{"id":"https://openalex.org/W1908640787","doi":"https://doi.org/10.5525/gla.thesis.5797","title":"Androgen receptor phosphorylation in prostate diseases","display_name":"Androgen receptor phosphorylation in prostate diseases","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1908640787","doi":"https://doi.org/10.5525/gla.thesis.5797","mag":"1908640787"},"language":"en","primary_location":{"id":"pmh:oai:theses.gla.ac.uk:5797","doi":null,"is_oa":true,"landing_page_url":"https://theses.gla.ac.uk/5797/1/2014WillderPhDed.pdf","pdf_url":"https://theses.gla.ac.uk/5797/1/2014WillderPhDed.pdf","source":{"id":"https://openalex.org/S4306401724","display_name":"Enlighten: Theses (The University of Glasgow)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I7882870","host_organization_name":"University of Glasgow","host_organization_lineage":["https://openalex.org/I7882870"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://theses.gla.ac.uk/5797/1/2014WillderPhDed.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060714436","display_name":"Jennifer M. Willder","orcid":"https://orcid.org/0000-0003-4843-8717","observed_orcids":["https://orcid.org/0000-0003-4843-8717"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Willder, Jennifer Mary","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060714436"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9330000281333923},{"id":"https://openalex.org/keywords/serine-phosphorylation","display_name":"serine phosphorylation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9079999923706055},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phospho-specific-antibodies","display_name":"phospho-specific antibodies","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cdk1","display_name":"CDK1","score":0.6159999966621399},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9829999804496765},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.9750000238418579},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8650000095367432},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.746999979019165},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.5600000023841858},{"id":"https://openalex.org/keywords/hormone-naive-prostate-cancer","display_name":"hormone-naive prostate cancer","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.6734429597854614},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5829726457595825},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5702347755432129},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.4130706191062927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37627190351486206},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3750515282154083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3360954523086548},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2959161698818207},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24049842357635498},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08507564663887024}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:theses.gla.ac.uk:5797","doi":null,"is_oa":true,"landing_page_url":"https://theses.gla.ac.uk/5797/1/2014WillderPhDed.pdf","pdf_url":"https://theses.gla.ac.uk/5797/1/2014WillderPhDed.pdf","source":{"id":"https://openalex.org/S4306401724","display_name":"Enlighten: Theses (The University of Glasgow)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I7882870","host_organization_name":"University of Glasgow","host_organization_lineage":["https://openalex.org/I7882870"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"doi:10.5525/gla.thesis.5797","doi":"https://doi.org/10.5525/gla.thesis.5797","is_oa":true,"landing_page_url":"https://doi.org/10.5525/gla.thesis.5797","pdf_url":null,"source":{"id":"https://openalex.org/S7407050753","display_name":"University of