{"id":"https://openalex.org/W1908969923","doi":null,"title":"Effective therapy for a murine model of adult T-cell leukemia with the humanized anti-CD52 monoclonal antibody, Campath-1H.","display_name":"Effective therapy for a murine model of adult T-cell leukemia with the humanized anti-CD52 monoclonal antibody, Campath-1H.","publication_year":2003,"publication_date":"2003-10-01","ids":{"openalex":"https://openalex.org/W1908969923","mag":"1908969923","pmid":"https://pubmed.ncbi.nlm.nih.gov/14559836"},"language":"en","primary_location":{"id":"pmid:14559836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14559836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100429707","display_name":"Zhuo Zhang","orcid":"https://orcid.org/0000-0002-3086-7022","observed_orcids":["https://orcid.org/0000-0002-3086-7022"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuo Zhang","raw_affiliation_strings":["Metabolism Branch, Center for Cancer Research, National Cancer Institute/NIH, Building 10, Room 4N115, 10 Center Drive, Bethesda, MD 20892-1374, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Branch, Center for Cancer Research, National Cancer Institute/NIH, Building 10, Room 4N115, 10 Center Drive, Bethesda, MD 20892-1374, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100696943","display_name":"Meili Zhang","orcid":"https://orcid.org/0000-0001-9515-0420","observed_orcids":["https://orcid.org/0000-0001-9515-0420"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meili Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111895320","display_name":"Carolyn K. Goldman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolyn K Goldman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007474253","display_name":"Jeffrey V. Ravetch","orcid":"https://orcid.org/0000-0003-2024-9041","observed_orcids":["https://orcid.org/0000-0003-2024-9041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey V Ravetch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035996420","display_name":"Thomas A. Waldmann","orcid":"https://orcid.org/0000-0003-4500-6660","observed_orcids":["https://orcid.org/0000-0003-4500-6660"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas A Waldmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9181,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.91348112,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"63","issue":"19","first_page":"6453","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adult-t-cell-leukemia-lymphoma","display_name":"adult T-cell leukemia/lymphoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/campath-1h","display_name":"Campath-1H","score":0.9129999876022339},{"id":"https://openalex.org/keywords/alemtuzumab","display_name":"alemtuzumab","score":1.0},{"id":"https://openalex.org/keywords/cd52","display_name":"CD52","score":0.8980000019073486},{"id":"https://openalex.org/keywords/humanized-antibody","display_name":"humanized monoclonal antibody","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.6800000071525574},{"id":"https://openalex.org/keywords/anti-cd25-antibody","display_name":"anti-CD25 antibody","score":0.8159999847412109},{"id":"https://openalex.org/keywords/anti-cd2-antibody","display_name":"anti-CD2 antibody","score":0.8569999933242798},{"id":"https://openalex.org/keywords/fc-gamma-receptor","display_name":"Fc gamma receptor","score":0.578000009059906},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5210000276565552},{"id":"https://openalex.org/keywords/il-2-receptor-alpha","display_name":"IL-2 receptor alpha","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2778384904","wikidata":"https://www.wikidata.org/wiki/Q21108353","display_name":"CD52","level":4,"score":0.8395967483520508},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6633532047271729},{"id":"https://openalex.org/C2779015954","wikidata":"https://www.wikidata.org/wiki/Q420164","display_name":"Alemtuzumab","level":3,"score":0.6342765092849731},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5277051329612732},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.497334748506546},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.48567020893096924},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.4534684121608734},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.42781710624694824},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3960198163986206},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36893707513809204},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.31365829706192017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22440895438194275},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.11194318532943726},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074301","descriptor_name":"CD52 