{"id":"https://openalex.org/W1908884533","doi":"https://doi.org/10.1093/genetics/116.3.423","title":"enhancer of seizure: A New Genetic Locus in Drosophila melanogaster Defined by Interactions With Temperature-Sensitive Paralytic Mutations","display_name":"enhancer of seizure: A New Genetic Locus in Drosophila melanogaster Defined by Interactions With Temperature-Sensitive Paralytic Mutations","publication_year":1987,"publication_date":"1987-07-01","ids":{"openalex":"https://openalex.org/W1908884533","doi":"https://doi.org/10.1093/genetics/116.3.423","mag":"1908884533","pmid":"https://pubmed.ncbi.nlm.nih.gov/2440763","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1203154"},"language":"en","primary_location":{"id":"doi:10.1093/genetics/116.3.423","doi":"https://doi.org/10.1093/genetics/116.3.423","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/116.3.423","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080013916","display_name":"Durgadas P. Kasbekar","orcid":"https://orcid.org/0000-0002-5269-8020","observed_orcids":["https://orcid.org/0000-0002-5269-8020"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Durgadas P Kasbekar","raw_affiliation_strings":["Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110238103","display_name":"James C. Nelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C Nelson","raw_affiliation_strings":["Department of Biology, Yale University, New Haven, Connecticut 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Yale University, New Haven, Connecticut 06511","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110726906","display_name":"Linda M. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda M Hall","raw_affiliation_strings":["Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":0.5515,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.6174098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"116","issue":"3","first_page":"423","last_page":"431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.04780000075697899,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.8889999985694885},{"id":"https://openalex.org/keywords/neuronal-hyperactivity","display_name":"neuronal hyperactivity","score":0.5960000157356262},{"id":"https://openalex.org/keywords/giant-fiber","display_name":"giant fiber","score":0.6790000200271606},{"id":"https://openalex.org/keywords/flight-muscle","display_name":"flight muscle","score":0.6899999976158142},{"id":"https://openalex.org/keywords/membrane-excitability","display_name":"membrane excitability","score":0.8080000281333923},{"id":"https://openalex.org/keywords/voltage-gated-sodium-channels","display_name":"voltage-gated sodium channels","score":0.9589999914169312},{"id":"https://openalex.org/keywords/saxitoxin-binding","display_name":"saxitoxin binding","score":0.9750000238418579},{"id":"https://openalex.org/keywords/chromosome-3","display_name":"chromosome 3","score":0.5640000104904175},{"id":"https://openalex.org/keywords/p-element-insertion","display_name":"P-element insertion","score":0.75},{"id":"https://openalex.org/keywords/para","display_name":"Par\u00e1","score":0.5759999752044678},{"id":"https://openalex.org/keywords/nap","display_name":"NAP","score":0.847000002861023},{"id":"https://openalex.org/keywords/shibire","display_name":"shibire","score":0.9490000009536743}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7603936195373535},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.6983029246330261},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6577108502388},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6537415385246277},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6278923749923706},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4918077290058136},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.4642181396484375},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4238629937171936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3204635977745056},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09724503755569458}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010243","descriptor_name":"Paralysis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010243","descriptor_name":"Paralysis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010243","descriptor_name":"Paralysis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012530","descriptor_name":"Saxitoxin