{"id":"https://openalex.org/W190744546","doi":null,"title":"Angiogenesis in the nasal mucosa","display_name":"Angiogenesis in the nasal mucosa","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W190744546","mag":"190744546"},"language":"en","primary_location":{"id":"pmh:oai:etheses.bham.ac.uk:4032","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/4032/1/Ahmed13PhD.pdf","pdf_url":"http://etheses.bham.ac.uk/4032/1/Ahmed13PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://etheses.bham.ac.uk/4032/1/Ahmed13PhD.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004040119","display_name":"Shahzada K. Ahmed","orcid":"https://orcid.org/0000-0003-3815-9888","observed_orcids":["https://orcid.org/0000-0003-3815-9888"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shahzada Ahmed","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3815-9888","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004040119"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11812","display_name":"Nasal Surgery and Airway Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasal-polyps","display_name":"nasal polyps","score":0.8859999775886536},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/nasal-mucosa","display_name":"nasal mucosa","score":0.9160000085830688},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9409999847412109},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.550000011920929},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.6269999742507935},{"id":"https://openalex.org/keywords/cell-turnover","display_name":"cell turnover","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6169999837875366},{"id":"https://openalex.org/keywords/inflammatory-gene-expression","display_name":"inflammatory gene expression","score":0.6290000081062317},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.8389999866485596},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9869999885559082},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7120000123977661},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tissue-remodeling","display_name":"tissue remodeling","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8276793956756592},{"id":"https://openalex.org/C2781390199","wikidata":"https://www.wikidata.org/wiki/Q8055111","display_name":"Nasal polyps","level":2,"score":0.6407991647720337},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5912849307060242},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4733864367008209},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.47291144728660583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45261767506599426},{"id":"https://openalex.org/C59377437","wikidata":"https://www.wikidata.org/wiki/Q515471","display_name":"Mucous membrane of nose","level":2,"score":0.44690272212028503},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42715075612068176},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42000824213027954},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.397301584482193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3728575110435486},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2185605764389038},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15303239226341248},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:etheses.bham.ac.uk:4032","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/4032/1/Ahmed13PhD.pdf","pdf_url":"http://etheses.bham.ac.uk/4032/1/Ahmed13PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:uilis.unsyiah.ac.id:56313","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/56313","pdf_url":"http://etheses.bham.ac.uk/4032/1/Ahmed13PhD.pdf","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:190744546","doi":null,"is_oa":false,"landing_page_url":"http://etheses.bham.ac.uk/4032/1/Ahmed13PhD.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:56313","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/56313","pdf_url":"http://etheses.bham.ac.uk/4032/1/Ahmed13PhD.pdf","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W190744546.pdf","grobid_xml":"https://content.openalex.org/works/W190744546.grobid-xml"},"referenced_works_count":208,"referenced_works":["https://openalex.org/W13561045","https://openalex.org/W32167704","https://openalex.org/W55291501","https://openalex.org/W56201781","https://openalex.org/W66877726","https://openalex.org/W88599473","https://openalex.org/W142125945","https://openalex.org/W168616544","https://openalex.org/W189322819","https://openalex.org/W195870951","https://openalex.org/W207250171","https://openalex.org/W613537537","https://openalex.org/W1235263458","https://openalex.org/W1485795734","https://openalex.org/W1489873347","https://openalex.org/W1493572453","https://openalex.org/W1495287184","https://openalex.org/W1560039524","https://openalex.