{"id":"https://openalex.org/W1908810138","doi":"https://doi.org/10.1002/macp.1981.021820206","title":"Polym\u00e8res \u00e0 propri\u00e9t\u00e9s pharmacologiques potentiels: greffage par liaison amide et (ou) ester d'un hypoglyc\u00e9miant","display_name":"Polym\u00e8res \u00e0 propri\u00e9t\u00e9s pharmacologiques potentiels: greffage par liaison amide et (ou) ester d'un hypoglyc\u00e9miant","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W1908810138","doi":"https://doi.org/10.1002/macp.1981.021820206","mag":"1908810138"},"language":"en","primary_location":{"id":"doi:10.1002/macp.1981.021820206","doi":"https://doi.org/10.1002/macp.1981.021820206","is_oa":false,"landing_page_url":"https://doi.org/10.1002/macp.1981.021820206","pdf_url":null,"source":{"id":"https://openalex.org/S4210221479","display_name":"Die Makromolekulare Chemie","issn_l":"0025-116X","issn":["0025-116X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Die Makromolekulare Chemie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027214628","display_name":"Gilbert Friedmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096046","display_name":"Institut de Chimie de Strasbourg","ror":"https://ror.org/00se7bf12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096046","https://openalex.org/I4210128300","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Gilbert Friedmann","raw_affiliation_strings":["Laboratoire de Synthe\u0300se Organique \u2013 Institut de Chimie de Strasbourg, F-67008 Strasbourg, Cedex, France","Laboratoire de Synth\u00e8se Organique \u2013 Institut de Chimie de Strasbourg, F\u201067008 Strasbourg, Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Synthe\u0300se Organique \u2013 Institut de Chimie de Strasbourg, F-67008 Strasbourg, Cedex, France","institution_ids":["https://openalex.org/I4210096046"]},{"raw_affiliation_string":"Laboratoire de Synth\u00e8se Organique \u2013 Institut de Chimie de Strasbourg, F\u201067008 Strasbourg, Cedex, France","institution_ids":["https://openalex.org/I4210096046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109427104","display_name":"Hocine Aichaoui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096046","display_name":"Institut de Chimie de Strasbourg","ror":"https://ror.org/00se7bf12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096046","https://openalex.org/I4210128300","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hocine Aichaoui","raw_affiliation_strings":["Laboratoire de Synthe\u0300se Organique \u2013 Institut de Chimie de Strasbourg, F-67008 Strasbourg, Cedex, France","Laboratoire de Synth\u00e8se Organique \u2013 Institut de Chimie de Strasbourg, F\u201067008 Strasbourg, Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Synthe\u0300se Organique \u2013 Institut de Chimie de Strasbourg, F-67008 Strasbourg, Cedex, France","institution_ids":["https://openalex.org/I4210096046"]},{"raw_affiliation_string":"Laboratoire de Synth\u00e8se Organique \u2013 Institut de Chimie de Strasbourg, F\u201067008 Strasbourg, Cedex, France","institution_ids":["https://openalex.org/I4210096046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086600227","display_name":"Mathilde Brini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096046","display_name":"Institut de Chimie de Strasbourg","ror":"https://ror.org/00se7bf12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096046","https://openalex.org/I4210128300","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mathilde Brini","raw_affiliation_strings":["Laboratoire de Synthe\u0300se Organique \u2013 Institut de Chimie de Strasbourg, F-67008 Strasbourg, Cedex, France","Laboratoire de Synth\u00e8se Organique \u2013 Institut de Chimie de Strasbourg, F\u201067008 Strasbourg, Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Synthe\u0300se Organique \u2013 Institut de Chimie de Strasbourg, F-67008 Strasbourg, Cedex, France","institution_ids":["https://openalex.org/I4210096046"]},{"raw_affiliation_string":"Laboratoire de Synth\u00e8se Organique \u2013 Institut de Chimie de Strasbourg, F\u201067008 