of a phenol-water extract from Haemophilus influenzae type a","display_name":"Chemical composition and biological activities of a phenol-water extract from Haemophilus influenzae type a","publication_year":1979,"publication_date":"1979-11-01","ids":{"openalex":"https://openalex.org/W1909284136","doi":"https://doi.org/10.1128/iai.26.2.415-421.1979","mag":"1909284136","pmid":"https://pubmed.ncbi.nlm.nih.gov/317593","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/414630"},"language":"en","primary_location":{"id":"doi:10.1128/iai.26.2.415-421.1979","doi":"https://doi.org/10.1128/iai.26.2.415-421.1979","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.26.2.415-421.1979","pdf_url":"https://iai.asm.org/content/iai/26/2/415.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iai.asm.org/content/iai/26/2/415.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029075770","display_name":"Denis Raichvarg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Raichvarg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110116190","display_name":"C Brossard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Brossard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111436600","display_name":"Jean AGNERAY","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Agneray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0314,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.8983351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"2","first_page":"415","last_page":"421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.7685999870300293,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.7685999870300293,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.1687999963760376,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haemophilus-influenzae-type-a","display_name":"Haemophilus influenzae type a","score":0.9950000047683716},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.5830000042915344},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8320000171661377},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/pyrogenicity","display_name":"pyrogenicity","score":0.9079999923706055},{"id":"https://openalex.org/keywords/limulus-test","display_name":"Limulus test","score":0.8550000190734863},{"id":"https://openalex.org/keywords/peptidoglycan","display_name":"peptidoglycan","score":0.8700000047683716},{"id":"https://openalex.org/keywords/chemical-composition","display_name":"chemical composition","score":0.6620000004768372},{"id":"https://openalex.org/keywords/bacterial-cell-wall","display_name":"bacterial cell wall","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C2776621215","wikidata":"https://www.wikidata.org/wiki/Q424182","display_name":"Heptose","level":4,"score":0.9014381170272827},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.7960197925567627},{"id":"https://openalex.org/C2776925733","wikidata":"https://www.wikidata.org/wiki/Q1141979","display_name":"Haemophilus influenzae","level":3,"score":0.6964212656021118},{"id":"https://openalex.org/C2778125326","wikidata":"https://www.wikidata.org/wiki/Q327506","display_name":"Glucosamine","level":2,"score":0.6818974614143372},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6417655944824219},{"id":"https://openalex.org/C2775887612","wikidata":"https://www.wikidata.org/wiki/Q10809118","display_name":"Mannose","level":2,"score":0.616719663143158},{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.5956682562828064},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.592481255531311},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5752660036087036},{"id":"https://openalex.org/C2776487282","wikidata":"https://www.wikidata.org/wiki/Q2104567","display_name":"Limulus","level":2,"score":0.5524253249168396},{"id":"https://openalex.org/C2910339780","wikidata":"https://www.wikidata.org/wiki/Q228106","display_name":"Sugar acids","level":3,"score":0.48689404129981995},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4865652620792389},{"id":"https://openalex.org/C2778173381","wikidata":"https://www.wikidata.org/wiki/Q66589593","display_name":"Galactose","level":2,"score":0.4606618285179138},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.16245296597480774},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09129145741462708},{"id":"https://openalex.org/C2777108408","wikidata":"https://www.wikidata.org/wiki/Q11002","display_name":"Sugar","level":2,"score":0.08517289161682129},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014574","descriptor_name":"Uronic Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.26.2.415-421.1979","doi":"https://doi.org/10.1128/iai.26.2.415-421.1979","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.26.2.415-421.1979","pdf_url":"https://iai.asm.org/content/iai/26/2/415.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:222129","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC414630","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:414630","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/414630","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:317593","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/317593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/iai.26.2.415-421.1979","doi":"https://doi.org/10.1128/iai.26.2.415-421.1979","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.26.2.415-421.1979","pdf_url":"https://iai.asm.org/content/iai/26/2/415.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1909284136.pdf"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W108822333","https://openalex.org/W180137185","https://openalex.org/W1510858660","https://openalex.org/W1521819354","https://openalex.org/W1580023435","https://openalex.org/W1603727416","https://openalex.org/W1775749144","https://openalex.org/W1861389859","https://openalex.org/W1986241242","https://openalex.org/W1993295349","https://openalex.org/W1995335513","https://openalex.org/W2015236450","https://openalex.org/W2036035765","https://openalex.org/W2047082791","https://openalex.org/W2069676891","https://openalex.org/W2085229766","https://openalex.org/W2104969950","https://openalex.org/W2106339254","https://openalex.org/W2409303443","https://openalex.org/W2409833289","https://openalex.org/W2418657679"],"related_works":["https://openalex.org/W2060271493","https://openalex.org/W2158412618","https://openalex.org/W2099167202","https://openalex.org/W2411050402","https://openalex.org/W2336819482","https://openalex.org/W2127124516","https://openalex.org/W2044840904","https://openalex.org/W1767090927","https://openalex.org/W2343989321","https://openalex.org/W2421459504"],"abstract_inverted_index":{"Ribonucleic":[0],"acid":[1,41],"was":[2,18,107,115,150],"removed":[3],"from":[4,130,140,167],"a":[5,12,172],"phenol-water":[6,165],"extract":[7,166],"of":[8,55,57,104,145,158],"Haemophilus":[9],"influenzae":[10,169],"type":[11],"by":[13,110],"streptomycin":[14],"sulfate.":[15],"This":[16],"preparation":[17,21,99,106,114,147],"called":[19],"purified":[20,98,105,146,159],"or":[22,60],"PP.":[23],"It":[24],"contained":[25],"neutral":[26],"sugars":[27],"(glucose,":[28],"galactose,":[29],"mannose,":[30],"pentose),":[31],"glucosamine,":[32],"amino":[33],"acids,":[34],"and":[35,39,48,72,74,88,100,152],"fatty":[36],"acids.":[37],"Heptose":[38],"2-keto-3-deoxyoctonic":[40],"were":[42,50,65,81,128],"not":[43,108,116,171],"present.":[44],"The":[45,85,126,143],"biological":[46,156],"properties":[47],"immunogenicity":[49],"compared":[51],"with":[52,77,83,97,133,148],"the":[53,94,155,164],"activities":[54,157],"lipopolysaccharide":[56,134],"Escherichia":[58],"coli":[59],"Salmonella":[61],"typhimurium.":[62],"Higher":[63],"doses":[64],"necessary":[66,82],"to":[67,137],"obtain":[68],"lethality":[69],"in":[70,91],"mice":[71],"Sanarelli":[73],"Shwartzman":[75],"reactions":[76],"our":[78],"preparations":[79],"than":[80],"lipopolysaccharide.":[84,125],"Limulus":[86],"test":[87],"pyrogen":[89],"assay":[90],"rabbits":[92,123],"gave":[93],"same":[95],"results":[96,127],"lipopolysaccharide,":[101],"but":[102,135,175],"pyrogenicity":[103],"destroyed":[109],"NaOH":[111],"treatment.":[112],"Purified":[113],"as":[117,124],"immunogenic":[118],"at":[119],"low":[120],"doeses":[121],"for":[122],"different":[129],"those":[131,138],"obtained":[132],"similar":[136],"known":[139],"peptidoglycan":[141,149],"studies.":[142],"contamination":[144],"negligible":[151],"cannot":[153],"explain":[154],"preparation.":[160],"We":[161],"suggest":[162],"that":[163],"H.":[168],"is":[170],"classical":[173],"endotoxin,":[174],"rather":[176],"an":[177],"endotoxin-like":[178],"substance.":[179]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
