{"id":"https://openalex.org/W1908801172","doi":"https://doi.org/10.3233/jad-131589","title":"Structural Diversity of Alzheimer's Disease Amyloid-\u03b2 Dimers and Their Role in Oligomerization and Fibril Formation","display_name":"Structural Diversity of Alzheimer's Disease Amyloid-\u03b2 Dimers and Their Role in Oligomerization and Fibril Formation","publication_year":2014,"publication_date":"2014-02-07","ids":{"openalex":"https://openalex.org/W1908801172","doi":"https://doi.org/10.3233/jad-131589","mag":"1908801172","pmid":"https://pubmed.ncbi.nlm.nih.gov/24240640","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4449729"},"language":"en","primary_location":{"id":"doi:10.3233/jad-131589","doi":"https://doi.org/10.3233/jad-131589","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jad-131589","pdf_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad131589?id=journal-of-alzheimers-disease%2Fjad131589","source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad131589?id=journal-of-alzheimers-disease%2Fjad131589","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047059421","display_name":"Igor F. Tsigelny","orcid":"https://orcid.org/0000-0002-7155-8947","observed_orcids":["https://orcid.org/0000-0002-7155-8947"]},"institutions":[{"id":"https://openalex.org/I181653535","display_name":"San Diego Supercomputer Center","ror":"https://ror.org/04mg3nk07","country_code":"US","type":"facility","lineage":["https://openalex.org/I181653535","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor F. Tsigelny","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA","Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA","San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]},{"raw_affiliation_string":"San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I181653535","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081505014","display_name":"Yuriy Sharikov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181653535","display_name":"San Diego Supercomputer Center","ror":"https://ror.org/04mg3nk07","country_code":"US","type":"facility","lineage":["https://openalex.org/I181653535","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuriy Sharikov","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA","San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I181653535","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050071283","display_name":"Valentina L. Kouznetsova","orcid":"https://orcid.org/0000-0001-9457-7027","observed_orcids":["https://orcid.org/0000-0001-9457-7027"]},"institutions":[{"id":"https://openalex.org/I181653535","display_name":"San Diego Supercomputer Center","ror":"https://ror.org/04mg3nk07","country_code":"US","type":"facility","lineage":["https://openalex.org/I181653535","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valentina L. Kouznetsova","raw_affiliation_strings":["Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA","San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]},{"raw_affiliation_string":"San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I181653535","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111557964","display_name":"Jerry P. Greenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181653535","display_name":"San Diego Supercomputer Center","ror":"https://ror.org/04mg3nk07","country_code":"US","type":"facility","lineage":["https://openalex.org/I181653535","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry P. Greenberg","raw_affiliation_strings":["San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I181653535","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109101617","display_name":"Wolfgang Wrasidlo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wolfgang Wrasidlo","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA","Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048919332","display_name":"Tania Gonzalez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tania Gonzalez","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058385646","display_name":"Paula Desplats","orcid":"https://orcid.org/0000-0002-4758-4280","observed_orcids":["https://orcid.org/0000-0002-4758-4280"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula Desplats","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sarah E. Michael","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah E. Michael","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079765420","display_name":"Margarita Trejo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margarita Trejo-Morales","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015198649","display_name":"Cassia Overk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cassia R. Overk","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074775445","display_name":"Eliezer Masliah","orcid":"https://orcid.org/0000-0002-2117-5569","observed_orcids":["https://orcid.org/0000-0002-2117-5569"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eliezer Masliah","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA","Department of