{"id":"https://openalex.org/W1908268992","doi":"https://doi.org/10.1046/j.1365-2125.1998.00772.x","title":"Terfenadine and risk of acute liver disease","display_name":"Terfenadine and risk of acute liver disease","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W1908268992","doi":"https://doi.org/10.1046/j.1365-2125.1998.00772.x","mag":"1908268992","pmid":"https://pubmed.ncbi.nlm.nih.gov/9764966","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1873681"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2125.1998.00772.x","doi":"https://doi.org/10.1046/j.1365-2125.1998.00772.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2125.1998.00772.x","pdf_url":null,"source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1873681/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086707051","display_name":"Marian Wald Myers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210115736","display_name":"Boston Collaborative Drug Surveillance Program","ror":"https://ror.org/0228drn10","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210115736"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marian Wald Myers","raw_affiliation_strings":["The Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Lexington, MA 02173, USA","The Boston Collaborative Drug Surveillance Program, Boston University Medical Center, 11 Muzzey Street, Lexington, MA 02173 USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Lexington, MA 02173, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210115736"]},{"raw_affiliation_string":"The Boston Collaborative Drug Surveillance Program, Boston University Medical Center, 11 Muzzey Street, Lexington, MA 02173 USA,","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210115736"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065681509","display_name":"Hershel Jick","orcid":"https://orcid.org/0000-0003-4270-5992","observed_orcids":["https://orcid.org/0000-0003-4270-5992"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210115736","display_name":"Boston Collaborative Drug Surveillance Program","ror":"https://ror.org/0228drn10","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210115736"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hershel Jick","raw_affiliation_strings":["The Boston Collaborative Drug Surveillance Program, Boston University Medical Center, 11 Muzzey Street, Lexington, MA 02173, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Boston Collaborative Drug Surveillance Program, Boston University Medical Center, 11 Muzzey Street, Lexington, MA 02173, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210115736"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065681509"],"corresponding_institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210115736"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.6918,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.63160482,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"46","issue":"3","first_page":"251","last_page":"253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/terfenadine","display_name":"terfenadine","score":1.0},{"id":"https://openalex.org/keywords/acute-liver-disease","display_name":"acute liver disease","score":0.8479999899864197},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8899999856948853},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6259999871253967},{"id":"https://openalex.org/keywords/antihistamines","display_name":"antihistamines","score":0.7440000176429749},{"id":"https://openalex.org/keywords/risk-estimation","display_name":"risk estimation","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2779303165","wikidata":"https://www.wikidata.org/wiki/Q417909","display_name":"Terfenadine","level":2,"score":0.9034478664398193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8597587943077087},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.6582776308059692},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5694259405136108},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5372865200042725},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4951418936252594},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48987525701522827},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44700998067855835},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.43603190779685974},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4317496120929718},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13858351111412048},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016593","descriptor_name":"Terfenadine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1365-2125.1998.00772.x","doi":"https://doi.org/10.1046/j.1365-2125.1998.00772.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2125.1998.00772.x","pdf_url":null,"source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:9764966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9764966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1873681","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1873681/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1873681","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1873681/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W38847137","https://openalex.org/W39427089","https://openalex.org/W207624539","https://openalex.org/W1581232918","https://openalex.org/W1996239854","https://openalex.org/W2009675245","https://openalex.org/W2045907267","https://openalex.org/W2053504762","https://openalex.org/W2093519496","https://openalex.org/W2157604999"],"related_works":["https://openalex.org/W2045907267","https://openalex.org/W2009675245","https://openalex.org/W173151610","https://openalex.org/W1585256489","https://openalex.org/W1982116453","https://openalex.org/W2979187291","https://openalex.org/W2403931220","https://openalex.org/W1998416434","https://openalex.org/W2054220490","https://openalex.org/W2143793372"],"abstract_inverted_index":{"AIMS:":[0],"To":[1],"estimate":[2,138],"the":[3,23,30,43,51],"risk":[4,137],"of":[5,12,63,77,110,113,120,139,170],"idiopathic":[6,176],"acute":[7,121,177],"liver":[8,65,104,122,178],"disease":[9,123],"among":[10],"users":[11,141],"terfenadine.":[13,82],"METHODS:":[14],"We":[15,83],"conducted":[16],"a":[17,61,64,72,78,101,108,125,136,157,164],"population-based":[18],"cohort":[19,109],"study":[20],"based":[21],"on":[22],"General":[24],"Practice":[25],"Research":[26],"Database":[27],"(GPRD)":[28],"in":[29,97],"U.K.":[31],"All":[32,153],"persons":[33],"who":[34],"received":[35],"at":[36],"least":[37],"one":[38],"prescription":[39,80],"for":[40,50,81],"terfenadine":[41,129,171],"during":[42],"period":[44],"1991":[45],"through":[46],"1995":[47],"were":[48,155],"eligible":[49],"study.":[52],"Among":[53],"these":[54],"patients":[55],"we":[56,115],"identified":[57],"all":[58,162],"those":[59],"with":[60,175],"diagnosis":[62],"disorder":[66],"requiring":[67],"hospitalization":[68],"or":[69],"referral":[70],"to":[71,99,128],"consultant":[73,91],"within":[74],"60":[75],"days":[76],"prior":[79],"obtained":[84],"clinical":[85],"records,":[86],"including":[87],"hospital":[88],"discharge":[89],"summaries,":[90],"reports":[92],"and":[93,146,161],"relevant":[94],"laboratory":[95],"results":[96],"order":[98],"identify":[100],"potentially":[102],"drug-inducible":[103],"illness.":[105],"RESULTS:":[106],"From":[107],"210683":[111],"recipients":[112],"terfenadine,":[114],"found":[116],"only":[117],"three":[118],"cases":[119,154],"where":[124],"causal":[126],"connection":[127],"could":[130],"not":[131],"be":[132],"ruled":[133],"out,":[134],"yielding":[135],"1.4/100000":[140],"(95%":[142,149],"CI":[143,150],"0.5,":[144],"4.2)":[145],"0.5/100000":[147],"prescriptions":[148],"0.2,":[151],"1.4).":[152],"receiving":[156],"concomitant":[158],"hepatotoxic":[159],"drug":[160],"had":[163],"full":[165],"recovery.":[166],"CONCLUSION:":[167],"The":[168],"use":[169],"is":[172],"rarely":[173],"associated":[174],"disease.":[179]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}