Strasbourg, Cedex, France","institution_ids":["https://openalex.org/I4210096046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027214628"],"corresponding_institution_ids":["https://openalex.org/I4210096046"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.04406365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"182","issue":"2","first_page":"337","last_page":"347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5795999765396118,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5795999765396118,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.1615000069141388,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14303","display_name":"Polymer Synthesis and Characterization","score":0.08150000125169754,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.7639999985694885},{"id":"https://openalex.org/keywords/polymer-drug-conjugates","display_name":"polymer-drug conjugates","score":0.7239999771118164},{"id":"https://openalex.org/keywords/graft-copolymerization","display_name":"graft copolymerization","score":0.718999981880188},{"id":"https://openalex.org/keywords/amide-bond","display_name":"amide bond","score":0.7210000157356262},{"id":"https://openalex.org/keywords/ester-bonds","display_name":"ester bonds","score":0.968999981880188},{"id":"https://openalex.org/keywords/spacer-length","display_name":"spacer length","score":0.6100000143051147},{"id":"https://openalex.org/keywords/water-soluble-polymers","display_name":"water-soluble polymers","score":0.8899999856948853},{"id":"https://openalex.org/keywords/drug-carriers","display_name":"drug carriers","score":0.4440000057220459},{"id":"https://openalex.org/keywords/hypoglycemic-effect","display_name":"hypoglycemic effect","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.7910038232803345},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7396134734153748},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.5915868282318115},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4376758635044098},{"id":"https://openalex.org/C31684184","wikidata":"https://www.wikidata.org/wiki/Q33293","display_name":"Peptide bond","level":3,"score":0.4295389652252197},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.35752394795417786},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2276986539363861},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.19240176677703857},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1785605251789093}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/macp.1981.021820206","doi":"https://doi.org/10.1002/macp.1981.021820206","is_oa":false,"landing_page_url":"https://doi.org/10.1002/macp.1981.021820206","pdf_url":null,"source":{"id":"https://openalex.org/S4210221479","display_name":"Die Makromolekulare Chemie","issn_l":"0025-116X","issn":["0025-116X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Die Makromolekulare Chemie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W383891904","https://openalex.org/W2322280164","https://openalex.org/W2952201742","https://openalex.org/W4235455072"],"related_works":["https://openalex.org/W2054782251","https://openalex.org/W1976392084","https://openalex.org/W2319152349","https://openalex.org/W2018840529","https://openalex.org/W2084971500","https://openalex.org/W2157962256","https://openalex.org/W7015445223","https://openalex.org/W2051084806","https://openalex.org/W2093662079","https://openalex.org/W3093494271"],"abstract_inverted_index":{"Abstract":[0],"N\u2010(4\u2010aminobenzenesulfonyl)\u2010N\u2032\u2010butylurea":[1],"(8)":[2],"(glibutamide\u00ae)":[3],"and":[4,13,39],"several":[5],"amino":[6],"compounds":[7],"were":[8],"grafted":[9],"on":[10,28],"water":[11],"soluble":[12],"non\u2010toxic":[14],"polymeric":[15,53],"backbones,":[16],"with":[17],"the":[18,22,29,33,47,52,62,80,84],"intention":[19],"to":[20,51,57,79,89],"study":[21],"influence":[23],"of":[24,32,65,83],"such":[25],"a":[26],"carrier":[27,54],"hypoglycemic":[30,63],"effects":[31],"drug,":[34],"covalently":[35],"linked":[36],"by":[37,45],"ester":[38],"(or)":[40],"amide":[41,81],"bonds.":[42],"The":[43],"spacer":[44],"which":[46,86],"drug":[48,85],"was":[49,70],"fixed":[50],"contained":[55],"1":[56],"10":[58],"atoms.":[59],"So":[60],"far,":[61],"effect":[64],"only":[66],"one":[67],"polymer":[68],"(13d)":[69],"tested.":[71],"It":[72],"showed,":[73],"however,":[74],"negative":[75],"results":[76],"probably":[77],"due":[78],"bond":[82],"is":[87],"difficult":[88],"split":[90],"off.":[91]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}