Glasgow","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:1908640787","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.646715","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:theses.gla.ac.uk:5797","doi":null,"is_oa":true,"landing_page_url":"https://theses.gla.ac.uk/5797/1/2014WillderPhDed.pdf","pdf_url":"https://theses.gla.ac.uk/5797/1/2014WillderPhDed.pdf","source":{"id":"https://openalex.org/S4306401724","display_name":"Enlighten: Theses (The University of Glasgow)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I7882870","host_organization_name":"University of Glasgow","host_organization_lineage":["https://openalex.org/I7882870"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320337","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1908640787.pdf","grobid_xml":"https://content.openalex.org/works/W1908640787.grobid-xml"},"referenced_works_count":123,"referenced_works":["https://openalex.org/W74699402","https://openalex.org/W323781630","https://openalex.org/W1490833936","https://openalex.org/W1504213150","https://openalex.org/W1523426257","https://openalex.org/W1532654778","https://openalex.org/W1548275617","https://openalex.org/W1557861865","https://openalex.org/W1558007424","https://openalex.org/W1558623255","https://openalex.org/W1575945383","https://openalex.org/W1590098473","https://openalex.org/W1963749564","https://openalex.org/W1967449713","https://openalex.org/W1968840300","https://openalex.org/W1971318487","https://openalex.org/W1971622516","https://openalex.org/W1972459670","https://openalex.org/W1973455999","https://openalex.org/W1974667009","https://openalex.org/W1976672681","https://openalex.org/W1977496497","https://openalex.org/W1990845638","https://openalex.org/W1992142098","https://openalex.org/W1993040599","https://openalex.org/W1993060456","https://openalex.org/W1993875664","https://openalex.org/W1998060347","https://openalex.org/W2009869135","https://openalex.org/W2014948512","https://openalex.org/W2015794788","https://openalex.org/W2016381211","https://openalex.org/W2017682357","https://openalex.org/W2018009871","https://openalex.org/W2018069915","https://openalex.org/W2025288244","https://openalex.org/W2026309467","https://openalex.org/W2026907934","https://openalex.org/W2027264386","https://openalex.org/W2030288965","https://openalex.org/W2030694663","https://openalex.org/W2030869113","https://openalex.org/W2030912819","https://openalex.org/W2032972450","https://openalex.org/W2035440087","https://openalex.org/W2038704446","https://openalex.org/W2041705103","https://openalex.org/W2042126216","https://openalex.org/W2044466825","https://openalex.org/W2051980021","https://openalex.org/W2053198390","https://openalex.org/W2053286013","https://openalex.org/W2053535211","https://openalex.org/W2056303044","https://openalex.org/W2060374612","https://openalex.org/W2062071319","https://openalex.org/W2062974833","https://openalex.org/W2065579733","https://openalex.org/W2068748474","https://openalex.org/W2069480574","https://openalex.org/W2070044201","https://openalex.org/W2070998226","https://openalex.org/W2073297535","https://openalex.org/W2074220607","https://openalex.org/W2075163176","https://openalex.org/W2079295335","https://openalex.org/W2079817613","https://openalex.org/W2080588158","https://openalex.org/W2080944306","https://openalex.org/W2083926838","https://openalex.org/W2086933275","https://openalex.org/W2089561494","https://openalex.org/W2090957192","https://openalex.org/W2092136711","https://openalex.org/W2092709844","https://openalex.org/W2092886494","https://openalex.org/W2093199757","https://openalex.org/W2094859123","https://openalex.org/W2097226696","https://openalex.org/W2099540110","https://openalex.org/W2104586902","https://openalex.org/W2106501078","https://openalex.org/W2106642283","https://openalex.org/W2107633226","https://openalex.org/W2109298591","https://openalex.org/W2109992853","