org/W1560709577","https://openalex.org/W1562012836","https://openalex.org/W1562908125","https://openalex.org/W1566392033","https://openalex.org/W1573372314","https://openalex.org/W1576876113","https://openalex.org/W1587020653","https://openalex.org/W1679229092","https://openalex.org/W1761459396","https://openalex.org/W1775749144","https://openalex.org/W1807482481","https://openalex.org/W1863103714","https://openalex.org/W1957992664","https://openalex.org/W1965210871","https://openalex.org/W1967435469","https://openalex.org/W1975519085","https://openalex.org/W1977013517","https://openalex.org/W1977467727","https://openalex.org/W1980341272","https://openalex.org/W1980766276","https://openalex.org/W1980969801","https://openalex.org/W1981648195","https://openalex.org/W1982662562","https://openalex.org/W1984038456","https://openalex.org/W1984340047","https://openalex.org/W1985712533","https://openalex.org/W1986361201","https://openalex.org/W1986547603","https://openalex.org/W1987097712","https://openalex.org/W1987699928","https://openalex.org/W1987703588","https://openalex.org/W1988106051","https://openalex.org/W1988475162","https://openalex.org/W1988798193","https://openalex.org/W1989606153","https://openalex.org/W1991869169","https://openalex.org/W1995336786","https://openalex.org/W1996061492","https://openalex.org/W1997081772","https://openalex.org/W1997107937","https://openalex.org/W1999017851","https://openalex.org/W1999296939","https://openalex.org/W2000000541","https://openalex.org/W2000292756","https://openalex.org/W2002049222","https://openalex.org/W2002925249","https://openalex.org/W2002961488","https://openalex.org/W2003025783","https://openalex.org/W2003245918","https://openalex.org/W2004295511","https://openalex.org/W2005873197","https://openalex.org/W2006122901","https://openalex.org/W2007178464","https://openalex.org/W2007487522","https://openalex.org/W2009188834","https://openalex.org/W2009382856","https://openalex.org/W2009622599","https://openalex.org/W2010848569","https://openalex.org/W2013038209","https://openalex.org/W2016219312","https://openalex.org/W2016353211","https://openalex.org/W2017558835","https://openalex.org/W2018505166","https://openalex.org/W2019414147","https://openalex.org/W2019927236","https://openalex.org/W2020292310","https://openalex.org/W2021371448","https://openalex.org/W2023052504","https://openalex.org/W2023612095","https://openalex.org/W2025933554","https://openalex.org/W2028369954","https://openalex.org/W2030776545","https://openalex.org/W2031374454","https://openalex.org/W2032491383","https://openalex.org/W2033772867","https://openalex.org/W2034393061","https://openalex.org/W2036059538","https://openalex.org/W2036465840","https://openalex.org/W2036867429","https://openalex.org/W2037158294","https://openalex.org/W2044788795","https://openalex.org/W2045247659","https://openalex.org/W2047783153","https://openalex.org/W2048034690","https://openalex.org/W2049708133","https://openalex.org/W2049827480","https://openalex.org/W2050499474","https://openalex.org/W2053704719","https://openalex.org/W2054959330","https://openalex.org/W2056975585","https://openalex.org/W2057777597","https://openalex.org/W2058198715","https://openalex.org/W2058460635","https://openalex.org/W2058651524","https://openalex.org/W2058738080","https://openalex.org/W2061230824","https://openalex.org/W2062594120","https://openalex.org/W2063737523","https://openalex.org/W2064679863","https://openalex.org/W2064735092","https://openalex.org/W2064889529","https://openalex.org/W2065550467","https://openalex.org/W2065695519","https://openalex.org/W2065884286","https://openalex.org/W2066782344","https://openalex.org/W2071158029","https://openalex.org/W2071274045","https://openalex.org/W2071403652","https://openalex.org/W2072927676","https://openalex.org/W2072928113","https://openalex.org/W2074597198","https://openalex.org/W2074897148","https://openalex.org/W2074922229","https://openalex.org/W2076374640","https://openalex.org/W2076415360","https://openalex.org/W2078514067","https://openalex.org/W2081679138","https://openalex.org/W2087254547","https://openalex.org/W2088162492","https://openalex.org/W2088377055","https://openalex.org/W2091139028","https://openalex.org/W2091271697","https://openalex.org/W2093498435","https://openalex.org/W2094553007","https://openalex.org/W2094736888","https://openalex.org/W2096472145","https://openalex.org/W2097382995","https://openalex.org/W2100025529","https://openalex.org/W2102471433","https://openalex.org/W2102858324","https://openalex.org/W2104332007","https://openalex.org/W2108267334","https://openalex.org/W2108321829","https://openalex.org/W2110121929","https://openalex.org/W2110863171","https://openalex.org/W2111560717","https://openalex.org/W2111704421","https://openalex.org/