{"id":"https://openalex.org/W1908619062","doi":null,"title":"Somatic mutations of PTEN in glioblastoma multiforme.","display_name":"Somatic mutations of PTEN in glioblastoma multiforme.","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W1908619062","mag":"1908619062","pmid":"https://pubmed.ncbi.nlm.nih.gov/9331071"},"language":"en","primary_location":{"id":"pmid:9331071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9331071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020172968","display_name":"S I Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S I Wang","raw_affiliation_strings":["Department of Pathology and Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070949512","display_name":"Janusz A. Puc","orcid":"https://orcid.org/0000-0003-1541-3687","observed_orcids":["https://orcid.org/0000-0003-1541-3687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Puc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055848888","display_name":"Jeffrey N. Bruce","orcid":"https://orcid.org/0000-0002-6844-0286","observed_orcids":["https://orcid.org/0000-0002-6844-0286"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J N Bruce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109044336","display_name":"P Cairns","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Cairns","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109152183","display_name":"David Sidransky","orcid":"https://orcid.org/0000-0003-4178-2072","observed_orcids":["https://orcid.org/0000-0003-4178-2072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Sidransky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082690187","display_name":"Ramon E. Parsons","orcid":"https://orcid.org/0000-0002-6656-3514","observed_orcids":["https://orcid.org/0000-0002-6656-3514"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Parsons","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":27.0828,"has_fulltext":false,"cited_by_count":506,"citation_normalized_percentile":{"value":0.99910394,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"57","issue":"19","first_page":"4183","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9800000190734863},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.9800000190734863},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9739999771118164},{"id":"https://openalex.org/keywords/chromosome-10q","display_name":"chromosome 10q","score":0.8930000066757202},{"id":"https://openalex.org/keywords/homozygous-deletion","display_name":"homozygous deletion","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tumor-suppressor-inactivation","display_name":"tumor suppressor inactivation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/polymorphic-markers","display_name":"polymorphic markers","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9901436567306519},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.925987720489502},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6670544743537903},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.6473380923271179},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.6042071580886841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5932019948959351},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.538001298904419},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5083629488945007},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5008828639984131},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.42451542615890503},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.42212074995040894},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.41475510597229004},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3126496970653534},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2437669038772583},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.12000507116317749},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.04641881585121155},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002879","descriptor_name":"Chromosomes, Human, Pair 10","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056741","descriptor_name":"Cyclin D","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9331071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9331071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.328.1445","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.1445","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/57/19/4183.full.pdf","raw_type":"text"},{"id":"mag:1908619062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9331071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1497143324","https://openalex.org/W1499660750","https://openalex.org/W1879520773","https://openalex.org/W1935114338","https://openalex.org/W1953089061","https://openalex.org/W1991311764","https://openalex.org/W2068345721","https://openalex.org/W2091736771","https://openalex.org/W2093014822","https://openalex.org/W2150233389","https://openalex.org/W2159178451","https://openalex.org/W2161810908","https://openalex.org/W2166708153","https://openalex.org/W2326655300"],"related_works":["https://openalex.org/W2316897574","https://openalex.org/W2035855874","https://openalex.org/W1651628650","https://openalex.org/W2011264036","https://openalex.org/W2125915186","https://openalex.org/W2076699304","https://openalex.org/W2181347889","https://openalex.org/W2100377699","https://openalex.org/W2466965857","https://openalex.org/W1975491629"],"abstract_inverted_index":{"Alterations":[0],"of":[1,13,25,37,54,61,71,79,81,88,90,104],"the":[2,11,26,43,69,101],"PTEN":[3,14,44,73,97],"gene":[4,45],"occur":[5],"in":[6,21,59,68,76,109],"glioblastoma":[7,110],"multiforme.":[8,111],"To":[9],"determine":[10],"frequency":[12],"alteration,":[15],"34":[16,62],"consecutive":[17],"glioblastomas":[18,83],"were":[19],"studied":[20,84],"detail.":[22],"Sequencing":[23],"each":[24],"nine":[27],"exons":[28],"amplified":[29],"from":[30],"tumor":[31],"DNA":[32],"revealed":[33],"11":[34],"mutations.":[35,52],"Analysis":[36],"polymorphic":[38],"markers":[39],"within":[40],"and":[41,85],"surrounding":[42],"identified":[46],"an":[47],"additional":[48],"four":[49],"homozygous":[50],"deletion":[51],"Loss":[53],"heterozygosity":[55],"(LOH)":[56],"was":[57,74],"observed":[58],"25":[60],"(74%)":[63],"cases.":[64],"All":[65],"mutations":[66],"occurred":[67],"presence":[70],"LOH.":[72],"mutated":[75],"44%":[77],"(15":[78,87],"34)":[80],"all":[82],"60%":[86],"25)":[89],"tumors":[91],"with":[92],"LOH":[93],"on":[94,106],"10q.":[95],"Thus,":[96],"appears":[98],"to":[99],"be":[100],"major":[102],"target":[103],"inactivation":[105],"chromosome":[107],"10q":[108]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