https://openalex.org/W2121111735","https://openalex.org/W2121963546","https://openalex.org/W2123559875","https://openalex.org/W2124662269","https://openalex.org/W2126071672","https://openalex.org/W2126974525","https://openalex.org/W2128635872","https://openalex.org/W2130115296","https://openalex.org/W2130791546","https://openalex.org/W2131605616","https://openalex.org/W2131915710","https://openalex.org/W2134909548","https://openalex.org/W2138602205","https://openalex.org/W2139566281","https://openalex.org/W2141838252","https://openalex.org/W2145274312","https://openalex.org/W2149464366","https://openalex.org/W2151840649","https://openalex.org/W2155079554","https://openalex.org/W2156095111","https://openalex.org/W2156196736","https://openalex.org/W2157191335","https://openalex.org/W2160248368","https://openalex.org/W2161439053","https://openalex.org/W2161810908","https://openalex.org/W2161915108","https://openalex.org/W2162147642","https://openalex.org/W2162197351","https://openalex.org/W2165170481","https://openalex.org/W2171039998","https://openalex.org/W2171367875","https://openalex.org/W2172024571","https://openalex.org/W2400217765","https://openalex.org/W2411849420","https://openalex.org/W2736080144","https://openalex.org/W4232211224","https://openalex.org/W7099717845"],"related_works":["https://openalex.org/W3208359093","https://openalex.org/W277876724","https://openalex.org/W2924239733","https://openalex.org/W2088012234","https://openalex.org/W1789132408","https://openalex.org/W3006786924","https://openalex.org/W2165846310","https://openalex.org/W1966236782","https://openalex.org/W2553158978","https://openalex.org/W2069484452"],"abstract_inverted_index":{"Prostatic":[0],"diseases":[1,39,82,99],"are":[2,47,111],"common;":[3],"benign":[4],"prostate":[5,20,72,106,196,202,235,328,488,613,694,868,1013],"hyperplasia":[6],"(BPH)":[7],"is":[8,29,103,144,497,710,729],"almost":[9],"ubiquitous":[10],"in":[11,23,76,149,174,195,198,234,420,486,528,532,563,577,598,608,618,632,639,662,665,680,689,727,747,772,840,852,882,911,948,959,998,1012,1041],"elderly":[12],"men":[13,16],"and":[14,31,78,88,109,139,201,216,237,245,268,297,303,346,369,388,402,423,526,535,572,652,703,724,737,761,782,788,808,923,992,1015,1017,1038,1044],"899,000":[15],"were":[17,291,305,348,379,397,549,587,636,790,817,933],"diagnosed":[18],"with":[19,83,241,263,351,382,400,416,428,439,463,551,590,647,676,691,700,766,792,824,846,936,953,961],"cancer":[21,236,329,461,489,614,695,1014],"worldwide":[22],"2008.":[24],"The":[25,90,178,204,630],"incidence":[26,848],"of":[27,80,97,116,164,181,190,207,220,252,338,511,517,537,542,560,574,604,625,735,743,756,779,798,838,849,867,885,940,946,956,986,1008,1030],"both":[28,81,199,419,666],"increasing":[30],"expected":[32],"to":[33,35,53,61,185,272,332,385,443,508,592,595,649,682,768,826,829,895,938],"continue":[34],"rise.":[36],"Therefore,":[37],"prostatic":[38,98,154,1042],"represent":[40],"a":[41,218,352,464,498,505,515,599,619,732,753,908,996,1036,1048],"considerable":[42],"economic":[43],"burden,":[44],"but":[45,688],"there":[46],"currently":[48],"no":[49],"reliable":[50,672],"markers":[51,726,742],"available":[52,679],"accurately":[54],"differentiate":[55],"indolent":[56],"from":[57,66],"aggressive":[58,524],"disease":[59,155,390,525,533,715,1043],"nor":[60],"predict":[62],"who":[63],"will":[64],"benefit":[65],"treatment":[67,477,501,513,529,596,900],"for":[68,278,474,1023,1051],"either":[69],"BPH":[70,200,238,709,728,749,774,1016],"or":[71,167],"cancer.":[73,203],"This":[74,258,447,876,980],"results":[75,606,631],"over":[77,512,854],"under-treatment":[79],"consequent":[84],"patient":[85,239,663],"related":[86],"morbidity":[87],"mortality.":[89],"molecular":[91],"mechanisms":[92],"underlying":[93],"the":[94,117,162,168,175,187,208,250,314,421,424,509,543,564,578,605,609,633,640,677,683,692,718,773