{"id":"https://openalex.org/W1909282011","doi":"https://doi.org/10.3906/kim-1501-112","title":"Synthesis and biological evaluation of a new series of 4-alkoxy-2-arylquinoline derivatives as potential antituberculosis agents","display_name":"Synthesis and biological evaluation of a new series of 4-alkoxy-2-arylquinoline derivatives as potential antituberculosis agents","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1909282011","doi":"https://doi.org/10.3906/kim-1501-112","mag":"1909282011"},"language":"en","primary_location":{"id":"doi:10.3906/kim-1501-112","doi":"https://doi.org/10.3906/kim-1501-112","is_oa":false,"landing_page_url":"https://doi.org/10.3906/kim-1501-112","pdf_url":null,"source":{"id":"https://openalex.org/S185920249","display_name":"TURKISH JOURNAL OF CHEMISTRY","issn_l":"1300-0527","issn":["1300-0527","1303-6130"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TURKISH JOURNAL OF CHEMISTRY","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.3906/kim-1501-112","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109937027","display_name":"Gonca Tosun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gonca TOSUN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058426349","display_name":"Tayfun Arslan","orcid":"https://orcid.org/0000-0002-1426-5857","observed_orcids":["https://orcid.org/0000-0002-1426-5857"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tayfun ARSLAN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111781992","display_name":"Zeynep \u0130skefiyeli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeynep \u0130SKEF\u0130YEL\u0130","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102909396","display_name":"Murat K\u00fc\u00e7\u00fck","orcid":"https://orcid.org/0000-0002-1669-5797","observed_orcids":["https://orcid.org/0000-0002-1669-5797"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Murat K\u00dc\u00c7\u00dcK","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011449190","display_name":"\u015eeng\u00fcl Alpay Karao\u011flu","orcid":"https://orcid.org/0000-0003-1047-8350","observed_orcids":["https://orcid.org/0000-0003-1047-8350"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u015eeng\u00fcl ALPAY KARAO\u011eLU","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036375943","display_name":"Nurettin Yayl\u0131","orcid":"https://orcid.org/0000-0003-4174-3014","observed_orcids":["https://orcid.org/0000-0003-4174-3014"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nurettin YAYLI","raw_affiliation_strings":["Karadeniz Technical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karadeniz Technical University","institution_ids":["https://openalex.org/I162720556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1371,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.43309006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"39","issue":null,"first_page":"850","last_page":"866"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.5679000020027161,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.5679000020027161,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.2687999904155731,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.07349999994039536,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.8799999952316284},{"id":"https://openalex.org/keywords/alkyl-halide-substitution","display_name":"alkyl halide substitution","score":0.6909999847412109},{"id":"https://openalex.org/keywords/mycobacterium-smegmatis","display_name":"Mycobacterium smegmatis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.9129999876022339},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.902999997138977},{"id":"https://openalex.org/keywords/dpph-radical-scavenging-activity","display_name":"DPPH radical scavenging","score":0.9629999995231628},{"id":"https://openalex.org/keywords/frap-assay","display_name":"FRAP","score":0.8389999866485596},{"id":"https://openalex.org/keywords/alkyl-chain-length","display_name":"alkyl chain length","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9401499032974243},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.7367786169052124},{"id":"https://openalex.org/C2776309666","wikidata":"https://www.wikidata.org/wiki/Q408384","display_name":"Quinoline","level":2,"score":0.6260768175125122},{"id":"https://openalex.org/C2777204207","wikidata":"https://www.wikidata.org/wiki/Q606230","display_name":"Mycobacterium