{"id":"https://openalex.org/W1908398785","doi":"https://doi.org/10.1002/alr.21467","title":"Impact of saline irrigation and topical corticosteroids on the postsurgical sinonasal microbiota","display_name":"Impact of saline irrigation and topical corticosteroids on the postsurgical sinonasal microbiota","publication_year":2014,"publication_date":"2014-12-29","ids":{"openalex":"https://openalex.org/W1908398785","doi":"https://doi.org/10.1002/alr.21467","mag":"1908398785","pmid":"https://pubmed.ncbi.nlm.nih.gov/25556553","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4628778"},"language":"en","primary_location":{"id":"doi:10.1002/alr.21467","doi":"https://doi.org/10.1002/alr.21467","is_oa":false,"landing_page_url":"https://doi.org/10.1002/alr.21467","pdf_url":null,"source":{"id":"https://openalex.org/S2506670899","display_name":"International Forum of Allergy & Rhinology","issn_l":"2042-6976","issn":["2042-6976","2042-6984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Forum of Allergy & Rhinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4628778","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013480850","display_name":"Cindy M. Liu","orcid":"https://orcid.org/0000-0003-4537-173X","observed_orcids":["https://orcid.org/0000-0003-4537-173X","https://orcid.org/0000-0002-1075-1436"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I203172682","display_name":"Northern Arizona University","ror":"https://ror.org/0272j5188","country_code":"US","type":"education","lineage":["https://openalex.org/I203172682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy M. Liu","raw_affiliation_strings":["Center for Microbial Genetics and Genomics Northern Arizona University  Flagstaff AZ","Department of Pathology, School of Medicine Johns Hopkins University  Baltimore MD","Division of Pathogen Genomics Translational Genomics Research Institute  Flagstaff AZ","Center for Microbial Genetics and Genomics; Northern Arizona University; Flagstaff AZ","Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD","Division of Pathogen Genomics, Translational Genomics Research Institute, Flagstaff, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbial Genetics and Genomics Northern Arizona University  Flagstaff AZ","institution_ids":["https://openalex.org/I203172682"]},{"raw_affiliation_string":"Department of Pathology, School of Medicine Johns Hopkins University  Baltimore MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Division of Pathogen Genomics Translational Genomics Research Institute  Flagstaff AZ","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Center for Microbial Genetics and Genomics; Northern Arizona University; Flagstaff AZ","institution_ids":["https://openalex.org/I203172682"]},{"raw_affiliation_string":"Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Division of Pathogen Genomics, Translational Genomics Research Institute, Flagstaff, AZ","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085935400","display_name":"Michael A. Kohanski","orcid":"https://orcid.org/0000-0001-8399-364X","observed_orcids":["https://orcid.org/0000-0001-8399-364X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Kohanski","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins School of Medicine  Baltimore MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins School of Medicine  Baltimore MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057567270","display_name":"Michelle Mendiola","orcid":"https://orcid.org/0000-0001-9348-7708","observed_orcids":["https://orcid.org/0000-0001-9348-7708"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Mendiola","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins School of Medicine  Baltimore MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins School of Medicine  Baltimore MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108378924","display_name":"Katerina Soldanova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]},{"id":"https://openalex.org/I203172682","display_name":"Northern Arizona University","ror":"https://ror.org/0272j5188","country_code":"US","type":"education","lineage":["https://openalex.org/I203172682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katerina Soldanova","raw_affiliation_strings":["Center for Microbial Genetics and Genomics Northern Arizona University  Flagstaff AZ","Division of Pathogen Genomics Translational Genomics Research Institute  Flagstaff AZ","Center for Microbial Genetics and Genomics; Northern Arizona University; Flagstaff AZ","Division of Pathogen Genomics; Translational Genomics Research Institute; Flagstaff AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbial Genetics and Genomics Northern Arizona University  Flagstaff AZ","institution_ids":["https://openalex.org/I203172682"]},{"raw_affiliation_string":"Division of Pathogen Genomics Translational Genomics Research Institute  Flagstaff AZ","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Center for Microbial Genetics and Genomics; Northern