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012530","descriptor_name":"Saxitoxin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012530","descriptor_name":"Saxitoxin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/genetics/116.3.423","doi":"https://doi.org/10.1093/genetics/116.3.423","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/116.3.423","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmid:2440763","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2440763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1735144974","display_name":null,"funder_award_id":"NS07314","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5698716844","display_name":null,"funder_award_id":"NS 16209","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1539561424","https://openalex.org/W1608124574","https://openalex.org/W1962484858","https://openalex.org/W1964265834","https://openalex.org/W1968841992","https://openalex.org/W1983649348","https://openalex.org/W1993288432","https://openalex.org/W2032972160","https://openalex.org/W2059602440","https://openalex.org/W2095391491","https://openalex.org/W2118397392","https://openalex.org/W2133612017","https://openalex.org/W2137088189","https://openalex.org/W2152027398","https://openalex.org/W2406788322","https://openalex.org/W2418359239"],"related_works":["https://openalex.org/W2162835045","https://openalex.org/W61918870","https://openalex.org/W658573254","https://openalex.org/W3196603312","https://openalex.org/W2128946071","https://openalex.org/W2006402788","https://openalex.org/W7095688197","https://openalex.org/W1967122819","https://openalex.org/W7034686231","https://openalex.org/W2103197717"],"abstract_inverted_index":{"Mutations":[0],"in":[1,160,171,181,189],"the":[2,12,24,43,64,69,75,89,103,129,134,146,152,161,190,197,201,226],"enhancer":[3,39,65,112,135],"of":[4,14,21,71,92,131,154],"seizure":[5,25,44,76,132,220],"(e(sei]":[6],"locus":[7,27,45],"have":[8],"been":[9],"isolated":[10,115],"on":[11,50,88,102,157],"basis":[13],"their":[15],"ability":[16],"to":[17,42,68,86,225],"cause":[18,210],"temperature-induced":[19],"paralysis":[20,72],"alleles":[22],"at":[23,28,30,100,126],"(sei)":[26],"temperatures":[29],"which":[31,84,237],"these":[32],"mutations":[33],"ordinarily":[34],"do":[35],"not":[36,180],"paralyze.":[37],"This":[38,61],"is":[40,47,80],"specific":[41],"and":[46,59,143,174,200,208],"without":[48],"effect":[49],"other":[51],"temperature-sensitive":[52],"paralytic":[53],"mutants":[54,221],"including":[55],"para,":[56],"nap,":[57],"tip-E":[58],"shi.":[60],"suggests":[62,204],"that":[63,205,219],"responds":[66],"specifically":[67],"mechanism":[70],"mediated":[73],"by":[74],"mutations.":[77],"The":[78,184,194],"e(sei)":[79,173,209,230],"a":[81,110,122,234],"recessive":[82],"mutation":[83,136],"maps":[85],"39.0":[87],"left":[90],"arm":[91],"chromosome":[93,107],"3.":[94],"Deficiency":[95],"mapping":[96],"has":[97,217],"placed":[98],"it":[99],"69A4-B5":[101],"salivary":[104],"gland":[105],"polytene":[106],"map.":[108],"When":[109],"new":[111],"allele":[113],"was":[114,121,169,186],"following":[116],"P-M":[117],"hybrid":[118],"dysgenesis,":[119],"there":[120],"concomitant":[123],"P-element":[124],"insertion":[125],"69B.":[127],"In":[128],"absence":[130],"mutations,":[133],"causes":[137],"non-temperature":[138],"dependent":[139],"hyperactivity":[140,168,185],"when":[141],"agitated":[142],"interferes":[144],"with":[145,239],"climbing":[147],"response.":[148],"Electrophysiological":[149],"studies":[150],"examined":[151],"effects":[153,199],"increasing":[155],"temperature":[156],"electrical":[158],"activity":[159],"adult":[162],"giant":[163],"fiber/flight":[164],"muscle":[165],"system.":[166],"Neuronal":[167],"seen":[170],"both":[172,206],"sei":[175,207],"single":[176],"mutant":[177,202],"homozygotes,":[178],"but":[179],"wild":[182],"type.":[183],"more":[187],"severe":[188],"sei;e(sei)":[191],"double":[192],"mutants.":[193],"correlation":[195],"between":[196],"physiological":[198],"behavior":[203],"membrane":[211],"excitability":[212],"defects.":[213],"Since":[214],"previous":[215],"work":[216],"shown":[218],"affect":[222],"[3H]saxitoxin":[223],"binding":[224],"voltage-sensitive":[227],"sodium":[228],"channel,":[229],"may":[231],"code":[232],"for":[233],"gene":[235],"product":[236],"interacts":[238],"this":[240],"channel.":[241]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}