{"id":"https://openalex.org/W1908167292","doi":"https://doi.org/10.1111/j.1526-4610.2010.01842.x","title":"Zonisamide for Migraine Prophylaxis in Topiramate\u2010Intolerant Patients: An Observational Study","display_name":"Zonisamide for Migraine Prophylaxis in Topiramate\u2010Intolerant Patients: An Observational Study","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W1908167292","doi":"https://doi.org/10.1111/j.1526-4610.2010.01842.x","mag":"1908167292","pmid":"https://pubmed.ncbi.nlm.nih.gov/21284610"},"language":"en","primary_location":{"id":"doi:10.1111/j.1526-4610.2010.01842.x","doi":"https://doi.org/10.1111/j.1526-4610.2010.01842.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1526-4610.2010.01842.x","pdf_url":null,"source":{"id":"https://openalex.org/S96331937","display_name":"Headache The Journal of Head and Face Pain","issn_l":"0017-8748","issn":["0017-8748","1526-4610"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Headache: The Journal of Head and Face Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025399863","display_name":"Veronica Villani","orcid":"https://orcid.org/0000-0001-8769-9966","observed_orcids":["https://orcid.org/0000-0001-8769-9966"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Veronica Villani","raw_affiliation_strings":["Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy","Department of Neurology and Psichiatry, Sapienza University, Department of Neurology and Psichiatry Rome, Italy (L. Prosperini)","From the Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy (V. Villani, A. Ciuffoli, and G. Sette)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Department of Neurology and Psichiatry, Sapienza University, Department of Neurology and Psichiatry Rome, Italy (L. Prosperini)","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"From the Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy (V. Villani, A. Ciuffoli, and G. Sette)","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034357367","display_name":"Alessandro Ciuffoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Ciuffoli","raw_affiliation_strings":["From the Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy (V. Villani, A. Ciuffoli, and G. Sette); Department of Neurology and Psichiatry, Sapienza University, Department of Neurology and Psichiatry Rome, Italy (L. Prosperini)","Department of Neurology and Psichiatry, Sapienza University, Department of Neurology and Psichiatry Rome, Italy (L. Prosperini)","From the Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy (V. Villani, A. Ciuffoli, and G. Sette)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy (V. Villani, A. Ciuffoli, and G. Sette); Department of Neurology and Psichiatry, Sapienza University, Department of Neurology and Psichiatry Rome, Italy (L. Prosperini)","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Department of Neurology and Psichiatry, Sapienza University, Department of Neurology and Psichiatry Rome, Italy (L. Prosperini)","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"From the Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy (V. Villani, A. Ciuffoli, and G. Sette)","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079407899","display_name":"Luca Prosperini","orcid":"https://orcid.org/0000-0003-3237-6267","observed_orcids":["https://orcid.org/0000-0003-3237-6267"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Prosperini","raw_affiliation_strings":["From the Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy (V. Villani, A. Ciuffoli, and G. Sette); Department of Neurology and Psichiatry, Sapienza University, Department of Neurology and Psichiatry Rome, Italy (L. Prosperini)","Department of Neurology and Psichiatry, Sapienza University, Department of Neurology and Psichiatry Rome, Italy (L. Prosperini)","From the Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy (V. Villani, A. Ciuffoli, and G. Sette)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy (V. Villani, A. Ciuffoli, and G. Sette); Department of Neurology and Psichiatry, Sapienza University, Department of Neurology and Psichiatry Rome, Italy (L. Prosperini)","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Department of Neurology and Psichiatry, Sapienza University, Department of Neurology and Psichiatry Rome, Italy (L. Prosperini)","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"From the Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy (V. Villani, A. Ciuffoli, and G. Sette)","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080839042","display_name":"Giuliano Sette","orcid":"https://orcid.org/0000-0002-8324-4371","observed_orcids":["https://orcid.org/0000-0002-8324-4371"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuliano Sette","raw_affiliation_strings":["From the Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy (V. Villani, A. Ciuffoli, and G. Sette); Department of Neurology and Psichiatry, Sapienza University, Department of Neurology and Psichiatry Rome, Italy (L. Prosperini)","Department of Neurology and Psichiatry, Sapienza University, Department of Neurology and Psichiatry Rome, Italy (L. Prosperini)","From the Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy (V. Villani, A. Ciuffoli, and G. Sette)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy (V. Villani, A. Ciuffoli, and G. Sette); Department of Neurology and Psichiatry, Sapienza University, Department of Neurology and Psichiatry Rome, Italy (L. Prosperini)","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Department of Neurology and Psichiatry, Sapienza University, Department of Neurology and Psichiatry Rome, Italy (L. Prosperini)","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"From the Neurology Headache Centre, S. Andrea Hospital, Sapienza University, Rome, Italy (V. Villani, A. Ciuffoli, and G. Sette)","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":2.3289,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.87061527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"51","issue":"2","first_page":"287","last_page":"291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zonisamide","display_name":"zonisamide","score":1.0},{"id":"https://openalex.org/keywords/migraine-prevention","display_name":"migraine