{"id":"https://openalex.org/W1908004152","doi":"https://doi.org/10.4049/jimmunol.177.1.437","title":"Secreted Proteins from Mycobacterium tuberculosis Gain Access to the Cytosolic MHC Class-I Antigen-Processing Pathway","display_name":"Secreted Proteins from Mycobacterium tuberculosis Gain Access to the Cytosolic MHC Class-I Antigen-Processing Pathway","publication_year":2006,"publication_date":"2006-07-01","ids":{"openalex":"https://openalex.org/W1908004152","doi":"https://doi.org/10.4049/jimmunol.177.1.437","mag":"1908004152","pmid":"https://pubmed.ncbi.nlm.nih.gov/16785540"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.177.1.437","doi":"https://doi.org/10.4049/jimmunol.177.1.437","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.177.1.437","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1908004152"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032119661","display_name":"David Michael Lewinsohn","orcid":"https://orcid.org/0000-0001-9906-9494","observed_orcids":["https://orcid.org/0000-0001-9906-9494"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M Lewinsohn","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Oregon Health Sciences University , Portland, OR 97239","Division of Pulmonary and Critical Care Medicine, Oregon Health Sciences University/Portland Veterans Affairs (VA) Medical Center , Portland, OR 97239","\u2020Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97239; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Oregon Health Sciences University , Portland, OR 97239","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Oregon Health Sciences University/Portland Veterans Affairs (VA) Medical Center , Portland, OR 97239","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977"]},{"raw_affiliation_string":"\u2020Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97239; and","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030360500","display_name":"Jeff E. Grotzke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff E Grotzke","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Oregon Health Sciences University , Portland, OR 97239","\u2020Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97239; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Oregon Health Sciences University , Portland, OR 97239","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"\u2020Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97239; and","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048898303","display_name":"Amy S. Heinzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy S Heinzel","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Oregon Health Sciences University/Portland Veterans Affairs (VA) Medical Center , Portland, OR 97239"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Oregon Health Sciences University/Portland Veterans Affairs (VA) Medical Center , Portland, OR 97239","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2803065977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109907457","display_name":"LiQing Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799696014","display_name":"Corixa Corporation","ror":"https://ror.org/01bthtp68","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I2799696014","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LiQing Zhu","raw_affiliation_strings":["\u2021Corixa, Seattle, WA 98104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Corixa, Seattle, WA 98104","institution_ids":["https://openalex.org/I2799696014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000025071","display_name":"Pamela J. Ovendale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799696014","display_name":"Corixa Corporation","ror":"https://ror.org/01bthtp68","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I2799696014","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela J Ovendale","raw_affiliation_strings":["\u2021Corixa, Seattle, WA 98104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Corixa, Seattle, WA 98104","institution_ids":["https://openalex.org/I2799696014"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mark Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799696014","display_name":"Corixa Corporation","ror":"https://ror.org/01bthtp68","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I2799696014","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Johnson","raw_affiliation_strings":["\u2021Corixa, Seattle, WA 98104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Corixa, Seattle, WA 98104","institution_ids":["https://openalex.org/I2799696014"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060338193","display_name":"Mark R. Alderson","orcid":"https://orcid.org/0000-0002-0697-6149","observed_orcids":["https://orcid.org/0000-0002-0697-6149"]},"institutions":[{"id":"https://openalex.org/I2799696014","display_name":"Corixa Corporation","ror":"https://ror.org/01bthtp68","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I2799696014","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R Alderson","raw_affiliation_strings":["\u2021Corixa, Seattle, WA 98104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Corixa, Seattle, WA 98104","institution_ids":["https://openalex.org/I2799696014"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.761,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.92878095,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"177","issue":"1","first_page":"437","last_page":"442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0892999991774559,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":1.0},{"id":"https://openalex.org/keywords/secreted-proteins","display_name":"secreted proteins","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cfp-10","display_name":"CFP-10","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mhc-class-i-antigen-processing","display_name":"MHC class I antigen processing","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8349999785423279},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/brefeldin-a","display_name":"brefeldin A","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tap","display_name":"TAP","score":0.9139999747276306},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.9620000123977661},{"id":"https://openalex.org/keywords/lactacystin","display_name":"lactacystin","score":0.8640000224113464},{"id":"https://openalex.org/keywords/phagosome","display_name":"phagosome","score":0.6050000190734863},{"id":"https://openalex.org/keywords/early-endosomes","display_name":"early