{"id":"https://openalex.org/W1908943487","doi":null,"title":"NICOTINA Y ADICCI\u00d3N: UN ENFOQUE MOLECULAR DEL TABAQUISMO Nicotine and addiction","display_name":"NICOTINA Y ADICCI\u00d3N: UN ENFOQUE MOLECULAR DEL TABAQUISMO Nicotine and addiction","publication_year":2007,"publication_date":"2007-03-01","ids":{"openalex":"https://openalex.org/W1908943487","mag":"1908943487"},"language":"es","primary_location":{"id":"pmh:oai:doaj.org/article:63a40550f2824cab892f1ed0ed8da11a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/63a40550f2824cab892f1ed0ed8da11a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Habanera de Ciencias M\u00e9dicas, Vol 6, Iss 1, p 0 (2007)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/f4f51afd76464618bf42c91e094ad34d","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037086060","display_name":"Nuvia P\u00e9rez Cruz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153181","display_name":"Universidad de Ciencias M\u00e9dicas de la Habana","ror":"https://ror.org/04kgp9g48","country_code":"CU","type":"education","lineage":["https://openalex.org/I4210122314","https://openalex.org/I4210153181"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Nuvia P\u00e9rez Cruz","raw_affiliation_strings":["Facultad de Ciencias M\u00e9dicas Dr. Salvador Allende, Ciudad de La Habana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias M\u00e9dicas Dr. Salvador Allende, Ciudad de La Habana","institution_ids":["https://openalex.org/I4210153181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004827834","display_name":"Hayvin P\u00e9rez Cruz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153181","display_name":"Universidad de Ciencias M\u00e9dicas de la Habana","ror":"https://ror.org/04kgp9g48","country_code":"CU","type":"education","lineage":["https://openalex.org/I4210122314","https://openalex.org/I4210153181"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Hayvin P\u00e9rez Cruz","raw_affiliation_strings":["Facultad de Ciencias M\u00e9dicas Dr. Salvador Allende, Ciudad de La Habana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias M\u00e9dicas Dr. Salvador Allende, Ciudad de La Habana","institution_ids":["https://openalex.org/I4210153181"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028553747","display_name":"Eduardo J. Fern\u00e1ndez Manch\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153181","display_name":"Universidad de Ciencias M\u00e9dicas de la Habana","ror":"https://ror.org/04kgp9g48","country_code":"CU","type":"education","lineage":["https://openalex.org/I4210122314","https://openalex.org/I4210153181"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Eduardo J. Fern\u00e1ndez Manch\u00f3n","raw_affiliation_strings":["Facultad de Ciencias M\u00e9dicas Dr. Salvador Allende, Ciudad de La Habana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias M\u00e9dicas Dr. Salvador Allende, Ciudad de La Habana","institution_ids":["https://openalex.org/I4210153181"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210153181"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.9520000219345093},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.49799999594688416},{"id":"https://openalex.org/keywords/nicotine-dependence","display_name":"nicotine dependence","score":0.8090000152587891},{"id":"https://openalex.org/keywords/dopamine-release","display_name":"dopamine release","score":0.6859999895095825},{"id":"https://openalex.org/keywords/reward-systems","display_name":"reward systems","score":0.9470000267028809},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/noradrenergic-system","display_name":"noradrenergic system","score":0.9679999947547913},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.968999981880188},{"id":"https://openalex.org/keywords/nicotine-replacement-therapy","display_name":"nicotine replacement therapy","score":0.7049999833106995},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.7070000171661377},{"id":"https://openalex.org/keywords/nicotine-vaccine","display_name":"nicotine vaccine","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tobacco-control","display_name":"tobacco control","score":0.6019999980926514},{"id":"https://openalex.org/keywords/smoking-related-morbidity-and-mortality","display_name":"smoking-related morbidity and mortality","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4087934195995331},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.35577839612960815},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.1996084749698639}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:doaj.org/article:63a40550f2824cab892f1ed0ed8da11a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/63a40550f2824cab892f1ed0ed8da11a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Habanera de Ciencias M\u00e9dicas, Vol 6, Iss 1, p 0 (2007)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f4f51afd76464618bf42c91e094ad34d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f4f51afd76464618bf42c91e094ad34d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Habanera