{"id":"https://openalex.org/W1908343053","doi":"https://doi.org/10.1111/1440-1681.12492","title":"Oxygen\u2010glucose deprivation preconditioning protects neurons against oxygen\u2010glucose deprivation/reperfusion induced injury via bone morphogenetic protein\u20107 mediated ERK , p38 and Smad signalling pathways","display_name":"Oxygen\u2010glucose deprivation preconditioning protects neurons against oxygen\u2010glucose deprivation/reperfusion induced injury via bone morphogenetic protein\u20107 mediated ERK , p38 and Smad signalling pathways","publication_year":2015,"publication_date":"2015-09-19","ids":{"openalex":"https://openalex.org/W1908343053","doi":"https://doi.org/10.1111/1440-1681.12492","mag":"1908343053","pmid":"https://pubmed.ncbi.nlm.nih.gov/26385023"},"language":"en","primary_location":{"id":"doi:10.1111/1440-1681.12492","doi":"https://doi.org/10.1111/1440-1681.12492","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1440-1681.12492","pdf_url":null,"source":{"id":"https://openalex.org/S168193669","display_name":"Clinical and Experimental Pharmacology and Physiology","issn_l":"0305-1870","issn":["0305-1870","1440-1681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Pharmacology and Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100635939","display_name":"Junhong Guan","orcid":"https://orcid.org/0000-0001-5082-3206","observed_orcids":["https://orcid.org/0000-0001-5082-3206"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Junhong Guan","raw_affiliation_strings":["Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I2800370534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068843559","display_name":"Shaonan Du","orcid":"https://orcid.org/0000-0001-8372-6779","observed_orcids":["https://orcid.org/0000-0001-8372-6779"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaonan Du","raw_affiliation_strings":["Department of Neurosurgery, Shenyang Red Cross Hospital, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Shenyang Red Cross Hospital, Shenyang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100715718","display_name":"Tao\ufffd Lv","orcid":"https://orcid.org/0009-0003-7446-8191","observed_orcids":["https://orcid.org/0009-0003-7446-8191"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Lv","raw_affiliation_strings":["Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I2800370534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101108120","display_name":"Shengtao Qu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengtao Qu","raw_affiliation_strings":["Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I2800370534"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qiang Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Fu","raw_affiliation_strings":["Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I2800370534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101549249","display_name":"Ye Yuan","orcid":"https://orcid.org/0000-0001-9628-6944","observed_orcids":["https://orcid.org/0000-0001-9628-6944"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ye Yuan","raw_affiliation_strings":["Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I2800370534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100635939"],"corresponding_institution_ids":["https://openalex.org/I2800370534"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.4182,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.64793748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"43","issue":"1","first_page":"125","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.3921000063419342,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.3921000063419342,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.31709998846054077,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.03790000081062317,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-ischemic-preconditioning","display_name":"cerebral ischemic preconditioning","score":0.8019999861717224},{"id":"https://openalex.org/keywords/bone-morphogenetic-protein-7","display_name":"bone morphogenetic protein-7","score":0.9570000171661377},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9670000076293945},{"id":"https://openalex.org/keywords/neuronal-damage","display_name":"neuronal injury","score":0.4189999997615814},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.7450000047683716},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8190000057220459},{"id":"https://openalex.org/keywords/smad1","display_name":"Smad1","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.9409999847412109},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/neurofilaments","display_name":"neurofilaments","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.8121526837348938},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.6471297144889832},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6445491909980774},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5959794521331787},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.5572527050971985},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5242241621017456},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.5021531581878662},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4642769694328308},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.46039313077926636},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4120929539203644},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2847754657268524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22883638739585876},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000066829","descriptor_name":"Neuroprotection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019194","descriptor_name":"Ischemic Preconditioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055419","descriptor_name":"Bone Morphogenetic Protein 7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055419","descriptor_name":"Bone Morphogenetic Protein 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055419","descriptor_name":"Bone Morphogenetic Protein 7","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/1440-1681.12492","doi":"https://doi.org/10.1111/1440-1681.12492","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1440-1681.12492","pdf_url":null,"source":{"id":"https://openalex.org/S168193669","display_name":"Clinical and Experimental Pharmacology and Physiology","issn_l":"0305-1870","issn":["0305-1870","1440-1681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Pharmacology and Physiology","raw_type":"journal-article"},{"id":"pmid:26385023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26385023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental pharmacology & physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1600770312","https://openalex.org/W1965987404","https://openalex.org/W1969032814","https://openalex.org/W1972548606","https://openalex.org/W1976385326","https://openalex.org/W1980658087","https://openalex.org/W1980930604","https://openalex.org/W1983959609","https://openalex.org/W1984086000","https://openalex.org/W1995024997","https://openalex.org/W2002933697","https://openalex.org/W2010047045","https://openalex.org/W2014441885","https://openalex.org/W2014850988","https://openalex.org/W2016392725","https://openalex.org/W2018597616","https://openalex.org/W2040027102","https://openalex.org/W2040125444","https://openalex.org/W2041147135","https://openalex.org/W2041380761","https://openalex.org/W2048130120","https://openalex.org/W2048584018","https://openalex.org/W2051728071","https://openalex.org/W2053658244","https://openalex.org/W2055210216","https://openalex.org/W2060022091","https://openalex.org/W2060763531","https://openalex.org/W2063175209","https://openalex.org/W2068770406","https://openalex.org/W2081003067","https://openalex.org/W2082876877","https://openalex.org/W2091746084","https://openalex.org/W2093271566","https://openalex.org/W2096048016","https://openalex.org/W2146217294","https://openalex.org/W2155277431","https://openalex.org/W2156167849","https://openalex.org/W2156789300","https://openalex.org/W2166660871","https://openalex.org/W2170084205","https://openalex.org/W2792583460"],"related_works":["https://openalex.org/W2068770406","https://openalex.org/W2018597616","https://openalex.org/W2315512256","https://openalex.org/W2032481539","https://openalex.org/W2047848331","https://openalex.org/W2161363180","https://openalex.org/W3117240914","https://openalex.org/W2091770093","https://openalex.org/W2014441885","https://openalex.org/W2100797291"],"abstract_inverted_index":{"Bone":[0],"morphogenetic":[1],"protein":[2,92,102,158],"(BMP)-7":[3],"mediated":[4,174,189],"neuroprotective":[5,55,148,172],"effect":[6],"of":[7,47,57,69,94,109,118,130,140,186,198],"cerebral":[8],"ischemic":[9,17],"preconditioning":[10,60],"(IPC)":[11],"has":[12],"been":[13,27],"studied":[14],"in":[15,53,71,122,132,151,170],"an":[16],"animal":[18],"model,":[19],"but":[20],"the":[21,37,45,54,67,83,91,116,123,147,171,183,187],"underlying":[22],"cellular":[23,184],"mechanisms":[24,185],"have":[25],"not":[26],"clearly":[28],"clarified.":[29],"In":[30,154],"this":[31,199],"study,":[32],"primary":[33,133],"cortical":[34,134],"neurons":[35,135],"and":[36,49,74,96,107,136,142,161,192],"SH-SY5Y":[38,137],"cell":[39],"line":[40],"were":[41,79,112,165],"used":[42,64,80,88,113],"to":[43,65,81,89,114,167],"investigate":[44,115],"role":[46,117],"BMP-7":[48,95,131,144],"its":[50],"downstream":[51,97],"signals":[52],"effects":[56,149,173],"oxygen-glucose":[58],"deprivation":[59],"(OGDPC).":[61],"Immunocytochemistry":[62],"was":[63,87],"detect":[66,90],"expression":[68,93],"neurofilament":[70],"neurons.":[72],"MTT":[73],"lactate":[75],"dehydrogenase":[76],"activity":[77],"assays":[78],"measure":[82],"cytotoxicity.":[84],"Western":[85],"blot":[86],"signals.":[98],"BMP":[99],"inhibitor,":[100],"mitogen-activated":[101],"kinase":[103],"inhibitors,":[104],"Smad":[105,110,162],"inhibitor":[106],"siRNA":[108],"1":[111],"corresponding":[119],"signalling":[120,163],"pathways":[121],"OGDPC.":[124],"Results":[125],"showed":[126],"that":[127],"OGDPC-induced":[128],"overexpression":[129],"cells.":[138],"Both":[139],"endogenous":[141],"exogenous":[143],"could":[145],"replicate":[146],"seen":[150],"OGDPC":[152,176],"pretreatment.":[153],"addition,":[155],"extracellular":[156],"regulated":[157],"kinases,":[159],"p38":[160],"pathway":[164],"found":[166],"be":[168],"involved":[169],"by":[175,190],"via":[177],"BMP-7.":[178],"This":[179],"study":[180],"primarily":[181],"reveals":[182],"neuroprotection":[188],"OGDPC,":[191],"provides":[193],"evidence":[194],"for":[195],"better":[196],"understanding":[197],"intrinsic":[200],"factor":[201],"against":[202],"ischemia.":[203]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
