{"id":"https://openalex.org/W1907459083","doi":"https://doi.org/10.1200/jco.1988.6.7.1147","title":"An intensive, five course, alternating combination chemotherapy induction regimen used in patients with advanced, unresectable head and neck cancer.","display_name":"An intensive, five course, alternating combination chemotherapy induction regimen used in patients with advanced, unresectable head and neck cancer.","publication_year":1988,"publication_date":"1988-07-01","ids":{"openalex":"https://openalex.org/W1907459083","doi":"https://doi.org/10.1200/jco.1988.6.7.1147","mag":"1907459083","pmid":"https://pubmed.ncbi.nlm.nih.gov/3292714"},"language":"en","primary_location":{"id":"doi:10.1200/jco.1988.6.7.1147","doi":"https://doi.org/10.1200/jco.1988.6.7.1147","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.1988.6.7.1147","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021506059","display_name":"John F. Ensley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Ensley","raw_affiliation_strings":["Department of Internal Medicine, Wayne State School of Medicine, Wayne State University Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Wayne State School of Medicine, Wayne State University Detroit, MI","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064640302","display_name":"Julie Ann Kish","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Kish","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041923874","display_name":"Efstathios Tapazoglou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Tapazoglou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Jacobs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Jacobs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109103592","display_name":"Arthur Weaver","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Weaver","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"D Atkinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Atkinson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Ahmed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Ahmed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079570579","display_name":"Robert H. Mathog","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Mathog","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112624914","display_name":"Muhyi Al\u2010Sarraf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Al-Sarraf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.1768,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.96800294,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"7","first_page":"1147","last_page":"1153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/induction-chemotherapy","display_name":"induction chemotherapy","score":0.800000011920929},{"id":"https://openalex.org/keywords/high-dose-methotrexate","display_name":"high-dose methotrexate","score":0.8659999966621399},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/leucovorin-rescue","display_name":"leucovorin rescue","score":0.9430000185966492},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.7239999771118164},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.8100000023841858},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mucositis","display_name":"mucositis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/skin-toxicity","display_name":"skin toxicity","score":0.5389999747276306},{"id":"https://openalex.org/keywords/stage-iv-disease","display_name":"stage IV disease","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9307944774627686},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.7785418033599854},{"id":"https://openalex.org/C2776611710","wikidata":"https://www.wikidata.org/wiki/Q16888295","display_name":"Induction chemotherapy","level":3,"score":0.5786904692649841},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.5753226280212402},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5177413821220398},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5111570954322815},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.49250563979148865},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.4731123149394989},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4213183522224426},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.38698652386665344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37589842081069946}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.1988.6.7.1147","doi":"https://doi.org/10.1200/