de Ciencias M\u00e9dicas, Vol 6, Iss 1 (2007)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:f4f51afd76464618bf42c91e094ad34d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f4f51afd76464618bf42c91e094ad34d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Habanera de Ciencias M\u00e9dicas, Vol 6, Iss 1 (2007)","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W92147400","https://openalex.org/W136657926","https://openalex.org/W202162952","https://openalex.org/W1549559727","https://openalex.org/W1627638691","https://openalex.org/W1955803833","https://openalex.org/W2002446599","https://openalex.org/W2029963927","https://openalex.org/W2042615930","https://openalex.org/W2078927587","https://openalex.org/W2113673711","https://openalex.org/W2163970224","https://openalex.org/W2463861392"],"related_works":["https://openalex.org/W6983712309","https://openalex.org/W4407356551","https://openalex.org/W1974874020","https://openalex.org/W7044064741","https://openalex.org/W4407136956","https://openalex.org/W7000379513","https://openalex.org/W7038953088","https://openalex.org/W3194580344","https://openalex.org/W6987516849","https://openalex.org/W2047106911"],"abstract_inverted_index":{"El":[0,105],"tabaquismo":[1,108],"debe":[2,16],"ser":[3,75],"considerado":[4],"como":[5,49],"una":[6],"drogodependencia.":[7],"La":[8,41],"nicotina":[9],"es":[10,80],"su":[11,33],"principal":[12],"ingrediente":[13],"psicoactivo":[14],"y":[15,52,100,117,145],"sus":[17,59],"propiedades":[18,60],"adictivas":[19],"al":[20,129],"aumento":[21],"de":[22,25,30,47,83,97,103,113,124,136],"la":[23,90,111,138],"liberaci\u00f3n":[24],"dopamina":[26],"en":[27,58],"los":[28,71],"circuitos":[29],"recompensa,":[31],"por":[32,77],"acci\u00f3n":[34],"agonista":[35],"sobre":[36,44,120],"receptores":[37],"colin\u00e9rgicos":[38],"nicot\u00ednicos":[39],".":[40],"estimulaci\u00f3n":[42],"indirecta":[43],"otros":[45],"sistemas":[46],"neurotransmisi\u00f3n,":[48],"el":[50,53,68,81,95,101],"noradren\u00e9rgico":[51],"cannabinoide,":[54],"ha":[55],"sido":[56],"implicada":[57],"reforzadoras.":[61],"Exponer":[62],"este":[63,84],"enfoque":[64],"molecular":[65,216],"del":[66,107,141],"tabaquismo,":[67],"cual":[69],"descubre":[70],"blancos":[72],"susceptibles":[73],"a":[74,143,153,257,269,295,298],"modificados":[76],"intervenciones":[78],"farmacol\u00f3gicas,":[79],"objetivo":[82],"trabajo.":[85],"Las":[86],"estrategias":[87],"actuales":[88],"incluyen":[89],"terapia":[91],"sustitutiva":[92],"con":[93],"nicotina,":[94],"uso":[96],"f\u00e1rmacos":[98],"antidepresivos":[99],"desarrollo":[102],"vacunas.":[104],"tratamiento":[106],"implica":[109],"adem\u00e1s":[110],"consideraci\u00f3n":[112],"medidas":[114],"impositivas,":[115],"legislativas":[116],"laborales":[118],"y,":[119],"todo,":[121],"un":[122,133],"cambio":[123],"conducta,":[125],"lo":[126],"que":[127],"sumado":[128],"apoyo":[130],"farmacol\u00f3gico":[131],"constituye":[132],"modo":[134],"eficaz":[135],"reducir":[137],"morbimortalidad":[139],"derivada":[140],"tabaco":[142],"corto":[144],"largo":[146],"plazos.":[147],"Smoking":[148],"must":[149,264],"be":[150,227],"considered":[151],"as":[152,195],"drug":[154],"dependence.Nicotine":[155],"is":[156,212,281],"its":[157,164,179,204],"main":[158,208],"psicoactive":[159],"ingredient":[160],"and":[161,198,245,261,289,297],"it":[162,267,280],"ows":[163],"addictive":[165],"propieties":[166],"to":[167,178,213,226],"the":[168,174,183,196,215,223,236,241,246,253,277,287],"increase":[169],"of":[170,209,218,243,248,252,259,265,271,285],"dopamine":[171],"liberation":[172],"in":[173,203,274],"reward":[175],"circuits,":[176],"due":[177],"agonist":[180],"action":[181],"on":[182],"nicotinic":[184],"cholinergic":[185],"receptors.":[186],"Non":[187],"direct":[188],"stimulation":[189],"over":[190],"other":[191],"neurotransmission":[192],"systems,":[193],"such":[194],"noradrenergic":[197],"cannabinoid,":[199],"has":[200],"been":[201],"involved":[202],"reinforcing":[205],"propieties.":[206],"The":[207,232,250],"this":[210],"paper":[211],"express":[214],"approach":[217],"smoking":[219,254],",":[220],"which":[221,273],"uncovers":[222],"susceptible":[224],"targets":[225],"modified":[228],"by":[229],"pharmacological":[230,278],"interventions.":[231],"current":[233],"strategies":[234],"include":[235],"substitutive":[237],"therapy":[238],"with":[239,276],"nicotine,":[240],"use":[242],"antidepressants":[244],"development":[247],"vaccines.":[249],"treatment":[251],"habit":[255],"involves":[256,268],"series":[258],"regulations":[260],"legislations":[262],";":[263],"all,":[266],"change":[270],"behavior,":[272],"conjunction":[275],"support,":[279],"an":[282],"efficacious":[283],"way":[284],"reducing":[286],"morbidity":[288],"mortality":[290],"derived":[291],"from":[292],"tobacco":[293],"at":[294],"short":[296],"long":[299],"term.":[300]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}