{"id":"https://openalex.org/W1908352451","doi":"https://doi.org/10.1002/jez.b.22516","title":"Macroevolutionary diversity of amniote limb proportions predicted by developmental interactions","display_name":"Macroevolutionary diversity of amniote limb proportions predicted by developmental interactions","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W1908352451","doi":"https://doi.org/10.1002/jez.b.22516","mag":"1908352451","pmid":"https://pubmed.ncbi.nlm.nih.gov/23913472"},"language":"en","primary_location":{"id":"doi:10.1002/jez.b.22516","doi":"https://doi.org/10.1002/jez.b.22516","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jez.b.22516","pdf_url":null,"source":{"id":"https://openalex.org/S4210222104","display_name":"Journal of Experimental Zoology Part B Molecular and Developmental Evolution","issn_l":"1552-5007","issn":["1552-5007","1552-5015"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Zoology Part B: Molecular and Developmental Evolution","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009438585","display_name":"Nathan M. Young","orcid":"https://orcid.org/0000-0002-3437-7493","observed_orcids":["https://orcid.org/0000-0002-3437-7493"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nathan M. Young","raw_affiliation_strings":["Department of Orthopaedic Surgery; University of California; San Francisco; California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery; University of California; San Francisco; California","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009438585"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":3460,"currency":"USD","value_usd":3460},"apc_paid":null,"fwci":0.895,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.72038725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"320","issue":"7","first_page":"n/a","last_page":"n/a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.7896000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.7896000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12417","display_name":"Morphological variations and asymmetry","score":0.1793999969959259,"subfield":{"id":"https://openalex.org/subfields/2608","display_name":"Geometry and Topology"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/developmental-interactions","display_name":"developmental interactions","score":0.4580000042915344},{"id":"https://openalex.org/keywords/evolvability","display_name":"evolvability","score":0.9150000214576721},{"id":"https://openalex.org/keywords/autopod","display_name":"autopod","score":0.9900000095367432},{"id":"https://openalex.org/keywords/zeugopod","display_name":"zeugopod","score":0.9929999709129333},{"id":"https://openalex.org/keywords/limb-development","display_name":"limb development","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C2781011139","wikidata":"https://www.wikidata.org/wiki/Q181537","display_name":"Amniote","level":4,"score":0.9582642912864685},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.6518238186836243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6070747971534729},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5361686944961548},{"id":"https://openalex.org/C2778961482","wikidata":"https://www.wikidata.org/wiki/Q25241","display_name":"Vertebrate","level":3,"score":0.13706186413764954},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.09377038478851318},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0919756293296814},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001717","descriptor_name":"Birds","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D001717","descriptor_name":"Birds","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D001717","descriptor_name":"Birds","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005121","descriptor_name":"Extremities","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D005121","descriptor_name":"Extremities","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D005121","descriptor_name":"Extremities","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D005121","descriptor_name":"Extremities","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D005121","descriptor_name":"Extremities","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D005121","descriptor_name":"Extremities","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012104","descriptor_name":"Reptiles","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D012104","descriptor_name":"Reptiles","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D012104","descriptor_name":"Reptiles","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jez.b.22516","doi":"https://doi.org/10.1002/jez.b.22516","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jez.b.22516","pdf_url":null,"source":{"id":"https://openalex.org/S4210222104","display_name":"Journal