{"id":"https://openalex.org/W1908532874","doi":null,"title":"Nonimmunogenic hyperthyroidism: cumulative hypothyroidism incidence after radioiodine and surgical treatment.","display_name":"Nonimmunogenic hyperthyroidism: cumulative hypothyroidism incidence after radioiodine and surgical treatment.","publication_year":1989,"publication_date":"1989-12-01","ids":{"openalex":"https://openalex.org/W1908532874","mag":"1908532874","pmid":"https://pubmed.ncbi.nlm.nih.gov/2585096"},"language":"en","primary_location":{"id":"pmid:2585096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2585096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081347229","display_name":"Jane A. Kinser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J A Kinser","raw_affiliation_strings":["Department of Nuclear Medicine, University of Berne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, University of Berne, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112697409","display_name":"Helmuth Roesler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Roesler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004480692","display_name":"Th Furrer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Furrer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106090273","display_name":"D Gr\u00fctter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Gr\u00fctter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018643203","display_name":"H Zimmermann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Zimmermann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5475,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.62233581,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"30","issue":"12","first_page":"1960","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.047200001776218414,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radioactive-iodine-therapy","display_name":"radioiodine therapy","score":0.824999988079071},{"id":"https://openalex.org/keywords/thyroidectomy","display_name":"thyroidectomy","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hypothyroidism-incidence","display_name":"hypothyroidism incidence","score":0.8939999938011169},{"id":"https://openalex.org/keywords/toxic-adenoma","display_name":"toxic adenoma","score":0.8640000224113464},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.7710000276565552},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8915985822677612},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6215090751647949},{"id":"https://openalex.org/C2776254400","wikidata":"https://www.wikidata.org/wiki/Q165135","display_name":"Goiter","level":3,"score":0.5383720397949219},{"id":"https://openalex.org/C3018694869","wikidata":"https://www.wikidata.org/wiki/Q927316","display_name":"Radioiodine therapy","level":4,"score":0.5275846719741821},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5155274868011475},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.4683263599872589},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4288523197174072},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4188554584980011},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.4110778570175171},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.372750461101532},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3347565829753876},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.19956836104393005},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D013965","descriptor_name":"Thyroidectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2585096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2585096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"mag:1908532874","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2585096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2472402249","https://openalex.org/W2057228795","https://openalex.org/W4225386782","https://openalex.org/W2151007816","https://openalex.org/W2016529399","https://openalex.org/W2412401958","https://openalex.org/W2143825723","https://openalex.org/W2462275555","https://openalex.org/W2409787679","https://openalex.org/W1971126778"],"abstract_inverted_index":{"During":[0],"1977,":[1],"246":[2],"hyperthyroid":[3],"patients":[4,29,49,56,95,141],"were":[5,50,83,96,126,142],"seen":[6],"in":[7],"our":[8],"departments,":[9],"140":[10],"(57%)":[11],"with":[12,16,23],"nonimmunogenic":[13],"hyperthyroidism":[14,70],"(NIH)--101":[15],"a":[17,60],"toxic":[18],"adenoma":[19],"(TA)":[20],"and":[21,80,111,122],"39":[22],"multifocal":[24],"functional":[25],"autonomy":[26],"(MFA).":[27],"All":[28],"but":[30],"one":[31],"could":[32],"be":[33],"followed":[34],"over":[35],"9":[36,73,99],"yr,":[37],"101":[38],"after":[39,45,75,87,98,109,113,157],"131I":[40],"treatment":[41,165],"(RIT),":[42],"another":[43],"29":[44],"surgery":[46,169],"(S).":[47],"Ten":[48],"left":[51],"untreated.":[52],"Thirty-four":[53],"treated":[54,93],"(24%)":[55],"died,":[57],"none":[58],"as":[59],"result":[61],"of":[62,91,105,131,146],"thyroid":[63],"or":[64,101,137],"post-treatment":[65],"complications.":[66],"There":[67],"was":[68,153],"no":[69],"later":[71],"than":[72,156],"mo":[74],"therapy.":[76],"Only":[77],"1%":[78],"(RIT)":[79],"24%":[81],"(S)":[82],"hypothyroid":[84,97],"1":[85],"yr":[86,100],"treatment.":[88],"But":[89],"19%":[90],"all":[92],"NIH":[94],"at":[102],"the":[103,132,164],"time":[104],"their":[106],"death,":[107],"12%":[108],"RIT":[110,121,136,147,162],"41%":[112],"S.":[114,158],"The":[115,144],"cumulative":[116],"hypothyroidism":[117],"incidences":[118],"1.4%/yr":[119],"for":[120,124,166,170],"2.2%/yr":[123],"S,":[125,138],"not":[127,154],"significantly":[128],"different.":[129],"Out":[130],"five":[133],"survivers":[134],"without":[135],"two":[139],"TA":[140],"hypothyroid.":[143],"effect":[145],"on":[148],"goiter":[149],"related":[150],"loco-regional":[151],"complications":[152],"worse":[155],"We":[159],"conclude":[160],"that":[161],"is":[163],"NIH,":[167],"leaving":[168],"exceptional":[171],"cases.":[172]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}