endosomes","score":0.6669999957084656},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C108249834","wikidata":"https://www.wikidata.org/wiki/Q3922363","display_name":"Antigen processing","level":5,"score":0.6673409938812256},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.6472913026809692},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.5885528922080994},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5844518542289734},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5672953128814697},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.5521586537361145},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4551614820957184},{"id":"https://openalex.org/C156399914","wikidata":"https://www.wikidata.org/wiki/Q7444454","display_name":"Secretory protein","level":3,"score":0.4175776243209839},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.4143153429031372},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41146785020828247},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.3833251893520355},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.382335364818573},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.3445873260498047},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33697766065597534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14640530943870544},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11804857850074768},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000260","descriptor_name":"Adenoviruses, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000260","descriptor_name":"Adenoviruses, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007976","descriptor_name":"Leupeptins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020126","descriptor_name":"Brefeldin A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D061988","descriptor_name":"Proteasome Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.177.1.437","doi":"https://doi.org/10.4049/jimmunol.177.1.437","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.177.1.437","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:16785540","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16785540","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1473840404","display_name":"Recognition of Mtb-infected cells by CD8+ T lymphocytes","funder_award_id":"R01AI048090","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6095199518","display_name":"HUMAN T CELL RESPONES TO MYCOBACTERIUM TUBERCULOSIS","funder_award_id":"K08AI001644","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1488861798","https://openalex.org/W1531750039","https://openalex.org/W1553697637","https://openalex.org/W1558384554","https://openalex.org/W1596274918","https://openalex.org/W1597086056","https://openalex.org/W1933647785","https://openalex.org/W1968418964","https://openalex.org/W1977812921","https://openalex.org/W1985004048","https://openalex.org/W1999384262","https://openalex.org/W2008626549","https://openalex.org/W2009607549","https://openalex.org/W2019766188","https://openalex.org/W2024974612","https://openalex.org/W2036635548","https://openalex.org/W2042411369","https://openalex.org/W2042470561","https://openalex.org/W2068051174","https://openalex.org/W2079439306","https://openalex.org/W2080781566","https://openalex.org/W2104941073","https://openalex.org/W2106942635","https://openalex.org/W2107721036","https://openalex.org/W2111354206","https://openalex.org/W2113554018","https://openalex.org/W2124376809","https://openalex.org/W2130074351","https://openalex.org/W2147251439","https://openalex.org/W2155757073","https://openalex.org/W2160239525","https://openalex.org/W2164101815","https://openalex.org/W2165948328","https://openalex.org/W2171553929","https://openalex.org/W4313347805"],"related_works":["https://openalex.org/W2130906551","https://openalex.org/W2033232488","https://openalex.org/W2132079649","https://openalex.org/W2110132503","https://openalex.org/W1985552228","https://openalex.org/W2062307034","https://openalex.org/W1627868131","https://openalex.org/W4313347805","https://openalex.org/W2008626549","https://openalex.org/W2021037655"],"abstract_inverted_index":{"CD8+":[0,48,93],"T":[1,49,94],"cells":[2,107],"play":[3],"an":[4,20,28,64],"important":[5],"role":[6],"in":[7,19,63,113,122,202],"the":[8,40,60,79,86,99,143,154,173,214],"host":[9],"response":[10],"to":[11,27,39,59,119,153],"infection":[12],"with":[13,47,110,209],"Mycobacterium":[14],"tuberculosis":[15],"(Mtb).":[16],"Mtb":[17,55,101,198],"resides":[18],"arrested":[21],"phagosome":[22],"that":[23,54,68,180,194],"is":[24,69],"phenotypically":[25],"similar":[26],"early":[29],"endosome.":[30],"The":[31],"mechanisms":[32],"by":[33,126,130,139,161],"which":[34],"Mtb-derived":[35],"Ags":[36,56],"gain":[37,57],"access":[38,58],"HLA-I-processing":[41],"pathway":[42,62,67,186],"are":[43],"incompletely":[44],"characterized.":[45],"Studies":[46],"cell":[50,95],"lines":[51],"have":[52,90],"suggested":[53],"HLA-I":[61,87],"alternate":[65],"vacuolar":[66],"both":[70,140],"brefeldin":[71],"A":[72],"(BFA)":[73],"and":[74,133,142,169,205,216],"TAP":[75,170],"independent.":[76],"To":[77],"define":[78],"requirements":[80],"of":[81,83,135,150,156,163,175,211,219],"entry":[82],"Ag":[84,102,212],"into":[85,213],"pathway,":[88],"we":[89],"used":[91],"human":[92],"clones":[96],"specific":[97],"for":[98,187],"secreted":[100,189,195],"CFP10.":[103],"Human":[104],"monocyte-derived":[105],"dendritic":[106,177],"were":[108,137],"pulsed":[109],"CFP10":[111,136,151],"expressed":[112],"a":[114,184,203],"recombinant":[115],"adenovirus,":[116,131],"surface":[117,155],"adsorbed":[118,152],"microspheres,":[120],"or":[121],"its":[123],"native":[124],"form":[125],"Mtb.":[127],"When":[128],"delivered":[129],"processing":[132,149,181],"presentation":[134],"blocked":[138,172],"BFA":[141],"proteasomal":[144],"blocker":[145],"lactacystin.":[146],"In":[147],"contrast,":[148],"microspheres":[157],"was":[158,182],"not":[159],"affected":[160],"either":[162],"these":[164],"Ag-processing":[165],"inhibitors.":[166],"BFA,":[167],"lactacystin,":[168],"inhibition":[171],"recognition":[174],"Mtb-infected":[176],"cells,":[178],"suggesting":[179],"via":[183],"cytosolic":[185],"this":[188],"protein":[190],"Ag.":[191],"We":[192],"conclude":[193],"proteins":[196],"from":[197],"can":[199],"be":[200],"processed":[201],"BFA-":[204],"proteasome-dependent":[206],"manner,":[207],"consistent":[208],"egress":[210],"cytosol":[215],"subsequent":[217],"loading":[218],"proteasomally":[220],"derived":[221],"peptides.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