of Experimental Zoology Part B Molecular and Developmental Evolution","issn_l":"1552-5007","issn":["1552-5007","1552-5015"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Zoology Part B: Molecular and Developmental Evolution","raw_type":"journal-article"},{"id":"pmid:23913472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23913472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental zoology. Part B, Molecular and developmental evolution","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life on land","score":0.41999998688697815,"id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1484229145","https://openalex.org/W1517473420","https://openalex.org/W1939881246","https://openalex.org/W1969365435","https://openalex.org/W1972737244","https://openalex.org/W1995427440","https://openalex.org/W2004342256","https://openalex.org/W2010025771","https://openalex.org/W2010655791","https://openalex.org/W2015634447","https://openalex.org/W2016350172","https://openalex.org/W2019963258","https://openalex.org/W2027064033","https://openalex.org/W2027527429","https://openalex.org/W2030789263","https://openalex.org/W2036528696","https://openalex.org/W2037486322","https://openalex.org/W2049129959","https://openalex.org/W2052535884","https://openalex.org/W2061116363","https://openalex.org/W2069812994","https://openalex.org/W2072284669","https://openalex.org/W2081123716","https://openalex.org/W2088262090","https://openalex.org/W2098062068","https://openalex.org/W2103558364","https://openalex.org/W2125266519","https://openalex.org/W2143600444","https://openalex.org/W2153452535","https://openalex.org/W2154367724","https://openalex.org/W2157137464","https://openalex.org/W2158859599","https://openalex.org/W2159299974","https://openalex.org/W2178951958","https://openalex.org/W2188730133","https://openalex.org/W2332826352","https://openalex.org/W2582743722","https://openalex.org/W4234277332","https://openalex.org/W4243773319","https://openalex.org/W4296224447","https://openalex.org/W4299542564"],"related_works":["https://openalex.org/W4318067784","https://openalex.org/W2591021847","https://openalex.org/W2751464800","https://openalex.org/W1968056527","https://openalex.org/W3129162765","https://openalex.org/W2137608147","https://openalex.org/W595627435","https://openalex.org/W2112502653","https://openalex.org/W2075819956","https://openalex.org/W2160386376"],"abstract_inverted_index":{"Mammals,":[0],"birds,":[1],"and":[2,22,33,83,85,141],"reptiles":[3],"exhibit":[4,78],"a":[5,86,133,147,158],"remarkable":[6],"diversity":[7,107],"of":[8,50,64,75,91,105,111,132,154,161],"limb":[9,51,67,139,155],"proportions.":[10],"These":[11,126],"evolved":[12],"differences":[13,119],"are":[14],"thought":[15],"to":[16,46],"reflect":[17],"selection":[18],"for":[19],"biomechanical,":[20],"postural,":[21],"locomotor":[23],"requirements":[24],"primarily":[25],"acting":[26],"on":[27],"independent":[28],"variation":[29,58,112],"in":[30,89,113,120,137,151,157],"later":[31],"fetal":[32],"postnatal":[34],"segmental":[35,114],"growth.":[36],"However,":[37],"earlier":[38],"conserved":[39,134],"developmental":[40,100],"events":[41],"also":[42],"have":[43],"the":[44,48,65,92,109,152],"potential":[45],"impact":[47],"evolvability":[49,153],"proportions":[52,74,156],"by":[53],"limiting":[54],"or":[55,123],"biasing":[56],"initial":[57,73],"among":[59],"segments.":[60],"Notably,":[61],"proximo-distal":[62,138],"patterning":[63],"amniote":[66,162],"through":[68],"activation-inhibition":[69],"dynamics":[70],"predicts":[71,103],"that":[72,98,143],"segments":[76],"should":[77],"both":[79],"tradeoffs":[80],"between":[81],"stylopod":[82],"autopod":[84],"diagnostic":[87],"reduction":[88],"variance":[90],"zeugopod.":[93],"Here":[94],"it":[95],"is":[96],"demonstrated":[97],"this":[99],"\"design":[101],"rule\"":[102],"patterns":[104],"macroevolutionary":[106],"despite":[108],"effects":[110],"growth":[115],"over":[116],"ontogeny,":[117],"lineage-specific":[118],"phylogenetic":[121],"history,":[122],"functional":[124],"adaptation.":[125],"results":[127],"provide":[128],"critical":[129],"comparative":[130],"evidence":[131],"Turing-like":[135],"mechanism":[136],"segmentation,":[140],"suggest":[142],"development":[144],"has":[145],"played":[146],"previously":[148],"unrecognized":[149],"role":[150],"wide":[159],"range":[160],"taxa.":[163]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