smegmatis","level":4,"score":0.6190786957740784},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.5677955150604248},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5387678146362305},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.5045422315597534},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4913157522678375},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.41180115938186646},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.36713844537734985},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3505336344242096},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.33525776863098145},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.09345224499702454},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3906/kim-1501-112","doi":"https://doi.org/10.3906/kim-1501-112","is_oa":false,"landing_page_url":"https://doi.org/10.3906/kim-1501-112","pdf_url":null,"source":{"id":"https://openalex.org/S185920249","display_name":"TURKISH JOURNAL OF CHEMISTRY","issn_l":"1300-0527","issn":["1300-0527","1303-6130"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TURKISH JOURNAL OF CHEMISTRY","raw_type":"journal-article"},{"id":"pmh:oai:acikerisim.giresun.edu.tr:20.500.12697/3991","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.3906/kim-1501-112","pdf_url":null,"source":{"id":"https://openalex.org/S7407055334","display_name":"DSpace@Giresun","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:acikerisim.gumushane.edu.tr:20.500.12440/4083","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12440/4083","pdf_url":null,"source":{"id":"https://openalex.org/S7407055169","display_name":"G\u00fcm\u00fc\u015fhane University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dergipark.gov.tr:article/143368","doi":null,"is_oa":false,"landing_page_url":"http://dergipark.gov.tr/tbtkchem/issue/11969/143368","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\\n Volume: 39, Issue: 4\\n 850-866\\n \\n","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dergipark.org.tr:article/143368","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/tr/pub/tbtkchem/issue/11969/143368","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\\n Volume: 39, Issue: 4\\n 850-866\\n \\n","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:acikerisim.giresun.edu.tr:20.500.12697/3991","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.3906/kim-1501-112","pdf_url":null,"source":{"id":"https://openalex.org/S7407055334","display_name":"DSpace@Giresun","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322313","display_name":"Karadeniz Teknik \u00dcniversitesi","ror":"https://ror.org/03z8fyr40"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2980659148"],"related_works":["https://openalex.org/W1974514965","https://openalex.org/W2889202839","https://openalex.org/W2907468250","https://openalex.org/W2034722895","https://openalex.org/W2088612582","https://openalex.org/W2022800786","https://openalex.org/W2047970268","https://openalex.org/W2036172744","https://openalex.org/W2425146834","https://openalex.org/W3178233413"],"abstract_inverted_index":{"Three":[0],"new":[1,38,53],"series":[2],"of":[3,29,95,152,155,168,178],"33":[4],"quinolone":[5],"compounds,":[6],"2-(2-,":[7,18],"3-,":[8,19],"and":[9,13,20,24,42,68,140,159,172],"4-fluorophenyl)-4-O-alkyl(C$_{5-15})$quinolines":[10],"(7a-k,":[11,66],"8a-k,":[12,41,67,171],"9a-k),":[14],"were":[15,44,70,110,127],"synthesized":[16,45,124],"from":[17,46],"4-fluorophenyl)-2,3-dihydroquinolin-4(1H)-one":[21],"(4,":[22],"5,":[23],"6)":[25],"by":[26],"the":[27,63,84,111,176,179],"reaction":[28],"alkyl":[30,180],"halides":[31],"under":[32],"basic":[33],"conditions":[34],"in":[35,74,132],"DMF.":[36],"The":[37,122,165],"compounds":[39,65,114,126,169],"7a-k,":[40,170],"9a-k":[43,173],"flavonones":[47],"4-6,":[48],"which":[49],"can":[50],"be":[51],"considered":[52],"precursors":[54],"for":[55,72,130],"quinoline":[56],"synthesis":[57],"through":[58],"a":[59,146,150],"one-step":[60],"reaction.":[61],"All":[62],"target":[64],"9a-k)":[69],"evaluated":[71,129],"their":[73,100,131],"vitro":[75,133],"antimicrobial":[76],"activity":[77,86],"against":[78,87,115],"nine":[79],"test":[80],"microorganisms.":[81],"They":[82,143],"showed":[83,144],"most":[85,112],"Mycobacterium":[88],"smegmatis":[89,117],"with":[90,185],"minimum":[91],"inhibitory":[92],"concentrations":[93],"(MIC)":[94],"62.5-500":[96],"$\\mu":[97,120,161],"$g/mL,":[98],"indicating":[99],"potential":[101],"uses":[102],"as":[103],"antituberculosis":[104],"agents.":[105],"Among":[106],"them":[107],"8a-k":[108],"(m-fluoride)":[109],"active":[113],"M.":[116],"(MIC,":[118],"62.5-125":[119],"$g/mL).":[121],"newly":[123],"title":[125],"also":[128],"antioxidant":[134,166,186],"activities":[135],"using":[136],"DPPH\u2022":[137],"radical":[138],"scavenging":[139],"FRAP":[141],"tests.":[142],"at":[145],"low":[147],"concentration":[148],"(mg/mL)":[149],"range":[151],"SC$_{50}$":[153],"values":[154],"0.03-12.48":[156],"mg/mL":[157],"(DPPH\u2022)":[158],"0-722":[160],"$M":[162],"(FRAP),":[163],"respectively.":[164],"results":[167],"revealed":[174],"that":[175],"length":[177],"chain":[181],"was":[182],"negatively":[183],"correlated":[184],"capacity.":[187]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