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074323","descriptor_name":"Alemtuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000912","descriptor_name":"Antibodies, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000912","descriptor_name":"Antibodies, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000912","descriptor_name":"Antibodies, Neoplasm","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015459","descriptor_name":"Leukemia-Lymphoma, Adult T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015459","descriptor_name":"Leukemia-Lymphoma, Adult T-Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14559836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14559836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1908969923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14559836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W9635739","https://openalex.org/W35887377","https://openalex.org/W1499156289","https://openalex.org/W1780319921","https://openalex.org/W1833241997","https://openalex.org/W1923936497","https://openalex.org/W1978451233","https://openalex.org/W1989091670","https://openalex.org/W1995670792","https://openalex.org/W2009621572","https://openalex.org/W2050430487","https://openalex.org/W2054493028","https://openalex.org/W2128402413","https://openalex.org/W2132661000","https://openalex.org/W2141800961","https://openalex.org/W2152194478","https://openalex.org/W2336865896","https://openalex.org/W2428307302"],"related_works":["https://openalex.org/W2093719891","https://openalex.org/W1499156289","https://openalex.org/W2612012925","https://openalex.org/W2919132089","https://openalex.org/W2960267449","https://openalex.org/W2568918165","https://openalex.org/W2066104625","https://openalex.org/W2032551378","https://openalex.org/W2766524640","https://openalex.org/W2116168134"],"abstract_inverted_index":{"Adult":[0],"T-cell":[1,11,273],"leukemia":[2,12],"(ATL)":[3],"develops":[4],"in":[5,78,190,202,204,235,267],"a":[6,69,150,224,262],"small":[7],"proportion":[8],"of":[9,27,66,110,116,121,130,153,156,165,209,218,265,270],"human":[10],"virus":[13],"I-infected":[14],"individuals.":[15],"Presently,":[16],"there":[17],"is":[18],"no":[19],"effective":[20],"therapy":[21],"for":[22,145,186,261],"ATL.":[23],"A":[24],"murine":[25],"model":[26],"ATL":[28,38,201],"was":[29,125,161,214],"produced":[30],"by":[31],"introducing":[32],"leukemic":[33],"cells":[34,48,52],"(MET-1)":[35],"from":[36],"an":[37],"patient":[39],"into":[40],"nonobese":[41],"diabetic/severe":[42],"combined":[43],"immunodeficient":[44],"mice.":[45,112],"The":[46,228],"MET-1":[47,157],"are":[49,184],"activated":[50],"T":[51],"that":[53,99,129,160,164,177,195,205,217,220,247],"express":[54],"CD2,":[55],"CD3,":[56],"CD4,":[57],"CD25,":[58],"CD122,":[59],"and":[60,77,182,245,275],"CD52.":[61],"We":[62,97],"evaluated":[63],"the":[64,114,131,154,206,210,268],"efficacy":[65,199],"Campath-1H":[67,124,144,196,211,234,266],"(alemtuzumab;":[68],"humanized":[70,81],"monoclonal":[71],"antibody":[72],"directed":[73,84,94],"to":[74,85,95,149],"CD52),":[75],"alone":[76],"combination":[79],"with":[80,92,103,137,143,163,216,233,272],"anti-Tac":[82],"(HAT)":[83],"CD25":[86],"(interleukin":[87],"2":[88],"receptor":[89,171],"alpha)":[90],"or":[91,226],"MEDI-507":[93],"CD2.":[96],"observed":[98],"four":[100,134],"weekly":[101,135],"treatments":[102,136],"4":[104,119,122,146],"mg/kg":[105,123],"HAT":[106,138],"significantly":[107,126],"prolonged":[108],"survival":[109,115,155],"MET-1-bearing":[111],"However,":[113],"mice":[117,159,219],"receiving":[118,133],"weeks":[120,147],"longer":[127],"than":[128],"group":[132,213],"(P":[139],"<":[140],"0.001).":[141],"Treatment":[142],"led":[148],"striking":[151],"prolongation":[152],"ATL-bearing":[158],"comparable":[162,215],"tumor-free":[166],"nontreated":[167],"controls.":[168],"Using":[169],"Fc":[170],"(FcR)":[172],"gamma(-/-)":[173],"mice,":[174],"we":[175],"found":[176],"FcRgammas":[178],"on":[179,200,242],"polymorphonuclear":[180,243],"leukocytes":[181,244],"monocytes":[183],"required":[185],"Campath-1H-mediated":[187],"tumor":[188,225,230],"killing":[189,231],"vivo.":[191],"These":[192],"results":[193],"demonstrate":[194],"has":[197],"therapeutic":[198],"vivo":[203,236],"life":[207],"span":[208],"treatment":[212,269],"did":[221],"not":[222],"receive":[223],"therapy.":[227],"main":[229],"mechanism":[232],"involves":[237],"FcRgamma-containing":[238],"receptors":[239],"(e.g.,":[240],"FcRgammaIII)":[241],"macrophages":[246],"mediate":[248],"antibody-dependent":[249],"cellular":[250],"cytotoxicity":[251],"and/or":[252],"trigger":[253],"cross-linking":[254],"induced":[255],"apoptosis.":[256],"This":[257],"study":[258],"provides":[259],"support":[260],"clinical":[263],"trial":[264],"patients":[271],"leukemias":[274],"lymphomas.":[276]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
