{"id":"https://openalex.org/W1908200366","doi":"https://doi.org/10.1016/s0022-2275(20)31647-3","title":"Two novel quantitative trait loci on mouse chromosomes 6 and 4 independently and synergistically regulate plasma apoB levels","display_name":"Two novel quantitative trait loci on mouse chromosomes 6 and 4 independently and synergistically regulate plasma apoB levels","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W1908200366","doi":"https://doi.org/10.1016/s0022-2275(20)31647-3","mag":"1908200366","pmid":"https://pubmed.ncbi.nlm.nih.gov/11352992"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-2275(20)31647-3","doi":"https://doi.org/10.1016/s0022-2275(20)31647-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)31647-3","pdf_url":"http://www.jlr.org/article/S0022227520316473/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jlr.org/article/S0022227520316473/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089649832","display_name":"Carol Ko","orcid":"https://orcid.org/0000-0002-3273-4514","observed_orcids":["https://orcid.org/0000-0002-3273-4514"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Ko","raw_affiliation_strings":["Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032","Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055030338","display_name":"Tsai-Ling Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tsai-Ling Lee","raw_affiliation_strings":["Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012673555","display_name":"Philip W. Lau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip W. Lau","raw_affiliation_strings":["Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336943","display_name":"Jing Li","orcid":"https://orcid.org/0000-0002-5102-4315","observed_orcids":["https://orcid.org/0000-0002-5102-4315","https://orcid.org/0000-0002-8107-8613"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063971820","display_name":"Brandi Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandi T. Davis","raw_affiliation_strings":["Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026821742","display_name":"Emanuel Voyiaziakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emanuel Voyiaziakis","raw_affiliation_strings":["Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062622249","display_name":"David B. Allison","orcid":"https://orcid.org/0000-0003-3566-9399","observed_orcids":["https://orcid.org/0000-0003-3566-9399","https://orcid.org/0000-0002-6047-2603","https://orcid.org/0000-0002-8101-4265"]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B. Allison","raw_affiliation_strings":["Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032","Obesity Research Center, St. Luke's Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York, NY 10025"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Obesity Research Center, St. Luke's Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York, NY 10025","institution_ids":["https://openalex.org/I1321572752","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066893639","display_name":"Streamson C. Chua","orcid":"https://orcid.org/0000-0002-9437-9925","observed_orcids":["https://orcid.org/0000-0002-9437-9925"]},"institutions":[{"id":"https://openalex.org/I1321572752","display_name":"St. Luke's-Roosevelt Hospital Center","ror":"https://ror.org/011t2cn48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321572752"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Streamson C. Chua","raw_affiliation_strings":["Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032","Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032","Obesity Research Center, St. Luke's Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York, NY 10025"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Obesity Research Center, St. Luke's Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York, NY 10025","institution_ids":["https://openalex.org/I1321572752","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113660793","display_name":"Li-Shin Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Li-Shin Huang","raw_affiliation_strings":["Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032","Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113660793"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.3752,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79068826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"42","issue":"5","first_page":"844","last_page":"855"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.2930000126361847,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.2930000126361847,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.24560000002384186,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.2069000005722046,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.9629999995231628},{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.9959999918937683},{"id":"https://openalex.org/keywords/epistasis","display_name":"epistasis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/mouse-chromosome-6","display_name":"mouse