Arizona University; Flagstaff AZ","institution_ids":["https://openalex.org/I203172682"]},{"raw_affiliation_string":"Division of Pathogen Genomics; Translational Genomics Research Institute; Flagstaff AZ","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016291820","display_name":"Michael G. Dwan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]},{"id":"https://openalex.org/I203172682","display_name":"Northern Arizona University","ror":"https://ror.org/0272j5188","country_code":"US","type":"education","lineage":["https://openalex.org/I203172682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Dwan","raw_affiliation_strings":["Center for Microbial Genetics and Genomics Northern Arizona University  Flagstaff AZ","Division of Pathogen Genomics Translational Genomics Research Institute  Flagstaff AZ","Center for Microbial Genetics and Genomics; Northern Arizona University; Flagstaff AZ","Division of Pathogen Genomics; Translational Genomics Research Institute; Flagstaff AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbial Genetics and Genomics Northern Arizona University  Flagstaff AZ","institution_ids":["https://openalex.org/I203172682"]},{"raw_affiliation_string":"Division of Pathogen Genomics Translational Genomics Research Institute  Flagstaff AZ","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Center for Microbial Genetics and Genomics; Northern Arizona University; Flagstaff AZ","institution_ids":["https://openalex.org/I203172682"]},{"raw_affiliation_string":"Division of Pathogen Genomics; Translational Genomics Research Institute; Flagstaff AZ","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003715359","display_name":"Richard Todd Lester","orcid":"https://orcid.org/0000-0003-1759-2236","observed_orcids":["https://orcid.org/0000-0003-1759-2236"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Lester","raw_affiliation_strings":["Division of Pathogen Genomics Translational Genomics Research Institute  Flagstaff AZ","Division of Pathogen Genomics; Translational Genomics Research Institute; Flagstaff AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathogen Genomics Translational Genomics Research Institute  Flagstaff AZ","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Division of Pathogen Genomics; Translational Genomics Research Institute; Flagstaff AZ","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055292354","display_name":"Lora Nordstrom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lora Nordstrom","raw_affiliation_strings":["Division of Pathogen Genomics Translational Genomics Research Institute  Flagstaff AZ","Division of Pathogen Genomics; Translational Genomics Research Institute; Flagstaff AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathogen Genomics Translational Genomics Research Institute  Flagstaff AZ","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Division of Pathogen Genomics; Translational Genomics Research Institute; Flagstaff AZ","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030762180","display_name":"Lance Bradley Price","orcid":"https://orcid.org/0000-0002-8746-5307","observed_orcids":["https://orcid.org/0000-0002-8746-5307"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]},{"id":"https://openalex.org/I1302991022","display_name":"Milken Institute","ror":"https://ror.org/03f5t6469","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1302991022"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance B. Price","raw_affiliation_strings":["Department of Environmental and Occupational Health, Milken Institute School of Public Health George Washington University  Washington DC","Division of Pathogen Genomics Translational Genomics Research Institute  Flagstaff AZ","Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC","Division of Pathogen Genomics, Translational Genomics Research Institute, Flagstaff, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health, Milken Institute School of Public Health George Washington University  Washington DC","institution_ids":["https://openalex.org/I1302991022","https://openalex.org/I193531525"]},{"raw_affiliation_string":"Division of Pathogen Genomics Translational Genomics Research Institute  Flagstaff AZ","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Division of Pathogen Genomics, Translational Genomics Research Institute, Flagstaff, AZ","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050041671","display_name":"Andrew P. Lane","orcid":"https://orcid.org/0000-0001-6369-5469","observed_orcids":["https://orcid.org/0000-0001-6369-5469"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew P. Lane","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins School of Medicine  Baltimore MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins School of Medicine  Baltimore MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5050041671"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":4.1654,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.93244564,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"5","issue":"3","first_page":"185","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11812","display_name":"Nasal