W2112991269","https://openalex.org/W2114065426","https://openalex.org/W2115446927","https://openalex.org/W2118755827","https://openalex.org/W2120500721","https://openalex.org/W2120575866","https://openalex.org/W2121594719","https://openalex.org/W2122034269","https://openalex.org/W2122427986","https://openalex.org/W2125376011","https://openalex.org/W2127209890","https://openalex.org/W2129379317","https://openalex.org/W2131782272","https://openalex.org/W2132815577","https://openalex.org/W2135655283","https://openalex.org/W2137864150","https://openalex.org/W2138550913","https://openalex.org/W2143570029","https://openalex.org/W2145921809","https://openalex.org/W2146021659","https://openalex.org/W2146953551","https://openalex.org/W2147963008","https://openalex.org/W2149932234","https://openalex.org/W2150319482","https://openalex.org/W2151136341","https://openalex.org/W2152065691","https://openalex.org/W2154709093","https://openalex.org/W2157520030","https://openalex.org/W2159518379","https://openalex.org/W2166156136","https://openalex.org/W2166842157","https://openalex.org/W2167903736","https://openalex.org/W2170165234","https://openalex.org/W2171998177","https://openalex.org/W2221719760","https://openalex.org/W2237229964","https://openalex.org/W2250017028","https://openalex.org/W2286575733","https://openalex.org/W2320954279","https://openalex.org/W2355920171","https://openalex.org/W2385358747","https://openalex.org/W2390424400","https://openalex.org/W2395999467","https://openalex.org/W2398388611","https://openalex.org/W2398674094","https://openalex.org/W2400627415","https://openalex.org/W2403596471","https://openalex.org/W2415513317","https://openalex.org/W2431312353","https://openalex.org/W2460919980","https://openalex.org/W2600085134","https://openalex.org/W2993259418","https://openalex.org/W3146298412"],"related_works":["https://openalex.org/W1485795734","https://openalex.org/W2134728143","https://openalex.org/W1982662562","https://openalex.org/W7219436377","https://openalex.org/W2323936402","https://openalex.org/W2008043655","https://openalex.org/W1968679025","https://openalex.org/W2042459647","https://openalex.org/W2781055161","https://openalex.org/W2118755827"],"abstract_inverted_index":{"Nasal":[0],"polyposis":[1,47],"is":[2,111,220],"a":[3,63],"common":[4,85],"disease":[5],"affecting":[6],"2-4%":[7],"of":[8,25,33,43,87,100,115,118,134,161],"the":[9,41,54,71,75,84,103,116,141,151,170,179,189,194,199],"general":[10],"population.":[11],"The":[12,31],"aetiology":[13],"and":[14,39,48,97,106,215],"pathogenesis":[15,117],"are":[16,147,211],"far":[17,155],"from":[18],"clear.":[19],"Recent":[20],"publications":[21],"have":[22,203],"suggested":[23],"up-regulation":[24],"several":[26],"pro-angiogenic":[27],"factors":[28],"including":[29],"VEGF.":[30],"aim":[32],"this":[34,175],"study":[35],"was":[36,53,125],"to":[37,49,67,81],"assess":[38,68],"quantify":[40],"degree":[42],"angiogenesis":[44,52,88],"in":[45,70,136,188,198,213,217],"nasal":[46,72,119,137],"determine":[50],"if":[51],"driving":[55],"force":[56],"behind":[57],"polyposis.":[58,90],"We":[59,91,164,202],"started":[60],"by":[61,127],"developing":[62],"novel":[64],"triple":[65],"stain":[66],"remodelling":[69],"mucosa.":[73],"For":[74],"first":[76],"time":[77],"we":[78],"were":[79,186],"able":[80],"categorically":[82],"refute":[83],"belief":[86],"driven":[89],"then":[92],"carried":[93,165],"out":[94,166],"genomic":[95],"studies":[96,168],"identified":[98],"upregulation":[99],"genes":[101,146],"controlling":[102],"cell":[104,109,143],"cycle":[105],"apoptosis,":[107],"suggesting":[108],"turnover":[110],"an":[112,131],"important":[113],"part":[114],"polyps.":[120],"Our":[121],"gene":[122,190],"expression":[123],"data":[124,152],"confirmed":[126],"TUNEL":[128],"staining,":[129],"indicating":[130],"increased":[132,142],"level":[133],"apoptosis":[135],"polyp":[138],"tissue,":[139],"counterbalancing":[140],"proliferation.":[144],"Inflammatory":[145],"also":[148],"upregulated,":[149],"however":[150],"collected":[153],"so":[154],"cannot":[156],"distinguish":[157],"between":[158],"different":[159],"types":[160],"inflammatory":[162],"response.":[163],"proteomic":[167],"using":[169,182],"lu":[171],"minex":[172],"system":[173],"but":[174],"did":[176],"not":[177],"clarify":[178],"situation":[180],"despite":[181],"matched":[183],"samples":[184],"that":[185],"used":[187],"array.":[191],"They":[192],"highlight":[193],"protein":[195],"differences":[196],"occurring":[197],"polyps":[200],"themselves.":[201],"shown":[204],"chemoattractants":[205],"for":[206],"eosinophils":[207],"&":[208],"macrophages":[209],"(which":[210],"found":[212],"polyps),":[214],"significantly":[216],"iNOS,":[218],"which":[219],"novel.":[221],"\\n":[222]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}