Pathology, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pathology, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074775445"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":3.5495,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.92182854,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"39","issue":"3","first_page":"583","last_page":"600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9380000233650208},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.875}],"concepts":[{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.7570419311523438},{"id":"https://openalex.org/C2780642029","wikidata":"https://www.wikidata.org/wiki/Q726004","display_name":"Oligomer","level":2,"score":0.6957322359085083},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.6831055879592896},{"id":"https://openalex.org/C30765947","wikidata":"https://www.wikidata.org/wiki/Q899119","display_name":"Salt bridge","level":4,"score":0.675865113735199},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6477912664413452},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5981767177581787},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.5419010519981384},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.39469391107559204},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36628708243370056},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3604642152786255},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.2268880307674408},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.1811116337776184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15587425231933594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12184882164001465},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.12157461047172546},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3233/jad-131589","doi":"https://doi.org/10.3233/jad-131589","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jad-131589","pdf_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad131589?id=journal-of-alzheimers-disease%2Fjad131589","source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmid:24240640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24240640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3410743","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4449729","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4449729","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4449729","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Alzheimers Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3233/jad-131589","doi":"https://doi.org/10.3233/jad-131589","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jad-131589","pdf_url":"https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad131589?id=journal-of-alzheimers-disease%2Fjad131589","source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","score":0.46000000834465027,"display_name":"Life on land"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2793432280","display_name":"a-synuclein clearance strategies for the treatment of Lewy body disease","funder_award_id":"R37AG018440","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2976272768","display_name":"a-Synuclein vulnerability mechanisms and therapeutics in Alzheimer's Disease","funder_award_id":"R01AG018440","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3317175073","display_name":"UCSD Alzheimer's Disease Research Center P50","funder_award_id":"P50AG005131","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G360413817","display_name":"Molecular Mechanisms linking Aging, Abeta Proteotoxicity and Neurodegeneration","funder_award_id":"P01AG031097","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4064735010","display_name":null,"funder_award_id":"AG022074","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G486772123","display_name":null,"funder_award_id":"AG 18440","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5889150347","display_name":"Proteinopathies of the Aging Central Nervous System","funder_award_id":"P01AG022074","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8250056910","display_name":null,"funder_award_id":"AG043384","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8546941174","display_name":"Clearance Pathways in the CNS in Aging and HIV","funder_award_id":"R01AG043384","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8575943337","display_name":null,"funder_award_id":"AG 031097","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000034646","display_name":null,"funder_award_id":"AG\u2010022074","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000035899","display_name":null,"funder_award_id":"AG\u201018440","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000039906","display_name":null,"funder_award_id":"AG043384","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1908801172.pdf","grobid_xml":"https://content.openalex.org/works/W1908801172.