Surgery and Airway Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-rhinosinusitis-with-nasal-polyps","display_name":"chronic rhinosinusitis with nasal polyps","score":0.8930000066757202},{"id":"https://openalex.org/keywords/sinonasal-microbiota","display_name":"sinonasal microbiota","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nasal-irrigation","display_name":"nasal irrigation","score":0.953000009059906},{"id":"https://openalex.org/keywords/budesonide","display_name":"budesonide","score":0.9929999709129333},{"id":"https://openalex.org/keywords/corynebacterium","display_name":"Corynebacterium","score":0.9739999771118164},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9309999942779541},{"id":"https://openalex.org/keywords/pseudomonas","display_name":"Pseudomonas","score":0.9779999852180481},{"id":"https://openalex.org/keywords/commensal-bacteria","display_name":"commensal bacteria","score":0.9419999718666077},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6230000257492065},{"id":"https://openalex.org/keywords/dolosigranulum","display_name":"Dolosigranulum","score":0.8669999837875366},{"id":"https://openalex.org/keywords/campylobacter","display_name":"Campylobacter","score":0.9789999723434448}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8267180919647217},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.6762443780899048},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5891876220703125},{"id":"https://openalex.org/C125009961","wikidata":"https://www.wikidata.org/wiki/Q2342248","display_name":"Pyrosequencing","level":3,"score":0.5760615468025208},{"id":"https://openalex.org/C2909814679","wikidata":"https://www.wikidata.org/wiki/Q1425813","display_name":"Nasal Lavage","level":3,"score":0.5378078818321228},{"id":"https://openalex.org/C2777911650","wikidata":"https://www.wikidata.org/wiki/Q133976","display_name":"Corynebacterium","level":3,"score":0.5130599737167358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45520690083503723},{"id":"https://openalex.org/C2781390199","wikidata":"https://www.wikidata.org/wiki/Q8055111","display_name":"Nasal polyps","level":2,"score":0.4100356101989746},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3254922926425934},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3207348883152008},{"id":"https://openalex.org/C2778311950","wikidata":"https://www.wikidata.org/wiki/Q7363","display_name":"Nose","level":2,"score":0.2602177858352661},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.23130294680595398},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.20863455533981323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.127476304769516},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003352","descriptor_name":"Corynebacterium","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003352","descriptor_name":"Corynebacterium","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003352","descriptor_name":"Corynebacterium","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010256","descriptor_name":"Paranasal Sinuses","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010256","descriptor_name":"Paranasal Sinuses","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010256","descriptor_name":"Paranasal Sinuses","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011549","descriptor_name":"Pseudomonas","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011549","descriptor_name":"Pseudomonas","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011549","descriptor_name":"Pseudomonas","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055556","descriptor_name":"Nasal Lavage","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055556","descriptor_name":"Nasal Lavage","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055556","descriptor_name":"Nasal Lavage","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059085","descriptor_name":"Nasal Sprays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059085","descriptor_name":"Nasal Sprays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059085","descriptor_name":"Nasal Sprays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/alr.21467","doi":"https://doi.org/10.1002/alr.21467","is_oa":false,"landing_page_url":"https://doi.org/10.1002/alr.21467","pdf_url":null,"source":{"id":"https://openalex.org/S2506670899","display_name":"International Forum of Allergy & Rhinology","issn_l":"2042-6976","issn":["2042-6976","2042-6984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Forum of Allergy & Rhinology","raw_type":"journal-article"},{"id":"pmid:25556553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25556553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International forum of allergy & rhinology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4628778","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4628778","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int