prophylaxis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.8259999752044678},{"id":"https://openalex.org/keywords/sulfonamide-analogs","display_name":"sulfonamide analogs","score":0.8859999775886536},{"id":"https://openalex.org/keywords/drug-switching","display_name":"drug switching","score":0.4129999876022339},{"id":"https://openalex.org/keywords/headache-frequency","display_name":"headache frequency","score":0.6000000238418579},{"id":"https://openalex.org/keywords/migraine-disability","display_name":"migraine disability","score":0.7609999775886536},{"id":"https://openalex.org/keywords/analgesic-use","display_name":"analgesic use","score":0.8679999709129333},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C2777138316","wikidata":"https://www.wikidata.org/wiki/Q219957","display_name":"Zonisamide","level":4,"score":0.9972439408302307},{"id":"https://openalex.org/C2777683783","wikidata":"https://www.wikidata.org/wiki/Q221174","display_name":"Topiramate","level":3,"score":0.9511171579360962},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.8214583396911621},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8145663738250732},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.786882758140564},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5331876277923584},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.4815102517604828},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.37675344944000244},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.3308141827583313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.267905056476593},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.26010507345199585},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077236","descriptor_name":"Topiramate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078305","descriptor_name":"Zonisamide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010292","descriptor_name":"Paresthesia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019964","descriptor_name":"Mood Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1526-4610.2010.01842.x","doi":"https://doi.org/10.1111/j.1526-4610.2010.01842.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1526-4610.2010.01842.x","pdf_url":null,"source":{"id":"https://openalex.org/S96331937","display_name":"Headache The Journal of Head and Face Pain","issn_l":"0017-8748","issn":["0017-8748","1526-4610"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Headache: The Journal of Head and Face Pain","raw_type":"journal-article"},{"id":"pmid:21284610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21284610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Headache","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/355964","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000286836400011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1973511428","https://openalex.org/W1988400098","https://openalex.org/W2016929210","https://openalex.org/W2018343495","https://openalex.org/W2021837413","https://openalex.org/W2032666115","https://openalex.org/W2034623572","https://openalex.org/W2045567183","https://openalex.org/W2052144033","https://openalex.org/W2055183512","https://openalex.org/W2062526596","https://openalex.org/W2075183866","https://openalex.org/W2083669656","https://openalex.org/W2109987671","https://openalex.org/W2133465674","https://openalex.org/W2395360570","https://openalex.org/W3015167373"],"related_works":["https://openalex.org/W2335316218","https://openalex.org/W2052144033","https://openalex.org/W2105615052","https://openalex.org/W46420322","https://openalex.org/W7100563422","https://openalex.org/W2016929210","https://openalex.org/W2020435967","https://openalex.org/W1561644580","https://openalex.org/W6893675358","https://openalex.org/W2016030981"],"abstract_inverted_index":{"BACKGROUND:":[0],"Zonisamide,":[1],"a":[2,43,61,73,128,158],"sulfonamide":[3],"analog,":[4],"is":[5,24],"an":[6,180],"antiepileptic":[7],"drug":[8],"with":[9,42,69,100,150,188],"mechanisms":[10],"of":[11,17,35,64,98,121,161,168,177],"action":[12],"similar":[13],"to":[14,46,72,114,155,194],"topiramate.":[15,195],"Because":[16],"its":[18],"pharmacodynamic":[19],"and":[20,33,92,134,142],"pharmacokinetics":[21],"profiles,":[22],"zonisamide":[23,36,70,122,178],"also":[25],"potentially":[26],"suitable":[27],"for":[28,37,51,77,183],"migraine":[29,38,143,184],"prevention.":[30],"METHODS:":[31],"Tolerability":[32],"effectiveness":[34],"prophylaxis":[39],"in":[40,57,131,186],"patients":[41,66,89,187],"good":[44,189],"response":[45],"topiramate,":[47],"but":[48,191],"interrupting":[49],"it":[50],"intolerable":[52],"side":[53,94],"effects,":[54],"were":[55,67],"evaluated":[56],"34":[58],"patients.":[59],"After":[60],"1-month":[62,152],"period":[63,113,153],"wash-out,":[65],"treated":[68],"(up":[71],"100":[74],"mg/day":[75],"dosage)":[76],"6":[78,119],"consecutive":[79],"months.":[80],"RESULTS:":[81],"Zonisamide":[82],"was":[83,104,163],"well":[84],"tolerated,":[85],"only":[86],"4":[87],"(12%)":[88],"reported":[90],"transient":[91],"tolerable":[93],"effects.":[95],"Mean":[96],"number":[97],"days":[99],"headache":[101,132],"per":[102],"month":[103],"reduced":[105,159],"from":[106],"14.9":[107],"\u00b1":[108,116],"5.3":[109],"during":[110],"the":[111,151,166,169,175],"wash-out":[112],"2.5":[115],"0.6":[117],"after":[118],"months":[120],"(P":[123],"<":[124],".001).":[125],"We":[126],"observed":[127],"significant":[129],"reduction":[130],"severity":[133],"disability,":[135],"as":[136,179],"assessed":[137],"by":[138],"visual":[139],"analog":[140],"scale":[141],"disability":[144],"assessment":[145],"scale.":[146],"Finally,":[147],"when":[148],"compared":[149],"prior":[154],"starting":[156],"zonisamide,":[157],"use":[160,176],"analgesics":[162],"recorded":[164],"at":[165],"end":[167],"follow-up.":[170],"CONCLUSION:":[171],"Our":[172],"findings":[173],"support":[174],"alternative":[181],"therapy":[182],"prevention":[185],"response,":[190],"poor":[192],"tolerance":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}