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W77683630","https://openalex.org/W1039605956","https://openalex.org/W1166867742","https://openalex.org/W1516306407","https://openalex.org/W1677883125","https://openalex.org/W1780764429","https://openalex.org/W1965895512","https://openalex.org/W1966687817","https://openalex.org/W1970874743","https://openalex.org/W1972567838","https://openalex.org/W1978721215","https://openalex.org/W1980146626","https://openalex.org/W1980825524","https://openalex.org/W1984964811","https://openalex.org/W1988480171","https://openalex.org/W1989762591","https://openalex.org/W1989906022","https://openalex.org/W1990405999","https://openalex.org/W1990752558","https://openalex.org/W1991435932","https://openalex.org/W1994097282","https://openalex.org/W1997678320","https://openalex.org/W1997758497","https://openalex.org/W2000769077","https://openalex.org/W2014451295","https://openalex.org/W2016170088","https://openalex.org/W2016579226","https://openalex.org/W2016819659","https://openalex.org/W2022325790","https://openalex.org/W2024473468","https://openalex.org/W2029653438","https://openalex.org/W2035687084","https://openalex.org/W2035891349","https://openalex.org/W2037383962","https://openalex.org/W2038758364","https://openalex.org/W2040186907","https://openalex.org/W2045756045","https://openalex.org/W2049878053","https://openalex.org/W2055530055","https://openalex.org/W2056544504","https://openalex.org/W2059804089","https://openalex.org/W2065878937","https://openalex.org/W2066418720","https://openalex.org/W2066750067","https://openalex.org/W2070487321","https://openalex.org/W2075075217","https://openalex.org/W2075481535","https://openalex.org/W2088865014","https://openalex.org/W2091812444","https://openalex.org/W2093041670","https://openalex.org/W2100216915","https://openalex.org/W2103815459","https://openalex.org/W2106210646","https://openalex.org/W2109727228","https://openalex.org/W2110613705","https://openalex.org/W2114524505","https://openalex.org/W2118280241","https://openalex.org/W2122814674","https://openalex.org/W2123733934","https://openalex.org/W2124929769","https://openalex.org/W2132562756","https://openalex.org/W2136651889","https://openalex.org/W2137261793","https://openalex.org/W2140831051","https://openalex.org/W2151747945","https://openalex.org/W2152184357","https://openalex.org/W2152326664","https://openalex.org/W2155073864","https://openalex.org/W2156326104","https://openalex.org/W2156835500","https://openalex.org/W2157418491","https://openalex.org/W2165021720","https://openalex.org/W2165620713","https://openalex.org/W2170709967","https://openalex.org/W2320660005","https://openalex.org/W2398866206"],"related_works":["https://openalex.org/W2051792081","https://openalex.org/W2087947478","https://openalex.org/W1978721215","https://openalex.org/W2020399830","https://openalex.org/W2089399875","https://openalex.org/W1617188648","https://openalex.org/W2137261793","https://openalex.org/W7095402953","https://openalex.org/W2328196102","https://openalex.org/W2119404766"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"is":[3,44,52],"associated":[4],"with":[5,176],"the":[6,35,84,120,133,149,162,168,172,181,194,213,230,239],"formation":[7,214,247],"of":[8,38,50,57,74,104,125,143,161,217,226,232,242,248],"toxic":[9,249],"amyloid-\u03b2":[10],"(A\u03b2)42":[11],"oligomers,":[12],"and":[13,54,81,187,215],"recent":[14],"evidence":[15],"supports":[16],"a":[17,47,94,102,109,223],"role":[18],"for":[19,25,34,66,205,238],"A\u03b2":[20,113,126,227,233],"dimers":[21,51,58,114,127,150,234],"as":[22],"building":[23],"blocks":[24],"oligomers.":[26,157,250],"Molecular":[27],"dynamics":[28],"simulation":[29],"studies":[30,221],"have":[31],"identified":[32,204],"clans":[33],"dominant":[36],"conformations":[37,73],"A\u03b242":[39,174],"forming":[40],"dimers;":[41],"however,":[42],"it":[43],"unclear":[45],"if":[46],"larger":[48],"spectrum":[49],"involved":[53],"which":[55],"set(s)":[56],"might":[59,235],"evolve":[60,136,153],"to":[61,100,135,154],"oligomers":[62,166],"verse":[63],"fibrils.":[64],"Therefore,":[65],"this":[67],"study":[68],"we":[69,107,147],"generated":[70],"multiple":[71],"structural":[72],"A\u03b242,":[75],"using":[76],"explicit":[77],"all-atom":[78],"molecular":[79],"dynamics,":[80],"then":[82,98],"clustering":[83],"different":[85,123],"structures":[86],"based":[87],"on":[88,119,193,197],"key":[89,200],"conformational":[90],"similarities.":[91],"Those":[92],"matching":[93],"selection":[95],"threshold":[96],"were":[97,128,203],"used":[99],"model":[101],"process":[103],"oligomerization.":[105],"Remarkably,":[106],"showed":[108],"greater":[110,224],"diversity":[111,225],"in":[112],"than":[115],"previously":[116],"described.":[117],"Depending":[118],"clan":[121],"family,":[122],"types":[124],"obtained.":[129],"While":[130],"some":[131],"had":[132,167],"tendency":[134],"into":[137],"oligomeric":[138],"rings,":[139],"others":[140],"formed":[141],"fibrils":[142],"diverse":[144],"characteristics.":[145],"Then":[146],"selected":[148],"that":[151,208,245],"would":[152],"membranephilic":[155],"annular":[156,165],"Nearly":[158],"one":[159,185],"third":[160],"28":[163],"evaluated":[164],"dimer":[169],"interfaces":[170],"between":[171,180],"neighboring":[173],"monomers":[175],"possible":[177],"salt":[178],"bridges":[179],"residue":[182,189],"K28":[183],"from":[184],"side":[186],"either":[188,209],"E22":[190],"or":[191,211],"D23":[192],"other.":[195],"Based":[196],"these":[198],"results,":[199],"amino":[201],"acids":[202],"point":[206],"mutations":[207],"enhanced":[210],"suppressed":[212],"toxicity":[216],"oligomer":[218],"rings.":[219],"Our":[220],"suggest":[222],"dimers.":[228],"Understanding":[229],"structure":[231],"be":[236],"important":[237],"rationale":[240],"design":[241],"small":[243],"molecules":[244],"block":[246]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