chromosome 6","score":0.6919999718666077},{"id":"https://openalex.org/keywords/mouse-chromosome-4","display_name":"mouse chromosome 4","score":1.0},{"id":"https://openalex.org/keywords/genetic-variance","display_name":"genetic variance","score":0.5569999814033508},{"id":"https://openalex.org/keywords/familial-hypobetalipoproteinemia","display_name":"familial hypobetalipoproteinemia","score":0.9470000267028809},{"id":"https://openalex.org/keywords/atherosclerosis-risk","display_name":"atherosclerosis risk","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.7975101470947266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7424893379211426},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.7205910682678223},{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.6427360773086548},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6211320757865906},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5594651699066162},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.4746169149875641},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46942976117134094},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.45575255155563354},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.44784820079803467},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44110891222953796},{"id":"https://openalex.org/C190789776","wikidata":"https://www.wikidata.org/wiki/Q767511","display_name":"Genetic marker","level":3,"score":0.4371117055416107},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31799954175949097},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.27448922395706177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07969436049461365},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008126","descriptor_name":"Lod Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-2275(20)31647-3","doi":"https://doi.org/10.1016/s0022-2275(20)31647-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)31647-3","pdf_url":"http://www.jlr.org/article/S0022227520316473/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmid:11352992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11352992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:73fb8eeffd30418ea7a61631ee75701c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/73fb8eeffd30418ea7a61631ee75701c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 42, Iss 5, Pp 844-855 (2001)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/s0022-2275(20)31647-3","doi":"https://doi.org/10.1016/s0022-2275(20)31647-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-2275(20)31647-3","pdf_url":"http://www.jlr.org/article/S0022227520316473/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G11972507","display_name":"QUANTITATIVE SYNTHESIS OF CLINICAL OBESITY RESEARCH","funder_award_id":"R01DK051716","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1842753135","display_name":"Regulation of ApoB Secretion in Inbred Mouse Strains","funder_award_id":"R01HL062583","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3300085187","display_name":null,"funder_award_id":"DK-51716","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3308111012","display_name":null,"funder_award_id":"HL-62583","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4414776803","display_name":null,"funder_award_id":"ES-09912","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G692308744","display_name":null,"funder_award_id":"DK 26687","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8288538074","display_name":"Positional Gene Identification of Complex Traits","funder_award_id":"R01ES009912","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000867824","display_name":"New York Obesity Research Center","funder_award_id":"P30DK026687","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1908200366.pdf","grobid_xml":"https://content.openalex.org/works/W1908200366.