{"id":"https://openalex.org/W1908112684","doi":"https://doi.org/10.1523/jneurosci.22-17-07526.2002","title":"Matrix Metalloproteinases Limit Functional Recovery after Spinal Cord Injury by Modulation of Early Vascular Events","display_name":"Matrix Metalloproteinases Limit Functional Recovery after Spinal Cord Injury by Modulation of Early Vascular Events","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W1908112684","doi":"https://doi.org/10.1523/jneurosci.22-17-07526.2002","mag":"1908112684","pmid":"https://pubmed.ncbi.nlm.nih.gov/12196576","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2792199"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.22-17-07526.2002","doi":"https://doi.org/10.1523/jneurosci.22-17-07526.2002","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.22-17-07526.2002","pdf_url":"http://www.jneurosci.org/content/jneuro/22/17/7526.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1908112684"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jneurosci.org/content/jneuro/22/17/7526.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053910431","display_name":"Linda J. Noble\u2010Haeusslein","orcid":"https://orcid.org/0000-0002-2653-7047","observed_orcids":["https://orcid.org/0000-0002-2653-7047"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda J. Noble","raw_affiliation_strings":["Departments of Neurosurgery and","Department of Neurosurgery and Anatomy, University of California at San Francisco, San Francisco, California 94143-0520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery and","institution_ids":[]},{"raw_affiliation_string":"Department of Neurosurgery and Anatomy, University of California at San Francisco, San Francisco, California 94143-0520, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067168515","display_name":"Frances M. Donovan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frances Donovan","raw_affiliation_strings":["Anatomy, University of California at San Francisco, San Francisco, California 94143-0520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy, University of California at San Francisco, San Francisco, California 94143-0520","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034767384","display_name":"Takuji Igarashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takuji Igarashi","raw_affiliation_strings":["Departments of Neurosurgery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057361676","display_name":"Staci Goussev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Staci Goussev","raw_affiliation_strings":["Departments of Neurosurgery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048523154","display_name":"Zena Werb","orcid":"https://orcid.org/0000-0002-6525-3872","observed_orcids":["https://orcid.org/0000-0002-6525-3872"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zena Werb","raw_affiliation_strings":["Anatomy, University of California at San Francisco, San Francisco, California 94143-0520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy, University of California at San Francisco, San Francisco, California 94143-0520","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.9876,"has_fulltext":true,"cited_by_count":505,"citation_normalized_percentile":{"value":0.98676596,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"22","issue":"17","first_page":"7526","last_page":"7535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9559999704360962},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9980000257492065},{"id":"https://openalex.org/keywords/blood-spinal-cord-barrier","display_name":"blood-spinal cord barrier","score":0.8130000233650208},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.8399999737739563},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.9760000109672546},{"id":"https://openalex.org/keywords/locomotor-recovery","display_name":"locomotor recovery","score":0.9279999732971191},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-inhibitors","display_name":"matrix metalloproteinase inhibitors","score":0.6669999957084656},{"id":"https://openalex.org/keywords/hydroxamate-inhibitors","display_name":"hydroxamate inhibitors","score":0.8029999732971191},{"id":"https://openalex.org/keywords/tissue-inhibitors-of-metalloproteinases","display_name":"tissue inhibitors of metalloproteinases","score":0.8230000138282776},{"id":"https://openalex.org/keywords/white-matter-injury","display_name":"white matter injury","score":0.5680000185966492},{"id":"https://openalex.org/keywords/secondary-injury","display_name":"secondary injury","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.7822645902633667},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.7182799577713013},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6886254549026489},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6632087230682373},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5917437076568604},{"id":"https://openalex.org/C2779632786","wikidata":"https://www.wikidata.org/wiki/Q920297","display_name":"Cord","level":2,"score":0.5175896883010864},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.44224128127098083},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4085507392883301},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3959331512451172},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23070389032363892},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.10642409324645996},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.06928405165672302},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001808","descriptor_name":"Blood Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008578","descriptor_name":"Meninges","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008578","descriptor_name":"Meninges","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020556","descriptor_name":"Neutrophil Infiltration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061965","descriptor_name":"Matrix Metalloproteinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.22-17-07526.2002","doi":"https://doi.org/10.1523/jneurosci.22-17-07526.2002","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.22-17-07526.2002","pdf_url":"http://www.jneurosci.org/content/jneuro/22/17/7526.