Forum Allergy Rhinol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4628778","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4628778","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int Forum Allergy Rhinol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.699999988079071,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G7709624451","display_name":"Microbial ecology in the Chronic Rhinosinusitis Microbiome","funder_award_id":"R15DE021194","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W118892205","https://openalex.org/W1801109321","https://openalex.org/W1916852496","https://openalex.org/W1922221875","https://openalex.org/W1973454736","https://openalex.org/W1975947879","https://openalex.org/W1978079965","https://openalex.org/W1993077698","https://openalex.org/W2003914246","https://openalex.org/W2044104178","https://openalex.org/W2049878378","https://openalex.org/W2081122263","https://openalex.org/W2096256245","https://openalex.org/W2096511107","https://openalex.org/W2101743012","https://openalex.org/W2106773047","https://openalex.org/W2109136013","https://openalex.org/W2113189038","https://openalex.org/W2122157985","https://openalex.org/W2139944208","https://openalex.org/W2140843031","https://openalex.org/W2152885278","https://openalex.org/W2163910698","https://openalex.org/W2316442308","https://openalex.org/W2582743722","https://openalex.org/W3174993126"],"related_works":["https://openalex.org/W6990638613","https://openalex.org/W4384922644","https://openalex.org/W3122428387","https://openalex.org/W2581878525","https://openalex.org/W2886939874","https://openalex.org/W6987753189","https://openalex.org/W1708208039","https://openalex.org/W1916852496","https://openalex.org/W3044411599","https://openalex.org/W4388452927"],"abstract_inverted_index":{"BACKGROUND:":[0],"Topical":[1],"treatments":[2],"with":[3,35,61,109,146,154,237,267,296],"nasal":[4,47,62,196],"saline":[5,144,183,197,262],"irrigation,":[6,145],"topical":[7,107,124,232,287],"steroid":[8,233],"sprays,":[9],"or":[10,71,147,160,164,171,278],"corticosteroid":[11,289],"rinses":[12],"can":[13],"improve":[14],"sinonasal":[15,110,121,157,299],"symptoms":[16],"in":[17,73,178,209,241,271,281,291],"chronic":[18],"rhinosinusitis":[19],"(CRS).":[20],"However,":[21,212,284],"the":[22,74,200,272],"impact":[23],"of":[24,94,104,106,120,203,231,249,258,275,286],"these":[25],"therapies":[26,108],"on":[27,31],"commensals":[28],"(Corynebacterium)":[29],"and":[30,39,48,57,85,99,127,138,199,207,251,253],"biofilm":[32],"pathogens":[33,280],"associated":[34,153,236,266,295],"CRS":[36,59],"(Staphylococcus":[37],"aureus":[38,166],"Pseudomonas)":[40],"is":[41,264,294],"not":[42,67,152,265],"well":[43],"characterized.":[44],"METHODS:":[45],"Paired":[46],"sinus":[49],"swabs":[50],"were":[51,83,97,129,216],"collected":[52],"endoscopically":[53],"from":[54,80],"28":[55],"controls":[56,137,170,179],"14":[58],"patients":[60,215],"polyposis":[63],"(CRSwNP)":[64],"who":[65,187],"had":[66],"received":[68],"systemic":[69],"antibiotics":[70],"corticosteroids":[72],"previous":[75],"8":[76],"weeks.":[77],"Total":[78],"DNA":[79],"swab":[81],"eluents":[82],"extracted":[84],"analyzed":[86],"by":[87,115,132,245],"16S":[88],"rRNA":[89],"gene-based":[90],"pyrosequencing.":[91],"A":[92],"total":[93],"359,077":[95],"reads":[96],"obtained":[98],"classified":[100],"taxonomically.":[101],"The":[102,117,229],"association":[103,192],"use":[105,230,285],"microbiota":[111,158,240],"composition":[112,159],"was":[113,151,175,193,235],"assessed":[114],"factor/vector-fitting.":[116],"proportional":[118,201,223,247,256,273],"abundances":[119,167,202,224,248],"bacteria":[122,277],"between":[123,195],"therapy":[125],"users":[126],"nonusers":[128],"further":[130],"compared":[131],"2-tailed":[133],"Kolmogorov-Smirnov":[134],"test":[135],"among":[136,139,168],"CRSwNP":[140,172,210,214,282],"participants.":[141,173,211],"RESULTS:":[142],"Nasal":[143,261],"without":[148],"added":[149],"budesonide,":[150],"significantly":[155,161,220],"distinct":[156,239,269,298],"decreased":[162],"Pseudomonas":[163],"S.":[165,205],"either":[169],"Corynebacterium":[174,208,222],"slightly":[176],"lower":[177,255],"that":[180],"reported":[181],"using":[182],"irrigation":[184,198,263],"than":[185,225],"those":[186],"did":[188],"not.":[189],"No":[190],"significant":[191],"found":[194],"Pseudomonas,":[204],"aureus,":[206],"male":[213],"noted":[217],"to":[218],"have":[219],"higher":[221,246],"their":[226],"female":[227],"counterparts.":[228],"sprays":[234,290],"a":[238,254,268,297],"control":[242,292],"subjects,":[243],"characterized":[244],"Dolosigranulum":[250],"Simonsiella":[252],"abundance":[257,274],"Campylobacter.":[259],"CONCLUSION:":[260],"alteration":[270],"commensal":[276],"biofilm-forming":[279],"patients.":[283],"intranasal":[288],"subjects":[293],"microbiota.":[300]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}