,841,893,949,999,1005,1031],"natural":[95],"history":[96],"remain":[100],"elusive.":[101],"It":[102,143,1002],"accepted":[104],"that":[105,147],"cell":[107],"growth":[108],"survival":[110,392,453,456],"exquisitely":[112],"dependent":[113,716],"upon":[114,717],"activation":[115],"androgen":[118,713],"receptor":[119],"(AR)":[120],"by":[121,406,492],"androgens.":[122],"Following":[123,356,751],"ligand":[124],"binding,":[125],"AR":[126,138,141,150,165,171,191,221,229,274,282,311,339,545,562,757,781,783,989,1009,1032],"undergoes":[127],"further":[128],"phosphorylation":[129,151,173,193,231,275,312,340,547,759,991,1011,1029],"at":[130,341,430,469,785,861,925,964,969],"serine":[131,172,192,230,342,546,758,990,1010,1028],"residues,":[132],"which":[133,503],"inhibit":[134],"proteolytic":[135],"degradation,":[136],"stabilise":[137],"influence":[140,892],"transactivation.":[142],"therefore":[145,484],"plausible":[146],"alterations":[148],"may":[152,471,530,668,877,891,1033],"drive":[153],"progression.":[156],"However,":[157],"few":[158],"studies":[159],"have":[160,669,878],"explored":[161],"significance":[163,1007],"phosphorylation,":[166],"kinases":[169,254,309,994],"driving":[170],"clinical":[176,188,243,266,354,552,736,769,794,880,1006],"setting.":[177],"over-riding":[179],"objective":[180],"this":[182,270,752],"study":[183,210,982],"was":[184,322,413,437,483,616,645,698,745,764,844,951],"establish":[186,215,273],"relevance":[189],"status":[194],"tissue":[197,261,271,330],"specific":[205,228,391,988,1027],"aims":[206],"current":[209,1000],"were:":[211],"\u2022":[212,224,247],"To":[213,225,248],"firstly":[214],"validate":[217],"panel":[219,755],"phosphospecific":[222,283],"antibodies.":[223],"evaluate":[226],"site":[227,987],"expression":[232,251,276,336,362,372,412,418,436,559,654,777,797,837,916,945,985],"levels":[233,337,778],"cohorts,":[240],"full":[242],"data":[244],"follow-up.":[246],"investigate":[249],"candidate":[253],"mediating":[255,310],"such":[256],"phosphorylation.":[257],"involved":[259],"establishing":[260],"banks":[262],"linked":[264],"comprehensive":[265,733,981],"databases,":[267],"utilising":[269],"profiles":[277],"each":[279,349],"patient.":[280],"Six":[281],"antibodies":[284],"(pARS81,":[285],"pARS94,":[286],"pARS213,":[287],"pARS515,":[288],"pARS578,":[289],"pARS650)":[290],"verified":[292],"using":[293,313],"peptide":[294],"competition":[295],"assays":[296],"western":[298],"blotting.":[299],"Cdk1,":[300],"ERK1/2,":[301],"Akt":[302],"PKC":[304,411],"identified":[306],"as":[307,404,514,1035,1047],"putative":[308],"online":[315],"kinase":[316],"search":[317],"tool":[318],"Scansite":[319,407],"2.0.":[320,408],"Immunohistochemistry":[321],"performed":[323,746],"on":[324,555,820,907,983],"hormone":[325],"na\u00efve":[326],"diagnostic":[327],"relating":[331],"90":[333],"patients.":[334,629,750,887,913],"High":[335],"sites":[343,548],"81,":[344],"515":[345,787],"578":[347],"associated":[350,381,399,415,438,550,646,699,762,791,845,935,952,993],"poorer":[353,793],"outcome.":[355],"cox":[357,600,821],"regression":[358,601,822],"analysis,":[359,557],"cytoplasmic":[360,434,643],"pARS515":[361,403,435,653,701,801,839],"(p=0.038,":[363],"HR":[364,374,567,582,803,812,871,918,928,975],"4.5":[365],"(95%":[366,569,584,805,814,873,920,930,977],"CI":[367,377,570,585,806,815,874,921,931,978],"1.1\u201320.6))":[368],"pARS81":[370,401,644],"nuclear":[371,410],"(p=0.030,":[373],"0.033":[375],"95%":[376],"0.002-0.721)":[378],"independently":[380,934],"shorter":[383,389,441,451,593,827],"time":[384,442,594,648,828,937],"biochemical":[386,444],"relapse":[387,445],"respectively.":[393],"Cdk1":[394,697],"and/or":[395,904],"pCdk1161":[396,704],"significantly":[398,414,440,450],"predicted":[405],"Similarly,":[409],"pARS578":[417],"cytoplasm":[422,565,950],"nucleus.":[425],"In":[426,888],"patients":[427,462,490