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W193344081","https://openalex.org/W193617093","https://openalex.org/W1486776518","https://openalex.org/W1488559297","https://openalex.org/W1527649416","https://openalex.org/W1537961425","https://openalex.org/W1607521051","https://openalex.org/W1820484722","https://openalex.org/W1887362885","https://openalex.org/W1898264975","https://openalex.org/W1921948331","https://openalex.org/W1926822606","https://openalex.org/W1971458029","https://openalex.org/W1976064433","https://openalex.org/W1980786839","https://openalex.org/W1994273046","https://openalex.org/W1997498129","https://openalex.org/W2000072871","https://openalex.org/W2002345850","https://openalex.org/W2002737871","https://openalex.org/W2012305341","https://openalex.org/W2012555257","https://openalex.org/W2015843973","https://openalex.org/W2017825539","https://openalex.org/W2029152767","https://openalex.org/W2040171866","https://openalex.org/W2040377539","https://openalex.org/W2045649324","https://openalex.org/W2061200469","https://openalex.org/W2064085930","https://openalex.org/W2075390416","https://openalex.org/W2082014162","https://openalex.org/W2095272104","https://openalex.org/W2102041351","https://openalex.org/W2103658595","https://openalex.org/W2105732728","https://openalex.org/W2123717499","https://openalex.org/W2134812217","https://openalex.org/W2143745368","https://openalex.org/W2145513372","https://openalex.org/W2147487368","https://openalex.org/W2161174158","https://openalex.org/W2164409290","https://openalex.org/W2288462365","https://openalex.org/W2333284976","https://openalex.org/W2397017265"],"related_works":["https://openalex.org/W1887362885","https://openalex.org/W2104319042","https://openalex.org/W7095663347","https://openalex.org/W1537961425","https://openalex.org/W2137618921","https://openalex.org/W1981135463","https://openalex.org/W1965937924","https://openalex.org/W1964953478","https://openalex.org/W2134830120","https://openalex.org/W2152563384"],"abstract_inverted_index":{"An":[0],"elevated":[1],"plasma":[2,32,64,99,144,271,296,325],"apolipoprotein":[3],"B":[4],"(apoB)":[5],"level":[6],"is":[7,55],"a":[8,24,40,56,168,289],"strong":[9,317],"predictor":[10],"of":[11,31,59,71,88,98,143,171,176,190,208,218,237,253,259,270,295,307],"atherosclerosis":[12],"and":[13,18,62,75,106,119,164,244,248,299,331],"coronary":[14],"heart":[15],"disease.":[16],"Epidemiologic":[17],"family":[19],"linkage":[20],"studies":[21],"have":[22,48,282,288],"suggested":[23],"genetic":[25,192,239,255],"basis":[26],"for":[27,250,312,319],"the":[28,36,60,72,81,86,104,117,132,141,179,191,226,238,254,268,276,293,304,313],"wide":[29],"variations":[30],"apoB":[33,42,66,101,145,273,297,326],"levels":[34,67,102,146,274,298],"in":[35,68,103,140,161,210,221,275,292],"general":[37],"population.":[38,278],"Using":[39],"human":[41,65,100,272,310,320],"transgenic":[43],"(HuBTg)":[44],"mouse":[45,121],"model,":[46],"we":[47,84,281],"previously":[49],"shown":[50],"that":[51,287],"hepatic":[52],"apoB-100":[53],"secretion":[54],"major":[57,96,264,290],"determinant":[58],"high":[61],"low":[63],"HuBTg":[69],"mice":[70,166,213,224],"C57BL/6":[73],"(B6)":[74],"129/Sv":[76],"(129)":[77],"strains,":[78],"respectively.":[79],"In":[80,279],"present":[82,85],"article,":[83],"identification":[87],"two":[89,261,284],"novel":[90,285],"quantitative":[91],"trait":[92],"loci":[93,124,286,315],"(QTL)":[94],"as":[95,329],"regulators":[97],"F(2)":[105],"N(2)":[107],"(backcrossed)":[108],"offspring":[109],"(n":[110],"=":[111],"572)":[112],"derived":[113],"from":[114],"crosses":[115],"between":[116,242],"B6":[118],"129":[120],"strains.":[122],"These":[123],"were":[125],"designated":[126,154,197],"ApoB":[127],"regulator":[128],"genes":[129],"(Abrg),":[130],"because":[131],"gene":[133],"products":[134],"are":[135,300,316],"likely":[136,301],"to":[137,158,201,302],"be":[138],"involved":[139],"regulation":[142,269,294],"either":[147],"directly":[148],"or":[149],"indirectly.":[150],"The":[151,194,257,309],"first":[152],"locus,":[153,196],"Abrg1,":[155],"was":[156,199,246],"mapped":[157,200],"chromosome":[159,202],"6":[160],"8-week-old":[162,211,222],"male":[163,212],"female":[165,223],"with":[167,204],"combined":[169],"logarithm":[170],"odds":[172],"ratio":[173],"(LOD)":[174],"score":[175,207,217],"14":[177],"at":[178,225],"D6Mit55":[180],"marker":[181,228],"(":[182,229],"approximately":[183,188,230,235,251],"45.9":[184],"cM).":[185,232],"Abrg1":[186,243],"contributed":[187,234],"35%":[189],"variance.":[193,240,256],"second":[195],"Abrg2,":[198],"4":[203],"an":[205,215],"LOD":[206,216],"8.6":[209],"but":[214],"only":[219],"2.0":[220],"D4Mit27":[227],"35":[231],"Abrg2":[233,245],"26%":[236],"Epistasis":[241],"detected":[247],"accounted":[249],"12%":[252],"combination":[258],"these":[260],"QTL":[262],"has":[263],"effects":[265],"(>70%)":[266],"on":[267],"tested":[277],"summary,":[280],"identified":[283],"role":[291],"regulate":[303],"secretory":[305],"pathway":[306],"apoB.":[308],"orthologs":[311],"Abrg":[314],"candidates":[318],"disorders":[321],"characterized":[322],"by":[323],"altered":[324],"levels,":[327],"such":[328],"FCHL":[330],"familial":[332],"hypobetalipoproteinemia.":[333]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}