{"id":"https://openalex.org/W1908076243","doi":null,"title":"Aging, metabolic syndrome and the heart.","display_name":"Aging, metabolic syndrome and the heart.","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W1908076243","mag":"1908076243","pmid":"https://pubmed.ncbi.nlm.nih.gov/22724085","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3375083"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2384889","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3375083","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3375083","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Guarner Veronica","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157394","display_name":"Instituto Nacional de Cardiolog\u00eda","ror":"https://ror.org/046e90j34","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210157394"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Guarner Veronica","raw_affiliation_strings":["Department Of Physiology, Instituto Nacional De Cardiologia \"Ignacio Chavez\", M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Physiology, Instituto Nacional De Cardiologia \"Ignacio Chavez\", M\u00e9xico","institution_ids":["https://openalex.org/I4210157394"]}]},{"author_position":"last","author":{"id":null,"display_name":"Rubio-Ruiz Maria Esther","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rubio-Ruiz Maria Esther","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.119,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.94052035,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"3","first_page":"269","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.7910000085830688,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.7910000085830688,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.08389999717473984,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.06080000102519989,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.984000027179718},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":1.0},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9449999928474426},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.875},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":1.0},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7739999890327454},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9319999814033508},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.8690000176429749},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8169999718666077},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7827649712562561},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.746751606464386},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6936089396476746},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.6495805978775024},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6438602209091187},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6052427291870117},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.572290301322937},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5371373891830444},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5360506176948547},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5030919909477234},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4607331454753876},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4307379424571991},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.42346012592315674},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39877840876579285},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3550654947757721},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2384889","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3375083","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3375083","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3375083","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Dis","raw_type":"Text"},{"id":"pmid:22724085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22724085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging and disease","raw_type":"Journal Article"},{"id":"mag:1908076243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22724085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2384889","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3375083","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W62073711","https://openalex.org/W154047992","https://openalex.org/W1490819582","https://openalex.org/W1586199023","https://openalex.org/W1638473681","https://openalex.org/W1793096995","https://openalex.org/W1967828371","https://openalex.org/W1975547401","https://openalex.org/W1980023923","https://openalex.org/W1981444005","https://openalex.org/W1983515210","https://openalex.org/W1985601140","https://openalex.org/W1989807669","https://openalex.org/W1990319624","https://openalex.org/W1990826584","https://openalex.org/W1992566993","https://openalex.org/W1994124971","https://openalex.org/W1994573880","https://openalex.org/W1996166472","https://openalex.org/W1996414762","https://openalex.org/W2000215893","https://openalex.org/W2001276401","https://openalex.org/W2012494798","https://openalex.org/W2023647145","https://openalex.org/W2024233889","https://openalex.org/W2025037814","https://openalex.org/W2030206530","https://openalex.org/W2035967698","https://openalex.org/W2036209053","https://openalex.org/W2036439292","https://openalex.org/W2037229939","https://openalex.org/W2043523148","https://openalex.org/W2055019461","https://openalex.org/W2058484936","https://openalex.org/W2059633339","https://openalex.org/W2066179126","https://openalex.org/W2067927355","https://openalex.org/W2072411790","https://openalex.org/W2073101309","https://openalex.org/W2073237351","https://openalex.org/W2075125837","https://openalex.org/W2075897901","https://openalex.org/W2077371500","https://openalex.org/W2077741216","https://openalex.org/W2079479408","https://openalex.org/W2084611612","https://openalex.org/W2086868392","https://openalex.org/W2087212409","https://openalex.org/W2087285715","https://openalex.org/W2087507271","https://openalex.org/W2093434164","https://openalex.org/W2095084418","https://openalex.org/W2097792029","https://openalex.org/W2100888435","https://openalex.org/W2103077445","https://openalex.org/W2103268140","https://openalex.org/W2106366246","https://openalex.org/W2109212247","https://openalex.org/W2117187480","https://openalex.org/W2126372118","https://openalex.org/W2129529988","https://openalex.org/W2131395694","https://openalex.org/W2131927337","https://openalex.org/W2134096679","https://openalex.org/W2136429434","https://openalex.org/W2142653737","https://openalex.org/W2145306215","https://openalex.org/W2148391873","https://openalex.org/W2151336952","https://openalex.org/W2152377123","https://openalex.org/W2154476123","https://openalex.org/W2159984962","https://openalex.org/W2187185761","https://openalex.org/W2336857481","https://openalex.org/W2404007805","https://openalex.org/W2412319610","https://openalex.org/W2587336248"],"related_works":["https://openalex.org/W3094575443","https://openalex.org/W2019486401","https://openalex.org/W2394718646","https://openalex.org/W2079806638","https://openalex.org/W2404007805","https://openalex.org/W4402896702","https://openalex.org/W3204875794","https://openalex.org/W4309968089","https://openalex.org/W2099774043","https://openalex.org/W1921523468"],"abstract_inverted_index":{"Aging":[0,65],"is":[1],"accelerated":[2],"when":[3],"metabolic":[4,53],"and":[5,11,45,56,58,66,75,97,127,140,145,148],"cardiovascular":[6],"diseases":[7,16],"(CVD)":[8],"are":[9,68],"present":[10],"the":[12,37,40,106,129],"risk":[13],"of":[14,39,52,84,89,108,113,131],"these":[15],"increases":[17],"with":[18,142],"age.":[19],"Many":[20],"predisposing":[21],"conditions":[22,74],"which":[23,103],"increase":[24,50],"in":[25,36,62,137,153],"prevalence":[26,51,120],"during":[27],"aging,":[28],"such":[29,79],"as":[30,80],"obesity,":[31],"insulin":[32],"resistance,":[33],"inflammation,":[34],"changes":[35],"activity":[38],"hypothalamus-hypophysis":[41],"suprarenal":[42],"axis,":[43],"stress":[44,102],"hypertension":[46],"also":[47],"contribute":[48],"to":[49,93,117,123,128],"syndrome":[54],"(MS)":[55],"CVD":[57,119,149],"will":[59],"be":[60,151],"discussed":[61],"this":[63],"paper.":[64],"MS":[67,116,147],"frequently":[69],"accompanied":[70],"by":[71],"several":[72],"pathological":[73],"some":[76],"associated":[77],"phenomena":[78],"increased":[81,87,118],"lipoperoxidation,":[82],"generation":[83],"free":[85],"radicals,":[86],"peroxidation":[88],"nitric":[90],"oxide":[91],"(NO)":[92],"its":[94],"toxic":[95],"species,":[96],"others,":[98],"resulting":[99],"from":[100],"oxidative":[101],"significantly":[104],"alter":[105],"incidence":[107],"CVD.":[109],"The":[110],"better":[111],"knowledge":[112],"mechanisms":[114],"linking":[115],"has":[121],"led":[122],"new":[124,134],"predictive":[125],"measures":[126],"study":[130],"different":[132],"possible":[133],"therapeutic":[135],"strategies":[136],"elderly":[138],"patients":[139,141],"MS.":[143],"Preventing":[144],"treating":[146],"would":[150],"useful":[152],"promoting":[154],"normal":[155],"aging.":[156]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