,521,853,960],"PSA":[429,467,924,962],"diagnosis":[431,470,926,965],"\u226420ng/ml,":[432],"high":[433,558],"(p=0.019).":[446],"translated":[448],"into":[449,722],"disease-specific":[452],"(p<0.001,":[454],"10y":[455],"38.1%":[457],"vs":[458,859,967],"100%).":[459],"Prostate":[460],"low":[465,836,944],"serum":[466],"level":[468],"be":[472],"suitable":[473],"delayed":[475],"radical":[476,500,538],"via":[478],"active":[479,493,611,627,685],"surveillance.":[480,494],"An":[481],"investigation":[482],"undertaken":[485,617],"51":[487],"treated":[491],"Active":[495],"surveillance":[496,612,628,686],"deferred":[499],"approach":[502],"provides":[504],"potential":[506,1046],"solution":[507],"problem":[510],"result":[516,531],"over-diagnosis.":[518],"However":[519,674],"some":[520],"harbour":[522],"occult":[523],"delay":[527],"progression":[534],"failure":[536,939,955],"therapy.":[539],"Although":[540,642],"none":[541],"individual":[544],"outcome":[553,770],"measures":[554,771],"univariate":[556],"total":[561,780],"(p=0.021,":[566],"4.6":[568],"1.3-16.8))":[571],"presence":[573],"perineural":[575],"invasion":[576],"tumour":[579],"specimen":[580],"(p=0.003,":[581],"8.6":[583],"2.1-35.7))":[586],"deemed":[588,818],"independent":[589,819],"regards":[591,825],"intervention":[597,650,958],"analysis.":[602],"Validation":[603],"seen":[607],"first":[610,634,684],"cohort":[615,623,635],"second":[620],"prospectively":[621],"collected":[622],"consisting":[624],"84":[626],"not":[637],"replicated":[638],"second.":[641],"(p=0.032)":[651],"trended":[655,705],"towards":[656,706],"an":[657,660,707,712],"association":[658],"(p=0.072),":[659],"increase":[661],"numbers":[664,678],"cohorts":[667],"provided":[670],"more":[671],"results.":[673],"even":[675],"contrast":[681],"cohort,":[687,696],"line":[690],"pilot":[693],"expression,":[702],"association.":[708],"also":[711],"driven":[714],"AR.":[719],"Previous":[720],"research":[721],"predictive":[723,1039],"prognostic":[725,1037],"scant.":[730],"Therefore":[731],"analysis":[734,823],"novel":[738],"pathological":[739],"factors,":[740],"including":[741],"inflammation,":[744],"336":[748],"complete":[754],"sites,":[760],"kinases,":[763],"analysed":[765],"reference":[767],"cohort.":[775],"Low":[776,796],"phosphorylated":[784],"Ser-81,":[786],"650":[789],"outcomes.":[795],"smooth":[799,842],"muscle":[800,843],"(p=0.029,":[802],"0.31":[804],"0.10-0.94))":[807],"older":[809],"age":[810],"(p=0.004,":[811],"5.13":[813],"1.43-18.41))":[816],"postoperative":[830,850,883,898],"acute":[831],"urinary":[832],"retention":[833],"(AUR).":[834],"Furthermore,":[835,943],"increased":[847,954],"AUR":[851],"70":[855],"years":[856,863,971],"old":[857],"(25.1%":[858],"2.8%":[860],"10":[862],"following":[864],"transurethral":[865],"resection":[866],"(TUR)),":[869],"(p=0.002,":[870],"0.20":[872],"0.06-0.62)).":[875],"important":[879],"implications":[881],"counselling":[884],"these":[886,912],"addition":[889],"it":[890],"decision":[894],"commence":[896],"early":[897],"medical":[899],"(with":[901],"5-alpha-reductase":[902],"inhibitors":[903],"alpha":[905],"blockers)":[906],"prophylactic":[909],"basis":[910],"Cytoplasmic":[914],"pARS650":[915,947],"(p=0.010,":[917],"0.50":[919],"0.29-0.86))":[922],"(p=0.018,":[927],"1.89":[929],"1.11-3.16))":[932],"surgical":[941,957],"intervention.":[942,1053],"\u22654ng/ml":[963],"(45.5%":[966],"13%":[968],"5":[970],"post":[972],"TUR),":[973],"(p=0.026,":[974],"0.52":[976],"0.29-0.93)).":[979],"immunohistochemical":[984],"fills":[995],"gap":[997],"literature.":[1001],"has":[1003,1045],"demonstrated":[1004],"uncovered":[1018],"potentially":[1019],"exciting":[1020],"new":[1021],"avenues":[1022],"future":[1024,1049],"investigation.":[1025],"Site":[1026],"serve":[1034],"biomarker":[1040],"target":[1050],"therapeutic":[1052]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