jco.1988.6.7.1147","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.1988.6.7.1147","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:3292714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3292714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1969474597","https://openalex.org/W2004705063","https://openalex.org/W2041783595","https://openalex.org/W2043943046","https://openalex.org/W2096553072","https://openalex.org/W2138329937","https://openalex.org/W2146505874","https://openalex.org/W2180275997","https://openalex.org/W2263544428","https://openalex.org/W2412462667"],"related_works":["https://openalex.org/W4249819873","https://openalex.org/W1983293723","https://openalex.org/W2091776396","https://openalex.org/W2046261394","https://openalex.org/W2438353936","https://openalex.org/W2146819169","https://openalex.org/W2028581418","https://openalex.org/W2401880940","https://openalex.org/W1992815288","https://openalex.org/W2237190276"],"abstract_inverted_index":{"Progress":[0],"in":[1,48,68,83,262,313],"the":[2,11,20,73,154,162,171,193,265,268,284,314],"treatment":[3],"of":[4,10,22,54,77,88,98,118,122,140,161,170,179,213,222,267,277,288,292,299,307,316],"advanced":[5,86,285],"squamous":[6],"cell":[7],"cancer":[8],"(SCC)":[9],"head":[12],"and":[13,42,75,95,115,130,146,156,186,205,246,258,273,302,305],"neck":[14,176],"(H":[15],"&":[16,90,142],"N)":[17],"has":[18],"included":[19],"development":[21],"combination":[23,62],"chemotherapeutic":[24],"regimens":[25],"that":[26],"achieve":[27],"impressive":[28],"complete":[29,190],"response":[30,210],"(CR)":[31],"rates":[32],"using":[33],"two":[34],"to":[35,71,225,231,239,253],"three":[36],"courses":[37],"therapy":[38],"with":[39,85,105,138],"minimal":[40],"toxicity":[41,76,223,260,309],"good":[43],"patient":[44,201,296],"tolerance.":[45],"Further":[46],"improvements":[47],"these":[49,180],"results":[50],"will":[51,310],"require":[52],"intensification":[53],"induction":[55,64,81,319],"regimens.":[56],"Therefore,":[57],"a":[58,78,101,167,183,203,208],"five":[59],"course,":[60],"alternating":[61],"chemotherapy":[63],"trial":[65,269],"was":[66],"initiated":[67],"an":[69,109],"attempt":[70],"test":[72],"feasibility":[74],"prolonged,":[79],"intensive":[80,318],"regimen":[82,280],"patients":[84,137,152,164,173,195,289],"SCC":[87,139],"H":[89,141],"N.":[91],"Courses":[92,113],"1,":[93],"3,":[94],"5":[96],"consisted":[97,117],"fluorouracil":[99],"as":[100,108],"120-hour":[102],"infusion":[103],"(5FU-I)":[104],"cisplatin":[106],"(CACP)":[107],"intravenous":[110],"(IV)":[111],"bolus.":[112],"2":[114],"4":[116],"3":[119],"weekly":[120],"doses":[121],"high-dose":[123],"methotrexate":[124],"(HDMTX)":[125],"followed":[126],"by":[127,264],"5FU":[128],"(5FU-b)":[129],"leucovorin":[131],"rescue":[132],"(LR).":[133],"Forty-six":[134],"stage":[135],"IV":[136],"N":[143],"(85%":[144],"T4":[145],"58%":[147],"N3)":[148],"were":[149,216,236,271],"entered.":[150],"Thirty-one":[151],"completed":[153],"study":[155,219],"15":[157,194],"did":[158,188],"not.":[159],"Twenty-one":[160],"46":[163,172,214],"(46%)":[165],"achieved":[166,182,202,207],"CR.":[168],"Twenty-five":[169],"had":[174],"N3":[175],"disease,":[177],"ten":[178],"25":[181],"CR":[184,204],"(40%),":[185],"eight":[187,206],"not":[189,196],"therapy.":[191],"Of":[192],"completing":[197],"this":[198,278],"study,":[199],"one":[200,247],"partial":[209],"(PR).":[211],"Eight":[212],"(17%)":[215],"removed":[217,237],"from":[218],"for":[220],"reasons":[221],"(6%":[224],"13%)":[226],"or":[227,251],"tumor":[228],"progression":[229],"(2%":[230],"4%).":[232],"The":[233,275],"remaining":[234],"seven":[235],"due":[238],"intercurrent":[240],"medical":[241,294],"conditions":[242],"(four":[243],"uncomplicated":[244],"pneumonias":[245],"gun":[248],"shot":[249],"wound)":[250],"lost":[252],"follow-up":[254],"(2).":[255],"Myelosuppression,":[256],"mucositis,":[257],"skin":[259],"increased":[261],"frequency":[263],"end":[266],"but":[270],"acceptable":[272,308],"reversible.":[274],"activity":[276],"five-course":[279],"is":[281],"promising":[282],"given":[283],"disease":[286],"status":[287],"treated.":[290],"Consideration":[291],"concurrent":[293],"conditions,":[295],"compliance,":[297],"intensity":[298],"medical,":[300],"nutritional":[301],"social":[303],"support,":[304],"levels":[306],"be":[311],"necessary":[312],"design":[315],"future,":[317],"trials.":[320]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}