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:12196576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12196576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2792199","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2792199/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.22-17-07526.2002","doi":"https://doi.org/10.1523/jneurosci.22-17-07526.2002","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.22-17-07526.2002","pdf_url":"http://www.jneurosci.org/content/jneuro/22/17/7526.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G841159273","display_name":"Matrix Metalloproteinases and Spinal Cord Injury","funder_award_id":"R01NS039278","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1908112684.pdf","grobid_xml":"https://content.openalex.org/works/W1908112684.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W3355293","https://openalex.org/W368807300","https://openalex.org/W1523071123","https://openalex.org/W1529537509","https://openalex.org/W1669342624","https://openalex.org/W1781133616","https://openalex.org/W1894541755","https://openalex.org/W1966708171","https://openalex.org/W1976831807","https://openalex.org/W1977200209","https://openalex.org/W1987197699","https://openalex.org/W1987897015","https://openalex.org/W1990711278","https://openalex.org/W1991634993","https://openalex.org/W2001262287","https://openalex.org/W2001314174","https://openalex.org/W2004159587","https://openalex.org/W2010267991","https://openalex.org/W2011411078","https://openalex.org/W2011875859","https://openalex.org/W2016411107","https://openalex.org/W2019805210","https://openalex.org/W2025118259","https://openalex.org/W2029782642","https://openalex.org/W2034436971","https://openalex.org/W2037711162","https://openalex.org/W2041533977","https://openalex.org/W2041800999","https://openalex.org/W2042427901","https://openalex.org/W2045528880","https://openalex.org/W2046329404","https://openalex.org/W2054565851","https://openalex.org/W2057819786","https://openalex.org/W2059450459","https://openalex.org/W2061672007","https://openalex.org/W2063412283","https://openalex.org/W2064387526","https://openalex.org/W2065012668","https://openalex.org/W2065871536","https://openalex.org/W2070816681","https://openalex.org/W2072245886","https://openalex.org/W2072796605","https://openalex.org/W2073138743","https://openalex.org/W2073629686","https://openalex.org/W2073748140","https://openalex.org/W2075262827","https://openalex.org/W2087242332","https://openalex.org/W2089440945","https://openalex.org/W2102677257","https://openalex.org/W2104660263","https://openalex.org/W2106361045","https://openalex.org/W2110688089","https://openalex.org/W2113892795","https://openalex.org/W2120928437","https://openalex.org/W2128049766","https://openalex.org/W2133236326","https://openalex.org/W2138266174","https://openalex.org/W2157338102","https://openalex.org/W2170645579","https://openalex.org/W2318318251","https://openalex.org/W2400049961","https://openalex.org/W2402260991","https://openalex.org/W2412395027","https://openalex.org/W2437563929","https://openalex.org/W2503323289","https://openalex.org/W4214589643","https://openalex.org/W4296941341"],"related_works":["https://openalex.org/W2054190000","https://openalex.org/W2121431626","https://openalex.org/W2103191564","https://openalex.org/W2051021959","https://openalex.org/W2033132847","https://openalex.org/W2101966356","https://openalex.org/W2368229018","https://openalex.org/W2058616658","https://openalex.org/W2139137961","https://openalex.org/W2381934518"],"abstract_inverted_index":{"Inflammation":[0],"in":[1,30,42,84,91,140,176,190],"general":[2],"and":[3,36,45,73,88,128,194,205,218],"proteinases":[4],"generated":[5],"as":[6],"a":[7,55,62,144,187],"result":[8],"are":[9],"likely":[10],"mediators":[11],"of":[12,47,105,119,125,165,208,230],"early":[13,228],"secondary":[14],"pathogenesis":[15],"after":[16,54,79,99,155,201],"spinal":[17,58,94,202,239],"cord":[18,32,59,95,122,203],"injury.":[19,80,100],"We":[20],"report":[21],"that":[22,184,206,227],"matrix":[23],"metalloproteinase-9":[24],"(MMP-9)":[25],"plays":[26,186],"an":[27,234],"important":[28],"role":[29,189],"blood-spinal":[31,121],"barrier":[33],"dysfunction,":[34],"inflammation,":[35],"locomotor":[37,130,222],"recovery.":[38,223],"MMP-9":[39,51,185],"was":[40,82,173],"present":[41],"the":[43,48,92,120,159,163,170,177,197,238],"meninges":[44],"neurons":[46],"uninjured":[49],"cord.":[50],"increased":[52],"rapidly":[53],"moderate":[56],"contusion":[57],"injury,":[60,156,204],"reaching":[61],"maximum":[63],"at":[64,76,96,169],"24":[65,97],"hr,":[66,72],"becoming":[67],"markedly":[68],"reduced":[69],"by":[70],"72":[71],"not":[74],"detectable":[75],"7":[77],"d":[78,154,200],"It":[81],"seen":[83],"glia,":[85],"macrophages,":[86],"neutrophils,":[87],"vascular":[89,192,216],"elements":[90],"injured":[93],"hr":[98,151],"The":[101],"natural":[102],"tissue":[103],"inhibitors":[104],"MMPs":[106,209,231],"were":[107,138],"unchanged":[108],"over":[109],"this":[110,211],"time":[111],"course.":[112],"MMP-9-null":[113],"mice":[114,141],"exhibited":[115],"significantly":[116,174],"less":[117],"disruption":[118],"barrier,":[123],"attenuation":[124],"neutrophil":[126],"infiltration,":[127],"significant":[129],"recovery":[131],"compared":[132,157],"with":[133,143,158],"wild-type":[134],"mice.":[135],"Similar":[136],"findings":[137,225],"observed":[139],"treated":[142],"hydroxamic":[145],"acid":[146],"MMP":[147],"inhibitor":[148],"from":[149],"3":[150,153,199],"to":[152,220],"vehicle":[160],"controls.":[161],"Moreover,":[162],"area":[164],"residual":[166],"white":[167],"matter":[168],"lesion":[171],"epicenter":[172],"greater":[175],"inhibitor-treated":[178],"group.":[179],"This":[180],"study":[181],"provides":[182],"evidence":[183],"key":[188],"abnormal":[191],"permeability":[193],"inflammation":[195],"within":[196],"first":[198],"blockade":[207],"during":[210],"critical":[212],"period":[213],"attenuates":[214],"these":[215],"events":[217],"leads":[219],"improved":[221],"Our":[224],"suggest":[226],"inhibition":[229],"may":[232],"be":[233],"efficacious":[235],"strategy":[236],"for":[237],"cord-injured":[240],"patient.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":30},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":31},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}