{"id":"https://openalex.org/W1908875893","doi":"https://doi.org/10.4049/jimmunol.174.3.1557","title":"Myeloperoxidase Plays Critical Roles in Killing Klebsiella pneumoniae and Inactivating Neutrophil Elastase: Effects on Host Defense","display_name":"Myeloperoxidase Plays Critical Roles in Killing Klebsiella pneumoniae and Inactivating Neutrophil Elastase: Effects on Host Defense","publication_year":2005,"publication_date":"2005-02-01","ids":{"openalex":"https://openalex.org/W1908875893","doi":"https://doi.org/10.4049/jimmunol.174.3.1557","mag":"1908875893","pmid":"https://pubmed.ncbi.nlm.nih.gov/15661916"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.174.3.1557","doi":"https://doi.org/10.4049/jimmunol.174.3.1557","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.174.3.1557","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113509365","display_name":"Tim Oliver Hirche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tim O Hirche","raw_affiliation_strings":["Departments of Medicine, Washington University School of Medicine , St. Louis, MO 63110","* Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"* Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074798932","display_name":"Joseph P. Gaut","orcid":"https://orcid.org/0000-0002-9580-3951","observed_orcids":["https://orcid.org/0000-0002-9580-3951"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph P Gaut","raw_affiliation_strings":["Departments of Medicine, Washington University School of Medicine , St. Louis, MO 63110","* Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"* Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035595391","display_name":"Jay W. Heinecke","orcid":"https://orcid.org/0000-0001-5246-0007","observed_orcids":["https://orcid.org/0000-0001-5246-0007"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay W Heinecke","raw_affiliation_strings":["\u2021Department of Medicine, University of Washington, Seattle, WA 98105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Department of Medicine, University of Washington, Seattle, WA 98105","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111561378","display_name":"Azzaq Belaaouaj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Azzaq Belaaouaj","raw_affiliation_strings":["Departments of Medicine, Washington University School of Medicine , St. Louis, MO 63110","Departments of Molecular Microbiology, Washington University School of Medicine , St. Louis, MO 63110","Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110","\u2020Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Departments of Molecular Microbiology, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"\u2020Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110; and","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.4826,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.89001853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"174","issue":"3","first_page":"1557","last_page":"1565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":1.0},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neutrophil-killing","display_name":"neutrophil killing","score":0.6359999775886536},{"id":"https://openalex.org/keywords/oxidative-inactivation","display_name":"oxidative inactivation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.7009999752044678},{"id":"https://openalex.org/keywords/gram-negative-infections","display_name":"gram-negative bacterial infection","score":0.7559999823570251},{"id":"https://openalex.org/keywords/neutrophil-proteases","display_name":"neutrophil proteases","score":0.4779999852180481},{"id":"https://openalex.org/keywords/tissue-destruction","display_name":"tissue destruction","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.8616726398468018},{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.8231732249259949},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.7273033857345581},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6749995350837708},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.6061062216758728},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5548582077026367},{"id":"https://openalex.org/C198677920","wikidata":"https://www.wikidata.org/wiki/Q3299937","display_name":"Neutrophile","level":3,"score":0.4380427598953247},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.41036301851272583},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38086172938346863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33168014883995056},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16696566343307495},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.14656779170036316},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1458812952041626},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10884609818458557},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10018345713615417},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.09582126140594482},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001770","descriptor_name":"Blood Bactericidal Activity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006997","descriptor_name":"Hypochlorous Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006997","descriptor_name":"Hypochlorous Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018375","descriptor_name":"Neutrophil Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019272","descriptor_name":"Leukocyte Elastase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019272","descriptor_name":"Leukocyte Elastase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019272","descriptor_name":"Leukocyte Elastase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D019272","descriptor_name":"Leukocyte Elastase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.174.3.1557","doi":"https://doi.org/10.4049/jimmunol.174.3.1557","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.174.3.1557","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:15661916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15661916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5600000023841858,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1690566065","display_name":null,"funder_award_id":"HL66415","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G174302924","display_name":null,"funder_award_id":"AG021191","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4618803395","display_name":null,"funder_award_id":"HL-64344","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6112551015","display_name":"OXIDATIVE MECHANISMS OF AAA FORMATION (COLLABORATIVE R01","funder_award_id":"R01HL064344","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6622787433","display_name":"SERINE PROTEINASES &LUNG HOST DEFENSE AGAINST BACTERIA","funder_award_id":"5r01hl066415-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8946346975","display_name":"Pathways for the Inflammatory Damage of Biomolecules","funder_award_id":"R01AG021191","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W97463538","https://openalex.org/W157205536","https://openalex.org/W176973416","https://openalex.org/W1528445472","https://openalex.org/W1541671026","https://openalex.org/W1873534235","https://openalex.org/W1902412925","https://openalex.org/W1905459797","https://openalex.org/W1915111028","https://openalex.org/W1974293339","https://openalex.org/W1978083259","https://openalex.org/W1980899805","https://openalex.org/W1981278668","https://openalex.org/W1995609060","https://openalex.org/W1996471647","https://openalex.org/W2000356352","https://openalex.org/W2018799206","https://openalex.org/W2022362501","https://openalex.org/W2027297714","https://openalex.org/W2028257547","https://openalex.org/W2047422624","https://openalex.org/W2048026321","https://openalex.org/W2051705991","https://openalex.org/W2055688463","https://openalex.org/W2056952563","https://openalex.org/W2059676378","https://openalex.org/W2069967133","https://openalex.org/W2081035749","https://openalex.org/W2084814184","https://openalex.org/W2090888252","https://openalex.org/W2104999462","https://openalex.org/W2105864925","https://openalex.org/W2111657224","https://openalex.org/W2112999311","https://openalex.org/W2113453073","https://openalex.org/W2113842263","https://openalex.org/W2120134837","https://openalex.org/W2133536720","https://openalex.org/W2140626436","https://openalex.org/W2142527036","https://openalex.org/W2152872648","https://openalex.org/W2182473668","https://openalex.org/W2258951277","https://openalex.org/W2338841990","https://openalex.org/W2343333218","https://openalex.org/W2406699320","https://openalex.org/W2414571050","https://openalex.org/W4235902209","https://openalex.org/W4239297083"],"related_works":["https://openalex.org/W2152221103","https://openalex.org/W2589615263","https://openalex.org/W2070256030","https://openalex.org/W2022520756","https://openalex.org/W1951235943","https://openalex.org/W2335954993","https://openalex.org/W2013125307","https://openalex.org/W1908544405","https://openalex.org/W2610615493","https://openalex.org/W2104999462"],"abstract_inverted_index":{"Activated":[0],"neutrophils":[1,131],"use":[2],"myeloperoxidase":[3],"(MPO)":[4],"to":[5,25,72,168],"generate":[6],"an":[7,41,106],"array":[8],"of":[9,29,86,104,116,122,156,176],"potent":[10],"toxic":[11],"oxidants.":[12],"In":[13,77],"the":[14,27,30,36,52,84,114,154,170,173],"current":[15],"studies":[16,79,97],"we":[17,47],"used":[18,48],"genetically":[19],"altered":[20],"mice":[21,49,61,135],"deficient":[22,50,62],"in":[23,32,51,63,88,95,113,153],"MPO":[24,65,82,100,164],"investigate":[26],"role":[28],"enzyme":[31,107],"host":[33,171],"defense":[34],"against":[35],"Gram-negative":[37],"bacterium":[38],"Klebsiella":[39],"pneumoniae,":[40],"important":[42],"human":[43],"pathogen.":[44],"For":[45],"comparison,":[46],"antimicrobial":[53],"molecule,":[54],"neutrophil":[55],"elastase":[56,138],"(NE).":[57],"When":[58],"challenged":[59],"i.p.,":[60],"either":[64],"or":[66],"NE":[67,167],"were":[68],"markedly":[69],"more":[70],"susceptible":[71],"bacterial":[73],"infection":[74],"and":[75],"death.":[76],"vitro":[78,96],"suggested":[80],"that":[81,99,108,145,163],"impairs":[83],"morphology":[85],"bacteria":[87],"a":[89,150],"distinctive":[90],"way.":[91],"Of":[92],"importance,":[93],"our":[94],"found":[98],"mediated":[101],"oxidative":[102,123],"inactivation":[103,124],"NE,":[105,148],"has":[109],"been":[110],"widely":[111],"implicated":[112],"pathogenesis":[115],"various":[117],"tissue-destructive":[118],"diseases.":[119],"This":[120],"pathway":[121],"may":[125,165],"be":[126],"physiologically":[127],"relevant,":[128],"because":[129],"activated":[130],"isolated":[132],"from":[133,172],"MPO-deficient":[134],"exhibited":[136],"increased":[137],"activity.":[139],"Our":[140],"observations":[141],"provide":[142],"strong":[143],"evidence":[144],"MPO,":[146],"like":[147],"is":[149],"key":[151],"player":[152],"killing":[155],"K.":[157],"pneumoniae":[158],"bacteria.":[159],"They":[160],"also":[161],"suggest":[162],"modulate":[166],"protect":[169],"tissue-degrading":[174],"activity":[175],"this":[177],"proteinase.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
